메뉴 건너뛰기




Volumn 298, Issue , 2015, Pages 424-435

Butyrylcholinesterase-knockout reduces brain deposition of fibrillar β-amyloid in an Alzheimer mouse model

Author keywords

5XFAD mouse; Alzheimer's disease; Butyrylcholinesterase; Butyrylcholinesterase knockout; Cholinergic system; amyloid

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; CHOLINESTERASE; PRESENILIN 1; AMYLOID;

EID: 84928901691     PISSN: 03064522     EISSN: 18737544     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2015.04.039     Document Type: Article
Times cited : (116)

References (70)
  • 1
    • 77953124945 scopus 로고    scopus 로고
    • Gender-related differences in circadian rhythm of rat plasma acetyl- and butyrylcholinesterase: Effects of sex hormone withdrawal
    • Alves-Amaral G., Pires-Oliveira M., Andrade-Lopes A., Chiavegatti T., Godinho R.O. Gender-related differences in circadian rhythm of rat plasma acetyl- and butyrylcholinesterase: Effects of sex hormone withdrawal. Chem Biol Interact 2010, 186:9-15.
    • (2010) Chem Biol Interact , vol.186 , pp. 9-15
    • Alves-Amaral, G.1    Pires-Oliveira, M.2    Andrade-Lopes, A.3    Chiavegatti, T.4    Godinho, R.O.5
  • 2
    • 84897481309 scopus 로고    scopus 로고
    • Alzheimer's disease facts and figures
    • Alzheimer's Association Alzheimer's disease facts and figures. Alzheimer's Dement 2014, 10(2):e47-92.
    • (2014) Alzheimer's Dement , vol.10 , Issue.2 , pp. e47-92
  • 3
    • 0023248810 scopus 로고
    • Molecular forms of butyrylcholinesterase in the human neocortex during development and degeneration of the cortical cholinergic system
    • Atack J.R., Perry E.K., Bonham J.R., Candy J.M., Perry R.H. Molecular forms of butyrylcholinesterase in the human neocortex during development and degeneration of the cortical cholinergic system. J Neurochem 1987, 48:1687-1692.
    • (1987) J Neurochem , vol.48 , pp. 1687-1692
    • Atack, J.R.1    Perry, E.K.2    Bonham, J.R.3    Candy, J.M.4    Perry, R.H.5
  • 5
    • 0026695539 scopus 로고
    • DNA Mutation Associated with the Human Butyrylcholinesterase K-Variant and Its Linkage to the Atypical Variant Mutation and Other Polymorphic Sites
    • Bartels C.F., Jensen F.S., Lockridge O., van der Spek A.F.L., Rubinstein H.M., Lubrano T., La Du B.N. DNA Mutation Associated with the Human Butyrylcholinesterase K-Variant and Its Linkage to the Atypical Variant Mutation and Other Polymorphic Sites. Am J Hum Genet 1992, 50:1086-1103.
    • (1992) Am J Hum Genet , vol.50 , pp. 1086-1103
    • Bartels, C.F.1    Jensen, F.S.2    Lockridge, O.3    van der Spek, A.F.L.4    Rubinstein, H.M.5    Lubrano, T.6    La Du, B.N.7
  • 6
    • 0025645557 scopus 로고
    • Neurosteroids: a new brain function?
    • Baulieu E.E., Robel P. Neurosteroids: a new brain function?. J Steroid Biochem Mol Biol 1990, 37(3):395-403.
    • (1990) J Steroid Biochem Mol Biol , vol.37 , Issue.3 , pp. 395-403
    • Baulieu, E.E.1    Robel, P.2
  • 8
    • 0030780109 scopus 로고    scopus 로고
    • 17 beta-Estradiol enhances the outgrowth and survival of neocortical neurons in culture
    • Brinton R.D., Tran J., Proffitt P., Montoya M. 17 beta-Estradiol enhances the outgrowth and survival of neocortical neurons in culture. Neurochem Res 1997, 22(11):1339-1351.
    • (1997) Neurochem Res , vol.22 , Issue.11 , pp. 1339-1351
    • Brinton, R.D.1    Tran, J.2    Proffitt, P.3    Montoya, M.4
  • 10
    • 36849045250 scopus 로고    scopus 로고
    • Progesterone and estrogen regulate Alzheimer-like neuropathology in female 3xTg-AD mice
    • Carroll J.C., Rosario E.R., Chang L., Stanczyk F.Z., Oddo S., LaFerla F.M., Pike C.J. Progesterone and estrogen regulate Alzheimer-like neuropathology in female 3xTg-AD mice. J Neurosci 2007, 27(48):13357-13365.
