-
2
-
-
0026418434
-
-
B. M. Trost Science 1991 254 1471 1477
-
(1991)
Science
, vol.254
, pp. 1471-1477
-
-
Trost, B.M.1
-
10
-
-
85083347784
-
-
Wiley-VCH, Weinheim
-
Biomimetic Organic Synthesis, ed., B. Nay, and, E. Poupon, Wiley-VCH, Weinheim, 2011, vol. 1/2
-
(2011)
Biomimetic Organic Synthesis
, vol.12
-
-
Nay, B.1
Poupon, E.2
-
14
-
-
81355123306
-
-
We do not discuss the important class of alkaloids, because they are not biosynthesised through a common biosynthetic pathway
-
M. Razzak J. K. de Brabander Nat. Chem. Biol. 2011 7 865 875
-
(2011)
Nat. Chem. Biol.
, vol.7
, pp. 865-875
-
-
Razzak, M.1
De Brabander, J.K.2
-
17
-
-
0019408557
-
-
R. B. Woodward E. Logusch K. P. Nambiar K. Sakan D. E. Ward B.-W. Au-Yeung P. Balaram L. J. Browne P. J. Card C. H. Chen R. B. Chênevert A. Fliri K. Frobel H.-J. Gais D. G. Garratt K. Hayakawa W. Heggie D. P. Hesson D. Hoppe I. Hoppe J. A. Hyatt D. Ikeda P. A. Jacobi K. S. Kim Y. Kobuke K. Kojima K. Krowicki V. J. Lee T. Leutert S. Malchenko J. Martens R. S. Matthews B. S. Ong J. B. Press T. V. Rajan Babu G. Rosseau H. M. Sauter M. Suzuki K. Tatsuta L. M. Tolbert E. A. Truesdale I. Uchida Y. Ueda T. Uyehara A. T. Vasella W. C. Vladuchick P. A. Wade R. M. Williams H. N.-C. Wong J. Am. Chem. Soc. 1981 103 3210 3213
-
(1981)
J. Am. Chem. Soc.
, vol.103
, pp. 3210-3213
-
-
Woodward, R.B.1
Logusch, E.2
Nambiar, K.P.3
Sakan, K.4
Ward, D.E.5
Au-Yeung, B.-W.6
Balaram, P.7
Browne, L.J.8
Card, P.J.9
Chen, C.H.10
Chênevert, R.B.11
Fliri, A.12
Frobel, K.13
Gais, H.-J.14
Garratt, D.G.15
Hayakawa, K.16
Heggie, W.17
Hesson, D.P.18
Hoppe, D.19
Hoppe, I.20
Hyatt, J.A.21
Ikeda, D.22
Jacobi, P.A.23
Kim, K.S.24
Kobuke, Y.25
Kojima, K.26
Krowicki, K.27
Lee, V.J.28
Leutert, T.29
Malchenko, S.30
Martens, J.31
Matthews, R.S.32
Ong, B.S.33
Press, J.B.34
Rajan Babu, T.V.35
Rosseau, G.36
Sauter, H.M.37
Suzuki, M.38
Tatsuta, K.39
Tolbert, L.M.40
Truesdale, E.A.41
Uchida, I.42
Ueda, Y.43
Uyehara, T.44
Vasella, A.T.45
Vladuchick, W.C.46
Wade, P.A.47
Williams, R.M.48
Wong, H.N.-C.49
more..
-
18
-
-
0019439350
-
-
R. B. Woodward E. Logusch K. P. Nambiar K. Sakan D. E. Ward B.-W. Au-Yeung P. Balaram L. J. Browne P. J. Card C. H. Chen R. B. Chênevert A. Fliri K. Frobel H.-J. Gais D. G. Garratt K. Hayakawa W. Heggie D. P. Hesson D. Hoppe I. Hoppe J. A. Hyatt D. Ikeda P. A. Jacobi K. S. Kim Y. Kobuke K. Kojima K. Krowicki V. J. Lee T. Leutert S. Malchenko J. Martens R. S. Matthews B. S. Ong J. B. Press T. V. Rajan Babu G. Rosseau H. M. Sauter M. Suzuki K. Tatsuta L. M. Tolbert E. A. Truesdale I. Uchida Y. Ueda T. Uyehara A. T. Vasella W. C. Vladuchick P. A. Wade R. M. Williams H. N.-C. Wong J. Am. Chem. Soc. 1981 103 3213 3215
-
(1981)
