Viral entry of hepatitis B and D viruses and bile salts transportation share common molecular determinants on sodium taurocholate cotransporting polypeptide

Journal of Virology

Volumn 88, Issue 6, 2014, Pages 3273-3284

  Yan, Huan ^a   Peng, Bo ^a   Liu, Yang ^a   Xu, Guangwei ^a,b   He, Wenhui ^a,b   Ren, Bijie ^a   Jing, Zhiyi ^a   Sui, Jianhua ^a   Li, Wenhui ^a  

^a NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES   (China)

^b INSTITUTE OF BASIC MEDICAL SCIENCES   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BILE SALT; LIPOPEPTIDE; SODIUM BILE ACID COTRANSPORTER; SODIUM ION;

ARTICLE; BINDING AFFINITY; BINDING SITE; CELL STRAIN HEPG2; CONTROLLED STUDY; DELTA AGENT HEPATITIS; DNA SEQUENCE; HEPATITIS B; HEPATITIS B VIRUS; HEPATITIS DELTA VIRUS; HUMAN; HUMAN CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; SINGLE NUCLEOTIDE POLYMORPHISM; TRANSPORT KINETICS; VIRUS ATTACHMENT; VIRUS ENTRY; VIRUS ENVELOPE; VIRUS INHIBITION;

AMINO ACID MOTIFS; BIOLOGICAL TRANSPORT; HEPATITIS B; HEPATITIS B VIRUS; HEPATITIS D; HEPATITIS DELTA VIRUS; HUMANS; ORGANIC ANION TRANSPORTERS, SODIUM-DEPENDENT; PROTEIN BINDING; RECEPTORS, VIRUS; SYMPORTERS; TAUROCHOLIC ACID; VIRAL ENVELOPE PROTEINS; VIRUS INTERNALIZATION;

EID: 84894230843     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.03478-13     Document Type: Article

References (25)

