-
1
-
-
80052266213
-
The amyloid cascade hypothesis for Alzheimer's disease: An appraisal for the development of therapeutics
-
Karran E, Mercken M, De Strooper B. The amyloid cascade hypothesis for Alzheimer's disease: An appraisal for the development of therapeutics. Nat Rev Drug Discov 2011; 10: 698-712
-
(2011)
Nat Rev Drug Discov
, Issue.10
, pp. 698-712
-
-
Karran, E.1
Mercken, M.2
De Strooper, B.3
-
2
-
-
84860215480
-
Correlation of Alzheimer disease neuropathologic changes with cognitive status: A review of the literature
-
Nelson PT, Alafuzoff I, Bigio EH, Bouras C, Braak H, Cairns NJ et al. Correlation of Alzheimer disease neuropathologic changes with cognitive status: A review of the literature. J Neuropathol Exp Neurol 2012; 71: 362-381
-
(2012)
J Neuropathol Exp Neurol
, Issue.71
, pp. 362-381
-
-
Nelson, P.T.1
Alafuzoff, I.2
Bigio, E.H.3
Bouras, C.4
Braak, H.5
Cairns, N.J.6
-
3
-
-
33646392455
-
Neuropathologic features of amnestic mild cognitive impairment
-
Petersen RC, Parisi JE, Dickson DW, Johnson KA, Knopman DS, Boeve BF et al. Neuropathologic features of amnestic mild cognitive impairment. Arch Neurol 2006; 63: 665-672
-
(2006)
Arch Neurol
, vol.63
, pp. 665-672
-
-
Petersen, R.C.1
Parisi, J.E.2
Dickson, D.W.3
Johnson, K.A.4
Knopman, D.S.5
Boeve, B.F.6
-
4
-
-
33745876233
-
Neuropathology of older persons without cognitive impairment from two community- based studies
-
Bennett DA, Schneider JA, Arvanitakis Z, Kelly JF, Aggarwal NT, Shah RC et al. Neuropathology of older persons without cognitive impairment from two community- based studies. Neurology 2006; 66: 1837-1844
-
(2006)
Neurology
, vol.66
, pp. 1837-1844
-
-
Bennett, D.A.1
Schneider, J.A.2
Arvanitakis, Z.3
Kelly, J.F.4
Aggarwal, N.T.5
Shah, R.C.6
-
5
-
-
75149138378
-
The pursuit of susceptibility genes for Alzheimer's disease: Progress and prospects
-
Sleegers K, Lambert JC, Bertram L, Cruts M, Amouyel P, Van Broeckhoven C. The pursuit of susceptibility genes for Alzheimer's disease: Progress and prospects. Trends Genet 2010; 26: 84-93
-
(2010)
Trends Genet
, Issue.26
, pp. 84-93
-
-
Sleegers, K.1
Lambert, J.C.2
Bertram, L.3
Cruts, M.4
Amouyel, P.5
Van Broeckhoven, C.6
-
6
-
-
79956098248
-
Toward defining the preclinical stages of Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
-
Sperling RA, Aisen PS, Beckett LA, Bennett DA, Craft S, Fagan AM et al. Toward defining the preclinical stages of Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement 2011; 7: 280-292
-
(2011)
Alzheimers Dement
, Issue.7
, pp. 280-292
-
-
Sperling, R.A.1
Aisen, P.S.2
Beckett, L.A.3
Bennett, D.A.4
Craft, S.5
Fagan, A.M.6
-
7
-
-
0027194791
-
Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families
-
Corder EH, Saunders AM, Strittmatter WJ, Schmechel DE, Gaskell PC, Small GW et al. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science 1993; 261: 921-923
-
(1993)
Science
, vol.261
, pp. 921-923
-
-
Corder, E.H.1
Saunders, A.M.2
Strittmatter, W.J.3
Schmechel, D.E.4
Gaskell, P.C.5
Small, G.W.6
-
8
-
-
68249134074
