메뉴 건너뛰기




Volumn 33, Issue 19, 2013, Pages 3920-3935

Molecular mechanism of SLC5A8 inactivation in breast cancer

Author keywords

[No Author keywords available]

Indexed keywords

DNA METHYLTRANSFERASE 1; PROTEIN; PROTEIN SLC5A8; UNCLASSIFIED DRUG;

EID: 84886790779     PISSN: 02707306     EISSN: 10985549     Source Type: Journal    
DOI: 10.1128/MCB.01702-12     Document Type: Article
Times cited : (30)

References (61)
  • 5
    • 19544379492 scopus 로고    scopus 로고
    • Sodium-coupled and electrogenic transport of B-complex vitamin nicotinic acid by slc5a8, a member of the Na/glucose co-transporter gene family
    • Gopal E, Fei YJ, Miyauchi S, Zhuang L, Prasad PD, Ganapathy V. 2005. Sodium-coupled and electrogenic transport of B-complex vitamin nicotinic acid by slc5a8, a member of the Na/glucose co-transporter gene family. Biochem. J. 388:309-316.
    • (2005) Biochem. J. , vol.388 , pp. 309-316
    • Gopal, E.1    Fei, Y.J.2    Miyauchi, S.3    Zhuang, L.4    Prasad, P.D.5    Ganapathy, V.6
  • 8
    • 57749111596 scopus 로고    scopus 로고
    • Nutrient transporters in cancer: relevance to Warburg hypothesis and beyond
    • Ganapathy V, Thangaraju M, Prasad PD. 2009. Nutrient transporters in cancer: relevance to Warburg hypothesis and beyond. Pharmacol. Ther. 121:29-40.
    • (2009) Pharmacol. Ther. , vol.121 , pp. 29-40
    • Ganapathy, V.1    Thangaraju, M.2    Prasad, P.D.3
  • 9
    • 33645969256 scopus 로고    scopus 로고
    • SLC5A8 (SMCT1)-mediated transport of butyrate forms the basis for the tumor suppressive function of the transporter
    • Gupta N, Martin PM, Prasad PD, Ganapathy V. 2006. SLC5A8 (SMCT1)-mediated transport of butyrate forms the basis for the tumor suppressive function of the transporter. Life Sci. 78:2419-2425.
    • (2006) Life Sci. , vol.78 , pp. 2419-2425
    • Gupta, N.1    Martin, P.M.2    Prasad, P.D.3    Ganapathy, V.4
  • 10
    • 0038676409 scopus 로고    scopus 로고
    • Inhibition of histone deacetylase activity by butyrate
    • Davie JR. 2003. Inhibition of histone deacetylase activity by butyrate. J. Nutr. 133(Suppl. 7):2485S-2493S.
    • (2003) J. Nutr. , vol.133 , Issue.7 SUPPL.
    • Davie, J.R.1
  • 13
    • 58249089741 scopus 로고    scopus 로고
    • Colon cancer cells maintain low levels of pyruvate to avoid cell death caused by inhibition of HDAC1/HDAC3
    • Thangaraju M, Carswell KN, Prasad PD, Ganapathy V. 2009. Colon cancer cells maintain low levels of pyruvate to avoid cell death caused by inhibition of HDAC1/HDAC3. Biochem. J. 417:379-389.
    • (2009) Biochem. J. , vol.417 , pp. 379-389
    • Thangaraju, M.1    Carswell, K.N.2    Prasad, P.D.3    Ganapathy, V.4
  • 15
    • 4344666663 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors upregulate death receptor 5/TRAIL-R2 and sensitize apoptosis induced by TRAIL/APO2-L in human malignant tumor cells
    • Nakata S, Yoshida T, Horinaka M, Shiraishi T, Wakada M, Sakai T. 2004. Histone deacetylase inhibitors upregulate death receptor 5/TRAIL-R2 and sensitize apoptosis induced by TRAIL/APO2-L in human malignant tumor cells. Oncogene 23:6261-6271.
