Tick immunobiology

Ticks: Biology, Disease and Control

Volumn , Issue , 2008, Pages 186-204

  Brossard, M ^a   Wikel, S K ^b  

^a Laboratory of Parasite Immunology   (Switzerland)

^b UNIVERSITY OF CONNECTICUT SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84928860366     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1017/CBO9780511551802.010     Document Type: Chapter

References (178)

1. Adams, M. D., Kelley, J. M., Gocayne, J. D., et al. (1991). Complementary DNA sequencing: expressed sequence tags and human genome project. Science 252, 1651–1656.
2. Alarcon-Chaidez, F. J., Sun, J. & Wikel, S. K. (2007). Transcriptome analysis of the salivary glands of the tick Dermacentor andersoni Stiles (Acari: Ixodidae). Insect Biochemistry and Molecular Biology 37, 48–71.
3. Allen, J. R. (1973). Tick resistance: basophils in skin reactions of resistant guinea pigs. International Journal for Parasitology 3, 195–200.
4. Allen, J. R., Doube, B. M. & Kemp, D. H. (1977). Histology of bovine skin reactions to Ixodes holocyclus Neuman. Canadian Journal of Comparative Medicine 41, 26–35.
5. Allen, J. R., Khalil, H. M. & Wikel, S. K. (1979). Langerhans cells trap tick salivary gland antigens in tick-resistant guinea pigs. Journal of Immunology 122, 563–565.
6. Andrade, B. B., Teixeira, C. R., Barral, A. & Barral-Netto, M. (2005). Haematophagous arthropod saliva and host defense system: a tale of tear and blood. Annals of the Brazilian Academy of Sciences 77, 665–693.
7. Anguita, J., Ramamoorthi, N., Hovius, J. W. R., et al. (2002). Salp15, and Ixodes scapularis salivary protein, inhibits CD4+ T cell activation. Immunity 16, 849–859.
8. Askenase, P. W., Debernardo, R., Tauben, D. & Kashgarian, M. (1978). Cutaneous basophil anaphylaxis: immediate vasopermeability increases and anaphylactic degranulation of basophils at delayed hypersensitivity reactions challenged with additional antigen. Immunology 35, 741–755.
9. Bell, J. F., Stewart, S. J. & Wikel, S. K. (1979). Resistance to tick-borne Francisella tularensis by tick-sensitized rabbits: allergic klendusity. American Journal of Tropical Medicine and Hygiene 28, 876–880.
10. Bergman, D. K., Palmer, M. J., Caimano, M. J., Radolf, J. D. & Wikel, S. K. (2000). Isolation and cloning of a secreted immunosuppressant protein from Dermacentor andersoni salivary gland. Journal of Parasitology 86, 516–525.
11. Bergman, D. K., Ramachandra, R. N. & Wikel, S. K. (1998). Characterization of an immunosuppressant protein from Dermacentor andersoni (Acari: Ixodidae) salivary glands. Journal of Medical Entomology 35, 505–509.
12. Berthier, R., Martinon-Ego, C., Laharie, A. M. & Marche, P. N. (2000). A two-step culture method starting with early growth factors permits enhanced production of functional dendritic cells from murine splenocytes. Journal of Immunological Methods 239, 95–107.
13. Bior, A. D., Essenberg, R. C. & Sauer, J. R. (2002). Comparison of differentially expressed genes in the salivary glands of male ticks, Amblyomma americanum and Dermacentor andersoni. Insect Biochemistry and Molecular Biology 32, 645–655.
14. Bowessidjaou, J., Brossard, M. & Aeschlimann, A. (1977). Effects and duration of resistance acquired by rabbits on feeding and egg laying in Ixodes ricinus L. Experientia 33, 548–550.
15. Bowman, A. S., Dillwith, J. W. & Sauer, J. R. (1996). Tick salivary prostaglandins: presence, origin and significance. Parasitology Today 12, 388–396.
16. Brossard, M. (1976). Relations immunologiques entre Bovins et Tiques, plus particulier`ement entre Bovins et Boophilus microplus. Acta Tropica 33, 15–36.
17. Brossard, M. (1982). Rabbits infested with adult Ixodes ricinus L.: effects of mepyramine on acquired resistance. Experientia 38, 702–704.
18. Brossard, M. & Fivaz, V. (1982). Ixodes ricinus L.: mast cells, basophils and eosinophils in the sequence of cellular events in the skin of infested or reinfested rabbits. Parasitology 85, 583–592.
19. Brossard, M. & Girardin, P. (1979). Passive transfer of resistance in rabbits infested with adult Ixodes ricinus L: Humoral factors influence feeding and egg laying. Experientia 35, 1395–1396.
20. Brossard, M. & Wikel, S. K. (1997). Immunology of interactions between ticks and hosts. Medical and Veterinary Entomology 11, 270–276.
21. Brossard, M. & Wikel, S. K. (2004). Tick immunobiology. Parasitology 129, S161–S176.
22. Brossard, M., Monneron, J. P. & Papatheodorou, V. (1982). Progressive sensitization of circulating basophils against Ixodes ricinus L. antigens during repeated infestations of rabbits. Parasite Immunology 4, 355–361.