-
The role of apolipoprotein E in Alzheimer's disease
-
Kim J, Basak JM, Holtzman DM. The role of apolipoprotein E in Alzheimer's disease. Neuron 2009; 63: 287-303
-
(2009)
Neuron
, vol.63
, pp. 287-303
-
-
Kim, J.1
Basak, J.M.2
Holtzman, D.M.3
-
9
-
-
84871239563
-
From alois to amyvid: Seeing Alzheimer disease
-
Furst AJ, Kerchner GA. From alois to amyvid: Seeing Alzheimer disease. Neurology 2012; 79: 1628-1629
-
(2012)
Neurology
, Issue.79
, pp. 1628-1629
-
-
Furst, A.J.1
Kerchner, G.A.2
-
10
-
-
78751546481
-
Use of florbetapir-PET for imaging beta-Amyloid pathology
-
Clark CM, Schneider JA, Bedell BJ, Beach TG, Bilker WB, Mintun MA et al. Use of florbetapir-PET for imaging beta-Amyloid pathology. JAMA 2011; 305: 275-283
-
(2011)
JAMA
, Issue.305
, pp. 275-283
-
-
Clark, C.M.1
Schneider, J.A.2
Bedell, B.J.3
Beach, T.G.4
Bilker, W.B.5
Mintun, M.A.6
-
11
-
-
84863869296
-
Cerebral PET with florbetapir compared with neuropathology at autopsy for detection of neuritic amyloid-b plaques: A prospective cohort study
-
Clark CM, Pontecorvo MJ, Beach TG, Bedell BJ, Coleman RE, Doraiswamy PM et al. Cerebral PET with florbetapir compared with neuropathology at autopsy for detection of neuritic amyloid-b plaques: A prospective cohort study. Lancet Neurol 2012; 11: 669-678
-
(2012)
Lancet Neurol
, Issue.11
, pp. 669-678
-
-
Clark, C.M.1
Pontecorvo, M.J.2
Beach, T.G.3
Bedell, B.J.4
Coleman, R.E.5
Doraiswamy, P.M.6
-
12
-
-
77955474351
-
The Alzheimer's disease neuroimaging initiative: Progress report and future plans
-
e207
-
Weiner MW, Aisen PS, Jack Jr. CR, Jagust WJ, Trojanowski JQ, Shaw L et al. The Alzheimer's disease neuroimaging initiative: Progress report and future plans. Alzheimers Dement 2010; 6: 202-211 e207
-
(2010)
Alzheimers Dement
, Issue.6
, pp. 202-211
-
-
Weiner, M.W.1
Aisen, P.S.2
Jack Jr., C.R.3
Jagust, W.J.4
Trojanowski, J.Q.5
Shaw, L.6
-
13
-
-
77955474542
-
The Alzheimer's disease neuroimaging initiative positron emission tomography core
-
Jagust WJ, Bandy D, Chen K, Foster NL, Landau SM, Mathis CA et al. The Alzheimer's disease neuroimaging initiative positron emission tomography core. Alzheimers Dement 2010; 6: 221-229
-
(2010)
Alzheimers Dement
, Issue.6
, pp. 221-229
-
-
Jagust, W.J.1
Bandy, D.2
Chen, K.3
Foster, N.L.4
Landau, S.M.5
Mathis, C.A.6
-
14
-
-
77954021537
-
Alzheimer's disease neuroimaging initiative biomarkers as quantitative phenotypes: Genetics core aims, progress, and plans
-
Saykin AJ, Shen L, Foroud TM, Potkin SG, Swaminathan S, Kim S et al. Alzheimer's disease neuroimaging initiative biomarkers as quantitative phenotypes: Genetics core aims, progress, and plans. Alzheimers Dement 2010; 6: 265-273
-
(2010)
Alzheimers Dement
, Issue.6
, pp. 265-273
-
-
Saykin, A.J.1
Shen, L.2
Foroud, T.M.3
Potkin, S.G.4
Swaminathan, S.5
Kim, S.6
-
15
-
-
34548292504
-
PLINK: A tool set for whole-genome association and population-based linkage analyses
-
Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, Bender D et al. PLINK: A tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 2007; 81: 559-575
