Identification of an IL-2 binding protein in the saliva of the lyme disease vector tick, Ixodes scapularis

Journal of Immunology

Volumn 166, Issue 7, 2001, Pages 4319-4327

  Gillespie, R D ^a   Dolan, M C ^a   Piesman, J ^a   Titus, R G ^a  

^a Department of Environmental and Radiological Health Sciences   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; INTERLEUKIN 2; INTERLEUKIN 2 BINDING PROTEIN; MONOCLONAL ANTIBODY CD3; TRYPSIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; EFFECTOR CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; IXODES SCAPULARIS; LYME DISEASE; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; RABBIT; SALIVA; SPLEEN CELL; T LYMPHOCYTE;

EID: 0035313541     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.166.7.4319     Document Type: Article

References (64)

1. Salivary gland lysates from the sand fly Lutzomyia longipalpis enhance Leishmania infectivity
2. Modification of the skin feeding site by tick saliva mediates virus transmission
3. Black fly (Diptera: Simuliidae) salivary secretions: Importance in vector competence and disease
4. Mosquito feeding modulates Th1 and Th2 cytokines in flavivirus susceptible mice: An effect mimicked by injection of sialokinins, but not demonstrated in flavivirus resistant mice
5. Role of saliva in tick/host interactions
6. How ticks make a living
7. Tick-host immunology: Significant advances and challenging opportunities
8. The immunomodulatory factors of bloodfeeding arthropod saliva
9. Tick saliva: Recent advances and implications for vector competence
10. Bloodsucking ticks (Ixodoidea): Vectors of diseases of man and animals
11. Lyme disease - United States. 1996
12. Coexistence of antibodies to tick-borne pathogens of babesiosis, ehrlichiosis, and Lyme borreliosis in human sera
13. Concurrent Borrelia burgdorferi and Babesia microti infection in nymphal Ixodes dammini
14. Perpetuation of the agent of human granulocytic ehrlichiosis in a deer tick-rodent cycle
15. Tick-transmitted infectious diseases in the United States
16. Antihemostatic, antiinflammatory, and immunosuppressive properties of the saliva of a tick, Ixodes dammini
17. + T cells, and expression of ICAM-1, la antigens, IL-1α and TNF-α in the skin lesion of BALB/c mice undergoing repeated infestations with nymphal Ixodes ricinus ticks
18. IFN-γ IL-2, and IL-4 mRNA expression in the skin and draining lymph nodes of BALB/c mice repeatedly infested with nymphal Ixodes ricinus ticks
19. In vitro production of interleukin-4 and interferon-γ by nymph node cells from BALB/c mice infested with nymphal Ixodes ricinus ticks
20. Cytokine production by lymph node cells from mice infested with Ixodes ricinus ticks and the effect of tick salivary gland extracts on IL-2 production
21. Immunology of interactions between ticks and hosts
22. Effects of Ixodes scapularis and Borrelia burgdorferi on modulation of the host immune response: Induction of a TH2 cytokine response in Lyme disease-susceptible (C3H/HeJ) mice but not in disease-resistant (BALB/c) mice
23. Modulation of host-immune responses by ticks (Acari: Ixodidoe): Effect of salivary gland extracts on host macrophages and lymphocyte cytokine production
24. 2-dependent mechanism
25. Influence of Dermacentor andersoni infestation on lymphocyte responsiveness to mitogens
26. Characterization of an immunosuppressant protein from Dermacentor andersoni (Acari: Ixodidae) salivary glands
27. Saliva of Rhipicephalus sanguineus tick impairs T cell proliferation and IFN-γ-induced macrophage microbicidal activity
28. Isolation and molecular cloning of a secreted immunosuppressant protein from Dermacentor andersoni salivary gland
29. 2 production by the cattle tick (Boophilus microplus) into feeding sites and its effect on the response of bovine mononuclear cells to mitogen
30. Effects of Dermacentor andersoni (Acari: Ixodidae) salivary gland extracts on Bos indicus and B. taurus lymphocytes and macrophages: In vitro cytokine elaboration and lymphocyte blastogenesis
31. Lymphokines and the immune response: The central role of interleukin-2
32. Isolation of human peripheral blood lymphocytes: Modification of a double discontinuous density gradient of Ficoll-Hypaque
33. Identification of a monoclonal antibody specific for murine T3 polypeptide
34. Presence of Ixodiphagus hookeri (Hymenotera: Encyrtidae) in two Connecticut populations of Ixodes scapularis (Acari: Ixodidae)
35. Ixodes dammini: Salivary anaphylatoxin inactivating activity
36. Measurement of human and murine interleukin 2 and interleukin 4
37. Ixodes scapularis: Salivary kininase activity is a metallo dipeptidyl carboxypeptidase
38. Biotinylation and analysis of membrane-bound and soluble proteins
39. Ixodid tick salivary gland extracts inhibit production of lipopolysaccharide-induced mRNA of several different human cytokines
40. Unique structure of murine interleukin-2 as deduced from cloned cDNAs
41. Species-specificity of T cell stimulating activities of IL-2 and BSF-I (IL-4): Comparison of normal and recombinant, mouse and human IL-2 and BSF-I (IL-4)
42. Tick salivary prostaglandins: Presence, origin and significance
43. Interleukin-2
44. Interleukin 2 and its receptors: Recent advances and new immunological functions
45. The IL-2 receptor β chain (p70): Role in mediating signals for LAK, NK, and proliferative activities
46. Suppressive effect of Ixodes ricinus salivary gland extract on mechanisms of natural immunity in vitro
47. Salivary gland extracts of partially fed Dermacentor reticulatus ticks decrease natural killer cell activity in vitro
48. Immune interferon: A plieotropic lymphokine with multiple effects
49. Excretion of host immunoglobulin in tick saliva and detection of IgG-binding proteins in tick haemolymph and salivary glands
50. Immunoglubulin-G binding proteins in the ixodid ticks, Rhipicephalus appendiculatus, Amblyomma variegatum and Ixodes hexagonus
51. Suppression of acute Ixodes scapularis-induced Borrelia burgdorferi infection using tumor necrosis factor-α, interleukin-2, and interferon-γ
52. Effects of human recombinant interleukin-2 on resistance, and on the humoral and cellular response of rabbits infested with adult Ixodes ricinus ticks
53. Effects of cyclosporin-A on the humoral immunity to ticks and on cutaneous immediate and delayed hypersensitivity reactions to Ixodes ricinus L. salivary-gland antigens in re-infested rabbits
54. Clethrionomys glareolus, but not Apodemus flavicollis, acquires resistance to Ixodes ricinus L., the main European vector of Borrelia burgdorferi
55. Ixodes scapularis: Effects of repeated infestations with pathogen-free nymphs on macrophage and T lymphocyte cytokine responses of BALB/c and C3H/HeN mice
56. The Th1/Th2 paradigm
57. Lymphocyte responses and cytokines
58. Clonal anergy in induced in vitro by T cell receptor occupancy in the absence of proliferation
59. Models of T cell anergy: Is there a common molecular mechanism?
60. Infestation with pathogen-free nymphs of the tick Ixodes scapularis induces host resistance to transmission of Borrelia burgdorferi by ticks
61. Prevention of Borrelia burgdorferi transmission in guinea pigs by tick immunity
62. Absence of acquired resistance to nymphal Ixodes ricinus ticks in BALB/c mice developing cutaneous reactions
63. Subversion of the immune system by pathogens