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Volumn 19, Issue 2, 2015, Pages 223-238

Global Epidemiology of Hepatocellular Carcinoma: An Emphasis on Demographic and Regional Variability

Author keywords

Aflatoxin; Alcohol; Chemoprevention; Coffee; Diabetes; Hepatitis B virus; Hepatitis C virus; Incidence

Indexed keywords

ACETYLSALICYLIC ACID; AFLATOXIN; ANTIDIABETIC AGENT; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR;

EID: 84928825539     PISSN: 10893261     EISSN: 15578224     Source Type: Journal    
DOI: 10.1016/j.cld.2015.01.001     Document Type: Review
Times cited : (690)

References (116)
  • 1
    • 79151482545 scopus 로고    scopus 로고
    • volumes I to X: IARC CANCERBase No. 10 [Internet]. Available at: Accessed November 25, 2014.
    • Ferlay J, Parkin DM, Curado MP, et al. Cancer incidence in five continents, volumes I to X: IARC CANCERBase No. 10 [Internet]. 2014. Available at: . Accessed November 25, 2014. http://ci5.iarc.fr.
    • (2014) Cancer incidence in five continents
    • Ferlay, J.1    Parkin, D.M.2    Curado, M.P.3
  • 2
    • 84892961071 scopus 로고    scopus 로고
    • GLOBOCAN 2012 v1.0, [Internet]. Lyon (France): International Agency for Research on Cancer. Available at: Accessed November 12, 2014.
    • Ferlay J, Soerjomataram I, Ervik M, et al. GLOBOCAN 2012 v1.0, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 11 [Internet]. Lyon (France): International Agency for Research on Cancer. 2013. Available at: . Accessed November 12, 2014. http://globocan.iarc.fr.
    • (2013) Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 11
    • Ferlay, J.1    Soerjomataram, I.2    Ervik, M.3
  • 3
    • 84898017095 scopus 로고    scopus 로고
    • Changing hepatocellular carcinoma incidence and liver cancer mortality rates in the United States
    • Altekruse S.F., Henley S.J., Cucinelli J.E., et al. Changing hepatocellular carcinoma incidence and liver cancer mortality rates in the United States. Am J Gastroenterol 2014, 109(4):542-553.
    • (2014) Am J Gastroenterol , vol.109 , Issue.4 , pp. 542-553
    • Altekruse, S.F.1    Henley, S.J.2    Cucinelli, J.E.3
  • 4
    • 84857993173 scopus 로고    scopus 로고
    • Declining rates of hepatocellular carcinoma in urban Shanghai: incidence trends in 1976-2005
    • Gao S., Yang W.S., Bray F., et al. Declining rates of hepatocellular carcinoma in urban Shanghai: incidence trends in 1976-2005. Eur J Epidemiol 2012, 27(1):39-46.
    • (2012) Eur J Epidemiol , vol.27 , Issue.1 , pp. 39-46
    • Gao, S.1    Yang, W.S.2    Bray, F.3
  • 5
    • 44649158914 scopus 로고    scopus 로고
    • Declining incidence of hepatocellular carcinoma in Osaka, Japan, from 1990 to 2003
    • Tanaka H., Imai Y., Hiramatsu N., et al. Declining incidence of hepatocellular carcinoma in Osaka, Japan, from 1990 to 2003. Ann Intern Med 2008, 148(11):820-826.
    • (2008) Ann Intern Med , vol.148 , Issue.11 , pp. 820-826
    • Tanaka, H.1    Imai, Y.2    Hiramatsu, N.3
  • 6
    • 84928824400 scopus 로고    scopus 로고
    • SEER*Stat Database: Incidence - SEER 18 Regs Research Data+ Hurricane Katrina Impacted Louisiana Cases
    • Nov 2013 Sub (1973-2011) Total U.S., National Cancer Institute, DCCPS, Surveillance Research Program, Surveillance Systems Branch, based on the November 2013 submission.
    • Surveillance, Epidemiology, and End Results (SEER) Program () SEER*Stat Database: Incidence - SEER 18 Regs Research Data+ Hurricane Katrina Impacted Louisiana Cases, Nov 2013 Sub (1973-2011) Total U.S., National Cancer Institute, DCCPS, Surveillance Research Program, Surveillance Systems Branch, based on the November 2013 submission. 2014. http://www.seer.cancer.gov.
    • (2014)
  • 7
    • 84928827938 scopus 로고    scopus 로고
    • SEER*Stat Database: North American Association of Central Cancer Registries (NAACCR) Incidence-CiNA Analytic File, 1995-2009.
    • Bethesda, MD: National Cancer Institute, Division of Cancer Control and Population Sciences, Surveillance Research Program, Surveillance Systems Branch.
    • Surveillance, Epidemiology and End Results (SEER) Program. SEER*Stat Database: North American Association of Central Cancer Registries (NAACCR) Incidence-CiNA Analytic File, 1995-2009. Bethesda, MD: National Cancer Institute, Division of Cancer Control and Population Sciences, Surveillance Research Program, Surveillance Systems Branch. 2012.
    • (2012)
  • 8
    • 33748114343 scopus 로고    scopus 로고
    • The contributions of hepatitis B virus and hepatitis C virus infections to cirrhosis and primary liver cancer worldwide
    • Perz J.F., Armstrong G.L., Farrington L.A., et al. The contributions of hepatitis B virus and hepatitis C virus infections to cirrhosis and primary liver cancer worldwide. JHepatol 2006, 45(4):529-538.
    • (2006) JHepatol , vol.45 , Issue.4 , pp. 529-538
    • Perz, J.F.1    Armstrong, G.L.2    Farrington, L.A.3
  • 9
    • 84874461841 scopus 로고    scopus 로고
    • Dating the origin and dispersal of hepatitis B virus infection in humans and primates
    • Paraskevis D., Magiorkinis G., Magiorkinis E., et al. Dating the origin and dispersal of hepatitis B virus infection in humans and primates. Hepatology 2013, 57(3):908-916.
    • (2013) Hepatology , vol.57 , Issue.3 , pp. 908-916
    • Paraskevis, D.1    Magiorkinis, G.2    Magiorkinis, E.3
  • 10
    • 0035968355 scopus 로고    scopus 로고
    • Reconstructing the origins of human hepatitis viruses
    • Simmonds P. Reconstructing the origins of human hepatitis viruses. Philos Trans R Soc Lond B Biol Sci 2001, 356(1411):1013-1026.
    • (2001) Philos Trans R Soc Lond B Biol Sci , vol.356 , Issue.1411 , pp. 1013-1026
    • Simmonds, P.1
  • 11
    • 0004201313 scopus 로고
    • International Agency for Research on Cancer, Lyon (France)
    • International Agency for Research on Cancer Hepatitis viruses 1994, International Agency for Research on Cancer, Lyon (France).
    • (1994) Hepatitis viruses
  • 12
    • 84857358267 scopus 로고    scopus 로고
    • Global epidemiology of hepatitis B virus infection: new estimates of age-specific HBsAg seroprevalence and endemicity
    • Ott J.J., Stevens G.A., Groeger J., et al. Global epidemiology of hepatitis B virus infection: new estimates of age-specific HBsAg seroprevalence and endemicity. Vaccine 2012, 30(12):2212-2219.
    • (2012) Vaccine , vol.30 , Issue.12 , pp. 2212-2219
    • Ott, J.J.1    Stevens, G.A.2    Groeger, J.3
  • 13
    • 1642337523 scopus 로고    scopus 로고
    • Available at: Accessed November 5, 2014.