    • (2007) J Neurosci , vol.27 , Issue.48 , pp. 13357-13365
    • Carroll, J.C.1    Rosario, E.R.2    Chang, L.3    Stanczyk, F.Z.4    Oddo, S.5    LaFerla, F.M.6    Pike, C.J.7
  • 13
    • 3242682466 scopus 로고    scopus 로고
    • The biphasic relationship between regional brain senile plaque and neurofibrillary tangle distributions: modification by age, sex, and APOE polymorphism
    • Corder E.H., Ghebremedhin E., Taylor M.G., Thal D.R., Ohm T.G., Braak H. The biphasic relationship between regional brain senile plaque and neurofibrillary tangle distributions: modification by age, sex, and APOE polymorphism. Ann N Y Acad Sci 2004, 1019:24-28.
    • (2004) Ann N Y Acad Sci , vol.1019 , pp. 24-28
    • Corder, E.H.1    Ghebremedhin, E.2    Taylor, M.G.3    Thal, D.R.4    Ohm, T.G.5    Braak, H.6
  • 15
    • 78549293899 scopus 로고    scopus 로고
    • Biochemical and histochemical comparison of cholinesterases in normal and Alzheimer brain tissues
    • Darvesh S., Reid G.A., Martin E. Biochemical and histochemical comparison of cholinesterases in normal and Alzheimer brain tissues. Curr Alzheimer Res 2010, 7:386-400.
    • (2010) Curr Alzheimer Res , vol.7 , pp. 386-400
    • Darvesh, S.1    Reid, G.A.2    Martin, E.3
  • 16
    • 84655161993 scopus 로고    scopus 로고
    • Butyrylcholinesterase, β-amyloid and Thioflavin-S Plaques in the Transgenic APPSWE/PSEN1dE9 mouse Model of Alzheimer's Disease
    • Darvesh S., Cash M.K., Reid G.A., Martin E., Mitniski A., Geula C. Butyrylcholinesterase, β-amyloid and Thioflavin-S Plaques in the Transgenic APPSWE/PSEN1dE9 mouse Model of Alzheimer's Disease. J Neuropathol Exp Neurol 2012, 71(1):2-14.
    • (2012) J Neuropathol Exp Neurol , vol.71 , Issue.1 , pp. 2-14
    • Darvesh, S.1    Cash, M.K.2    Reid, G.A.3    Martin, E.4    Mitniski, A.5    Geula, C.6
  • 19
    • 34047106626 scopus 로고    scopus 로고
    • Sensitivity of butyrylcholinesterase knockout mice to (-)-huperzine A and donepezil suggests humans with butyrylcholinesterase deficiency may not tolerate these Alzheimer's disease drugs and indicates butyrylcholinesterase function in neurotransmission
    • Duysen E.G., Li B., Darvesh S., Lockridge O. Sensitivity of butyrylcholinesterase knockout mice to (-)-huperzine A and donepezil suggests humans with butyrylcholinesterase deficiency may not tolerate these Alzheimer's disease drugs and indicates butyrylcholinesterase function in neurotransmission. Toxicology 2007, 233(1-3):60-69.
    • (2007) Toxicology , vol.233 , Issue.1-3 , pp. 60-69
    • Duysen, E.G.1    Li, B.2    Darvesh, S.3    Lockridge, O.4
  • 20
    • 0041883787 scopus 로고    scopus 로고
    • Preliminary evidence that estrogen protects against age-related hippocampal atrophy
    • Eberling J.L., Wu C., Haan M.N., Mungas D., Buonocore M., Jagust W.J. Preliminary evidence that estrogen protects against age-related hippocampal atrophy. Neurobiol Aging 2003, 24(5):725-732.
    • (2003) Neurobiol Aging , vol.24 , Issue.5 , pp. 725-732
    • Eberling, J.L.1    Wu, C.2    Haan, M.N.3    Mungas, D.4    Buonocore, M.5    Jagust, W.J.6
  • 21
    • 0020536866 scopus 로고
    • Effects of hypophysectomy on acetylcholinesterase and butyrylcholinesterase in the rat
    • Edwards J.A., Brimijoin S. Effects of hypophysectomy on acetylcholinesterase and butyrylcholinesterase in the rat. Biochem Pharmacol 1983, 32(7):1183-1189.