23. Brown, S. J. & Askenase, P. W. (1981). Cutaneous basophil responses and immune resistance of guinea pigs to ticks: passive transfer with peritoneal exudate cells or serum. Journal of Immunology 127, 2163–2167.
24. Brown, S. J., Barker, R. W. & Askenase, P. W. (1984). Bovine resistance to Amblyomma americanum ticks: an acquired immune response characterized by cutaneous basophil infiltrates. Veterinary Parasitology 16, 147–165.
25. Champagne, D. E. (1994). The role of salivary vasodilators in blood-feeding and parasite transmission. Parasitology Today 10, 430–433.
26. Champagne, D. E. & Valenzuela, J. G. (1996). Pharmacology of haematophagous arthropod saliva. In The Immunology of Host–Ectoparasitic Arthropod Relationships, ed. Wikel, S. K., 85–106. Wallingford, UK: CAB International.
27. Chinery, W. A. & Ayitey-Smith, E. (1977). Histamine blocking agent in the salivary gland homogenate of the tick, Rhipicephalus sanguineus. Nature 265, 366–367.
28. Christe, M., Rutti, B. & Brossard, M. (1999). Influence of genetic background and parasite load of mice on immune response developed against nymphs of Ixodes ricinus. Parasitology Research 85, 557–561.
29. Christe, M., Rutti, B. & Brossard, M. (2000). Cytokines (IL-4 and IFN-_) and antibodies (IgE and IgG2a) produced in mice infected with Borrelia burgdorferi sensu stricto via nymphs of Ixodes ricinus ticks or syringe inoculations. Parasitology Research 86, 491–496.
30. Couvreur, B., Beaufays, J., Charon, C., et al. (2008). Variability and action mechanism of a family of anticomplement proteins in Ixodes ricinus. PLoS ONE 3(1): e1400 doi:10.1371/journal.pone.0001400.
31. Crampton, A. L., Miller, C., Baxter, G. D. & Barker, S. C. (1998). Expressed sequence tags and new genes from the cattle tick, Boophilus microplus. Experimental and Applied Acarology 22, 177–186.
32. Cumberbatch, M. & Kimber, I. (1995). Tumour necrosis factor-_ is required for accumulation of dendritic cells in draining lymph nodes and for optimal contact sensitization. Immunology 84, 31–35.
33. Daix, V., Schroeder, H., Praet, N., et al. (2007). Ixodes ticks belonging to the Ixodes ricinus complex encode a family of anti-complement proteins. Insect Molecular Biology 16, 155–166.
34. Decrem, Y., Beaufays, J., Blasioli, V., et al. (2008). A family of putative metalloproteases in the salivary glands of the tick Ixodes ricinus. FEBS Journal 275, 1485–1489.
35. Demeure, C. E., Yang, L. P., Desjardins, C., Raynauld, P. & Delespesse, G. (1997). Prostaglandin E2 primes naive T cells for the production of anti-inflammatory cytokines. European Journal of Immunology 27, 3526–3531.
36. DenHollander, N. & Allen, J. R. (1985). Dermacentor variabilis: acquired resistance to ticks in BALB/c mice. Experimental Parasitology 59, 118–129.
37. Dizij, A. & Kurtenbach, K. (1995). Clethrionomys glareolus, but not Apodemus flavicollis, acquired resistance to Ixodes ricinus L., the main European vector of Borrelia burgdorferi. Parasite Immunology 17, 177–183.
38. Edwards, J. F., Higgs, S. & Beaty, B. J. (1998). Mosquito feeding-induced enhancement of Cache Valley virus (Bunyaviridae) infection in mice. Journal of Medical Entomology 35, 261–265.
39. Esmon, C. T. (2004). Interactions between the innate immune and blood coagulation systems. Trends in Immunology 25, 536–542.
40. Ferreira, B. R. & Silva, J. S. (1998). Saliva of Rhipicephalus sanguineus tick impairs T cell proliferation and IFN-gamma-induced macrophage microbicidal activity. Veterinary Immunology and Immunopathology 31, 279–293.
41. Ferreira, B. R. & Silva, J. S. (1999). Successive tick infestations selectively promote a T-helper 2 cytokine profile in mice. Immunology 96, 434–439.
42. Ferreira, C. A. S., Vaz, I. D. S. Jr, Da Silva, S. S., et al. (2002). Cloning and partial characterization of a Boophilus microplus (Acari: Ixodidae) calreticulin. Experimental Parasitology 101, 25–34.
43. Fivaz, B. H. (1989). Immune suppression induced by the brown ear tick Rhipicephalus appendiculatus Neumann, 1901. Journal of Parasitology 75, 946–952.
44. Francischetti I. M., Mather, T. N. & Ribeiro, J. M. (2003). Cloning of a salivary gland metalloprotease and characterization of gelatinase and fibrin(ogen)lytic activities in the saliva of the Lyme disease tick vector Ixodes scapularis. Biochemical and Biophysical Research Communications 305, 869–875.