    • Centers for Disease Control and Prevention. Hepatitis B. 2010. Available at: . Accessed November 5, 2014. http://wwwnc.cdc.gov/travel/yellowbook/2010/chapter-2/hepatitis-b.aspx.
    • (2010) Hepatitis B
  • 14
    • 0021998199 scopus 로고
    • Lack of perinatal transmission of hepatitis B virus infection in Senegal, West Africa
    • Marinier E., Barrois V., Larouze B., et al. Lack of perinatal transmission of hepatitis B virus infection in Senegal, West Africa. JPediatr 1985, 106(5):843-849.
    • (1985) JPediatr , vol.106 , Issue.5 , pp. 843-849
    • Marinier, E.1    Barrois, V.2    Larouze, B.3
  • 15
    • 0036828782 scopus 로고    scopus 로고
    • Dominant role of hepatitis B virus and cofactor role of aflatoxin in hepatocarcinogenesis in Qidong, China
    • Ming L., Thorgeirsson S.S., Gail M.H., et al. Dominant role of hepatitis B virus and cofactor role of aflatoxin in hepatocarcinogenesis in Qidong, China. Hepatology 2002, 36(5):1214-1220.
    • (2002) Hepatology , vol.36 , Issue.5 , pp. 1214-1220
    • Ming, L.1    Thorgeirsson, S.S.2    Gail, M.H.3
  • 16
    • 33746675024 scopus 로고    scopus 로고
    • Past HBV viral load as predictor of mortality and morbidity from HCC and chronic liver disease in a prospective study
    • Chen G., Lin W., Shen F., et al. Past HBV viral load as predictor of mortality and morbidity from HCC and chronic liver disease in a prospective study. Am J Gastroenterol 2006, 101(8):1797-1803.
    • (2006) Am J Gastroenterol , vol.101 , Issue.8 , pp. 1797-1803
    • Chen, G.1    Lin, W.2    Shen, F.3
  • 17
    • 66149187115 scopus 로고    scopus 로고
    • Hepatitis B virus DNA levels and outcomes in chronic hepatitis B
    • Chen C.J., Yang H.I., Iloeje U.H. Hepatitis B virus DNA levels and outcomes in chronic hepatitis B. Hepatology 2009, 49(Suppl 5):S72-S84.
    • (2009) Hepatology , vol.49 , pp. S72-S84
    • Chen, C.J.1    Yang, H.I.2    Iloeje, U.H.3
  • 18
    • 66149175804 scopus 로고    scopus 로고
    • The natural history of chronic hepatitis B virus infection
    • McMahon B.J. The natural history of chronic hepatitis B virus infection. Hepatology 2009, 49(Suppl 5):S45-S55.
    • (2009) Hepatology , vol.49 , pp. S45-S55
    • McMahon, B.J.1
  • 19
    • 77954650414 scopus 로고    scopus 로고
    • Natural history of chronic hepatitis B
    • McMahon B.J. Natural history of chronic hepatitis B. Clin Liver Dis 2010, 14(3):381-396.
    • (2010) Clin Liver Dis , vol.14 , Issue.3 , pp. 381-396
    • McMahon, B.J.1
  • 20
    • 0037219388 scopus 로고    scopus 로고
    • Influence of hepatitis B virus genotypes on the progression of chronic type B liver disease
    • Sumi H., Yokosuka O., Seki N., et al. Influence of hepatitis B virus genotypes on the progression of chronic type B liver disease. Hepatology 2003, 37(1):19-26.
    • (2003) Hepatology , vol.37 , Issue.1 , pp. 19-26
    • Sumi, H.1    Yokosuka, O.2    Seki, N.3
  • 21
    • 1642337523 scopus 로고    scopus 로고
    • Available at: Accessed November 3, 2014.
    • World Health Organization. Hepatitis B. 2010. Available at: . Accessed November 3, 2014. http://www.who.int/immunization/topics/hepatits_b/en/index.html.
    • (2010) Hepatitis B.
  • 22
    • 29244437488 scopus 로고    scopus 로고
    • Amathematical model to estimate global hepatitis B disease burden and vaccination impact
    • Goldstein S.T., Zhou F., Hadler S.C., et al. Amathematical model to estimate global hepatitis B disease burden and vaccination impact. Int J Epidemiol 2005, 34(6):1329-1339.
    • (2005) Int J Epidemiol , vol.34 , Issue.6 , pp. 1329-1339
    • Goldstein, S.T.1    Zhou, F.2    Hadler, S.C.3
  • 23
    • 1642337523 scopus 로고    scopus 로고
    • World Health Organization, Available at:, Accessed December 3, 2014 Fact sheet no. 204
    • World Health Organization Fact sheet no. 204, Hepatitis B 2014, World Health Organization, Available at:, Accessed December 3, 2014. http://www.who.int/mediacentre/factsheets/fs204/en/.
    • (2014) Hepatitis B
  • 24
    • 84920623099 scopus 로고    scopus 로고
    • Hepatitis B vaccine by intradermal route in non responder patients: an update
    • Filippelli M., Lionetti E., Gennaro A., et al. Hepatitis B vaccine by intradermal route in non responder patients: an update. World J Gastroenterol 2014, 20(30):10383-10394.
    • (2014) World J Gastroenterol , vol.20 , Issue.30 , pp. 10383-10394
    • Filippelli, M.1    Lionetti, E.2    Gennaro, A.3
  • 25
    • 70349939381 scopus 로고    scopus 로고
    • Decreased incidence of hepatocellular carcinoma in hepatitis B vaccinees: a 20-year follow-up study
    • Chang M.H., You S.L., Chen C.J., et al. Decreased incidence of hepatocellular carcinoma in hepatitis B vaccinees: a 20-year follow-up study. JNatl Cancer Inst 2009, 101(19):1348-1355.
    • (2009) JNatl Cancer Inst , vol.101 , Issue.19 , pp. 1348-1355
    • Chang, M.H.1    You, S.L.2    Chen, C.J.3
  • 26
    • 84883374441 scopus 로고    scopus 로고
    • Thirty-year outcomes of the national hepatitis B immunization program in Taiwan
    • Chiang C.J., Yang Y.W., You S.L., et al. Thirty-year outcomes of the national hepatitis B immunization program in Taiwan. JAMA 2013, 310(9):974-976.
    • (2013) JAMA , vol.310 , Issue.9 , pp. 974-976
    • Chiang, C.J.1    Yang, Y.W.2    You, S.L.3
  • 27
    • 67650670969 scopus 로고    scopus 로고
    • Evaluation of the impact of hepatitis B vaccination among children born during 1992-2005 in China
    • Liang X., Bi S., Yang W., et al. Evaluation of the impact of hepatitis B vaccination among children born during 1992-2005 in China. JInfect Dis 2009, 200(1):39-47.
    • (2009) JInfect Dis , vol.200 , Issue.1 , pp. 39-47
    • Liang, X.1    Bi, S.2    Yang, W.3
  • 28
    • 84891926517 scopus 로고    scopus 로고
    • Seroepidemiology of hepatitis B virus infection among adults in Singapore: a 12-year review
    • Ang L.W., Cutter J., James L., et al. Seroepidemiology of hepatitis B virus infection among adults in Singapore: a 12-year review. Vaccine 2013, 32(1):103-110.
    • (2013) Vaccine , vol.32 , Issue.1 , pp. 103-110
    • Ang, L.W.1    Cutter, J.2    James, L.3
  • 29
    • 84894230843 scopus 로고    scopus 로고
    • Viral entry of hepatitis B and D viruses and bile salts transportation share common molecular determinants on sodium taurocholate cotransporting polypeptide
    • Yan H., Peng B., Liu Y., et al. Viral entry of hepatitis B and D viruses and bile salts transportation share common molecular determinants on sodium taurocholate cotransporting polypeptide. JVirol 2014, 88(6):3273-3284.