J. Am. Chem. Soc.
, vol.103
, pp. 3213-3215
-
-
Woodward, R.B.1
Logusch, E.2
Nambiar, K.P.3
Sakan, K.4
Ward, D.E.5
Au-Yeung, B.-W.6
Balaram, P.7
Browne, L.J.8
Card, P.J.9
Chen, C.H.10
Chênevert, R.B.11
Fliri, A.12
Frobel, K.13
Gais, H.-J.14
Garratt, D.G.15
Hayakawa, K.16
Heggie, W.17
Hesson, D.P.18
Hoppe, D.19
Hoppe, I.20
Hyatt, J.A.21
Ikeda, D.22
Jacobi, P.A.23
Kim, K.S.24
Kobuke, Y.25
Kojima, K.26
Krowicki, K.27
Lee, V.J.28
Leutert, T.29
Malchenko, S.30
Martens, J.31
Matthews, R.S.32
Ong, B.S.33
Press, J.B.34
Rajan Babu, T.V.35
Rosseau, G.36
Sauter, H.M.37
Suzuki, M.38
Tatsuta, K.39
Tolbert, L.M.40
Truesdale, E.A.41
Uchida, I.42
Ueda, Y.43
Uyehara, T.44
Vasella, A.T.45
Vladuchick, W.C.46
Wade, P.A.47
Williams, R.M.48
Wong, H.N.-C.49
more..
-
19
-
-
0019440449
-
-
R. B. Woodward E. Logusch K. P. Nambiar K. Sakan D. E. Ward B.-W. Au-Yeung P. Balaram L. J. Browne P. J. Card C. H. Chen R. B. Chênevert A. Fliri K. Frobel H.-J. Gais D. G. Garratt K. Hayakawa W. Heggie D. P. Hesson D. Hoppe I. Hoppe J. A. Hyatt D. Ikeda P. A. Jacobi K. S. Kim Y. Kobuke K. Kojima K. Krowicki V. J. Lee T. Leutert S. Malchenko J. Martens R. S. Matthews B. S. Ong J. B. Press T. V. Rajan Babu G. Rosseau H. M. Sauter M. Suzuki K. Tatsuta L. M. Tolbert E. A. Truesdale I. Uchida Y. Ueda T. Uyehara A. T. Vasella W. C. Vladuchick P. A. Wade R. M. Williams H. N.-C. Wong J. Am. Chem. Soc. 1981 103 3215 3217
-
(1981)
J. Am. Chem. Soc.
, vol.103
, pp. 3215-3217
-
-
Woodward, R.B.1
Logusch, E.2
Nambiar, K.P.3
Sakan, K.4
Ward, D.E.5
Au-Yeung, B.-W.6
Balaram, P.7
Browne, L.J.8
Card, P.J.9
Chen, C.H.10
Chênevert, R.B.11
Fliri, A.12
Frobel, K.13
Gais, H.-J.14
Garratt, D.G.15
Hayakawa, K.16
Heggie, W.17
Hesson, D.P.18
Hoppe, D.19
Hoppe, I.20
Hyatt, J.A.21
Ikeda, D.22
Jacobi, P.A.23
Kim, K.S.24
Kobuke, Y.25
Kojima, K.26
Krowicki, K.27
Lee, V.J.28
Leutert, T.29
Malchenko, S.30
Martens, J.31
Matthews, R.S.32
Ong, B.S.33
Press, J.B.34
Rajan Babu, T.V.35
Rosseau, G.36
Sauter, H.M.37
Suzuki, M.38
Tatsuta, K.39
Tolbert, L.M.40
Truesdale, E.A.41
Uchida, I.42
Ueda, Y.43
Uyehara, T.44
Vasella, A.T.45
Vladuchick, W.C.46
Wade, P.A.47
Williams, R.M.48
Wong, H.N.-C.49
more..
-
21
-
-
0029572389
-
-
-1 as reported in ref. 11. It must be noted that exact fermentation conditions and yields of the continuously operated industrial process are not available
-
H. C. Lynch M. E. Bushell Microbiology 1995 141 3105 3111
-
(1995)
Microbiology
, vol.141
, pp. 3105-3111
-
-
Lynch, H.C.1
Bushell, M.E.2
-
23
-
-
77949567964
-
-
Convergency is not unknown in biosynthesis as exemplified for the biosynthesis of erythromycin A (2). The rare deoxysugars l-mycarose (O-methyation to yield l-cladinose is a tailouring step) and d-desosamine are attached to the aglycon at a late stage and both are biosynthesised in seven steps from d-glucose
-
C. M. Thomas J. Hothersall C. L. Willi T. J. Simpson Nat. Rev. Microbiol. 2010 8 281 289
-
(2010)
Nat. Rev. Microbiol.