-
(2007)
Am J Hum Genet
, vol.81
, pp. 559-575
-
-
Purcell, S.1
Neale, B.2
Todd-Brown, K.3
Thomas, L.4
Ferreira, M.A.5
Bender, D.6
-
16
-
-
84864417548
-
Fast and accurate genotype imputation in genome-wide association studies through pre-phasing
-
Howie B, Fuchsberger C, Stephens M, Marchini J, Abecasis GR. Fast and accurate genotype imputation in genome-wide association studies through pre-phasing. Nat Genet 2012; 44: 955-959
-
(2012)
Nat Genet
, Issue.44
, pp. 955-959
-
-
Howie, B.1
Fuchsberger, C.2
Stephens, M.3
Marchini, J.4
Abecasis, G.R.5
-
17
-
-
84860351742
-
Identification of common variants associated with human hippocampal and intracranial volumes
-
Stein JL, Medland SE, Vasquez AA, Hibar DP, Senstad RE, Winkler AM et al. Identification of common variants associated with human hippocampal and intracranial volumes. Nat Genet 2012; 44: 552-561
-
(2012)
Nat Genet
, Issue.44
, pp. 552-561
-
-
Stein, J.L.1
Medland, S.E.2
Vasquez, A.A.3
Hibar, D.P.4
Senstad, R.E.5
Winkler, A.M.6
-
18
-
-
43249125992
-
Estimation of the multiple testing burden for genomewide association studies of nearly all common variants
-
Péer I, Yelensky R, Altshuler D, Daly MJ. Estimation of the multiple testing burden for genomewide association studies of nearly all common variants. Genet Epidemiol 2008; 32: 381-385
-
(2008)
Genet Epidemiol
, vol.32
, pp. 381-385
-
-
Péer, I.1
Yelensky, R.2
Altshuler, D.3
Daly, M.J.4
-
19
-
-
13444269543
-
Haploview: Analysis and visualization of LD and haplotype maps
-
Barrett JC, Fry B, Maller J, Daly MJ. Haploview: Analysis and visualization of LD and haplotype maps. Bioinformatics 2005; 21: 263-265
-
(2005)
Bioinformatics
, vol.21
, pp. 263-265
-
-
Barrett, J.C.1
Fry, B.2
Maller, J.3
Daly, M.J.4
-
20
-
-
57249114505
-
SNAP: A web-based tool for identification and annotation of proxy SNPs using HapMap
-
Johnson AD, Handsaker RE, Pulit SL, Nizzari MM, O'Donnell CJ, de Bakker PI. SNAP: A web-based tool for identification and annotation of proxy SNPs using HapMap. Bioinformatics 2008; 24: 2938-2939
-
(2008)
Bioinformatics
, vol.24
, pp. 2938-2939
-
-
Johnson, A.D.1
Handsaker, R.E.2
Pulit, S.L.3
Nizzari, M.M.4
O'Donnell, C.J.5
De Bakker, P.I.6
-
21
-
-
79958226299
-
Clinical practice. Mild cognitive impairment
-
Petersen RC. Clinical practice. Mild cognitive impairment. N Engl J Med 2011; 364: 2227-2234
-
(2011)
N Engl J Med
, Issue.364
, pp. 2227-2234
-
-
Petersen, R.C.1
-
22
-
-
68449101567
-
Genome-wide strategies for discovering genetic influences on cognition and cognitive disorders: Methodological considerations
-
Potkin SG, Turner JA, Guffanti G, Lakatos A, Torri F, Keator DB et al. Genome-wide strategies for discovering genetic influences on cognition and cognitive disorders: Methodological considerations. Cogn Neuropsychiatry 2009; 14: 391-418
-
(2009)
Cogn Neuropsychiatry
, vol.14
, pp. 391-418
-
-
Potkin, S.G.1
Turner, J.A.2
Guffanti, G.3
Lakatos, A.4
Torri, F.5
Keator, D.B.6
-
23
-
-
77955664334
-
Endophenotype: A conceptual analysis