    • (2014) JVirol , vol.88 , Issue.6 , pp. 3273-3284
    • Yan, H.1    Peng, B.2    Liu, Y.3
  • 30
    • 84921902534 scopus 로고    scopus 로고
    • Cytidine deamination and cccDNA degradation: a new approach for curing HBV?
    • Ding S., Robek M.D. Cytidine deamination and cccDNA degradation: a new approach for curing HBV?. Hepatology 2014, 60(6):2118-2121.
    • (2014) Hepatology , vol.60 , Issue.6 , pp. 2118-2121
    • Ding, S.1    Robek, M.D.2
  • 31
    • 0024509701 scopus 로고
    • Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome
    • Choo Q.L., Kuo G., Weiner A.J., et al. Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. Science 1989, 244(4902):359-362.
    • (1989) Science , vol.244 , Issue.4902 , pp. 359-362
    • Choo, Q.L.1    Kuo, G.2    Weiner, A.J.3
  • 32
    • 7444256169 scopus 로고    scopus 로고
    • Genetic diversity and evolution of hepatitis C virus: 15 years on
    • Simmonds P. Genetic diversity and evolution of hepatitis C virus: 15 years on. JGen Virol 2004, 85(Pt 11):3173-3188.
    • (2004) JGen Virol , vol.85 , Issue.PART. 11 , pp. 3173-3188
    • Simmonds, P.1
  • 33
    • 0027522145 scopus 로고
    • Classification of hepatitis C virus into six major genotypes and a series of subtypes by phylogenetic analysis of the NS-5 region
    • Simmonds P., Holmes E.C., Cha T.A., et al. Classification of hepatitis C virus into six major genotypes and a series of subtypes by phylogenetic analysis of the NS-5 region. JGen Virol 1993, 74(Pt 11):2391-2399.
    • (1993) JGen Virol , vol.74 , pp. 2391-2399
    • Simmonds, P.1    Holmes, E.C.2    Cha, T.A.3
  • 34
    • 58149487593 scopus 로고    scopus 로고
    • Genetic history of hepatitis C virus in East Asia
    • Pybus O.G., Barnes E., Taggart R., et al. Genetic history of hepatitis C virus in East Asia. JVirol 2009, 83(2):1071-1082.
    • (2009) JVirol , vol.83 , Issue.2 , pp. 1071-1082
    • Pybus, O.G.1    Barnes, E.2    Taggart, R.3
  • 35
    • 34249947378 scopus 로고    scopus 로고
    • Investigating the endemic transmission of the hepatitis C virus
    • Pybus O.G., Markov P.V., Wu A., et al. Investigating the endemic transmission of the hepatitis C virus. Int J Parasitol 2007, 37(8-9):839-849.
    • (2007) Int J Parasitol , vol.37 , Issue.8-9 , pp. 839-849
    • Pybus, O.G.1    Markov, P.V.2    Wu, A.3
  • 36
    • 77950648470 scopus 로고    scopus 로고
    • An overview about hepatitis C: a devastating virus
    • Bostan N., Mahmood T. An overview about hepatitis C: a devastating virus. Crit Rev Microbiol 2010, 36(2):91-133.
    • (2010) Crit Rev Microbiol , vol.36 , Issue.2 , pp. 91-133
    • Bostan, N.1    Mahmood, T.2
  • 37
    • 0037180344 scopus 로고    scopus 로고
    • Inaugural Article: a comparison of the molecular clock of hepatitis C virus in the United States and Japan predicts that hepatocellular carcinoma incidence in the United States will increase over the next two decades
    • Tanaka Y., Hanada K., Mizokami M., et al. Inaugural Article: a comparison of the molecular clock of hepatitis C virus in the United States and Japan predicts that hepatocellular carcinoma incidence in the United States will increase over the next two decades. Proc Natl Acad Sci USA 2002, 99(24):15584-15589.
    • (2002) Proc Natl Acad Sci USA , vol.99 , Issue.24 , pp. 15584-15589
    • Tanaka, Y.1    Hanada, K.2    Mizokami, M.3
  • 38
    • 0032791973 scopus 로고    scopus 로고
    • Chronic Japanese schistosomiasis and hepatocellular carcinoma: ten years of follow-up in Yamanashi Prefecture, Japan
    • Iida F., Iida R., Kamijo H., et al. Chronic Japanese schistosomiasis and hepatocellular carcinoma: ten years of follow-up in Yamanashi Prefecture, Japan. Bull World Health Organ 1999, 77(7):573-581.
    • (1999) Bull World Health Organ , vol.77 , Issue.7 , pp. 573-581
    • Iida, F.1    Iida, R.2    Kamijo, H.3
  • 39
    • 0034635771 scopus 로고    scopus 로고
    • The role of parenteral antischistosomal therapy in the spread of hepatitis C virus in Egypt
    • Frank C., Mohamed M.K., Strickland G.T., et al. The role of parenteral antischistosomal therapy in the spread of hepatitis C virus in Egypt. Lancet 2000, 355(9207):887-891.
    • (2000) Lancet , vol.355 , Issue.9207 , pp. 887-891
    • Frank, C.1    Mohamed, M.K.2    Strickland, G.T.3
  • 40
    • 0033998786 scopus 로고    scopus 로고
    • The past incidence of hepatitis C virus infection: implications for the future burden of chronic liver disease in the United States
    • Armstrong G.L., Alter M.J., McQuillan G.M., et al. The past incidence of hepatitis C virus infection: implications for the future burden of chronic liver disease in the United States. Hepatology 2000, 31(3):777-782.
    • (2000) Hepatology , vol.31 , Issue.3 , pp. 777-782
    • Armstrong, G.L.1    Alter, M.J.2    McQuillan, G.M.3
  • 41
    • 0037108452 scopus 로고    scopus 로고
    • Empirically calibrated model of hepatitis C virus infection in the United States
    • Salomon J.A., Weinstein M.C., Hammitt J.K., et al. Empirically calibrated model of hepatitis C virus infection in the United States. Am J Epidemiol 2002, 156(8):761-773.
    • (2002) Am J Epidemiol , vol.156 , Issue.8 , pp. 761-773
    • Salomon, J.A.1    Weinstein, M.C.2    Hammitt, J.K.3
  • 42
    • 0033970836 scopus 로고    scopus 로고
    • 45-year follow-up of hepatitis C virus infection in healthy young adults
    • Seeff L.B., Miller R.N., Rabkin C.S., et al. 45-year follow-up of hepatitis C virus infection in healthy young adults. Ann Intern Med 2000, 132(2):105-111.
    • (2000) Ann Intern Med , vol.132 , Issue.2 , pp. 105-111
    • Seeff, L.B.1    Miller, R.N.2    Rabkin, C.S.3
  • 43
    • 75149163334 scopus 로고    scopus 로고
    • Aging of hepatitis C virus (HCV)-infected persons in the United States: a multiple cohort model of HCV prevalence and disease progression
    • 521.e1-6
    • Davis G.L., Alter M.J., El-Serag H., et al. Aging of hepatitis C virus (HCV)-infected persons in the United States: a multiple cohort model of HCV prevalence and disease progression. Gastroenterology 2010, 138(2):513-521. 521.e1-6.
    • (2010) Gastroenterology , vol.138 , Issue.2 , pp. 513-521
    • Davis, G.L.1    Alter, M.J.2    El-Serag, H.3
  • 44
    • 77957913871 scopus 로고    scopus 로고
    • Discovery of a beta-d-2'-deoxy-2'-alpha-fluoro-2'-beta-C-methyluridine nucleotide prodrug (PSI-7977) for the treatment of hepatitis C virus
    • Sofia M.J., Bao D., Chang W., et al. Discovery of a beta-d-2'-deoxy-2'-alpha-fluoro-2'-beta-C-methyluridine nucleotide prodrug (PSI-7977) for the treatment of hepatitis C virus. JMed Chem 2010, 53(19):7202-7218.
