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Volumn 6, Issue , 2015, Pages

DNMT1 is essential for mammary and cancer stem cell maintenance and tumorigenesis

Author keywords

[No Author keywords available]

Indexed keywords

DNA METHYLTRANSFERASE 1; ISL1 PROTEIN; PROTEIN; UNCLASSIFIED DRUG; DNA (CYTOSINE 5) METHYLTRANSFERASE; DNA (CYTOSINE-5-)-METHYLTRANSFERASE 1; INSULIN GENE ENHANCER BINDING PROTEIN ISL-1; LIM HOMEODOMAIN PROTEIN; TRANSCRIPTION FACTOR;

EID: 84928799024     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms7910     Document Type: Article
Times cited : (213)

References (44)
  • 1
    • 30144432901 scopus 로고    scopus 로고
    • Purification and unique properties of mammary epithelial stem cells
    • Stingl, J. et al. Purification and unique properties of mammary epithelial stem cells. Nature 439, 993-997 (2006).
    • (2006) Nature , vol.439 , pp. 993-997
    • Stingl, J.1
  • 3
    • 84901758365 scopus 로고    scopus 로고
    • Mammary stem cells and the differentiation hierarchy: Current status and perspectives
    • Visvader, J. E. & Stingl, J. Mammary stem cells and the differentiation hierarchy: current status and perspectives. Genes Dev. 28, 1143-1158 (2014).
    • (2014) Genes Dev , vol.28 , pp. 1143-1158
    • Visvader, J.E.1    Stingl, J.2
  • 4
    • 84894267586 scopus 로고    scopus 로고
    • In situ identification of bipotent stem cells in the mammary gland
    • Rios, A. C., Fu, N. Y., Lindeman, G. J. & Visvader, J. E. In situ identification of bipotent stem cells in the mammary gland. Nature 506, 322-327 (2014).
    • (2014) Nature , vol.506 , pp. 322-327
    • Rios, A.C.1    Fu, N.Y.2    Lindeman, G.J.3    Visvader, J.E.4
  • 5
    • 77953384898 scopus 로고    scopus 로고
    • Control of mammary stem cell function by steroid hormone signalling
    • Asselin-Labat, M. L. et al. Control of mammary stem cell function by steroid hormone signalling. Nature 465, 798-802 (2010).
    • (2010) Nature , vol.465 , pp. 798-802
    • Asselin-Labat, M.L.1
  • 6
    • 79952111066 scopus 로고    scopus 로고
    • Chromatin remodeling in mammary gland differentiation and breast tumorigenesis
    • Huang, T. H. & Esteller, M. Chromatin remodeling in mammary gland differentiation and breast tumorigenesis. Cold Spring Harb. Perspect. Biol. 2, a004515 (2010).
    • (2010) Cold Spring Harb. Perspect. Biol , vol.2 , pp. a004515
    • Huang, T.H.1    Esteller, M.2
  • 7
    • 84874231902 scopus 로고    scopus 로고
    • Global changes in the mammary epigenome are induced by hormonal cues and coordinated by Ezh2
    • Pal, B. et al. Global changes in the mammary epigenome are induced by hormonal cues and coordinated by Ezh2. Cell Rep. 3, 411-426 (2013).
    • (2013) Cell Rep , vol.3 , pp. 411-426
    • Pal, B.1
  • 8
    • 84874194072 scopus 로고    scopus 로고
    • DNA methylation: Roles in mammalian development
    • Smith, Z. D. & Meissner, A. DNA methylation: roles in mammalian development. Nat. Rev. Genet. 14, 204-220 (2013).
    • (2013) Nat. Rev. Genet , vol.14 , pp. 204-220
    • Smith, Z.D.1    Meissner, A.2
  • 9
    • 0036144048 scopus 로고    scopus 로고
    • DNA methylation patterns and epigenetic memory
    • Bird, A. DNA methylation patterns and epigenetic memory. Genes Dev. 16, 6-21 (2002).