, vol.8
, pp. 281-289
-
-
Thomas, C.M.1
Hothersall, J.2
Willi, C.L.3
Simpson, T.J.4
-
24
-
-
84928918102
-
-
Patent DE 25 52 403 C2, published
-
J. K. Chakrabarti and D. E. Tupper, Patent DE 25 52 403 C2, published: 19 June 1986
-
(1986)
-
-
Chakrabarti, J.K.1
Tupper, D.E.2
-
32
-
-
33845377824
-
-
For simplification, other topics such as diversification from a common advanced intermediate (see T. Newhouse, S. Baran and R. W. Hoffmann, Chem. Soc. Rev., 2009, 38, 3010-3021 and R. D. Firn and C G. Jones, Nat. Prod. Rep., 2003, 20, 382-391) or multicomponent reactions (MCR) are skipped. In fact, the latter is hardly found in nature
-
T. J. Burkey D. Griller J. Am. Chem. Soc. 1985 107 246 249
-
(1985)
J. Am. Chem. Soc.
, vol.107
, pp. 246-249
-
-
Burkey, T.J.1
Griller, D.2
-
50
-
-
0002553350
-
Biosynthesis of taxol.
-
ed. M. Suffness, CRC Press, Boca Raton, FL, USA
-
H. G. Floss and U. Mocek, Biosynthesis of taxol., in Taxol-Science and Applications, ed., M. Suffness, CRC Press, Boca Raton, FL, USA, 1995, pp. 191-208
-
(1995)
Taxol-Science and Applications
, pp. 191-208
-
-
Floss, H.G.1
Mocek, U.2
-
56
-
-
70350493673
-
-
S. M. Ma J. W.-H. Li J. W. Choi H. Zhou K. K. M. Lee V. A. Moorthie X. Xie J. T. Kealey N. A. Da Silva J. C. Vederas Y. Tang Science 2009 326 589 592
-
(2009)
Science
, vol.326
, pp. 589-592
-
-
Ma, S.M.1
Li, J.W.-H.2
Choi, J.W.3
Zhou, H.4
Lee, K.K.M.5
Moorthie, V.A.6
Xie, X.7
Kealey, J.T.8
Da Silva, N.A.9
Vederas, J.C.10
Tang, Y.11
-
57
-
-
84878928695
-
-
W. Xu Y.-H. Chooi J. W. Choi S. Li J. C. Vederas N. A. Da Silva Y. Tang Angew. Chem., Int. Ed. 2013 52 6472 6475
-
(2013)
Angew. Chem., Int. Ed.
, vol.52
, pp. 6472-6475
-
-
Xu, W.1
Chooi, Y.-H.2
Choi, J.W.3
Li, S.4
Vederas, J.C.5
Da Silva, N.A.6
Tang, Y.7
-
71
-
-
84901381097
-
-
In cell biology the term compartmentation comprises organelles in such as mitochondria, lysosomes, the endoplasmic reticulum, the cell nucleus etc. Here we use this term to refer to distinct catalytic domains on megaenzyme complexes such as the PKS. There are true uses of such organelles in biosynthesis-(a) morphine (b) p450 operate in peroxisomes etc.
-
E. M. Woerly J. Roy M. D. Burke Nat. Chem. 2014 6 484 491
-
(2014)
Nat. Chem.
, vol.6
, pp. 484-491
-
-
Woerly, E.M.1
Roy, J.2
Burke, M.D.3
-
80
-
-
84907882886
-
-
Angew. Chem., Int. Ed. 2014 53 4915 4920
-
S. Newton C. F. Carter C. M. Pearson L. d. C. Alves H. Lange P. Thansandote S. V. Ley Angew. Chem. 2014 126 5015 5020 Angew. Chem., Int. Ed. 2014 53 4915 4920
-
(2014)
Angew. Chem.
, vol.126
, pp. 5015-5020
-
-
Newton, S.1
Carter, C.F.2
Pearson, C.M.3
Alves D. L, C.4
Lange, H.5
Thansandote, P.6
Ley, S.V.7
-
82
-
-
0000681585
-
-
Angew. Chem., Int. Ed. 1998 37 2897 2899 Other important contributions of multistep flow synthesis in the preparation of drugs are
-
A. Lightfoot P. Schnider A. Pfaltz Angew. Chem. 1998 110 3047 3050 Angew. Chem., Int. Ed. 1998 37 2897 2899
-
(1998)
Angew. Chem.
, vol.110
, pp. 3047-3050
-
-
Lightfoot, A.1
Schnider, P.2
Pfaltz, A.3
|