    • (2010) JMed Chem , vol.53 , Issue.19 , pp. 7202-7218
    • Sofia, M.J.1    Bao, D.2    Chang, W.3
  • 45
    • 84892619580 scopus 로고    scopus 로고
    • Daclatasvir plus sofosbuvir for previously treated or untreated chronic HCV infection
    • Sulkowski M.S., Gardiner D.F., Rodriguez-Torres M., et al. Daclatasvir plus sofosbuvir for previously treated or untreated chronic HCV infection. NEngl J Med 2014, 370(3):211-221.
    • (2014) NEngl J Med , vol.370 , Issue.3 , pp. 211-221
    • Sulkowski, M.S.1    Gardiner, D.F.2    Rodriguez-Torres, M.3
  • 46
    • 0003415153 scopus 로고
    • Overall evaluations of carcinogenicity: an updating of IARC monographs volumes 1 to 42. Supplement 7
    • International Agency for Research on Cancer, Lyon (France)
    • IARC Overall evaluations of carcinogenicity: an updating of IARC monographs volumes 1 to 42. Supplement 7 1987, International Agency for Research on Cancer, Lyon (France).
    • (1987)
  • 47
    • 0034113808 scopus 로고    scopus 로고
    • Primary prevention of hepatocellular carcinoma in developing countries
    • Wild C.P., Hall A.J. Primary prevention of hepatocellular carcinoma in developing countries. Mutat Res 2000, 462(2-3):381-393.
    • (2000) Mutat Res , vol.462 , Issue.2-3 , pp. 381-393
    • Wild, C.P.1    Hall, A.J.2
  • 48
    • 70350768992 scopus 로고    scopus 로고
    • Control of hepatocellular carcinoma through hepatitis B vaccination in areas of high endemicity: perspectives for global liver cancer prevention
    • Plymoth A., Viviani S., Hainaut P. Control of hepatocellular carcinoma through hepatitis B vaccination in areas of high endemicity: perspectives for global liver cancer prevention. Cancer Lett 2009, 286(1):15-21.
    • (2009) Cancer Lett , vol.286 , Issue.1 , pp. 15-21
    • Plymoth, A.1    Viviani, S.2    Hainaut, P.3
  • 49
    • 0037152655 scopus 로고    scopus 로고
    • Determinants of formation of aflatoxin-albumin adducts: a seven-township study in Taiwan
    • Sun C.A., Wu D.M., Wang L.Y., et al. Determinants of formation of aflatoxin-albumin adducts: a seven-township study in Taiwan. Br J Cancer 2002, 87(9):966-970.
    • (2002) Br J Cancer , vol.87 , Issue.9 , pp. 966-970
    • Sun, C.A.1    Wu, D.M.2    Wang, L.Y.3
  • 50
    • 0028356088 scopus 로고
    • Afollow-up study of urinary markers of aflatoxin exposure and liver cancer risk in Shanghai, People's Republic of China
    • Qian G.S., Ross R.K., Yu M.C., et al. Afollow-up study of urinary markers of aflatoxin exposure and liver cancer risk in Shanghai, People's Republic of China. Cancer Epidemiol Biomarkers Prev 1994, 3(1):3-10.
    • (1994) Cancer Epidemiol Biomarkers Prev , vol.3 , Issue.1 , pp. 3-10
    • Qian, G.S.1    Ross, R.K.2    Yu, M.C.3
  • 51
    • 0026566829 scopus 로고
    • Urinary aflatoxin biomarkers and risk of hepatocellular carcinoma
    • Ross R.K., Yuan J.M., Yu M.C., et al. Urinary aflatoxin biomarkers and risk of hepatocellular carcinoma. Lancet 1992, 339(8799):943-946.
    • (1992) Lancet , vol.339 , Issue.8799 , pp. 943-946
    • Ross, R.K.1    Yuan, J.M.2    Yu, M.C.3
  • 52
    • 13944251714 scopus 로고    scopus 로고
    • Hepatitis B 1762T/1764A mutations, hepatitis C infection, and codon 249 p53 mutations in hepatocellular carcinomas from Thailand
    • Kuang S.Y., Lekawanvijit S., Maneekarn N., et al. Hepatitis B 1762T/1764A mutations, hepatitis C infection, and codon 249 p53 mutations in hepatocellular carcinomas from Thailand. Cancer Epidemiol Biomarkers Prev 2005, 14(2):380-384.
    • (2005) Cancer Epidemiol Biomarkers Prev , vol.14 , Issue.2 , pp. 380-384
    • Kuang, S.Y.1    Lekawanvijit, S.2    Maneekarn, N.3
  • 53
    • 77953237514 scopus 로고    scopus 로고
    • Global burden of aflatoxin-induced hepatocellular carcinoma: a risk assessment
    • Liu Y., Wu F. Global burden of aflatoxin-induced hepatocellular carcinoma: a risk assessment. Environ Health Perspect 2010, 118(6):818-824.
    • (2010) Environ Health Perspect , vol.118 , Issue.6 , pp. 818-824
    • Liu, Y.1    Wu, F.2
  • 54
    • 74049147153 scopus 로고    scopus 로고
    • Mycotoxins and human disease: a largely ignored global health issue
    • Wild C.P., Gong Y.Y. Mycotoxins and human disease: a largely ignored global health issue. Carcinogenesis 2010, 31(1):71-82.
    • (2010) Carcinogenesis , vol.31 , Issue.1 , pp. 71-82
    • Wild, C.P.1    Gong, Y.Y.2
  • 55
    • 84887899631 scopus 로고    scopus 로고
    • Reduced aflatoxin exposure presages decline in liver cancer mortality in an endemic region of China
    • Chen J.G., Egner P.A., Ng D., et al. Reduced aflatoxin exposure presages decline in liver cancer mortality in an endemic region of China. Cancer Prev Res (Phila) 2013, 6(10):1038-1045.
    • (2013) Cancer Prev Res (Phila) , vol.6 , Issue.10 , pp. 1038-1045
    • Chen, J.G.1    Egner, P.A.2    Ng, D.3
  • 56
    • 35449001153 scopus 로고    scopus 로고
    • Liver Cancer
    • Oxford University Press, New York, D. Schottenfeld, J.F. Fraumeni (Eds.)
    • London W.T., McGlynn K.A. Liver Cancer. Cancer epidemiology and prevention 2006, 763-786. Oxford University Press, New York. D. Schottenfeld, J.F. Fraumeni (Eds.).
    • (2006) Cancer epidemiology and prevention , pp. 763-786
    • London, W.T.1    McGlynn, K.A.2
  • 57
    • 0037083159 scopus 로고    scopus 로고
    • Alcohol and hepatocellular carcinoma: the effect of lifetime intake and hepatitis virus infections in men and women
    • Donato F., Tagger A., Gelatti U., et al. Alcohol and hepatocellular carcinoma: the effect of lifetime intake and hepatitis virus infections in men and women. Am J Epidemiol 2002, 155(4):323-331.
    • (2002) Am J Epidemiol , vol.155 , Issue.4 , pp. 323-331
    • Donato, F.1    Tagger, A.2    Gelatti, U.3
  • 58
    • 0033973253 scopus 로고    scopus 로고
    • Tobacco smoking, alcohol consumption and their interaction in the causation of hepatocellular carcinoma
    • Kuper H., Tzonou A., Kaklamani E., et al. Tobacco smoking, alcohol consumption and their interaction in the causation of hepatocellular carcinoma. Int J Cancer 2000, 85(4):498-502.