    • (2002) Genes Dev , vol.16 , pp. 6-21
    • Bird, A.1
  • 10
    • 0033615717 scopus 로고    scopus 로고
    • DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development
    • Okano, M., Bell, D. W., Haber, D. A. & Li, E. DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell 99, 247-257 (1999).
    • (1999) Cell , vol.99 , pp. 247-257
    • Okano, M.1    Bell, D.W.2    Haber, D.A.3    Li, E.4
  • 11
    • 0026708177 scopus 로고
    • Targeted mutation of the DNA methyltransferase gene results in embryonic lethality
    • Li, E., Bestor, T. H. & Jaenisch, R. Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell 69, 915-926 (1992).
    • (1992) Cell , vol.69 , pp. 915-926
    • Li, E.1    Bestor, T.H.2    Jaenisch, R.3
  • 12
    • 33745270104 scopus 로고    scopus 로고
    • Maintenance of self-renewal ability of mouse embryonic stem cells in the absence of DNA methyltransferases Dnmt1, Dnmt3a and Dnmt3b
    • Tsumura, A. et al. Maintenance of self-renewal ability of mouse embryonic stem cells in the absence of DNA methyltransferases Dnmt1, Dnmt3a and Dnmt3b. Genes Cells 11, 805-814 (2006).
    • (2006) Genes Cells , vol.11 , pp. 805-814
    • Tsumura, A.1
  • 13
    • 22844457491 scopus 로고    scopus 로고
    • DNA methylation and human disease
    • Robertson, K. D. DNA methylation and human disease. Nat. Rev. Genet. 6, 597-610 (2005).
    • (2005) Nat. Rev. Genet , vol.6 , pp. 597-610
    • Robertson, K.D.1
  • 14
    • 0343621494 scopus 로고    scopus 로고
    • Aberrant CpG-island methylation has non-random and tumour-type-specific patterns
    • Costello, J. F. et al. Aberrant CpG-island methylation has non-random and tumour-type-specific patterns. Nat. Genet. 24, 132-138 (2000).
    • (2000) Nat. Genet , vol.24 , pp. 132-138
    • Costello, J.F.1
  • 15
    • 0036098559 scopus 로고    scopus 로고
    • CpG island methylation in aberrant crypt foci of the colorectum
    • Chan, A. O. et al. CpG island methylation in aberrant crypt foci of the colorectum. Am. J. Pathol. 160, 1823-1830 (2002).
    • (2002) Am. J. Pathol , vol.160 , pp. 1823-1830
    • Chan, A.O.1
  • 16
    • 0038576158 scopus 로고    scopus 로고
    • The power and the promise of DNA methylation markers
    • Laird, P. W. The power and the promise of DNA methylation markers. Nat. Rev. Cancer 3, 253-266 (2003).
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 253-266
    • Laird, P.W.1
  • 17
    • 70349469788 scopus 로고    scopus 로고
    • DNA methyltransferase 1 is essential for and uniquely regulates hematopoietic stem and progenitor cells
    • Trowbridge, J. J., Snow, J. W., Kim, J. & Orkin, S. H. DNA methyltransferase 1 is essential for and uniquely regulates hematopoietic stem and progenitor cells. Cell Stem Cell 5, 442-449 (2009).
    • (2009) Cell Stem Cell , vol.5 , pp. 442-449
    • Trowbridge, J.J.1    Snow, J.W.2    Kim, J.3    Orkin, S.H.4
  • 18
    • 75749104729 scopus 로고    scopus 로고
    • DNMT1 maintains progenitor function in self-renewing somatic tissue
    • Sen, G. L., Reuter, J. A., Webster, D. E., Zhu, L. & Khavari, P. A. DNMT1 maintains progenitor function in self-renewing somatic tissue. Nature 463, 563-567 (2010).
    • (2010) Nature , vol.463 , pp. 563-567
    • Sen, G.L.1    Reuter, J.A.2    Webster, D.E.3    Zhu, L.4    Khavari, P.A.5
  • 19
    • 84864304203 scopus 로고    scopus 로고
    • Oct4 and Nanog directly regulate Dnmt1 to maintain self-renewal and undifferentiated state in mesenchymal stem cells
    • Tsai, C. C., Su, P. F., Huang, Y. F., Yew, T. L. & Hung, S. C. Oct4 and Nanog directly regulate Dnmt1 to maintain self-renewal and undifferentiated state in mesenchymal stem cells. Mol. Cell 47, 169-182 (2012).