    • (2004) Oncogene , vol.23 , pp. 6261-6271
    • Nakata, S.1    Yoshida, T.2    Horinaka, M.3    Shiraishi, T.4    Wakada, M.5    Sakai, T.6
  • 17
    • 27644556419 scopus 로고    scopus 로고
    • Inhibitors of histone deacetylases target the Rb-E2F1 pathway for apoptosis induction through activation of proapoptotic protein Bim
    • Zhao Y, Tan J, Zhang L, Jiang X, Liu ET, Yu Q. 2005. Inhibitors of histone deacetylases target the Rb-E2F1 pathway for apoptosis induction through activation of proapoptotic protein Bim. Proc. Natl. Acad. Sci. U. S. A. 102:16090-16095.
    • (2005) Proc. Natl. Acad. Sci. U.S.A. , vol.102 , pp. 16090-16095
    • Zhao, Y.1    Tan, J.2    Zhang, L.3    Jiang, X.4    Liu, E.T.5    Yu, Q.6
  • 18
    • 33847164080 scopus 로고    scopus 로고
    • Transport of nicotinate and structurally related compounds by human SMCT1 (SLC5A8) and its relevance to drug transport in the mammalian intestinal tract
    • Gopal E, Miyauchi S, Martin PM, Ananth S, Roon P, Smith SB, Ganapathy V. 2007. Transport of nicotinate and structurally related compounds by human SMCT1 (SLC5A8) and its relevance to drug transport in the mammalian intestinal tract. Pharm. Res. 24:575-584.
    • (2007) Pharm. Res. , vol.24 , pp. 575-584
    • Gopal, E.1    Miyauchi, S.2    Martin, P.M.3    Ananth, S.4    Roon, P.5    Smith, S.B.6    Ganapathy, V.7
  • 21
    • 0030006213 scopus 로고    scopus 로고
    • Increased cytosine DNA-methyltransferase activity is target-cell-specific and an early event in lung cancer
    • Belinsky SA, Nikula KJ, Baylin SB, Issa J-P. 1996. Increased cytosine DNA-methyltransferase activity is target-cell-specific and an early event in lung cancer. Proc. Natl. Acad. Sci. U. S. A. 93:4045-4050.
    • (1996) Proc. Natl. Acad. Sci. U.S.A. , vol.93 , pp. 4045-4050
    • Belinsky, S.A.1    Nikula, K.J.2    Baylin, S.B.3    Issa, J.-P.4
  • 23
    • 0036274359 scopus 로고    scopus 로고
    • The fundamental role of epigenetic events in cancer
    • Jones PA, Baylin SB. 2002. The fundamental role of epigenetic events in cancer. Nat. Rev. Genet. 3:415-428.
    • (2002) Nat. Rev. Genet. , vol.3 , pp. 415-428
    • Jones, P.A.1    Baylin, S.B.2
  • 24
    • 0022971594 scopus 로고
    • DNA methyltransferase levels in tumorigenic and nontumorigenic cells in culture
    • Kautiainen TL, Jones PA. 1986. DNA methyltransferase levels in tumorigenic and nontumorigenic cells in culture. J. Biol. Chem. 261:1594-1598.
    • (1986) J. Biol. Chem. , vol.261 , pp. 1594-1598
    • Kautiainen, T.L.1    Jones, P.A.2
  • 25
    • 33847065486 scopus 로고    scopus 로고
    • The epigenomics of cancer
    • Jones PA, Baylin SB. 2007. The epigenomics of cancer. Cell 128:683-692.
    • (2007) Cell , vol.128 , pp. 683-692
    • Jones, P.A.1    Baylin, S.B.2
  • 26
    • 33847076849 scopus 로고    scopus 로고
    • Chromatin modifications and their function
    • Kouzarides T. 2007. Chromatin modifications and their function. Cell 128:693-705.
    • (2007) Cell , vol.128 , pp. 693-705
    • Kouzarides, T.1
  • 27
    • 0026708177 scopus 로고
    • Targeted mutation of the DNA methyltransferases gene results in embryonic lethality
    • Li E, Bestor TH, Jaenisch R. 1992. Targeted mutation of the DNA methyltransferases gene results in embryonic lethality. Cell 69:915-926.