    • (2000) Int J Cancer , vol.85 , Issue.4 , pp. 498-502
    • Kuper, H.1    Tzonou, A.2    Kaklamani, E.3
  • 59
    • 4143065907 scopus 로고    scopus 로고
    • Synergism of alcohol, diabetes, and viral hepatitis on the risk of hepatocellular carcinoma in blacks and whites in the U.S.
    • Yuan J.M., Govindarajan S., Arakawa K., et al. Synergism of alcohol, diabetes, and viral hepatitis on the risk of hepatocellular carcinoma in blacks and whites in the U.S. Cancer 2004, 101(5):1009-1017.
    • (2004) Cancer , vol.101 , Issue.5 , pp. 1009-1017
    • Yuan, J.M.1    Govindarajan, S.2    Arakawa, K.3
  • 60
    • 0004213751 scopus 로고
    • International Agency for Research on Cancer, Lyon (France)
    • International Agency for Research on Cancer Alcohol drinking 1988, International Agency for Research on Cancer, Lyon (France).
    • (1988) Alcohol drinking
  • 61
    • 35448966378 scopus 로고    scopus 로고
    • Food, nutrition, physical activity, and the prevention of cancer: a global perspective
    • American Institute for Cancer Research, Washington, DC
    • World Cancer Research Fund/American Institute for Cancer Research Food, nutrition, physical activity, and the prevention of cancer: a global perspective 2007, American Institute for Cancer Research, Washington, DC.
    • (2007)
  • 62
    • 84905185146 scopus 로고    scopus 로고
    • Alcohol and liver cancer: a systematic review and meta-analysis of prospective studies
    • Turati F., Galeone C., Rota M., et al. Alcohol and liver cancer: a systematic review and meta-analysis of prospective studies. Ann Oncol 2014, 25(8):1526-1535.
    • (2014) Ann Oncol , vol.25 , Issue.8 , pp. 1526-1535
    • Turati, F.1    Galeone, C.2    Rota, M.3
  • 63
    • 79953285140 scopus 로고    scopus 로고
    • Mongolia's struggle with liver cancer
    • Alcorn T. Mongolia's struggle with liver cancer. Lancet 2011, 377(9772):1139-1140.
    • (2011) Lancet , vol.377 , Issue.9772 , pp. 1139-1140
    • Alcorn, T.1
  • 64
    • 84927653758 scopus 로고    scopus 로고
    • Effect of type 2 diabetes mellitus on the risk for hepatocellular carcinoma in chronic liver diseases: a meta-analysis of cohort studies
    • Chen J., Han Y., Xu C., et al. Effect of type 2 diabetes mellitus on the risk for hepatocellular carcinoma in chronic liver diseases: a meta-analysis of cohort studies. Eur J Cancer Prev 2015, 24:89-99.
    • (2015) Eur J Cancer Prev , vol.24 , pp. 89-99
    • Chen, J.1    Han, Y.2    Xu, C.3
  • 65
    • 0034881446 scopus 로고    scopus 로고
    • The role of diabetes in hepatocellular carcinoma: a case-control study among United States veterans
    • El-Serag H.B., Richardson P.A., Everhart J.E. The role of diabetes in hepatocellular carcinoma: a case-control study among United States veterans. Am J Gastroenterol 2001, 96(8):2462-2467.
    • (2001) Am J Gastroenterol , vol.96 , Issue.8 , pp. 2462-2467
    • El-Serag, H.B.1    Richardson, P.A.2    Everhart, J.E.3
  • 66
    • 79961218135 scopus 로고    scopus 로고
    • Increased risk of hepatocellular carcinoma in patients with diabetes mellitus: a systematic review and meta-analysis of cohort studies
    • Wang C., Wang X., Gong G., et al. Increased risk of hepatocellular carcinoma in patients with diabetes mellitus: a systematic review and meta-analysis of cohort studies. Int J Cancer 2012, 130(7):1639-1648.
    • (2012) Int J Cancer , vol.130 , Issue.7 , pp. 1639-1648
    • Wang, C.1    Wang, X.2    Gong, G.3
  • 67
    • 84863010936 scopus 로고    scopus 로고
    • Diabetes mellitus and risk of hepatocellular carcinoma: a systematic review and meta-analysis
    • Wang P., Kang D., Cao W., et al. Diabetes mellitus and risk of hepatocellular carcinoma: a systematic review and meta-analysis. Diabetes Metab Res Rev 2012, 28(2):109-122.
    • (2012) Diabetes Metab Res Rev , vol.28 , Issue.2 , pp. 109-122
    • Wang, P.1    Kang, D.2    Cao, W.3
  • 68
    • 77951222429 scopus 로고    scopus 로고
    • Systematic review: the association between obesity and hepatocellular carcinoma: epidemiological evidence
    • Saunders D., Seidel D., Allison M., et al. Systematic review: the association between obesity and hepatocellular carcinoma: epidemiological evidence. Aliment Pharmacol Ther 2010, 31(10):1051-1063.
    • (2010) Aliment Pharmacol Ther , vol.31 , Issue.10 , pp. 1051-1063
    • Saunders, D.1    Seidel, D.2    Allison, M.3
  • 69
    • 34948867745 scopus 로고    scopus 로고
    • Overweight, obesity and risk of liver cancer: a meta-analysis of cohort studies
    • Larsson S.C., Wolk A. Overweight, obesity and risk of liver cancer: a meta-analysis of cohort studies. Br J Cancer 2007, 97(7):1005-1008.
    • (2007) Br J Cancer , vol.97 , Issue.7 , pp. 1005-1008
    • Larsson, S.C.1    Wolk, A.2
  • 70
    • 84892942788 scopus 로고    scopus 로고
    • The association between metabolic syndrome and hepatocellular carcinoma: systemic review and meta-analysis
    • Jinjuvadia R., Patel S., Liangpunsakul S. The association between metabolic syndrome and hepatocellular carcinoma: systemic review and meta-analysis. JClin Gastroenterol 2014, 48(2):172-177.
    • (2014) JClin Gastroenterol , vol.48 , Issue.2 , pp. 172-177
    • Jinjuvadia, R.1    Patel, S.2    Liangpunsakul, S.3
  • 71
    • 73749083481 scopus 로고    scopus 로고
    • Global estimates of the prevalence of diabetes for 2010 and 2030
    • Shaw J.E., Sicree R.A., Zimmet P.Z. Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Res Clin Pract 2010, 87(1):4-14.
    • (2010) Diabetes Res Clin Pract , vol.87 , Issue.1 , pp. 4-14
    • Shaw, J.E.1    Sicree, R.A.2    Zimmet, P.Z.3
  • 72
    • 40349088822 scopus 로고    scopus 로고
    • The epidemiology of obesity: the size of the problem
    • James W.P. The epidemiology of obesity: the size of the problem. JIntern Med 2008, 263(4):336-352.
    • (2008) JIntern Med , vol.263 , Issue.4 , pp. 336-352
    • James, W.P.1
  • 73
    • 20144369093 scopus 로고    scopus 로고
    • Tobacco smoke and involuntary smoking
    • IARC Tobacco smoke and involuntary smoking. IARC Monogr Eval Carcinog Risks Hum 2004, 83:1-1438.
    • (2004) IARC Monogr Eval Carcinog Risks Hum , vol.83 , pp. 1-1438
  • 74
    • 84965339203 scopus 로고    scopus 로고
    • The health consequences of smoking: 50 years of progress.
    • Available at: Accessed December 10, 2014.