    • (1983) Biochem Pharmacol , vol.32 , Issue.7 , pp. 1183-1189
    • Edwards, J.A.1    Brimijoin, S.2
  • 22
    • 0029164755 scopus 로고
    • Cholinesterases and the pathology of Alzheimer disease
    • Geula C., Mesulam M.M. Cholinesterases and the pathology of Alzheimer disease. Alzheimer Dis Assoc Disord 1995, 2:23-28.
    • (1995) Alzheimer Dis Assoc Disord , vol.2 , pp. 23-28
    • Geula, C.1    Mesulam, M.M.2
  • 23
    • 0024417125 scopus 로고
    • Special properties of cholinesterases in the cerebral cortex of Alzheimer's disease
    • Geula C., Mesulam M.M. Special properties of cholinesterases in the cerebral cortex of Alzheimer's disease. Brain Res 1989, 498:185-189.
    • (1989) Brain Res , vol.498 , pp. 185-189
    • Geula, C.1    Mesulam, M.M.2
  • 25
    • 0028607581 scopus 로고
    • Estrogen and nerve growth factor-related systems in brain. Effects on basal forebrain cholinergic neurons and implications for learning and memory processes and aging
    • Gibbs R.B. Estrogen and nerve growth factor-related systems in brain. Effects on basal forebrain cholinergic neurons and implications for learning and memory processes and aging. Ann N Y Acad Sci 1994, 743:156-196.
    • (1994) Ann N Y Acad Sci , vol.743 , pp. 156-196
    • Gibbs, R.B.1
  • 26
    • 77952908171 scopus 로고    scopus 로고
    • Estrogen therapy and cognition: a review of the cholinergic hypothesis
    • Gibbs R.B. Estrogen therapy and cognition: a review of the cholinergic hypothesis. Endocr Rev 2010, 31(2):224-253.
    • (2010) Endocr Rev , vol.31 , Issue.2 , pp. 224-253
    • Gibbs, R.B.1
  • 28
    • 61449122720 scopus 로고    scopus 로고
    • Butyrylcholinesterase, the Cinderella cholinesterase, as a drug target for Alzheimer's disease and related dementias.
    • Kerala, India: Transworld Research Network.
    • Greig NH, Yu Q-S, Brossi A, Martin E, Lahiri DK Darvesh S (2008). Butyrylcholinesterase, the Cinderella cholinesterase, as a drug target for Alzheimer's disease and related dementias. In: Medicinal chemistry of Alzheimer's disease, (Gil AM ed.), pp. 79-109 Kerala, India: Transworld Research Network.
    • (2008) Medicinal chemistry of Alzheimer's disease, (Gil AM ed.) , pp. 79-109
    • Greig, N.H.1    Yu, Q.-S.2    Brossi, A.3    Martin, E.4    Lahiri, D.K.5    Darvesh, S.6
  • 30
    • 0031458235 scopus 로고    scopus 로고
    • Butyrylcholinesterase in the life cycle of amyloid plaques
    • Guillozet A.L., Smiley J.F., Mash D.C., Mesulam M.M. Butyrylcholinesterase in the life cycle of amyloid plaques. Ann Neurol 1997, 42:909-918.
    • (1997) Ann Neurol , vol.42 , pp. 909-918
    • Guillozet, A.L.1    Smiley, J.F.2    Mash, D.C.3    Mesulam, M.M.4
  • 31
    • 0028053251 scopus 로고
    • Cognitive deficits of men and women with Alzheimer's disease
    • Henderson V.W., Buckwalter J.G. Cognitive deficits of men and women with Alzheimer's disease. Neurology 1994, 44:90-96.
    • (1994) Neurology , vol.44 , pp. 90-96
    • Henderson, V.W.1    Buckwalter, J.G.2
  • 32
    • 0032568899 scopus 로고    scopus 로고
    • Butyrylcholinesterase K variant and apolipoprotein E4 genes do not act in synergy in Finnish late-onset Alzheimer's disease patients
    • Hiltunen M., Mannermaa A., Helisalmi S., Koivisto A., Lehtovirta M., Ryynänen M., Riekkinen P.S., Soininen H. Butyrylcholinesterase K variant and apolipoprotein E4 genes do not act in synergy in Finnish late-onset Alzheimer's disease patients. Neurosci Lett 1998, 250(1):69-71.