    • (2012) Mol. Cell , vol.47 , pp. 169-182
    • Tsai, C.C.1    Su, P.F.2    Huang, Y.F.3    Yew, T.L.4    Hung, S.C.5
  • 20
    • 84863176405 scopus 로고    scopus 로고
    • Haploinsufficiency of Dnmt1 impairs leukemia stem cell function through derepression of bivalent chromatin domains
    • Trowbridge, J. J. et al. Haploinsufficiency of Dnmt1 impairs leukemia stem cell function through derepression of bivalent chromatin domains. Genes Dev. 26, 344-349 (2012).
    • (2012) Genes Dev , vol.26 , pp. 344-349
    • Trowbridge, J.J.1
  • 21
    • 0033768857 scopus 로고    scopus 로고
    • The LIM/homeodomain protein islet-1 modulates estrogen receptor functions
    • Gay, F., Anglade, I., Gong, Z. & Salbert, G. The LIM/homeodomain protein islet-1 modulates estrogen receptor functions. Mol. Endocrinol. 14, 1627-1648 (2000).
    • (2000) Mol. Endocrinol , vol.14 , pp. 1627-1648
    • Gay, F.1    Anglade, I.2    Gong, Z.3    Salbert, G.4
  • 22
    • 70350654370 scopus 로고    scopus 로고
    • DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction
    • Broske, A. M. et al. DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction. Nat. Genet. 41, 1207-1215 (2009).
    • (2009) Nat. Genet , vol.41 , pp. 1207-1215
    • Broske, A.M.1
  • 23
    • 34247337999 scopus 로고    scopus 로고
    • De novo DNA methyltransferase is essential for self-renewal, but not for differentiation, in hematopoietic stem cells
    • Tadokoro, Y., Ema, H., Okano, M., Li, E. & Nakauchi, H. De novo DNA methyltransferase is essential for self-renewal, but not for differentiation, in hematopoietic stem cells. J. Exp. Med. 204, 715-722 (2007).
    • (2007) J. Exp. Med , vol.204 , pp. 715-722
    • Tadokoro, Y.1    Ema, H.2    Okano, M.3    Li, E.4    Nakauchi, H.5
  • 24
    • 29244469466 scopus 로고    scopus 로고
    • The epigenetic progenitor origin of human cancer
    • Feinberg, A. P., Ohlsson, R. & Henikoff, S. The epigenetic progenitor origin of human cancer. Nat. Rev. Genet. 7, 21-33 (2006).
    • (2006) Nat. Rev. Genet , vol.7 , pp. 21-33
    • Feinberg, A.P.1    Ohlsson, R.2    Henikoff, S.3
  • 25
    • 0026076727 scopus 로고
    • Abnormal patterns of DNA methylation in human neoplasia: Potential consequences for tumor progression
    • Baylin, S. B. et al. Abnormal patterns of DNA methylation in human neoplasia: potential consequences for tumor progression. Cancer Cells 3, 383-390 (1991).
    • (1991) Cancer Cells , vol.3 , pp. 383-390
    • Baylin, S.B.1
  • 26
    • 0028074299 scopus 로고
    • DNA methylation and cancer
    • Laird, P. W. & Jaenisch, R. DNA methylation and cancer. Hum. Mol. Genet. 3 Spec No, 1487-1495 (1994).
    • (1994) Hum. Mol. Genet , vol.3 , pp. 1487-1495
    • Laird, P.W.1    Jaenisch, R.2
  • 27
    • 0242584454 scopus 로고    scopus 로고
    • Chromosomal instability and tumors promoted by DNA hypomethylation
    • Eden, A., Gaudet, F., Waghmare, A. & Jaenisch, R. Chromosomal instability and tumors promoted by DNA hypomethylation. Science 300, 455 (2003).