-
Kendler KS, Neale MC. Endophenotype: A conceptual analysis. Mol Psychiatry 2010; 15: 789-797
-
(2010)
Mol Psychiatry
, Issue.15
, pp. 789-797
-
-
Kendler, K.S.1
Neale, M.C.2
-
24
-
-
79959772357
-
Human apoE isoforms differentially regulate brain amyloid-beta peptide clearance
-
Castellano JM, Kim J, Stewart FR, Jiang H, DeMattos RB, Patterson BW et al. Human apoE isoforms differentially regulate brain amyloid-beta peptide clearance. Sci Transl Med 2011; 3: 89ra57
-
(2011)
Sci Transl Med
-
-
Castellano, J.M.1
Kim, J.2
Stewart, F.R.3
Jiang, H.4
DeMattos, R.B.5
Patterson, B.W.6
-
26
-
-
84863192724
-
Apolipoprotein E4 effects in Alzheimer's disease are mediated by synaptotoxic oligomeric amyloid-beta
-
Koffie RM, Hashimoto T, Tai HC, Kay KR, Serrano-Pozo A, Joyner D et al. Apolipoprotein E4 effects in Alzheimer's disease are mediated by synaptotoxic oligomeric amyloid-beta. Brain 2012; 135: 2155-2168
-
(2012)
Brain
, Issue.135
, pp. 2155-2168
-
-
Koffie, R.M.1
Hashimoto, T.2
Tai, H.C.3
Kay, K.R.4
Serrano-Pozo, A.5
Joyner, D.6
-
27
-
-
0030731562
-
Synergy between the genes for butyrylcholinesterase K variant and apolipoprotein E4 in late-onset confirmed Alzheimer's disease
-
Lehmann DJ, Johnston C, Smith AD. Synergy between the genes for butyrylcholinesterase K variant and apolipoprotein E4 in late-onset confirmed Alzheimer's disease. Hum Mol Genet 1997; 6: 1933-1936
-
(1997)
Hum Mol Genet
, vol.6
, pp. 1933-1936
-
-
Lehmann, D.J.1
Johnston, C.2
Smith, A.D.3
-
30
-
-
40549134532
-
Synergistic effect of apolipoprotein E epsilon4 and butyrylcholinesterase K-variant on progression from mild cognitive impairment to Alzheimer's disease
-
Lane R, Feldman HH, Meyer J, He Y, Ferris SH, Nordberg A et al. Synergistic effect of apolipoprotein E epsilon4 and butyrylcholinesterase K-variant on progression from mild cognitive impairment to Alzheimer's disease. Pharmacogenet Genomics 2008; 18: 289-298
-
(2008)
Pharmacogenet Genomics
, vol.18
, pp. 289-298
-
-
Lane, R.1
Feldman, H.H.2
Meyer, J.3
He, Y.4
Ferris, S.H.5
Nordberg, A.6
-
31
-
-
48949087339
-
Butyrylcholinesterase K variant associated with higher enzyme activity in the temporal cortex of elderly patients
-
Tasker A, Ballard CG, Joachim C, Warden DR, Okello EJ, Perry RH et al. Butyrylcholinesterase K variant associated with higher enzyme activity in the temporal cortex of elderly patients. Neurosci Lett 2008; 442: 297-299
-
(2008)
Neurosci Lett
, vol.442
, pp. 297-299
-
-
Tasker, A.1
Ballard, C.G.2
Joachim, C.3
Warden, D.R.4
Okello, E.J.5
Perry, R.H.6
-
33
-
-
43049129669
-
Treatment options in Alzheimer's disease: Maximizing benefit, managing expectations
-
Farlow MR, Miller ML, Pejovic V. Treatment options in Alzheimer's disease: Maximizing benefit, managing expectations. Dement Geriatr Cogn Disord 2008; 25: 408-422
-
(2008)
Dement Geriatr Cogn Disord
, vol.25
, pp. 408-422
-
-
Farlow, M.R.1
Miller, M.L.2
Pejovic, V.3
-
34
-
-
33645756861
-
Do cholinergic therapies have disease-modifying effects in Alzheimer's disease?