45. Francischetti I. M., Mather, T. N. & Ribeiro, J. M. (2004). Penthalaris, a novel recombinant five-Kunitz tissue factor pathway inhibitor (TFPI) from the salivary gland of the tick vector of Lyme disease, Ixodes scapularis. Thrombosis and Haemostasis 91, 886–898.
46. Francischetti I. M., Mather, T. N. & Ribeiro, J. M. (2005). Tick saliva is a potent inhibitor of endothelial cell proliferation and angiogenesis. Thrombosis and Haemostasis 94, 167–174.
47. Francischetti I. M. B., Pham, V. M., Mans, B. J., et al. (2005). The transcriptome of the salivary glands of the female western black-legged tick Ixodes pacificus (Acari: Ixodidae). Insect Biochemistry and Molecular Biology 35, 1142–1161.
48. Fuchsberger, N., Kita, M., Hajnicka, V., et al. (1995). Ixodid tick salivary gland extracts inhibit production of lipopolysaccharide-induced mRNA of several different human cytokines. Experimental and Applied Acarology 19, 671–676.
49. Furie, B. & Furie, B. C. (2005). Molecular basis of blood coagulation. In Hematology: Basic Principles and Practice, 4th edn, eds. Hoffman, R., Benz, E. J. Jr, Shatti, S. J., et al., 1931–1953.Philadelphia, PA: Elsevier.
50. Ganapamo, F., Rutti, B. & Brossard, M. (1995a). In vitro production of interleukin-4 and interferon-gamma by lymph node cells from BALB/c mice infested with nymphal Ixodes ricinus ticks. Immunology 85, 120–124.
51. Ganapamo, F., Rutti, B. & Brossard, M. (1995b). Spleen accessory cells antigen processing and in vitro induction of specific lymphocyte proliferation in BALB/c mice infested with nymphal Ixodes ricinus ticks. In Dendritic Cells in Fundamental and Clinical Immunology, vol. 2, eds. Banchereau, J. & Schmitt, D., 195–197. New York: Plenum Press.
52. Ganapamo, F., Rutti, B. & Brossard, M. (1996a). Cytokine production by lymph node cells from mice infested with Ixodes ricinus ticks and the effect of tick salivary gland extracts on IL-2 production. Scandinavian Journal of Immunology 44, 388–393.
53. Ganapamo, F., Rutti, B. & Brossard, M. (1996b). Immunosuppression and cytokine production in mice infested with Ixodes ricinus ticks: a possible role of laminin and interleukin-10 on the in vitro responsiveness of lymphocytes to mitogens. Immunology 87, 259–263.
54. Ganapamo, F., Rutti, B. & Brossard, M. (1997). Identification of an Ixodes ricinus salivary gland fraction through its ability to stimulate CD4 T cells present in BALB/c mice lymph nodes draining the tick fixation site. Parasitology 115, 91–96.
55. Gebbia, J. A., Coleman, J. L. & Benach, J. L. (2001). Borrelia spirochetes upregulate release and activation of matrix metalloproteinase gelatinase B (MMP-9) and collagenase (MMP-1) in human cells. Infection and Immunity 69, 456–462.
56. George, J. E., Osburn, R. L. & Wikel, S. K. (1985). Acquisition and expression of resistance by Bos indicus and Bos indicus × Bos taurus calves to Amblyomma americanum infestation. Journal of Parasitology 71, 174–182.
57. Gill, H. S. (1986). Kinetics of mast cell, basophil and eosinophil populations at Hyalomma anatolicum anatolicum feeding sites on cattle and the acquisition of resistance. Parasitology 93, 305–315.
58. Gill, H. S. & Walker, A. R. (1985). Differential cellular responses at Hyalomma anatolicum anatolicum feeding sites on susceptible and tick-resistant rabbits. Parasitology 91, 591–607.
59. Gillespie, R. D., Dolan, M. C., Piesman, J. & Titus, R. G. (2001). Identification of an IL-2 binding protein in the saliva of the Lyme disease vector tick, Ixodes scapularis. Journal of Immunology 166, 4319–4327.
60. Girardin, P. & Brossard, M. (1989). Effects of cyclosporin-A on the humoral immunity to ticks, and on the cutaneous immediate (type I) and delayed (type IV) hypersensitivity reactions to Ixodes ricinus, L. salivary gland antigens in re-infested rabbits. Parasitology Research 75, 657–662.
61. Girardin, P. & Brossard, M. (1990). Rabbits infested with Ixodes ricinus L. adults: effects of treatment with cyclosporine A on the biology of ticks fed on resistant or naive hosts. Annales de Parasitologie Humain et Comparative 65, 262–266.
62. Grakoui, A., Bromley, S. K., Sumen, C., et al. (1999). The immunological synapse: a molecular machine controlling T cell activation. Science 285, 221–227.
63. Guerrero, F. D., Miller, R. J., Rousseau, M.-E., et al. (2005). BmiGI: a database of cDNAs expressed in Boophilus microplus, the tropical/southern cattle tick. Insect Biochemistry and Molecular Biology 35, 585–595.