    • (1992) Cell , vol.69 , pp. 915-926
    • Li, E.1    Bestor, T.H.2    Jaenisch, R.3
  • 28
    • 0026299037 scopus 로고
    • DNA methylation patterns: an additional level of information?
    • Szyf M. 1991. DNA methylation patterns: an additional level of information? Biochem. Cell Biol. 69:764-767.
    • (1991) Biochem. Cell Biol. , vol.69 , pp. 764-767
    • Szyf, M.1
  • 31
    • 0033973226 scopus 로고    scopus 로고
    • Transcriptional regulation of the humanDNAmethyltransferase (dnmt1) gene
    • Bigey P, Ramchandani S, Theberg JM, Araujo FD, Szyf M. 2000. Transcriptional regulation of the humanDNAmethyltransferase (dnmt1) gene. Gene 242:407-418.
    • (2000) Gene , vol.242 , pp. 407-418
    • Bigey, P.1    Ramchandani, S.2    Theberg, J.M.3    Araujo, F.D.4    Szyf, M.5
  • 32
    • 0035816688 scopus 로고    scopus 로고
    • A conserved 3=-untranslated element mediates growth regulation of DNA methyltransferase 1 and inhibits its transforming activity
    • Detich N, Ramchandani S, Szyf M. 2001. A conserved 3=-untranslated element mediates growth regulation of DNA methyltransferase 1 and inhibits its transforming activity. J. Biol. Chem. 276:24881-24890.
    • (2001) J. Biol. Chem. , vol.276 , pp. 24881-24890
    • Detich, N.1    Ramchandani, S.2    Szyf, M.3
  • 33
    • 0029046134 scopus 로고
    • Regulation of DNA methylation by the Ras signaling pathway
    • MacLeod AR, Rouleau J, Szyf M. 1995. Regulation of DNA methylation by the Ras signaling pathway. J. Biol. Chem. 70:11327-11337.
    • (1995) J. Biol. Chem. , vol.70 , pp. 11327-11337
    • MacLeod, A.R.1    Rouleau, J.2    Szyf, M.3
  • 34
    • 0033538072 scopus 로고    scopus 로고
    • DNA methyltransferase is a downstream effector of cellular transformation triggered by simian virus 40 large T antigen
    • Slack A, Cervoni N, Pinard M, Szyf M. 1999. DNA methyltransferase is a downstream effector of cellular transformation triggered by simian virus 40 large T antigen. J. Biol. Chem. 274:10105-10112.
    • (1999) J. Biol. Chem. , vol.274 , pp. 10105-10112
    • Slack, A.1    Cervoni, N.2    Pinard, M.3    Szyf, M.4
  • 35
    • 0028925009 scopus 로고
    • Regulation of the DNA methyltransferase by the Ras-AP-1 signaling pathway
    • Rouleau J, Macleod AR, Szyf M. 1995. Regulation of the DNA methyltransferase by the Ras-AP-1 signaling pathway. J. Biol. Chem. 270:1595-1601.
    • (1995) J. Biol. Chem. , vol.270 , pp. 1595-1601
    • Rouleau, J.1    Macleod, A.R.2    Szyf, M.3
  • 36
    • 0033555953 scopus 로고    scopus 로고
    • Role of DNA 5-methylcytosine transferase in cell transformation by fos
    • Bakin AV, Curran T. 1999. Role of DNA 5-methylcytosine transferase in cell transformation by fos. Science 283:387-390.
    • (1999) Science , vol.283 , pp. 387-390
    • Bakin, A.V.1    Curran, T.2
  • 37
    • 0023189452 scopus 로고
    • Quantitation of Harvey ras p21 enhanced expression in human breast and colon carcinomas
    • Hand PH, Vilasi V, Thor A, Ohuchi N, Schlom J. 1987. Quantitation of Harvey ras p21 enhanced expression in human breast and colon carcinomas. J. Natl. Cancer Inst. 79:59-65.