    • (2003) Science , vol.300 , pp. 455
    • Eden, A.1    Gaudet, F.2    Waghmare, A.3    Jaenisch, R.4
  • 28
    • 34548863946 scopus 로고    scopus 로고
    • Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors
    • Herschkowitz, J. I. et al. Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors. Genome Biol. 8, R76 (2007).
    • (2007) Genome Biol , vol.8 , pp. R76
    • Herschkowitz, J.I.1
  • 29
    • 0028116952 scopus 로고
    • Prostate and mammary adenocarcinoma in transgenic mice carrying a rat C3(1) simian virus 40 large tumor antigen fusion gene
    • Maroulakou, I. G., Anver, M., Garrett, L. & Green, J. E. Prostate and mammary adenocarcinoma in transgenic mice carrying a rat C3(1) simian virus 40 large tumor antigen fusion gene. Proc. Natl Acad. Sci. USA 91, 11236-11240 (1994).
    • (1994) Proc. Natl Acad. Sci. USA , vol.91 , pp. 11236-11240
    • Maroulakou, I.G.1    Anver, M.2    Garrett, L.3    Green, J.E.4
  • 30
    • 84877840834 scopus 로고    scopus 로고
    • A NIK-IKKalpha module expands ErbB2-induced tumorinitiating cells by stimulating nuclear export of p27/Kip1
    • Zhang, W. et al. A NIK-IKKalpha module expands ErbB2-induced tumorinitiating cells by stimulating nuclear export of p27/Kip1. Cancer Cell 23, 647-659 (2013).
    • (2013) Cancer Cell , vol.23 , pp. 647-659
    • Zhang, W.1
  • 31
    • 79952788617 scopus 로고    scopus 로고
    • Preparation of reduced representation bisulfite sequencing libraries for genome-scale DNA methylation profiling
    • Gu, H. et al. Preparation of reduced representation bisulfite sequencing libraries for genome-scale DNA methylation profiling. Nat. Protoc. 6, 468-481 (2011).
    • (2011) Nat. Protoc , vol.6 , pp. 468-481
    • Gu, H.1
  • 32
    • 49649125042 scopus 로고    scopus 로고
    • Genome-scale DNA methylation maps of pluripotent and differentiated cells
    • Meissner, A. et al. Genome-scale DNA methylation maps of pluripotent and differentiated cells. Nature 454, 766-770 (2008).
    • (2008) Nature , vol.454 , pp. 766-770
    • Meissner, A.1
  • 33
    • 84879260661 scopus 로고    scopus 로고
    • A double take on bivalent promoters
    • Voigt, P., Tee, W. W. & Reinberg, D. A double take on bivalent promoters. Genes Dev. 27, 1318-1338 (2013).
    • (2013) Genes Dev , vol.27 , pp. 1318-1338
    • Voigt, P.1    Tee, W.W.2    Reinberg, D.3
  • 34
    • 0037081290 scopus 로고    scopus 로고
    • Loss of Wnt-5a protein is associated with early relapse in invasive ductal breast carcinomas
    • Jonsson, M., Dejmek, J., Bendahl, P. O. & Andersson, T. Loss of Wnt-5a protein is associated with early relapse in invasive ductal breast carcinomas. Cancer Res. 62, 409-416 (2002).
    • (2002) Cancer Res , vol.62 , pp. 409-416
    • Jonsson, M.1    Dejmek, J.2    Bendahl, P.O.3    Andersson, T.4
  • 35
    • 0033578918 scopus 로고    scopus 로고
    • Synergy between tumor suppressor APC and the beta-catenin- Tcf4 target Tcf1
    • Roose, J. et al. Synergy between tumor suppressor APC and the beta-catenin- Tcf4 target Tcf1. Science 285, 1923-1926 (1999).
    • (1999) Science , vol.285 , pp. 1923-1926
    • Roose, J.1
  • 36
    • 78651073256 scopus 로고    scopus 로고
    • ABI3 ectopic expression reduces in vitro and in vivo cell growth properties while inducing senescence
    • Latini, F. R. et al. ABI3 ectopic expression reduces in vitro and in vivo cell growth properties while inducing senescence. BMC Cancer 11, 11 (2011).