64. Guerrero, F. D., Nene, V. M., George, J. E., Barker, S. C. & Willadsen, P. (2006). Sequencing a new target genome: the Boophilus microplus (Acari: Ixodidae) genome project. Journal of Medical Entomology 43, 9–16.
65. Gwakisa, P., Yoshihara, K., To, T. L., et al. (2001). Salivary gland extract of Rhipicephalus appendiculatus ticks inhibits in vitro transcription and secretion of cytokines and production of nitric oxide by LPS-stimulated JA-4 cells. Veterinary Parasitology 99, 53–61.
66. Hajnick´a, V., Kocakova, P., Slavikova, M., et al. (2001). Anti-interleukin-8 activity of tick salivary gland extracts. Parasite Immunology 23, 483–489.
67. Hannier, S., Liversidge, J., Sternberg, J. M. & Bowman, A. S. (2003). Ixodes ricinus tick salivary gland extract inhibits IL-10 secretion and CD69 expression by mitogen-stimulated murine splenocytes and induces hyporesponsiveness in B lymphocytes. Parasite Immunology 25, 27–37.
68. Hannier, S., Liversidge, J., Sternberg, J. M. & Bowman, A. S. (2004). Characterization of the B-cell inhibitory protein factor in Ixodes ricinus tick saliva: a potential role in enhanced Borrelia burgdorferi transmission. Immunology 113, 401–408.
69. Harris, S. G., Padilla, J., Koumas, L., Ray, D. & Phipps, R. P. (2002). Prostaglandins as modulators of immunity. Trends in Immunology 23, 144–150.
70. Hill, C. A. & Gutierrez, J. A. (2000). Analysis of the expressed genome of the lone star tick, Amblyomma americanum (Acari: Ixodidae) using expressed sequence tag approach. Microbial and Comparative Genomics 5, 89–101.
71. Hill, C. A. &Wikel, S. K. (2005). The Ixodes scapularis genome project: an opportunity for advancing tick research. Trends in Parasitology 21, 151–153.
72. Holt, R. A., Subramanian, G. M., Halpern, A., et al. (2002). The genome sequence of the malaria mosquito Anopheles gambiae. Science 298, 129–149.
73. Inokuma, H., Kemp, D. H. & Willadsen, P. (1994). Prostaglandin E2 production by the cattle tick (Boophilus microplus) into feeding sites and its effect on the response of bovine mononuclear cells to mitogen. Veterinary Parasitology 53, 293–299.
74. Janeway, C. A. Jr, Travers, P.,Walport, M. & Shlomchik, M. J. (2005). Immunobiology, 6th edn. New York: Garland.
75. Jaworski, D. C., Jasinskas, A., Metz, C. N., Bucala, R. & Barbour, A. G. (2001). Identification and characterization of a homologue of the pro-inflammatory cytokine macrophage migration inhibitory factor in the tick, Amblyomma americanum. Insect Molecular Biology 10, 323–331.
76. Jaworski, D. C., Simmen, F. A., Lamoreaux, W., et al. (1995). A secreted calreticulin protein in ixodid tick (Amblyomma americanum) saliva. Journal of Insect Physiology 41, 369–375.
77. Jones, L. D. & Nuttall, P. A. (1990). The effect of host resistance to tick infestation on the transmission of Thogoto virus by ticks. Journal of General Virology 71, 1039–1043.
78. Kamhawi, S., Belkaid, Y., Modi, G., Rowton, E. & Sacks, D. (2000). Protection against cutaneous leishmaniasis resulting from bites of uninfected sandflies. Science 290, 1351–1354.
79. Kopecky, J. & Kuthejlova, M. (1998). Suppressive effect of Ixodes ricinus salivary gland extract on mechanisms of natural immunity in vitro. Parasite Immunology 20, 169–174.
80. Kotsyfakis, M., Sa-Nu˜nes, A., Francischetti I. M. B., et al. (2006). Anti-inflammatory and immunosuppressive activity of sialostatin L, a salivary cystatin from the tick, Ixodes scapularis. Journal of Biological Chemistry 36, 26298–26307.
81. Koudstaal, D., Kemp, D. H. & Kerr, J. D. (1978). Boophilus microplus: rejection of larvae from British breed cattle. Parasitology 76, 379–386.
82. Krocova, Z., Macela, A., Hernychova, L., et al. (2003). Tick salivary gland extract accelerates proliferation of Francisella tularensis in the host. Journal of Parasitology 89, 14–20.
83. Kubes, M., Kocakova, P., Slovak, M., et al. (2002). Heterogeneity in the effect of different ixodid tick species on natural killer cell activity. Parasite Immunology 24, 23–28.
84. Kuthejlova, M., Kopecky, J., Stepanova, G. & Macela, A. (2001). Tick salivary gland extract inhibits killing of Borrelia afzelli spirochetes by mouse macrophages. Infection and Immunity 69, 575–578.