    • (1987) J. Natl. Cancer Inst. , vol.79 , pp. 59-65
    • Hand, P.H.1    Vilasi, V.2    Thor, A.3    Ohuchi, N.4    Schlom, J.5
  • 38
    • 0021742115 scopus 로고
    • Human malignant tumors of the breast, as compared to their respective normal tissue, have elevated expression of the Harvey ras oncogene
    • Spandidos DA, Agnantis NJ. 1984. Human malignant tumors of the breast, as compared to their respective normal tissue, have elevated expression of the Harvey ras oncogene. Anticancer Res. 4:269-272.
    • (1984) Anticancer Res. , vol.4 , pp. 269-272
    • Spandidos, D.A.1    Agnantis, N.J.2
  • 39
    • 0022597111 scopus 로고
    • Expression of the 21,000 molecular weight ras protein in a spectrum of benign and malignant human mammary tissues
    • Ohuchi N, Thor A, Page DL, Hand PH, Halter SA, Schlom J. 1986. Expression of the 21,000 molecular weight ras protein in a spectrum of benign and malignant human mammary tissues. Cancer Res. 46:2511-2519.
    • (1986) Cancer Res. , vol.46 , pp. 2511-2519
    • Ohuchi, N.1    Thor, A.2    Page, D.L.3    Hand, P.H.4    Halter, S.A.5    Schlom, J.6
  • 40
    • 0030044330 scopus 로고    scopus 로고
    • MCF10AT: a model for the evolution of cancer from proliferative breast disease
    • Dawson PJ, Wolman SR, Tait L, Heppner GH, Miller FR. 1996. MCF10AT: a model for the evolution of cancer from proliferative breast disease. Am. J. Pathol. 148:313-319.
    • (1996) Am. J. Pathol. , vol.148 , pp. 313-319
    • Dawson, P.J.1    Wolman, S.R.2    Tait, L.3    Heppner, G.H.4    Miller, F.R.5
  • 42
    • 54049157907 scopus 로고    scopus 로고
    • Lactaturia and loss of sodium-dependent lactate uptake in the colon of SLC5A8-deficient mice
    • Frank H, Groger N, Diener M, Becker C, Braun T, Boettger T. 2008. Lactaturia and loss of sodium-dependent lactate uptake in the colon of SLC5A8-deficient mice. J. Biol. Chem. 283:24729-24737.
    • (2008) J. Biol. Chem. , vol.283 , pp. 24729-24737
    • Frank, H.1    Groger, N.2    Diener, M.3    Becker, C.4    Braun, T.5    Boettger, T.6
  • 43
    • 0041335551 scopus 로고    scopus 로고
    • Silencing of H-ras gene expression by retrovirus-mediated siRNA decrease transformation efficiently and tumor growth in a model of human ovarian cancer
    • Yang G, Thompson JA, Fang B, Liu J. 2003. Silencing of H-ras gene expression by retrovirus-mediated siRNA decrease transformation efficiently and tumor growth in a model of human ovarian cancer. Oncogene 22:5694-5701.
    • (2003) Oncogene , vol.22 , pp. 5694-5701
    • Yang, G.1    Thompson, J.A.2    Fang, B.3    Liu, J.4
  • 44
    • 0003746046 scopus 로고
    • Principles of laboratory animal care
    • National Institutes of Health, National Institutes of Health, Bethesda, MD
    • National Institutes of Health. 1985. Principles of laboratory animal care. National Institutes of Health publication 85-23. National Institutes of Health, Bethesda, MD.
    • (1985) National Institutes of Health publication. , pp. 85-23
  • 45
    • 0242285692 scopus 로고    scopus 로고
    • TGF-beta switches from tumor suppressor to prometastatic factor in a model of breast cancer progression
    • Tang B, Vu M, Booker T, Santner SJ, Miller FR, Anver MR, Wakfield LM. 2003. TGF-beta switches from tumor suppressor to prometastatic factor in a model of breast cancer progression. J. Clin. Invest. 112:1116-1124.
