Nonstructural protein 1 (NS1)-mediated inhibition of c-Abl results in acute lung injury and priming for bacterial co-infections: Insights into 1918 H1N1 pandemic?

Journal of Infectious Diseases

Volumn 211, Issue 9, 2015, Pages 1418-1428

  Hrincius, Eike R ^a   Liedmann, Swantje ^c   Finkelstein, David ^a   Vogel, Peter ^a   Gansebom, Shane ^a   Ehrhardt, Christina ^c   Ludwig, Stephan ^c   Hains, David S ^b   Webby, Richard ^a   McCullers, Jonathan A ^a,b  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^c UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

Acute lung injury; Bacterial coinfections; c Abl; Influenza A virus; NS1 protein

Indexed keywords

ABELSON KINASE; NONSTRUCTURAL PROTEIN 1; BIOLOGICAL MARKER; INS1 PROTEIN, INFLUENZA VIRUS; VIRUS PROTEIN;

ACUTE LUNG INJURY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL PNEUMONIA; CONTROLLED STUDY; DOWN REGULATION; FEMALE; IMMUNE RESPONSE; INFLUENZA VIRUS A H1N1; LUNG EDEMA; MICROARRAY ANALYSIS; MIXED INFECTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SECONDARY INFECTION; STREPTOCOCCUS PNEUMONIA; TRANSCRIPTOMICS; VIRUS REPLICATION; VIRUS STRAIN; VIRUS VIRULENCE; ANIMAL; BACTERIAL INFECTIONS; COMPLICATION; GENETICS; HUMAN; LUNG; METABOLISM; ORTHOMYXOVIRUS INFECTION; PANDEMIC INFLUENZA; PATHOGENICITY; PATHOLOGY; VIROLOGY;

ACUTE LUNG INJURY; ANIMALS; BACTERIAL INFECTIONS; BIOLOGICAL MARKERS; HUMANS; INFLUENZA A VIRUS, H1N1 SUBTYPE; INFLUENZA PANDEMIC, 1918-1919; LUNG; MICE; ORTHOMYXOVIRIDAE INFECTIONS; PROTO-ONCOGENE PROTEINS C-ABL; VIRAL NONSTRUCTURAL PROTEINS;

EID: 84928902088     PISSN: 00221899     EISSN: 15376613     Source Type: Journal    
DOI: 10.1093/infdis/jiu609     Document Type: Article

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