An A13 repeat within the 3′-untranslated region of epidermal growth factor receptor (EGFR) is frequently mutated in microsatellite instability colon cancers and is associated with increased EGFR expression

Cancer Research

Volumn 69, Issue 19, 2009, Pages 7811-7818

  Ziqiang, Yuan ^a   Joongho, Shin ^a   Wilson, Andrew ^b   Goel, Sanjay ^b   Ling, Yi He ^b   Ahmed, Naseem ^b   Dopeso, Higinio ^c   Jhawer, Minaxi ^b   Nasser, Shannon ^b   Montagna, Cristina ^a   Fordyce, Kenneth ^d   Augenlicht, Leonard H ^b   Aaltonen, Lauri A ^e   Arango, Diego ^c   Weber, Thomas K ^a   Mariadason, John M ^b,f  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b MONTEFIORE MEDICAL CENTER   (United States)

^c Molecular Biology and Biochemistry Research Center (CIBBIM Nanomedicine)   (Spain)

^d IBM   (United States)

^e UNIVERSITY OF HELSINKI   (Finland)

^f LUDWIG INSTITUTE FOR CANCER RESEARCH   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

B RAF KINASE; CETUXIMAB; DACTINOMYCIN; EPIDERMAL GROWTH FACTOR RECEPTOR; MESSENGER RNA; PANITUMUMAB; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; RAS PROTEIN;

ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; CANCER CELL; CANCER CELL CULTURE; COLON CANCER; CONTROLLED STUDY; DOWNSTREAM PROCESSING; GENE IDENTIFICATION; GENE MUTATION; MICROSATELLITE INSTABILITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UNTRANSLATED REGION; WILD TYPE;

3' UNTRANSLATED REGIONS; ANIMALS; CELL LINE, TUMOR; COLONIC NEOPLASMS; GENE AMPLIFICATION; GENES, ERBB-1; HUMANS; MICE; MICE, SCID; MICROSATELLITE INSTABILITY; MUTATION; POLY A; RECEPTOR, EPIDERMAL GROWTH FACTOR; REPETITIVE SEQUENCES, NUCLEIC ACID; RIBONUCLEASE III; RNA, MESSENGER; SEQUENCE DELETION;

EID: 70350215709     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-09-0986     Document Type: Article

References (34)