    • (2003) J. Clin. Invest. , vol.112 , pp. 1116-1124
    • Tang, B.1    Vu, M.2    Booker, T.3    Santner, S.J.4    Miller, F.R.5    Anver, M.R.6    Wakfield, L.M.7
  • 47
    • 33747510748 scopus 로고    scopus 로고
    • Cancer biology: a game of subversion
    • Passegue E. 2006. Cancer biology: a game of subversion. Nature 442:754-755.
    • (2006) Nature , vol.442 , pp. 754-755
    • Passegue, E.1
  • 48
    • 33745633569 scopus 로고    scopus 로고
    • CIMPle origin for promoter hypermethylation in colorectal cancer?
    • Schuebel K, Chen W, Baylin SB. 2006. CIMPle origin for promoter hypermethylation in colorectal cancer? Nat. Genet. 38:738-740.
    • (2006) Nat. Genet. , vol.38 , pp. 738-740
    • Schuebel, K.1    Chen, W.2    Baylin, S.B.3
  • 49
    • 0022815366 scopus 로고
    • Specific activation of the cellular Harvey-ras oncogene in dimethylbenzanthracene-induced mouse mammary tumors
    • Dandekar S, Sukumar S, Zarbl H, Young LJ, Cardiff RD. 1986. Specific activation of the cellular Harvey-ras oncogene in dimethylbenzanthracene-induced mouse mammary tumors. Mol. Cell. Biol. 6:4104-4108.
    • (1986) Mol. Cell. Biol. , vol.6 , pp. 4104-4108
    • Dandekar, S.1    Sukumar, S.2    Zarbl, H.3    Young, L.J.4    Cardiff, R.D.5
  • 50
    • 0021871265 scopus 로고
    • Direct mutagenesis of Ha-ras-1 oncogenes by N-nitroso-N-methylurea during initiation of mammary carcinogenesis in rats
    • Zarbl H, Sukumar S, Arthur AV, Martin-Zanca D, Barbacid M. 1985. Direct mutagenesis of Ha-ras-1 oncogenes by N-nitroso-N-methylurea during initiation of mammary carcinogenesis in rats. Nature 315:382-385.
    • (1985) Nature , vol.315 , pp. 382-385
    • Zarbl, H.1    Sukumar, S.2    Arthur, A.V.3    Martin-Zanca, D.4    Barbacid, M.5
  • 52
    • 0036883940 scopus 로고    scopus 로고
    • Pancreatic cancer biology and genetics
    • Bardeesy N, DePinho RA. 2002. Pancreatic cancer biology and genetics. Nat. Rev. Cancer 2:897-909.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 897-909
    • Bardeesy, N.1    DePinho, R.A.2
  • 53
    • 0024376173 scopus 로고
    • Ras oncogenes in human cancer: a review
    • Bos JL. 1989. Ras oncogenes in human cancer: a review. Cancer Res. 49:4682-4689.
    • (1989) Cancer Res. , vol.49 , pp. 4682-4689
    • Bos, J.L.1
  • 54
    • 0024553109 scopus 로고
    • Evidence of enhancement of the ras oncogene protein product (p21) in a spectrum of human tumors
    • De Biasi F, Del Sal G, Hand PH. 1989. Evidence of enhancement of the ras oncogene protein product (p21) in a spectrum of human tumors. Int. J. Cancer 43:431-435.
    • (1989) Int. J. Cancer , vol.43 , pp. 431-435
    • De Biasi, F.1    Del Sal, G.2    Hand, P.H.3
  • 57
    • 0036024016 scopus 로고    scopus 로고
    • An old kinase on a new path: Raf and apoptosis
    • Baccarini M. 2002. An old kinase on a new path: Raf and apoptosis. Cell Death Differ. 9:783-785.
    • (2002) Cell Death Differ. , vol.9 , pp. 783-785
    • Baccarini, M.1
  • 58
    • 0034762203 scopus 로고    scopus 로고
    • The Raf/MEK/ERK pathway: new concepts of activation
    • Peyssonnaux C, Eychene A. 2001. The Raf/MEK/ERK pathway: new concepts of activation. Biol. Cell 93:53-62.
    • (2001) Biol. Cell , vol.93 , pp. 53-62
    • Peyssonnaux, C.1    Eychene, A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.