    • The health consequences of smoking: 50 years of progress. A report of the Surgeon General. Available at: . Accessed December 10, 2014. http://www.surgeongeneral.gov/library/reports/50-years-of-progress/.
    • A report of the Surgeon General.
  • 75
    • 75349105369 scopus 로고    scopus 로고
    • Meta-analysis of epidemiologic studies on cigarette smoking and liver cancer
    • Lee Y.C., Cohet C., Yang Y.C., et al. Meta-analysis of epidemiologic studies on cigarette smoking and liver cancer. Int J Epidemiol 2009, 38(6):1497-1511.
    • (2009) Int J Epidemiol , vol.38 , Issue.6 , pp. 1497-1511
    • Lee, Y.C.1    Cohet, C.2    Yang, Y.C.3
  • 76
    • 84885848163 scopus 로고    scopus 로고
    • Coffee reduces risk for hepatocellular carcinoma: an updated meta-analysis
    • Bravi F., Bosetti C., Tavani A., et al. Coffee reduces risk for hepatocellular carcinoma: an updated meta-analysis. Clin Gastroenterol Hepatol 2013, 11(11):1413-1421.e1.
    • (2013) Clin Gastroenterol Hepatol , vol.11 , Issue.11 , pp. 1413-1421.e1
    • Bravi, F.1    Bosetti, C.2    Tavani, A.3
  • 77
    • 79955068545 scopus 로고    scopus 로고
    • Epidemiological studies of the association between tea drinking and primary liver cancer: a meta-analysis
    • Fon Sing M., Yang W.S., Gao S., et al. Epidemiological studies of the association between tea drinking and primary liver cancer: a meta-analysis. Eur J Cancer Prev 2011, 20(3):157-165.
    • (2011) Eur J Cancer Prev , vol.20 , Issue.3 , pp. 157-165
    • Fon Sing, M.1    Yang, W.S.2    Gao, S.3
  • 78
    • 84922567205 scopus 로고    scopus 로고
    • Coffee, tea and decaffeinated coffee in relation to hepatocellular carcinoma in a European population: multicentre, prospective cohort study
    • Bamia C., Lagiou P., Jenab M., et al. Coffee, tea and decaffeinated coffee in relation to hepatocellular carcinoma in a European population: multicentre, prospective cohort study. Int J Cancer 2014, 10.1002/ijc.29214.
    • (2014) Int J Cancer
    • Bamia, C.1    Lagiou, P.2    Jenab, M.3
  • 79
    • 84922879137 scopus 로고    scopus 로고
    • Association of coffee intake with reduced incidence of liver cancer and death from chronic liver disease in the US multiethnic cohort
    • Setiawan V.W., Wilkens L.R., Lu S.C., et al. Association of coffee intake with reduced incidence of liver cancer and death from chronic liver disease in the US multiethnic cohort. Gastroenterology 2014, 148(1):118-125.
    • (2014) Gastroenterology , vol.148 , Issue.1 , pp. 118-125
    • Setiawan, V.W.1    Wilkens, L.R.2    Lu, S.C.3
  • 80
    • 0036279253 scopus 로고    scopus 로고
    • Cafestol and kahweol, two coffee specific diterpenes with anticarcinogenic activity
    • Cavin C., Holzhaeuser D., Scharf G., et al. Cafestol and kahweol, two coffee specific diterpenes with anticarcinogenic activity. Food Chem Toxicol 2002, 40(8):1155-1163.
    • (2002) Food Chem Toxicol , vol.40 , Issue.8 , pp. 1155-1163
    • Cavin, C.1    Holzhaeuser, D.2    Scharf, G.3
  • 81
    • 77954214167 scopus 로고    scopus 로고
    • Coffee and liver diseases
    • Muriel P., Arauz J. Coffee and liver diseases. Fitoterapia 2010, 81(5):297-305.
    • (2010) Fitoterapia , vol.81 , Issue.5 , pp. 297-305
    • Muriel, P.1    Arauz, J.2
  • 82
    • 79954610780 scopus 로고    scopus 로고
    • Coffee constituents as modulators of Nrf2 nuclear translocation and ARE (EpRE)-dependent gene expression
    • Boettler U., Sommerfeld K., Volz N., et al. Coffee constituents as modulators of Nrf2 nuclear translocation and ARE (EpRE)-dependent gene expression. JNutr Biochem 2011, 22(5):426-440.
    • (2011) JNutr Biochem , vol.22 , Issue.5 , pp. 426-440
    • Boettler, U.1    Sommerfeld, K.2    Volz, N.3
  • 83
    • 84901621547 scopus 로고    scopus 로고
    • Coffee: biochemistry and potential impact on health
    • Ludwig I.A., Clifford M.N., Lean M.E., et al. Coffee: biochemistry and potential impact on health. Food Funct 2014, 5(8):1695-1717.
    • (2014) Food Funct , vol.5 , Issue.8 , pp. 1695-1717
    • Ludwig, I.A.1    Clifford, M.N.2    Lean, M.E.3
  • 84
    • 67649449180 scopus 로고    scopus 로고
    • Cancer prevention by tea: animal studies, molecular mechanisms and human relevance
    • Yang C.S., Wang X., Lu G., et al. Cancer prevention by tea: animal studies, molecular mechanisms and human relevance. Nat Rev Cancer 2009, 9(6):429-439.
    • (2009) Nat Rev Cancer , vol.9 , Issue.6 , pp. 429-439
    • Yang, C.S.1    Wang, X.2    Lu, G.3
  • 85
    • 78449281377 scopus 로고    scopus 로고
    • Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trials
    • Baigent C., Blackwell L., Emberson J., et al. Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trials. Lancet 2010, 376(9753):1670-1681.
    • (2010) Lancet , vol.376 , Issue.9753 , pp. 1670-1681
    • Baigent, C.1    Blackwell, L.2    Emberson, J.3
  • 86
    • 0037233011 scopus 로고    scopus 로고
    • The statins as anticancer agents
    • Chan K.K., Oza A.M., Siu L.L. The statins as anticancer agents. Clin Cancer Res 2003, 9(1):10-19.
    • (2003) Clin Cancer Res , vol.9 , Issue.1 , pp. 10-19
    • Chan, K.K.1    Oza, A.M.2    Siu, L.L.3
  • 87
    • 83455163746 scopus 로고    scopus 로고
    • Pharmacological actions of statins: a critical appraisal in the management of cancer
    • Gazzerro P., Proto M.C., Gangemi G., et al. Pharmacological actions of statins: a critical appraisal in the management of cancer. Pharmacol Rev 2012, 64(1):102-146.
    • (2012) Pharmacol Rev , vol.64 , Issue.1 , pp. 102-146
    • Gazzerro, P.1    Proto, M.C.2    Gangemi, G.3
  • 88
    • 79955595053 scopus 로고    scopus 로고
    • Statin use and the risk of liver cancer: a population-based case-control study
    • Chiu H.F., Ho S.C., Chen C.C., et al. Statin use and the risk of liver cancer: a population-based case-control study. Am J Gastroenterol 2011, 106(5):894-898.
    • (2011) Am J Gastroenterol , vol.106 , Issue.5 , pp. 894-898
    • Chiu, H.F.1    Ho, S.C.2    Chen, C.C.3
  • 89
    • 84879843474 scopus 로고    scopus 로고
    • Statin use and risk of hepatocellular carcinoma
    • Lai S.W., Liao K.F., Lai H.C., et al. Statin use and risk of hepatocellular carcinoma. Eur J Epidemiol 2013, 28(6):485-492.