85. Latif, A. A. (1984). Resistance to Hyalomma anatolicum anatolicum Koch (1844) and Rhipicephalus evertsi Neumann (1897) (Ixodoidea: Ixodidae) by cattle in Sudan. Insect Science Applications 5, 509–511.
86. Latif, A. A., Punyua, D. K., Capstick, P. B. & Newson, R. M. (1991). Tick infestations on Zebu cattle in Western Kenya: host resistance to Rhipicephalus appendiculatus (Acari: Ixodidae). Journal of Medical Entomology 28, 127–132.
87. Lawrie, C. H., Randolph, S. E. & Nuttall, P. A. (1999). Ixodes ticks: serum species sensitivity of anti-complement activity. Experimental Parasitology 93, 207–214.
88. Leboulle, G., Crippa, M., Decrem, Y., et al. (2002a). Characterization of a novel salivary immunosuppressive protein from Ixodes ricinus ticks. Journal of Biological Chemistry 277, 10083–10089.
89. Leboulle, G., Rochez, C., Louahed, J., et al. (2002b). Isolation of Ixodes ricinus salivary gland mRNA encoding factors induced during blood feeding. American Journal of Tropical Medicine and Hygiene 66, 225–233.
90. Lorimier, Y. (2003). R´eponse immunitaire de souris `a la salive de tiques Ixodes ricinus: influence des cellules dendritiques et T__. Ph.D. thesis, University of Neuchˆatel, Switzerland. Available at http://doc.rero.ch/search.py?recid=2625&ln=fr.
91. Macaluso, K. R. & Wikel, S. K. (2001). Dermacentor andersoni: effects of repeated infestations on lymphocyte proliferation, cytokine production, and adhesion-molecule expression by BALB/c mice. Annals of Tropical Medicine and Parasitology 95, 413–427.
92. Machackova, M., Obornik, M. & Kopecky, J. (2006). Effect of salivary gland extract from Ixodes ricinus ticks on the proliferation of Borrelia burgdorferi sensu stricto in vivo. Folia Parasitologia 53, 153–158.
93. Maxwell, S. S., Stoklasek, T. A., Dash, Y., Macaluso, K. R. & Wikel, S. K. (2005). Tick modulation of the in-vitro expression of adhesion molecules by skin-derived endothelial cells. Annals of Tropical Medicine and Parasitology 99, 661–672.
94. Mbow, M. L., Christe, M., Rutti, B. & Brossard, M. (1994). Absence of acquired resistance to nymphal Ixodes ricinus ticks in BALB/c mice developing cutaneous reactions. Journal of Parasitology 80, 81–87.
95. Mejri, N. & Brossard, M. (2007). Splenic dendritic cells pulsed with Ixodes ricinus tick saliva prime naive CD4+ T to induce Th2 cell differentiation in vitro and in vivo. International Immunology 19, 535–543.
96. Mejri, N., Franscini, N., Rutti, B. & Brossard, M. (2001). Th2 polarization of the immune response of BALB/c mice to Ixodes ricinus instars, importance of several antigens in activation of specific Th2 subpopulations. Parasite Immunology 23, 61–69.
97. Mejri, N., Rutti, B. & Brossard, M. (2002). Immunosuppressive effects of Ixodes ricinus tick saliva or salivary gland extracts on innate and acquired immune response of BALB/c mice. Parasitology Research 88, 192–197.
98. Mosmann, T. R. & Coffman, R. L. (1989). Th1 and Th2 cells: different patterns of lymphokine secretion lead to different functional properties. Annual Review of Immunology 7, 145–173.
99. Mulenga, A. & Azad, A. F. (2005). The molecular and biological analysis of ixodid ticks histamine releasing factors. Experimental and Applied Acarology 37, 215–229.
100. Mulenga, A., Macaluso, K. R., Simser, J. A. & Azad, A. F. (2003). The American dog tick encodes a functional histamine release factor homolog. Insect Biochemistry and Molecular Biology 33, 911–919.
101. Nabi, I. R. (1999). The polarization of the motile cell. Journal of Cell Science 112, 1803–1811.
102. Nazareth, R. A., Tomaz, L. S., Ortiz-Costa, S., et al. (2006). Antithrombic properties of ixolaris, a potent inhibitor of the extrinsic pathway of the coagulation cascade. Thrombosis and Haemostasis 96, 7–13.
103. Nazario, S., Das, S., De Silva, A. M., et al. (1998). Prevention of Borrelia burgdorferi transmission in guinea pigs by tick immunity. American Journal of Tropical Medicine and Hygiene 58, 780–785.
104. Nene, V., Lee, D., Kang’A S., et al. (2004). Genes transcribed in the salivary glands of female Rhipicephalus appendiculatus ticks infected with Theileria parva. Insect Biochemistry and Molecular Biology 34, 1117–1128.
105. Nene, V., Lee, D., Quackenbush, J., et al. (2002). AvGI, and index of genes transcribed in the salivary glands of the ixodid tick Amblyomma variegatum. International Journal for Parasitology 32, 1447–1456.
106. Nithiuthai, S. & Allen, J. R. (1984a). Significant changes in epidermal Langerhans cells of guinea pigs infested with ticks (Dermacentor andersoni). Immunology 51, 133–141.