1. Hegde SR, Sun W, Lynch JP. Systemic and targeted therapy for advanced colon cancer. Expert Rev Gastroenterol Hepatol 2008;2:135-149
2. Mendelsohn J, Baselga J. The EGF receptor family as targets for cancer therapy. Oncogene 2000;19:6550-6565 (Pubitemid 32197693)
3. Jorissen RN, Walker F, Pouliot N, Garrett TP, Ward CW, Burgess AW. Epidermal growth factor receptor: mechanisms of activation and signalling. Exp Cell Res 2003; 284:31-53. (Pubitemid 36331965)
4. Salomon DS, Brandt R, Ciardiello F, Normanno N. Epidermal growth factor-related peptides and their receptors in human malignancies. Crit Rev Oncol Hematol 1995;19:183-232.
5. Quesnelle KM, Boehm AL, Grandis JR. STAT-mediated EGFR signaling in cancer. J Cell Biochem 2007;102:311-319
6. McKay JA, Murray LJ, Curran S, et al. Evaluation of the epidermal growth factor receptor (EGFR) in colorectal tumours and lymph node metastases. Eur J Cancer 2002; 38:2258-2264 (Pubitemid 35346467)
7. Galizia G, Lieto E, Ferraraccio F, et al. Prognostic significance of epidermal growth factor receptor expression in colon cancer patients undergoing curative surgery. Ann Surg Oncol 2006;13:823-835 (Pubitemid 43727367)
8. Shia J, Klimstra DS, Li AR, et al. Epidermal growth factor receptor expression and gene amplification in colorectal carcinoma: an immunohistochemical and chromogenic in situ hybridization study. Mod Pathol 2005;18:1350-1356 (Pubitemid 41348654)
9. Galizia G, Lieto E, Orditura M, et al. Epidermal growth factor receptor (EGFR) expression is associated with a worse prognosis in gastric cancer patients undergoing curative surgery. World J Surg 2007;31:1458-1468 (Pubitemid 46945355)
10. Gebhardt F, Zanker KS, Brandt B. Modulation of epidermal growth factor receptor gene transcription by a polymorphic dinucleotide repeat in intron 1. J Biol Chem 1999;274:13176-13180 (Pubitemid 129518521)
11. Kinzler KW, Vogelstein B. Lessons from hereditary colorectal cancer. Cell 1996;87:159-170
12. Toyota M, Ahuja N, Ohe-Toyota M, Herman JG, Baylin SB, Issa JP. CpG island methylator phenotype in colorectal cancer. Proc Natl Acad Sci U S A 1999;96: 8681-8686 (Pubitemid 29354851)
13. Goel A, Nagasaka T, Arnold CN, et al. The CpG island methylator phenotype and chromosomal instability are inversely correlated in sporadic colorectal cancer. Gastroenterology 2007;132:127-138 (Pubitemid 46108731)
14. Kim H, Jen J, Vogelstein B, Hamilton SR. Clinical and pathological characteristics of sporadic colorectal carcinomas with DNA replication errors in microsatellite sequences. Am J Pathol 1994;145:148-156 (Pubitemid 24217493)
15. Samowitz WS, Curtin K, Ma KN, et al. Microsatellite instability in sporadic colon cancer is associated with an improved prognosis at the population level. Cancer Epidemiol Biomarkers Prev 2001;10:917-923 (Pubitemid 32844897)
16. Markowitz S. DNA repair defects inactivate tumor suppressor genes and induce hereditary and sporadic colon cancers. J Clin Oncol 2000;18:75-80S. (Pubitemid 30813116)
17. Ribic CM, Sargent DJ, Moore MJ, et al. Tumor microsatellite-instability status as a predictor of benefit from fluorouracil-based adjuvant chemotherapy for colon cancer. N Engl J Med 2003;349:247-257
18. Cunningham JM, Christensen ER, Tester DJ, et al. Hypermethylation of the hMLH1 promoter in colon cancer with microsatellite instability. Cancer Res 1998;58:3455-3460
19. Markowitz S, Wang J, Myeroff L, et al. Inactivation of the type II TGF-h receptor in colon cancer cells with microsatellite instability. Science 1995;268:1336-1338
20. Rampino N, Yamamoto H, Ionov Y, et al. Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype. Science 1997; 275:967-969 (Pubitemid 27087710)
21. Mariadason JM, Arango D, Shi Q, et al. Gene expression profiling-based prediction of response of colon carcinoma cells to 5-fluorouracil and camptothecin. Cancer Res 2003;63:8791-8812 (Pubitemid 38064059)
22. Cummins JM, He Y, Leary RJ, et al. The colorectal microRNAome. Proc Natl Acad Sci U S A 2006;103:3687-3692
23. Jhawer M, Goel S, Wilson AJ, et al. PIK3CA mutation/ PTEN expression status predicts response of colon cancer cells to the epidermal growth factor receptor inhibitor cetuximab. Cancer Res 2008;68:1953-1961
24. Luo FR, Yang Z, Dong H, et al. Correlation of pharmacokinetics with the antitumor activity of cetuximab in nude mice bearing the GEO human colon carcinoma xenograft. Cancer Chemother Pharmacol 2005;56:455-464 (Pubitemid 41549146)
25. Buisine MP, Wacrenier A, Mariette C, et al. Frequent mutations of the CA simple sequence repeat in intron 1 of EGFR in mismatch repair-deficient colorectal cancers. World J Gastroenterol 2008;14:1053-1059 (Pubitemid 351325005)
26. Balmer LA, Beveridge DJ, Jazayeri JA, Thomson AM, Walker CE, Leedman PJ. Identification of a novel AUrich element in the 3′ untranslated region of epidermal growth factor receptor mRNA that is the target for regulated RNA-binding proteins. Mol Cell Biol 2001;21: 2070-2084
27. Barreau C, Paillard L, Osborne HB. AU-rich elements and associated factors: are there unifying principles? Nucleic Acids Res 2005;33:7138-7150
28. Ruggiero T, Olivero M, Follenzi A, Naldini L, Calogero R, Di Renzo MF. Deletion in a (T)8 microsatellite abrogates expression regulation by 3′-UTR. Nucleic Acids Res 2003;31:6561-6569 (Pubitemid 37508761)
29. di Pietro M, Sabates Bellver J, Menigatti M, et al. Defective DNA mismatch repair determines a characteristic transcriptional profile in proximal colon cancers. Gastroenterology 2005;129:1047-1059 (Pubitemid 41242695)
30. Sammalkorpi H, Alhopuro P, Lehtonen R, et al. Background mutation frequency in microsatelliteunstable colorectal cancer. Cancer Res 2007;67:5691-5698 (Pubitemid 46985001)
31. Nagahara H, Mimori K, Ohta M, et al. Somatic mutations of epidermal growth factor receptor in colorectal carcinoma. Clin Cancer Res 2005;11:1368-1371 (Pubitemid 40315215)
32. Barber TD, Vogelstein B, Kinzler KW, Velculescu VE. Somatic mutations of EGFR in colorectal cancers and glioblastomas. N Engl J Med 2004;351:2883. (Pubitemid 40051921)
33. Paez JG, Janne PA, Lee JC, et al. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science 2004;304:1497-1500 (Pubitemid 38720929)
34. Weihua Z, Tsan R, Huang WC, et al. Survival of cancer cells is maintained by EGFR independent of its kinase activity. Cancer Cell 2008;13:385-393 (Pubitemid 351609444)