    • (1998) Neurosci Lett , vol.250 , Issue.1 , pp. 69-71
    • Hiltunen, M.1    Mannermaa, A.2    Helisalmi, S.3    Koivisto, A.4    Lehtovirta, M.5    Ryynänen, M.6    Riekkinen, P.S.7    Soininen, H.8
  • 35
    • 0019824766 scopus 로고
    • Endocrine regulation of rat serum cholinesterase activity
    • Illsley N.P., Lamartiniere C.A. Endocrine regulation of rat serum cholinesterase activity. Endocrinology 1981, 108(5):1737-1743.
    • (1981) Endocrinology , vol.108 , Issue.5 , pp. 1737-1743
    • Illsley, N.P.1    Lamartiniere, C.A.2
  • 36
    • 84868666775 scopus 로고    scopus 로고
    • Greater cognitive deterioration in women than men with Alzheimer's disease: a meta analysis
    • Irvine K., Laws K.R., Gale T.M., Kondel T.K. Greater cognitive deterioration in women than men with Alzheimer's disease: a meta analysis. J Clin Exp Neuropsychol 2012, 34(9):989-998.
    • (2012) J Clin Exp Neuropsychol , vol.34 , Issue.9 , pp. 989-998
    • Irvine, K.1    Laws, K.R.2    Gale, T.M.3    Kondel, T.K.4
  • 37
    • 78651153462 scopus 로고
    • "Direct-coloring" thiocholine method for cholinesterases
    • Karnovsky M.J., Roots L.A. "Direct-coloring" thiocholine method for cholinesterases. J Histochem Cytochem 1964, 12:219-221.
    • (1964) J Histochem Cytochem , vol.12 , pp. 219-221
    • Karnovsky, M.J.1    Roots, L.A.2
  • 39
    • 0033574377 scopus 로고    scopus 로고
    • No association between the genes for butyrylcholinesterase K variant and apolipoprotein E4 in late-onset Alzheimer's disease
    • Ki C.-S., Na D.L., Kim J.-W., Kim H.J., Kim D.K., Yoon B.-K. No association between the genes for butyrylcholinesterase K variant and apolipoprotein E4 in late-onset Alzheimer's disease. Am J Med Genet 1999, 88:113-115.
    • (1999) Am J Med Genet , vol.88 , pp. 113-115
    • Ki, C.-S.1    Na, D.L.2    Kim, J.-W.3    Kim, H.J.4    Kim, D.K.5    Yoon, B.-K.6
  • 40
    • 0034018129 scopus 로고    scopus 로고
    • Association of butyrylcholinesterase K variant with cholinesterase-positive neuritic plaques in the temporal cortex in late-onset Alzheimer's disease
    • Lehmann D.J., Nagy Z., Litchfield S., Borja C., Smith A.D. Association of butyrylcholinesterase K variant with cholinesterase-positive neuritic plaques in the temporal cortex in late-onset Alzheimer's disease. Hum Genet 2000, 106:447-452.
    • (2000) Hum Genet , vol.106 , pp. 447-452
    • Lehmann, D.J.1    Nagy, Z.2    Litchfield, S.3    Borja, C.4    Smith, A.D.5
  • 41
    • 0035237706 scopus 로고    scopus 로고
    • Using meta-analysis to explain the diversity of results in genetic studies of late-onset Alzheimer's disease and to identify high-risk subgroups
    • Lehmann D.J., Williams J., Mcbroomc J., Smith A.D. Using meta-analysis to explain the diversity of results in genetic studies of late-onset Alzheimer's disease and to identify high-risk subgroups. Neuroscience 2001, 108:541-554.
    • (2001) Neuroscience , vol.108 , pp. 541-554
    • Lehmann, D.J.1    Williams, J.2    Mcbroomc, J.3    Smith, A.D.4
  • 42
    • 33845917988 scopus 로고    scopus 로고
    • Production of the butyrylcholinesterase knockout mouse
    • Li B., Duysen E.G., Saunders T.L., Lockridge O. Production of the butyrylcholinesterase knockout mouse. J Mol Neurosci 2006, 30(1-2):193-195.
    • (2006) J Mol Neurosci , vol.30 , Issue.1-2 , pp. 193-195
    • Li, B.1    Duysen, E.G.2    Saunders, T.L.3    Lockridge, O.4
  • 43
    • 40849102715 scopus 로고    scopus 로고
    • The butyrylcholinesterase knockout mouse as a model for human butyrylcholinesterase deficiency
    • Li B., Duysen E.G., Carlson M., Lockridge O. The butyrylcholinesterase knockout mouse as a model for human butyrylcholinesterase deficiency. J Pharmacol Exp Ther 2008, 324(3):1146-1154.