    • (2013) Eur J Epidemiol , vol.28 , Issue.6 , pp. 485-492
    • Lai, S.W.1    Liao, K.F.2    Lai, H.C.3
  • 90
    • 84871490146 scopus 로고    scopus 로고
    • Common cancer risk and statins: a population-based case-control study in a Chinese population
    • Leung H.W., Chan A.L., Lo D., et al. Common cancer risk and statins: a population-based case-control study in a Chinese population. Expert Opin Drug Saf 2013, 12(1):19-27.
    • (2013) Expert Opin Drug Saf , vol.12 , Issue.1 , pp. 19-27
    • Leung, H.W.1    Chan, A.L.2    Lo, D.3
  • 91
    • 84876516919 scopus 로고    scopus 로고
    • Statins and the risk of hepatocellular carcinoma in patients with hepatitis C virus infection
    • Tsan Y.T., Lee C.H., Ho W.C., et al. Statins and the risk of hepatocellular carcinoma in patients with hepatitis C virus infection. JClin Oncol 2013, 31(12):1514-1521.
    • (2013) JClin Oncol , vol.31 , Issue.12 , pp. 1514-1521
    • Tsan, Y.T.1    Lee, C.H.2    Ho, W.C.3
  • 92
    • 84863115964 scopus 로고    scopus 로고
    • Statins and the risk of hepatocellular carcinoma in patients with hepatitis B virus infection
    • Tsan Y.T., Lee C.H., Wang J.D., et al. Statins and the risk of hepatocellular carcinoma in patients with hepatitis B virus infection. JClin Oncol 2012, 30(6):623-630.
    • (2012) JClin Oncol , vol.30 , Issue.6 , pp. 623-630
    • Tsan, Y.T.1    Lee, C.H.2    Wang, J.D.3
  • 93
    • 14844292583 scopus 로고    scopus 로고
    • Cancer risk among statin users: a population-based cohort study
    • Friis S., Poulsen A.H., Johnsen S.P., et al. Cancer risk among statin users: a population-based cohort study. Int J Cancer 2005, 114(4):643-647.
    • (2005) Int J Cancer , vol.114 , Issue.4 , pp. 643-647
    • Friis, S.1    Poulsen, A.H.2    Johnsen, S.P.3
  • 94
    • 79960589702 scopus 로고    scopus 로고
    • Statins and risk of cancer: a retrospective cohort analysis of 45,857 matched pairs from an electronic medical records database of 11 million adult Americans
    • Marelli C., Gunnarsson C., Ross S., et al. Statins and risk of cancer: a retrospective cohort analysis of 45,857 matched pairs from an electronic medical records database of 11 million adult Americans. JAm Coll Cardiol 2011, 58(5):530-537.
    • (2011) JAm Coll Cardiol , vol.58 , Issue.5 , pp. 530-537
    • Marelli, C.1    Gunnarsson, C.2    Ross, S.3
  • 95
    • 65249190240 scopus 로고    scopus 로고
    • Statins are associated with a reduced risk of hepatocellular carcinoma in a large cohort of patients with diabetes
    • El-Serag H.B., Johnson M.L., Hachem C., et al. Statins are associated with a reduced risk of hepatocellular carcinoma in a large cohort of patients with diabetes. Gastroenterology 2009, 136(5):1601-1608.
    • (2009) Gastroenterology , vol.136 , Issue.5 , pp. 1601-1608
    • El-Serag, H.B.1    Johnson, M.L.2    Hachem, C.3
  • 96
    • 33746886824 scopus 로고    scopus 로고
    • Statins are protective against hepatocellular cancer in patients with hepatitis C virus infection: half a million U.S. veterans' study
    • Khurana V., Saluja A., Caldito G., et al. Statins are protective against hepatocellular cancer in patients with hepatitis C virus infection: half a million U.S. veterans' study. Gastroenterology 2005, 128:A714.
    • (2005) Gastroenterology , vol.128 , pp. A714
    • Khurana, V.1    Saluja, A.2    Caldito, G.3
  • 97
    • 38649095993 scopus 로고    scopus 로고
    • Screening statins for possible carcinogenic risk: up to 9 years of follow-up of 361,859 recipients
    • Friedman G.D., Flick E.D., Udaltsova N., et al. Screening statins for possible carcinogenic risk: up to 9 years of follow-up of 361,859 recipients. Pharmacoepidemiol Drug Saf 2008, 17(1):27-36.
    • (2008) Pharmacoepidemiol Drug Saf , vol.17 , Issue.1 , pp. 27-36
    • Friedman, G.D.1    Flick, E.D.2    Udaltsova, N.3
  • 98
    • 84908100617 scopus 로고    scopus 로고
    • Statin use and risk of hepatocellular carcinoma in a U.S. population
    • McGlynn K.A., Divine G.W., Sahasrabuddhe V.V., et al. Statin use and risk of hepatocellular carcinoma in a U.S. population. Cancer Epidemiol 2014, 38(5):523-527.
    • (2014) Cancer Epidemiol , vol.38 , Issue.5 , pp. 523-527
    • McGlynn, K.A.1    Divine, G.W.2    Sahasrabuddhe, V.V.3
  • 99
    • 84911808109 scopus 로고    scopus 로고
    • Statin treatment reduces the risk of hepatocellular carcinoma but not colon cancer-results from a nationwide case-control study in Sweden
    • Bjorkhem-Bergman L., Backheden M., Soderberg Lofdal K. Statin treatment reduces the risk of hepatocellular carcinoma but not colon cancer-results from a nationwide case-control study in Sweden. Pharmacoepidemiol Drug Saf 2014, 23(10):1101-1106.
    • (2014) Pharmacoepidemiol Drug Saf , vol.23 , Issue.10 , pp. 1101-1106
    • Bjorkhem-Bergman, L.1    Backheden, M.2    Soderberg Lofdal, K.3
  • 100
    • 84875849200 scopus 로고    scopus 로고
    • Statins and primary liver cancer: a meta-analysis of observational studies
    • Pradelli D., Soranna D., Scotti L., et al. Statins and primary liver cancer: a meta-analysis of observational studies. Eur J Cancer Prev 2012, 22(3):229-234.
    • (2012) Eur J Cancer Prev , vol.22 , Issue.3 , pp. 229-234
    • Pradelli, D.1    Soranna, D.2    Scotti, L.3
  • 101
    • 84881491358 scopus 로고    scopus 로고
    • Statins are associated with a reduced risk of hepatocellular cancer: a systematic review and meta-analysis
    • Singh S., Singh P.P., Singh A.G., et al. Statins are associated with a reduced risk of hepatocellular cancer: a systematic review and meta-analysis. Gastroenterology 2013, 144(2):323-332.
    • (2013) Gastroenterology , vol.144 , Issue.2 , pp. 323-332
    • Singh, S.1    Singh, P.P.2    Singh, A.G.3
  • 102
    • 84880974660 scopus 로고    scopus 로고
    • Metformin therapy and risk of cancer in patients with type 2 diabetes: systematic review
    • Franciosi M., Lucisano G., Lapice E., et al. Metformin therapy and risk of cancer in patients with type 2 diabetes: systematic review. PLoS one 2013, 8(8):e71583.
    • (2013) PLoS one , vol.8 , Issue.8 , pp. e71583
    • Franciosi, M.1    Lucisano, G.2    Lapice, E.3
  • 103
    • 84875964059 scopus 로고    scopus 로고
    • Anti-diabetic medications and risk of pancreatic cancer in patients with diabetes mellitus: a systematic review and meta-analysis
    • [quiz: 520]
    • Singh S., Singh P.P., Singh A.G., et al. Anti-diabetic medications and risk of pancreatic cancer in patients with diabetes mellitus: a systematic review and meta-analysis. Am J Gastroenterol 2013, 108(4):510-519. [quiz: 520].