107. Nithiuthai, S. & Allen, J. R. (1984b). Effects of ultraviolet irradiation on the acquisition and expression of tick resistance in guinea pigs. Immunology 51, 153–159.
108. Nuttall, P. A. & Labuda, M. (2004). Tick–host interactions: saliva-activated transmission. Parasitology 129, S177–S189.
109. Paesen, G. C., Adams, P. L., Harlos, K., Nuttall, P. A. & Stuart, D. I. (1999). Tick histamine-binding proteins: isolation, cloning, and three-dimensional structure. Molecular Cell 3, 661–671.
110. Paine, S. H., Kemp, D. H. & Allen, J. R. (1983). In vitro feeding of Dermacentor andersoni (Stiles): effects of histamine and other mediators. Parasitology 86, 419–428.
111. Papatheodorou, V. & Brossard, M. (1987). C3 levels in the sera of rabbits infested and reinfested with Ixodes ricinus L. and in midguts of fed ticks. Experimental and Applied Acarology 3, 53–59.
112. Plow, E. F. & Abrams, C. S. (2005). The molecular basis of platelet function. In Hematology: Basic Principles and Practice, 4th edn, eds. Hoffman, R., Benz, E. J. Jr, Shatti, S. J., et al., 1881–1897.Philadelphia, PA: Elsevier.
113. Pr´evˆot, P. P., Adam, B., Boudjeltia, K. Z., et al. (2006). Anti-hemostatic effects of a serpin from the saliva of the tick Ixodes ricinus. Journal of Biological Chemistry 281, 26361–26369.
114. Ramachandra, R. N. & Wikel, S. K. (1992). Modulation of host-immune responses by ticks (Acari: Ixodidae): effect of salivary gland extracts on host macrophages and lymphocyte cytokine production. Journal of Medical Entomology 29, 818–826.
115. Ramachandra, R. N. & Wikel, S. K. (1995). Effects of Dermacentor andersoni (Acari: Ixodidae) salivary gland extracts on Bos indicus and B. taurus lymphocytes and macrophages: in vitro cytokine elaboration and lymphocyte blastogenesis. Journal of Medical Entomology 32, 338– 345.
116. Ribeiro, J. M. C. (1987). Role of saliva in blood-feeding by arthropods. Annual Review of Entomology 32, 463–478.
117. Ribeiro, J. M. C. (1989). Role of saliva in tick/host interactions. Experimental and Applied Acarology 7, 15–20.
118. Ribeiro, J. M. C. (1995a). Blood-feeding arthropods: live syringes or invertebrate pharmacologists? Infectious Agents and Disease 4, 143–152.
119. Ribeiro, J. M. C. (1995b). How ticks make a living. Parasitology Today 11, 91–93.
120. Ribeiro, J. M. C. (2004). Bugs, blood, and blisters. Journal of Investigative Dermatology 123, 15.
121. Ribeiro, J. M. C. & Francischetti I. M. B. (2003). Role of arthropod saliva in blood feeding: sialome and post-sialome perspectives. Annual Review of Entomology 48, 73–88.
122. Ribeiro, J. M. C. & Mather, T. N. (1998). Ixodes scapularis: salivary kininase activity is a metallo dipeptidyl carboxypeptidase. Experimental Parasitology 89, 213–221.
123. Ribeiro, J. M. C. & Spielman, A. (1986). Ixodes dammini: salivary anaphylatoxin inactivating activity. Experimental Parasitology 62, 292–297.
124. Ribeiro, J., Alarcon-Chaidez, F., Francischetti I. M. B., et al. (2006). An annotated catalog of salivary gland transcripts from Ixodes scapularis ticks. Insect Biochemistry and Molecular Biology 36, 111–129.
125. Ribeiro, J. M. C., Makoul, G. T., Levine, J., Robinson, D. R. & Spielman, A. (1985). Antihemostatic, antiinflammatory, and immunosuppressive properties of the saliva of a tick, Ixodes dammini. Journal of Experimental Medicine 161, 332–344.
126. Roberts, J. A. & Kerr, J. D. (1976). Boophilus microplus: passive transfer of resistance in cattle. Journal of Parasitology 62, 485–488.
127. Rudenko, N., Golovchenko, M., Edwards & Grubhoffer, L. (2005). Differential expression of Ixodes ricinus tick genes induced by blood feeding or Borrelia burgdorferi infection. Journal of Medical Entomology 42, 36–41.
128. Sahibi, H. F., Rhalem, A., Tikki, N., Ben Kouka, F. & Barriga, O. (1997). Hyalomma ticks: bovine resistance under field conditions as related to host age and breed. Parasite 4, 159–165.
129. Salmon, J. K., Armstrong, C. A. & Ansel, J. C. (1994). The skin as an immune organ. Western Journal of Medicine 160, 146–152.
130. Sangamnatdej, S., Paesen, G. C., Slovak, M. & Nuttall, P. A. (2002). A high affinity serotonin- and histamine-binding lipocalin from tick saliva. Insect Molecular Biology 11, 79–86.