    • (2008) J Pharmacol Exp Ther , vol.324 , Issue.3 , pp. 1146-1154
    • Li, B.1    Duysen, E.G.2    Carlson, M.3    Lockridge, O.4
  • 44
    • 84903775420 scopus 로고    scopus 로고
    • Sex differences in cognitive impairment and Alzheimer's disease
    • Li R., Singh M. Sex differences in cognitive impairment and Alzheimer's disease. Front Neuroendocrinol 2014, 35(3):385-403.
    • (2014) Front Neuroendocrinol , vol.35 , Issue.3 , pp. 385-403
    • Li, R.1    Singh, M.2
  • 46
    • 0028239638 scopus 로고
    • Neurotrophic effects of testosterone on the medial nucleus of the amygdala in adult male rats
    • Malsbury C.W., McKay K. Neurotrophic effects of testosterone on the medial nucleus of the amygdala in adult male rats. J Neuroendocrinol 1994, 6(1):57-69.
    • (1994) J Neuroendocrinol , vol.6 , Issue.1 , pp. 57-69
    • Malsbury, C.W.1    McKay, K.2
  • 47
    • 84879829589 scopus 로고    scopus 로고
    • Biochemistry of amyloid β-protein and amyloid deposits in Alzheimer disease
    • Masters C.L., Selkoe D.J. Biochemistry of amyloid β-protein and amyloid deposits in Alzheimer disease. Cold Spring Harb Perspect Med 2012, 10.1101/cshperspect.a006262.
    • (2012) Cold Spring Harb Perspect Med
    • Masters, C.L.1    Selkoe, D.J.2
  • 49
    • 0036183539 scopus 로고    scopus 로고
    • Widely spread butyrylcholinesterase can hydrolyze acetylcholine in the normal and Alzheimer brain
    • Mesulam M.M., Guillozet A., Shaw P., Quinn B. Widely spread butyrylcholinesterase can hydrolyze acetylcholine in the normal and Alzheimer brain. Neurobiol Dis 2002, 9(1):88-93.
    • (2002) Neurobiol Dis , vol.9 , Issue.1 , pp. 88-93
    • Mesulam, M.M.1    Guillozet, A.2    Shaw, P.3    Quinn, B.4
  • 50
    • 0027973241 scopus 로고
    • Butyrylcholinesterase reactivity differentiates the amyloid plaques of aging from those of dementia
    • Mesulam M.M., Geula C. Butyrylcholinesterase reactivity differentiates the amyloid plaques of aging from those of dementia. Ann Neurol 1994, 36:722-727.
    • (1994) Ann Neurol , vol.36 , pp. 722-727
    • Mesulam, M.M.1    Geula, C.2
  • 51
    • 84892174473 scopus 로고    scopus 로고
    • Clinical epidemiology of Alzheimer's disease: assessing sex and gender differences
    • Mielke M.M., Vemuri P., Rocca W.A. Clinical epidemiology of Alzheimer's disease: assessing sex and gender differences. Clin Epidemiol 2014, 6:37-48.
    • (2014) Clin Epidemiol , vol.6 , pp. 37-48
    • Mielke, M.M.1    Vemuri, P.2    Rocca, W.A.3
  • 52
    • 51149217948 scopus 로고
    • Plasma cholinesterase in male and female rats
    • Mundell D.B. Plasma cholinesterase in male and female rats. Nature 1944, 3888(153):557-558.
    • (1944) Nature , vol.3888 , Issue.153 , pp. 557-558
    • Mundell, D.B.1
  • 53
    • 0038408676 scopus 로고    scopus 로고
    • Regulation of attention and response to therapy in dementia by butyrylcholinesterase
    • O'Brien K.K., Saxby B.K., Ballard C.G., et al. Regulation of attention and response to therapy in dementia by butyrylcholinesterase. Pharmacogenetics 2003, 13:231-239.
    • (2003) Pharmacogenetics , vol.13 , pp. 231-239
    • O'Brien, K.K.1    Saxby, B.K.2    Ballard, C.G.3
  • 54
    • 33749521100 scopus 로고    scopus 로고
    • Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation
    • Oakley H., Cole S.L., Logan S., Maus E., Shao P., Craft J., Guillozet-Bongaarts A., Ohno M., Disterhoft J., Van Eldik L., Berry R., Vassar R. Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation. J Neurosci 2006, 26:10129-10140.
