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Volumn 32, Issue 5, 2015, Pages 723-737

Lessons from the Synthetic Chemist Nature

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL PRODUCT; POLYKETIDE;

EID: 84928894579     PISSN: 02650568     EISSN: 14604752     Source Type: Journal    
DOI: 10.1039/c4np00160e     Document Type: Review
Times cited : (29)

References (84)
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    • Convergency is not unknown in biosynthesis as exemplified for the biosynthesis of erythromycin A (2). The rare deoxysugars l-mycarose (O-methyation to yield l-cladinose is a tailouring step) and d-desosamine are attached to the aglycon at a late stage and both are biosynthesised in seven steps from d-glucose
    • C. M. Thomas J. Hothersall C. L. Willi T. J. Simpson Nat. Rev. Microbiol. 2010 8 281 289
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    • Burkey, T.J.1    Griller, D.2
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    • ed. M. Suffness, CRC Press, Boca Raton, FL, USA
    • H. G. Floss and U. Mocek, Biosynthesis of taxol., in Taxol-Science and Applications, ed., M. Suffness, CRC Press, Boca Raton, FL, USA, 1995, pp. 191-208
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    • In cell biology the term compartmentation comprises organelles in such as mitochondria, lysosomes, the endoplasmic reticulum, the cell nucleus etc. Here we use this term to refer to distinct catalytic domains on megaenzyme complexes such as the PKS. There are true uses of such organelles in biosynthesis-(a) morphine (b) p450 operate in peroxisomes etc.
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    • Angew. Chem., Int. Ed. 1998 37 2897 2899 Other important contributions of multistep flow synthesis in the preparation of drugs are
    • A. Lightfoot P. Schnider A. Pfaltz Angew. Chem. 1998 110 3047 3050 Angew. Chem., Int. Ed. 1998 37 2897 2899
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* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.