-
Sabbagh MN, Farlow MR, Relkin N, Beach TG. Do cholinergic therapies have disease-modifying effects in Alzheimer's disease? Alzheimers Dement 2006; 2: 118-125
-
(2006)
Alzheimers Dement
, vol.2
, pp. 118-125
-
-
Sabbagh, M.N.1
Farlow, M.R.2
Relkin, N.3
Beach, T.G.4
-
35
-
-
84655161993
-
Butyrylcholinesterase is associated with beta-Amyloid plaques in the transgenic APPSWE/PSEN1dE9 mouse model of Alzheimer disease
-
Darvesh S, Cash MK, Reid GA, Martin E, Mitnitski A, Geula C. Butyrylcholinesterase is associated with beta-Amyloid plaques in the transgenic APPSWE/PSEN1dE9 mouse model of Alzheimer disease. J Neuropathol Exp Neurol 2012; 71: 2-14
-
(2012)
J Neuropathol Exp Neurol
, Issue.71
, pp. 2-14
-
-
Darvesh, S.1
Cash, M.K.2
Reid, G.A.3
Martin, E.4
Mitnitski, A.5
Geula, C.6
-
36
-
-
80053646543
-
Differential levels of apolipoprotein E and butyrylcholinesterase show strong association with pathological signs of Alzheimer's disease in the brain in vivo
-
Darreh-Shori T, Forsberg A, Modiri N, Andreasen N, Blennow K, Kamil C et al. Differential levels of apolipoprotein E and butyrylcholinesterase show strong association with pathological signs of Alzheimer's disease in the brain in vivo. Neurobiol Aging 2011; 32: 2320 e2315-2320.e2332
-
(2011)
Neurobiol Aging
, vol.32
-
-
Darreh-Shori, T.1
Forsberg, A.2
Modiri, N.3
Andreasen, N.4
Blennow, K.5
Kamil, C.6
-
37
-
-
79952231145
-
The apolipoprotein E e4 allele plays pathological roles in AD through high protein expression and interaction with butyrylcholinesterase
-
Darreh-Shori T, Modiri N, Blennow K, Baza S, Kamil C, Ahmed H et al. The apolipoprotein E e4 allele plays pathological roles in AD through high protein expression and interaction with butyrylcholinesterase. Neurobio Aging 2011; 32: 1236-1248
-
(2011)
Neurobio Aging
, Issue.32
, pp. 1236-1248
-
-
Darreh-Shori, T.1
Modiri, N.2
Blennow, K.3
Baza, S.4
Kamil, C.5
Ahmed, H.6
-
38
-
-
67349227745
-
Emerging hypotheses regarding the influences of butyrylcholinesterase- K variant, APOE e4, and hyperhomocysteinemia in neurodegenerative dementias
-
Lane RM, He Y. Emerging hypotheses regarding the influences of butyrylcholinesterase- K variant, APOE e4, and hyperhomocysteinemia in neurodegenerative dementias. MedHypotheses 2009; 73: 230-250
-
(2009)
MedHypotheses
, vol.73
, pp. 230-250
-
-
Lane, R.M.1
He, Y.2
-
39
-
-
35448969267
-
Serum butyrylcholinesterase is strongly associated with adiposity, the serum lipid profile and insulin resistance
-
Iwasaki T, Yoneda M, Nakajima A, Terauchi Y. Serum butyrylcholinesterase is strongly associated with adiposity, the serum lipid profile and insulin resistance. Intern Med 2007; 46: 1633-1639
-
(2007)
Intern Med
, vol.46