131. Schleger, A. V., Lincoln, D. T., Mckenna, R. V., Kemp, D. H. & Roberts, J. A. (1976). Boophilus microplus: cellular responses to larval attachment and their relationship to host resistance. Australian Journal of Biological Science 29, 499–512.
132. Schneider, B. S., Soong, L., Girard, Y. A., et al. (2006). Potentiation of West Nile encephalitis by mosquito feeding. Viral Immunology 19, 74–82.
133. Schoeler, G. B. & Wikel, S. K. (2001). Modulation of host immunity by haematophagous arthropods. Annals of Tropical Medicine and Parasitology 95, 755–771.
134. Schoeler, G. B., Manweiler, S. A. & Wikel, S. K. (2000). Cytokine responses of C3H/HeN mice infested with Ixodes scapularis or Ixodes pacificus nymphs. Parasite Immunology 22, 31–40.
135. Schorderet, S. & Brossard, M. (1994). Effects of human recombinant interleukin-2 on the resistance, and on the humoral and cellular response of rabbits infested with adult Ixodes ricinus ticks. Veterinary Parasitology 54, 375–387.
136. Snowball, G. J. (1956). The effect of self-licking by cattle on infestation of cattle tick, Boophilus microplus (Canestrini). Australian Journal of Agricultural Research 7, 227–232.
137. Soares, C. A. G., Lima, C. M. R., Dolan, M. C., et al. (2005). Capillary feeding of specific dsRNA induces silencing of the isac gene in nymphal Ixodes scapularis ticks. Insect Molecular Biology 14, 443–452.
138. Sonenshine, D. E. (1991). Biology of Ticks, vol. 1. Oxford, UK: Oxford University Press.
139. Steen, N. A., Barker, S. C. & Alewood, P. F. (2006). Proteins in the saliva of the Ixodidae (ticks): pharmacological features and biological significance. Toxicon 47, 1–20.
140. Steeves, E. B. & Allen, J. R. (1991). Tick resistance in mast cell-deficient mice: histological studies. International Journal for Parasitology 21, 265–268.
141. Styer, L. M., Bernard, K. A. & Kramer, L. D. (2006). Enhanced early West Nile virus infection in young chickens infected by mosquito bite: effect of viral dose. American Journal of Tropical Medicine and Hygiene 75, 337–345.
142. Titus, R. G. & Ribeiro, J. M. C. (1988). Salivary gland lysates from the sand fly, Lutzomyia longipalpis, enhance Leishmania infectivity. Science 239, 1306–1308.
143. Titus, R. G. & Ribeiro, J. M. C. (1990). The role of vector saliva in transmission of arthropod-borne disease. Parasitology Today 6, 157–160.
144. Trager, W. (1939). Acquired immunity to ticks. Journal of Parasitology 25, 57–81.
145. Ullmann, A. J., Lima, C. M. R., Guerrero, F. D., Piesman, J. & Black, W.C. IV (2005). Genome size and organization in the blacklegged tick, Ixodes scapularis, and the Southern cattle tick, Boophilus microplus. Insect Molecular Biology 14, 217–222.
146. Umemiya, R., Hatta, T., Liao, M., et al. (2007). Haemaphysalis longicornis: molecular characterization of a homologue of the macrophage migration inhibitory factor from the partially fed ticks. Experimental Parasitology 115, 135–142.
147. Untalan, P. M., Guerrero, F. D., Haines, L. R. & Pearson, T.W. (2005). Proteome analysis of abundantly expressed proteins from unfed larvae of the cattle tick, Boophilus microplus. Insect Biochemistry and Molecular Biology 35, 141–151.
148. Urioste, S., Hall, L. R., Telford, S. R. III & Titus, R. G. (1994). Saliva of the Lyme disease vector, Ixodes dammini, blocks cell activation by a nonprostaglandin E2-dependent mechanism. Journal of Experimental Medicine 180, 1077–1085.
149. Valbuena, G. & Walker, D. H. (2004). Effect of blocking the CXCL9/10-CXCR3 chemokine system on the outcome of endothelial-target rickettsial infections. American Journal of Tropical Medicine and Hygiene 71, 393–399.
150. Valenzuela, J. G. (2004). Exploring tick saliva: from biochemistry to ‘sialomes’ and functional genomics. Parasitology 129, S83–S94.
151. Valenzuela, J. G., Charlab, R., Mather, T. N. & Ribeiro, J. M. C. (2000). Purification, cloning, and expression of a novel salivary anticomplement protein from the tick, Ixodes scapularis. Journal of Biological Chemistry 275, 18717–18723.
152. Valenzuela, J. G., Francischetti I. M. B., Pham, V. M., et al. (2002). Exploring the sialome of the tick Ixodes scapularis. Journal of Experimental Biology 205, 2843–2864.
153. Van Gisbergen, K. P. J. M., Paessens, L. C., Geijtenbeek, T. B. H. & Van Kooyk, Y. (2005). Molecular mechanisms that set the stage for DC-T cell engagement. Immunology Letters 97, 199–208.