    • (2006) J Neurosci , vol.26 , pp. 10129-10140
    • Oakley, H.1    Cole, S.L.2    Logan, S.3    Maus, E.4    Shao, P.5    Craft, J.6    Guillozet-Bongaarts, A.7    Ohno, M.8    Disterhoft, J.9    Van Eldik, L.10    Berry, R.11    Vassar, R.12
  • 59
    • 77957982982 scopus 로고    scopus 로고
    • Testosterone regulation of Alzheimer-like neuropathology in male 3xTg-AD mice involves both estrogen and androgen pathways
    • Rosario E.R., Carroll J., Pike C.J. Testosterone regulation of Alzheimer-like neuropathology in male 3xTg-AD mice involves both estrogen and androgen pathways. Brain Res 2010, 1359:281-290.
    • (2010) Brain Res , vol.1359 , pp. 281-290
    • Rosario, E.R.1    Carroll, J.2    Pike, C.J.3
  • 61
    • 0031467629 scopus 로고    scopus 로고
    • Lifetime risk of dementia and Alzheimer's disease. The impact of mortality on risk estimates in the Framingham study
    • Seshadri S., Wolf P.A., Beiser A., Au R., McNulty K., White R., D'Agostino R.B. Lifetime risk of dementia and Alzheimer's disease. The impact of mortality on risk estimates in the Framingham study. Neurology 1997, 49(6):1498-1504.
    • (1997) Neurology , vol.49 , Issue.6 , pp. 1498-1504
    • Seshadri, S.1    Wolf, P.A.2    Beiser, A.3    Au, R.4    McNulty, K.5    White, R.6    D'Agostino, R.B.7
  • 64
    • 84898612025 scopus 로고    scopus 로고
    • Characterization of aromatase expression in the adult male and female mouse brain. I. Coexistence with oestrogen receptors α and β, and androgen receptors
    • Stanić D., Dubois S., Chua H.K., Tonge B., Rinehart N., Horne M.K., Boon W.C. Characterization of aromatase expression in the adult male and female mouse brain. I. Coexistence with oestrogen receptors α and β, and androgen receptors. PLoS One 2014, 9(3):e90451.
    • (2014) PLoS One , vol.9 , Issue.3 , pp. e90451
    • Stanić, D.1    Dubois, S.2    Chua, H.K.3    Tonge, B.4    Rinehart, N.5    Horne, M.K.6    Boon, W.C.7
  • 66
  • 67
    • 84872841524 scopus 로고    scopus 로고
    • Gender, sex steroid hormones, and Alzheimer's disease
    • Vest R.S., Pike C.J. Gender, sex steroid hormones, and Alzheimer's disease. Horm Behav 2013, 63:301-307.
    • (2013) Horm Behav , vol.63 , pp. 301-307
    • Vest, R.S.1    Pike, C.J.2
  • 68
    • 0033020325 scopus 로고    scopus 로고
    • Further evidence for a synergistic association between APOEe4 and BCHE-K in confirmed Alzheimer's disease
    • Wiebusch H., Poirier J., Sévigny P., Schappert K. Further evidence for a synergistic association between APOEe4 and BCHE-K in confirmed Alzheimer's disease. Hum Genet 1999, 104:158-163.
    • (1999) Hum Genet , vol.104 , pp. 158-163
    • Wiebusch, H.1    Poirier, J.2    Sévigny, P.3    Schappert, K.4
  • 69
    • 84888136272 scopus 로고    scopus 로고
    • Estrogen associated gene polymorphisms and their interactions in the progress of Alzheimer's disease
    • Xing Y., Jia J.P., Ji X.J., Tian T. Estrogen associated gene polymorphisms and their interactions in the progress of Alzheimer's disease. Prog Neurobiol 2013, 111:53-74.
    • (2013) Prog Neurobiol , vol.111 , pp. 53-74
    • Xing, Y.1    Jia, J.P.2    Ji, X.J.3    Tian, T.4
  • 70
    • 0033043013 scopus 로고    scopus 로고
    • Failure to confirm a synergistic effect between the K-variant of the butyrylcholinesterase gene and the e4 allele of the apolipoprotein gene in Japanese patients with Alzheimer's disease
    • Yamamoto Y., Yasuda M., Mori E., Maeda K. Failure to confirm a synergistic effect between the K-variant of the butyrylcholinesterase gene and the e4 allele of the apolipoprotein gene in Japanese patients with Alzheimer's disease. J Neurol Neurosurg Psychiatry 1999, 67:94-96.
    • (1999) J Neurol Neurosurg Psychiatry , vol.67 , pp. 94-96
    • Yamamoto, Y.1    Yasuda, M.2    Mori, E.3    Maeda, K.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.