    • (2011) BMC Cancer , vol.11 , pp. 11
    • Latini, F.R.1
  • 37
    • 0030051923 scopus 로고    scopus 로고
    • Requirement for LIM homeobox gene Isl1 in motor neuron generation reveals a motor neuron-dependent step in interneuron differentiation
    • Pfaff, S. L., Mendelsohn, M., Stewart, C. L., Edlund, T. & Jessell, T. M. Requirement for LIM homeobox gene Isl1 in motor neuron generation reveals a motor neuron-dependent step in interneuron differentiation. Cell 84, 309-320 (1996).
    • (1996) Cell , vol.84 , pp. 309-320
    • Pfaff, S.L.1    Mendelsohn, M.2    Stewart, C.L.3    Edlund, T.4    Jessell, T.M.5
  • 38
    • 33845457194 scopus 로고    scopus 로고
    • Multipotent embryonic isl1+ progenitor cells lead to cardiac, smooth muscle, and endothelial cell diversification
    • Moretti, A. et al. Multipotent embryonic isl1+ progenitor cells lead to cardiac, smooth muscle, and endothelial cell diversification. Cell 127, 1151-1165 (2006).
    • (2006) Cell , vol.127 , pp. 1151-1165
    • Moretti, A.1
  • 39
    • 79151483638 scopus 로고    scopus 로고
    • An online survival analysis tool to rapidly assess the effect of 22, 277 genes on breast cancer prognosis using microarray data of 1, 809 patients
    • Gyorffy, B. et al. An online survival analysis tool to rapidly assess the effect of 22, 277 genes on breast cancer prognosis using microarray data of 1, 809 patients. Breast Cancer Res. Treat. 123, 725-731 (2010).
    • (2010) Breast Cancer Res. Treat , vol.123 , pp. 725-731
    • Gyorffy, B.1
  • 40
    • 84886790779 scopus 로고    scopus 로고
    • Molecular mechanism of SLC5A8 inactivation in breast cancer
    • Elangovan, S. et al. Molecular mechanism of SLC5A8 inactivation in breast cancer. Mol. Cell. Biol. 33, 3920-3935 (2013).
    • (2013) Mol. Cell. Biol , vol.33 , pp. 3920-3935
    • Elangovan, S.1
  • 41
    • 84894261181 scopus 로고    scopus 로고
    • The niacin/butyrate receptor GPR109A suppresses mammary tumorigenesis by inhibiting cell survival
    • Elangovan, S. et al. The niacin/butyrate receptor GPR109A suppresses mammary tumorigenesis by inhibiting cell survival. Cancer Res. 74, 1166-1178 (2014).
    • (2014) Cancer Res , vol.74 , pp. 1166-1178
    • Elangovan, S.1
  • 42
    • 0037948854 scopus 로고    scopus 로고
    • In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells
    • Dontu, G. et al. In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells. Genes Dev. 17, 1253-1270 (2003).
    • (2003) Genes Dev , vol.17 , pp. 1253-1270
    • Dontu, G.1
  • 43
    • 84861922114 scopus 로고    scopus 로고
    • Genome-wide DNA methylation analysis reveals novel epigenetic changes in chronic lymphocytic leukemia
    • Pei, L. et al. Genome-wide DNA methylation analysis reveals novel epigenetic changes in chronic lymphocytic leukemia. Epigenetics 7, 567-578 (2012).
    • (2012) Epigenetics , vol.7 , pp. 567-578
    • Pei, L.1
  • 44
    • 79961002967 scopus 로고    scopus 로고
    • EsBAF facilitates pluripotency by conditioning the genome for LIF/STAT3 signalling and by regulating polycomb function
    • Ho, L. et al. esBAF facilitates pluripotency by conditioning the genome for LIF/STAT3 signalling and by regulating polycomb function. Nat. Cell. Biol. 13, 903-913 (2011).
    • (2011) Nat. Cell. Biol , vol.13 , pp. 903-913
    • Ho, L.1


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