154. Vaughan, J. A., Scheller, L. F., Wirtz, R. A. & Azad, A. F. (1999). Infectivity of Plasmodium berghei sporozoites delivered by intravenous inoculation versus mosquito bite: implications for sporozoite vaccine trials. Infection and Immunity 67, 4285–4289.
155. Vennestrom, J. & Jensin, P. M. (2007). Ixodes ricinus: the potential of two-dimensional gel electrophoresis as a tool for studying host–vector–pathogen interactions. Experimental Parasitology 115, 53–58.
156. Venter, J. C., Adams, M. D., Myers, E. W., et al. (2001). The sequence of the human genome. Science 291, 1304–1351.
157. Walker, D. H. (1998). Tick-transmitted infectious diseases in the United States. Annual Review of Public Health 19, 237–269.
158. Wang, H. & Nuttall, P. A. (1995). Immunoglobulin-G binding proteins in the ixodid ticks, Rhipicephalus appendiculatus, Amblyomma variegatum and Ixodes hexagonus. Parasitology 111, 161–165.
159. Wang, H., Kaufman, W. R. & Nuttall, P. A. (1999). Molecular individuality: polymorphism of salivary gland proteins in three species of ixodid tick. Experimental and Applied Acarology 23, 969–975.
160. Wikel, S. K. (1979). Acquired resistance to ticks: expression of resistance by C4-deficient guinea pigs. American Journal of Tropical Medicine and Hygiene 28, 586–590.
161. Wikel, S. K. (1982). Histamine content of tick attachment sites and the effects of H1 and H2 histamine antagonists on the expression of resistance. Annals of Tropical Medicine and Parasitology 76, 179–185.
162. Wikel, S. K. (1985). Effects of tick infestation on the plaque-forming cell response to a thymic dependent antigen. Annals of Tropical Medicine and Parasitology 79, 195–198.
163. Wikel, S. K. (1996). Host immunity to ticks. Annual Review of Entomology 41, 1–22.
164. Wikel, S. K. (1999). Tick modulation of host immunity: an important factor in pathogen transmission. International Journal for Parasitology 29, 851–859.
165. Wikel, S. K. & Allen, J. R. (1976). Acquired resistance to ticks. I. Passive transfer of resistance. Immunology 30, 311–316.
166. Wikel, S. K. & Allen, J. R. (1977). Acquired resistance to ticks. III. Cobra venom factor and the resistance response. Immunology 32, 457–465.
167. Wikel, S. K., Graham, J. E. & Allen, J. R. (1978). Acquired resistance to ticks. IV. Skin reactivity and in vitro lymphocyte responsiveness to salivary gland antigen. Immunology 34, 257–263.
168. Wikel, S. K., Ramachandra, R. N. & Bergman, D. K. (1994). Tick-induced modulation of the host immune response. International Journal for Parasitology 24, 59–66.
169. Wikel, S. K., Ramachandra, R. N., Bergman, D. K., Burkot, T. R. & Piesman, J. (1997). Infestation with pathogen-free nymphs of the tick Ixodes scapularis induces host resistance to transmission of Borrelia burgdorferi by ticks. Infection and Immunity 65, 335–338.
170. Willadsen, P. (1980). Immunity to ticks. Advances in Parasitology 18, 293–313.
171. Willadsen, P. (1987). Immunological approaches to the control of ticks. International Journal for Parasitology 17, 671–677.
172. Willadsen, P. & Jongejan, F. (1999). Immunology of the tick–host interaction and the control of ticks and tick-borne diseases. Parasitology Today 15, 258–262.
173. Willadsen, P., Wood, G. M. & Riding, G. A. (1979). The relation between skin histamine concentration, histamine sensitivity, and the resistance of cattle to the tick, Boophilus microplus. Zeitschrift fiir Parasitenkunde 59, 87–93.
174. Xu, G., Fang, Q. Q., Keirans, J. E. & Durden, L. A. (2004). Cloning and sequencing of putative calreticulin complementary DNAs from four hard tick species. Journal of Parasitology 90, 73–78.
175. Young, A. J. (1999). The physiology of lymphocyte migration through the single lymph node in vivo. Seminars in Immunology 11, 73–83.
176. Yu, D., Liang, J., Yu, H., et al. (2006). A tick B-cell inhibitory protein from salivary glands of the hard tick, Hyalomma asiaticum asiaticum. Biochemical and Biophysical Research Communications 343, 585–590.
177. Zeidner, N., Dolan, M., Massung, R., Piesman, J. & Fish, D. (2000). Coinfection with Borrelia burgdorferi and the agent of human granulocytic ehrlichiosis suppresses IL-2 and IFN-gamma production and promotes an IL-4 response in C3H/HeJ mice. Parasite Immunology 22, 581–588.
178. Zeidner, N. S., Schneider, B. S., Nuncio, M. S., Gern, L. & Piesman, J. (2002). Coinoculation of Borrelia s with tick salivary gland lysate enhances spirochete load in mice and is tick species-specific. Journal of Parasitology 88, 1276–1278.