    • (2013) Am J Gastroenterol , vol.108 , Issue.4 , pp. 510-519
    • Singh, S.1    Singh, P.P.2    Singh, A.G.3
  • 104
    • 84871384034 scopus 로고    scopus 로고
    • Metformin and reduced risk of hepatocellular carcinoma in diabetic patients: a meta-analysis
    • Zhang H., Gao C., Fang L., et al. Metformin and reduced risk of hepatocellular carcinoma in diabetic patients: a meta-analysis. Scand J Gastroenterol 2013, 48(1):78-87.
    • (2013) Scand J Gastroenterol , vol.48 , Issue.1 , pp. 78-87
    • Zhang, H.1    Gao, C.2    Fang, L.3
  • 105
    • 84908569769 scopus 로고    scopus 로고
    • Anti-diabetic medications and risk of primary liver cancer in persons with type II diabetes
    • Hagberg K.W., McGlynn K.A., Sahasrabuddhe V.V., et al. Anti-diabetic medications and risk of primary liver cancer in persons with type II diabetes. Br J Cancer 2014, 111(9):1710-1717.
    • (2014) Br J Cancer , vol.111 , Issue.9 , pp. 1710-1717
    • Hagberg, K.W.1    McGlynn, K.A.2    Sahasrabuddhe, V.V.3
  • 106
    • 84863868163 scopus 로고    scopus 로고
    • Aturbulent decade for NSAIDs: update on current concepts of classification, epidemiology, comparative efficacy, and toxicity
    • Conaghan P.G. Aturbulent decade for NSAIDs: update on current concepts of classification, epidemiology, comparative efficacy, and toxicity. Rheumatol Int 2012, 32(6):1491-1502.
    • (2012) Rheumatol Int , vol.32 , Issue.6 , pp. 1491-1502
    • Conaghan, P.G.1
  • 107
    • 23844462029 scopus 로고    scopus 로고
    • Correlation between expression of cyclooxygenase-2 and the presence of inflammatory cells in human primary hepatocellular carcinoma: possible role in tumor promotion and angiogenesis
    • Cervello M., Foderaa D., Florena A.M., et al. Correlation between expression of cyclooxygenase-2 and the presence of inflammatory cells in human primary hepatocellular carcinoma: possible role in tumor promotion and angiogenesis. World J Gastroenterol 2005, 11(30):4638-4643.
    • (2005) World J Gastroenterol , vol.11 , Issue.30 , pp. 4638-4643
    • Cervello, M.1    Foderaa, D.2    Florena, A.M.3
  • 108
    • 14944386105 scopus 로고    scopus 로고
    • Induction of apoptosis and inhibition of cell growth in human hepatocellular carcinoma cells by COX-2 inhibitors
    • Fodera D., D'Alessandro N., Cusimano A., et al. Induction of apoptosis and inhibition of cell growth in human hepatocellular carcinoma cells by COX-2 inhibitors. Ann N Y Acad Sci 2004, 1028:440-449.
    • (2004) Ann N Y Acad Sci , vol.1028 , pp. 440-449
    • Fodera, D.1    D'Alessandro, N.2    Cusimano, A.3
  • 109
    • 0041822007 scopus 로고    scopus 로고
    • Cyclooxygenase-2 promotes hepatocellular carcinoma cell growth through Akt activation: evidence for Akt inhibition in celecoxib-induced apoptosis
    • Leng J., Han C., Demetris A.J., et al. Cyclooxygenase-2 promotes hepatocellular carcinoma cell growth through Akt activation: evidence for Akt inhibition in celecoxib-induced apoptosis. Hepatology 2003, 38(3):756-768.
    • (2003) Hepatology , vol.38 , Issue.3 , pp. 756-768
    • Leng, J.1    Han, C.2    Demetris, A.J.3
  • 110
    • 0030848726 scopus 로고    scopus 로고
    • Rheumatoid arthritis and the risk of malignancy
    • Cibere J., Sibley J., Haga M. Rheumatoid arthritis and the risk of malignancy. Arthritis Rheum 1997, 40(9):1580-1586.
    • (1997) Arthritis Rheum , vol.40 , Issue.9 , pp. 1580-1586
    • Cibere, J.1    Sibley, J.2    Haga, M.3
  • 111
    • 0033968548 scopus 로고    scopus 로고
    • Nonsteroidal anti-inflammatory drugs and risk of digestive cancers at sites other than the large bowel
    • Coogan P.F., Rosenberg L., Palmer J.R., et al. Nonsteroidal anti-inflammatory drugs and risk of digestive cancers at sites other than the large bowel. Cancer Epidemiol Biomarkers Prev 2000, 9(1):119-123.
    • (2000) Cancer Epidemiol Biomarkers Prev , vol.9 , Issue.1 , pp. 119-123
    • Coogan, P.F.1    Rosenberg, L.2    Palmer, J.R.3
  • 112
    • 84870858674 scopus 로고    scopus 로고
    • Nonsteroidal anti-inflammatory drug use, chronic liver disease, and hepatocellular carcinoma
    • Sahasrabuddhe V.V., Gunja M.Z., Graubard B.I., et al. Nonsteroidal anti-inflammatory drug use, chronic liver disease, and hepatocellular carcinoma. JNatl Cancer Inst 2012, 104(23):1808-1814.
    • (2012) JNatl Cancer Inst , vol.104 , Issue.23 , pp. 1808-1814
    • Sahasrabuddhe, V.V.1    Gunja, M.Z.2    Graubard, B.I.3
  • 113
    • 78649357770 scopus 로고    scopus 로고
    • Defining the COX inhibitor selectivity of NSAIDs: implications for understanding toxicity
    • Knights K.M., Mangoni A.A., Miners J.O. Defining the COX inhibitor selectivity of NSAIDs: implications for understanding toxicity. Expert Rev Clin Pharmacol 2010, 3(6):769-776.
    • (2010) Expert Rev Clin Pharmacol , vol.3 , Issue.6 , pp. 769-776
    • Knights, K.M.1    Mangoni, A.A.2    Miners, J.O.3
  • 114
    • 78649616178 scopus 로고    scopus 로고
    • Aspirin chemoprevention of gastrointestinal cancer in the next decade. a review of the evidence
    • Jankowska H., Hooper P., Jankowski J.A. Aspirin chemoprevention of gastrointestinal cancer in the next decade. a review of the evidence. Pol Arch Med Wewn 2010, 120(10):407-412.
    • (2010) Pol Arch Med Wewn , vol.120 , Issue.10 , pp. 407-412
    • Jankowska, H.1    Hooper, P.2    Jankowski, J.A.3
  • 115
    • 0036788542 scopus 로고    scopus 로고
    • Proapoptotic and antiproliferative potential of selective cyclooxygenase-2 inhibitors in human liver tumor cells
    • Kern M.A., Schubert D., Sahi D., et al. Proapoptotic and antiproliferative potential of selective cyclooxygenase-2 inhibitors in human liver tumor cells. Hepatology 2002, 36(4 Pt 1):885-894.
    • (2002) Hepatology , vol.36 , Issue.4 , pp. 885-894
    • Kern, M.A.1    Schubert, D.2    Sahi, D.3
  • 116
    • 61749099391 scopus 로고    scopus 로고
    • Acetaminophen-induced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome
    • Imaeda A.B., Watanabe A., Sohail M.A., et al. Acetaminophen-induced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome. JClin Invest 2009, 119(2):305-314.
    • (2009) JClin Invest , vol.119 , Issue.2 , pp. 305-314
    • Imaeda, A.B.1    Watanabe, A.2    Sohail, M.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.