, pp. 1633-1639
-
-
Iwasaki, T.1
Yoneda, M.2
Nakajima, A.3
Terauchi, Y.4
-
40
-
-
35748976848
-
Genome-wide association with diabetes-related traits in the Framingham Heart Study
-
Meigs JB, Manning AK, Fox CS, Florez JC, Liu C, Cupples LA et al. Genome-wide association with diabetes-related traits in the Framingham Heart Study. BMC Med Genet 2007; 8(Suppl 1): S16
-
(2007)
BMC Med Genet
, vol.8
, Issue.SUPPL. 1
-
-
Meigs, J.B.1
Manning, A.K.2
Fox, C.S.3
Florez, J.C.4
Liu, C.5
Cupples, L.A.6
-
41
-
-
80054906871
-
GWAS of butyrylcholinesterase activity identifies four novel loci, independent effects within BCHE and secondary associations with metabolic risk factors
-
Benyamin B, Middelberg RP, Lind PA, Valle AM, Gordon S, Nyholt DR et al. GWAS of butyrylcholinesterase activity identifies four novel loci, independent effects within BCHE and secondary associations with metabolic risk factors. Hum Mol Genet 2011; 20: 4504-4514
-
(2011)
Hum Mol Genet
, Issue.20
, pp. 4504-4514
-
-
Benyamin, B.1
Middelberg, R.P.2
Lind, P.A.3
Valle, A.M.4
Gordon, S.5
Nyholt, D.R.6
-
42
-
-
34249088350
-
Genome-wide transcription and the implications for genomic organization
-
Kapranov P, Willingham AT, Gingeras TR. Genome-wide transcription and the implications for genomic organization. Nat Rev Genet 2007; 8: 413-423
-
(2007)
Nat Rev Genet
, vol.8
, pp. 413-423
-
-
Kapranov, P.1
Willingham, A.T.2
Gingeras, T.R.3
-
43
-
-
0037387147
-
A cell surface receptor complex for fibrillar beta-Amyloid mediates microglial activation
-
Bamberger ME, Harris ME, McDonald DR, Husemann J, Landreth GE. A cell surface receptor complex for fibrillar beta-Amyloid mediates microglial activation. J Neurosci 2003; 23: 2665-2674
-
(2003)
J Neurosci
, vol.23
, pp. 2665-2674
-
-
Bamberger, M.E.1
Harris, M.E.2
McDonald, D.R.3
Husemann, J.4
Landreth, G.E.5
-
44
-
-
84859726053
-
An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease- Associated Abeta oligomers
-
Bomfim TR, Forny-Germano L, Sathler LB, Brito-Moreira J, Houzel JC, Decker H et al. An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease- Associated Abeta oligomers. J Clin Invest 2012; 122: 1339-1353
-
(2012)
J Clin Invest
, Issue.122
, pp. 1339-1353
-
-
Bomfim, T.R.1
Forny-Germano, L.2
Sathler, L.B.3
Brito-Moreira, J.4
Houzel, J.C.5
Decker, H.6
-
45
-
-
43849083580
-
Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's disease
-
Ikonomovic MD, Klunk WE, Abrahamson EE, Mathis CA, Price JC, Tsopelas ND et al. Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's disease. Brain 2008; 131: 1630-1645.
-
(2008)
Brain
, vol.131
, pp. 1630-1645
-
-
Ikonomovic, M.D.1
Klunk, W.E.2
Abrahamson, E.E.3
Mathis, C.A.4
Price, J.C.5
Tsopelas, N.D.6
|