1. Ott JJ, Stevens GA, Groeger J, Wiersma ST. 2012. Global epidemiology of hepatitis B virus infection: new estimates of age-specific HBsAg seroprevalence and endemicity. Vaccine 30:2212-2219. http://dx.doi.org/10.1016/j.vaccine.2011.12.116.
2. Hughes SA, Wedemeyer H, Harrison PM. 2011. Hepatitis delta virus. Lancet 378:73-85. http://dx.doi.org/10.1016/S0140-6736(10)61931-9.
3. Yan H, Zhong G, Xu G, He W, Jing Z, Gao Z, Huang Y, Qi Y, Peng B, Wang H, Fu L, Song M, Chen P, Gao W, Ren B, Sun Y, Cai T, Feng X, Sui J, Li W. 2012. Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus. eLife 1:e00049. http://dx.doi.org/10.7554/eLife.00049.
4. Zhong G, Yan H, Wang H, He W, Jing Z, Qi Y, Fu L, Gao Z, Huang Y, Xu G, Feng X, Sui J, Li W. 2013. Sodium taurocholate cotransporting polypeptide mediates woolly monkey hepatitis B virus infection of Tupaia hepatocytes. J. Virol. 87:7176-7184. http://dx.doi.org/10.1128/JVI.03533-12.
5. Yan H, Peng B, He W, Zhong G, Qi Y, Ren B, Gao Z, Jing Z, Song M, Xu G, Sui J, Li W. 2013. Molecular determinants of hepatitis B and D virus entry restriction in mouse sodium taurocholate cotransporting polypeptide. J. Virol. 87:7977-7991. http://dx.doi.org/10.1128/JVI.03540-12.
6. Hagenbuch B, Meier PJ. 1994. Molecular cloning, chromosomal localization, and functional characterization of a human liver Na+/bile acid cotransporter. J. Clin. Invest. 93:1326-1331.
7. Stieger B. 2011. The role of the sodium-taurocholate cotransporting polypeptide (NTCP) and of the bile salt export pump (BSEP) in physiology and pathophysiology of bile formation. Handb. Exp. Pharmacol. 2011(201):205-259. http://dx.doi.org/10.1007/978-3-642-14541-4_5.
8. Kramer W, Stengelin S, Baringhaus KH, Enhsen A, Heuer H, Becker W, Corsiero D, Girbig F, Noll R, Weyland C. 1999. Substrate specificity of the ileal and the hepatic Na(+)/bile acid cotransporters of the rabbit. I. Transport studies with membrane vesicles and cell lines expressing the cloned transporters. J. Lipid Res. 40:1604-1617.
9. Kullak-Ublick GA, Stieger B, Meier PJ. 2004. Enterohepatic bile salt transporters in normal physiology and liver disease. Gastroenterology 126:322-342. http://dx.doi.org/10.1053/j.gastro.2003.06.005.
10. Seeger C, Mason WS. 2000. Hepatitis B virus biology. Microbiol. Mol. Biol. Rev. 64:51-68. http://dx.doi.org/10.1128/MMBR.64.1.51-68.2000.
11. Nassal M. 1996. Hepatitis B virus morphogenesis. Curr. Top. Microbiol. Immunol. 214:297-337.
12. Schulze A, Gripon P, Urban S. 2007. Hepatitis B virus infection initiates with a large surface protein-dependent binding to heparan sulfate proteoglycans. Hepatology 46:1759-1768. http://dx.doi.org/10.1002/hep.21896.
13. Leistner CM, Gruen-Bernhard S, Glebe D. 2008. Role of glycosaminoglycans for binding and infection of hepatitis B virus. Cell Microbiol. 10:122-133. http://dx.doi.org/10.1111/j.1462-5822.2007.01023.x.
14. Sureau C, Salisse J. 2013. A conformational heparan sulfate binding site essential to infectivity overlaps with the conserved hepatitis B virus a-determinant. Hepatology 57:985-994. http://dx.doi.org/10.1002/hep.26125.
15. Ho RH, Leake BF, Roberts RL, Lee W, Kim RB. 2004. Ethnicitydependent polymorphism in Na+-taurocholate cotransporting polypeptide (SLC10A1) reveals a domain critical for bile acid substrate recognition. J. Biol. Chem. 279:7213-7222. http://dx.doi.org/10.1074/jbc.M305782200.
16. Glebe D, Urban S, Knoop EV, Cag N, Krass P, Grun S, Bulavaite A, Sasnauskas K, Gerlich WH. 2005. Mapping of the hepatitis B virus attachment site by use of infection-inhibiting preS1 lipopeptides and tupaia hepatocytes. Gastroenterology 129:234-245. http://dx.doi.org/10.1053/j.gastro.2005.03.090.
17. Hu NJ, Iwata S, Cameron AD, Drew D. 2011. Crystal structure of a bacterial homologue of the bile acid sodium symporter ASBT. Nature 478:408-411. http://dx.doi.org/10.1038/nature10450.
18. Sun AQ, Balasubramaniyan N, Chen H, Shahid M, Suchy FJ. 2006. Identification of functionally relevant residues of the rat ileal apical sodium-dependent bile acid cotransporter. J. Biol. Chem. 281:16410-16418. http://dx.doi.org/10.1074/jbc.M600034200.
19. Zahner D, Eckhardt U, Petzinger E. 2003. Transport of taurocholate by mutants of negatively charged amino acids, cysteines, and threonines of the rat liver sodium-dependent taurocholate cotransporting polypeptide Ntcp. Eur. J. Biochem. 270:1117-1127. http://dx.doi.org/10.1046/j.1432-1033.2003.03463.x.
20. Pan W, Song IS, Shin HJ, Kim MH, Choi YL, Lim SJ, Kim WY, Lee SS, Shin JG. 2011. Genetic polymorphisms in Na+-taurocholate cotransporting polypeptide (NTCP) and ileal apical sodium-dependent bile acid transporter (ASBT) and ethnic comparisons of functional variants of NTCP among Asian populations. Xenobiotica 41:501-510. http://dx.doi.org/10.3109/00498254.2011.555567.
21. Hagenbuch B, Meier PJ. 1996. Sinusoidal (basolateral) bile salt uptake systems of hepatocytes. Semin. Liver Dis. 16:129-136.
22. Nelson D, Cox M. 2000. Lehninger principles of biochemistry, 3rd ed, p 389-436. Worth Publishers, New York, NY.
23. Esteller A. 2008. Physiology of bile secretion. World J. Gastroenterol. 14:5641-5649. http://dx.doi.org/10.3748/wjg.14.5641.
24. Chen W, Liu J, Gluud C. 2003. Bile acids for viral hepatitis. Cochrane Database Syst. Rev. 2003(2):CD003181. http://dx.doi.org/10.1002/14651858.CD003181.
25. Galsky J, Bansky G, Holubova T, Konig J. 1999. Effect of ursodeoxycholic acid in acute viral hepatitis. J. Clin. Gastroenterol. 28:249-253.