Characterization of differentially expressed genes involved in pathways associated with gastric cancer

PLoS ONE

Volumn 10, Issue 4, 2015, Pages

  Li, Hao ^a   Yu, Beiqin ^a   Li, Jianfang ^a   Su, Liping ^a   Yan, Min ^a   Zhang, Jun ^a   Li, Chen ^a   Zhu, Zhenggang ^a   Li, Bingya ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

LONG UNTRANSLATED RNA; MESSENGER RNA; MUCIN 6; NEUROPSIN; OSTEOPONTIN; PROSTATE STEM CELL ANTIGEN; SECRETED FRIZZLED RELATED PROTEIN 4;

ANGIOGENESIS; ARTICLE; CARCINOGENESIS; CELL MIGRATION; CHIA GENE; CLDN1 GENE; CLINICAL ARTICLE; CONTROLLED STUDY; CST1 GENE; DOWN REGULATION; FAP GENE; FBP2 GENE; GENE; GENE ACT NETWORK; GENE EXPRESSION; GENE INTERACTION; GENE ONTOLOGY; GENETIC ASSOCIATION; GKN2 GENE; HUMAN; HUMAN TISSUE; INHBA GENE; KLK8 GENE; KRT17 GENE; METABOLISM; MICROARRAY ANALYSIS; MUC6 GENE; OLFM4 GENE; PGC GENE; PSCA GENE; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SFRP4 GENE; SIGNAL TRANSDUCTION; SPP1 GENE; STOMACH CANCER; TUMOR MICROENVIRONMENT; UPREGULATION; DNA MICROARRAY; FEMALE; GENE EXPRESSION PROFILING; GENETICS; MALE; STOMACH TUMOR;

FEMALE; GENE EXPRESSION PROFILING; GENE ONTOLOGY; HUMANS; MALE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RNA, LONG NONCODING; RNA, MESSENGER; STOMACH NEOPLASMS;

EID: 84928785009     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0125013     Document Type: Article

References (63)

1. International Agency for Research on Cancer (IARC). GLOBOCAN2012 Database 2012.
2. Allison DB, Cui X, Page GP, Sabripour M. Microarray data analysis: from disarray to consolidation and consensus. Nat Rev Genet. 2006; 7(1):55-65. PMID: 16369572.
3. Cao W, Wu W, Shi F, Chen X, Wu L, Yang K, et al. Integrated analysis of long noncoding RNA and coding RNA expression in esophageal squamous cell carcinoma. Int J Genomics. 2013; 2013:480534. doi:10.1155/2013/480534 PMID: 24222893.
4. Dong R, Du J, Wang L, Wang J, Ding G, Wang S, et al. Comparison of long noncoding RNA and mRNA expression profiles in mesenchymal stem cells derived from human periodontal ligament and bone marrow. Biomed Res Int.2014; 2014:317853. doi:10.1155/2014/317853 PMID: 24790996.
5. Dai J, Zhang N, Wang J, Chen M, Chen J. Gastrokine-2 is downregulated in gastric cancer and its restoration suppresses gastric tumorigenesis and cancer metastasis. Tumour Biol. 2014; 35(5):4199-207. doi:10.1007/s13277-013-1550-0 PMID: 24408014.
6. Kim O, Yoon JH, Choi WS, Ashktorab H, Smoot DT, Nam SW, et al. GKN2 contributes to the homeostasis of gastric mucosa by inhibiting GKN1 activity. J Cell Physiol. 2014; 229(6):762-71. doi:10.1002/jcp.24496 PMID: 24151046.
7. Fahlbusch FB, Ruebner M, Huebner H, Volkert G, Zuern C, Thiel F, et al. The tumor suppressor gastrokine- 1 is expressed in placenta and contributes to the regulation of trophoblast migration. Placenta. 2013; 34(11):1027-35. doi:10.1016/j.placenta.2013.08.005 PMID: 23993393.
8. Xiao JW, Chen JH, Ren MY, Tian XB, Wang CS. Relationship between expression of gastrokine 1 and clinicopathological characteristics in gastric cancer patients. Asian Pac J Cancer Prev. 2012; 13 (11):5897-901. PMID: 23317277.
9. Yoshida T, Kato J, Inoue I, Yoshimura N, Deguchi H, Mukoubayashi C, et al. Cancer development based on chronic active gastritis and resulting gastric atrophy as assessed by serum levels of pepsinogen and Helicobacter pylori antibody titer. Int J Cancer. 2014; 134(6):1445-57. doi:10.1002/ijc.28470 PMID: 24009139.
10. Cao XY, Jia ZF, Jin MS, Cao DH, Kong F, Suo J, et al. Serum pepsinogen II is a better diagnostic marker in gastric cancer. World J Gastroenterol. 2012; 18(48):7357-61. doi:10.3748/wjg.v18.i48.7357 PMID: 23326145.
11. Leir SH, Harris A. MUC6 mucin expression inhibits tumor cell invasion. Exp Cell Res. 2011; 317 (17):2408-19. doi:10.1016/j.yexcr.2011.07.021 PMID: 21851820.
12. Jung SH, Chung WC, Lee KM, Paik CN, Jung JH, Lee MK, et al. Risk factors in malignant transformation of gastric epithelial neoplasia categorized by the revised Vienna classification: endoscopic, pathological, and immunophenotypic features. Gastric Cancer. 2010; 13(2):123-30. doi:10.1007/s10120-010-0550-7 PMID: 20602200.
13. Nookaew I, Thorell K, Worah K, Wang S, Hibberd ML, Sjövall H, et al. Transcriptome signatures in Helicobacter pylori-infected mucosa identifies acidic mammalian chitinase loss as a corpus atrophy marker. BMC Med Genomics. 2013; 6:41. doi:10.1186/1755-8794-6-41 PMID: 24119614.
14. Hartl D, He CH, Koller B, Da Silva CA, Kobayashi Y, Lee CG, et al. Acidic mammalian chitinase regulates epithelial cell apoptosis via a chitinolytic-independent mechanism. J Immunol. 2009; 182 (8):5098-106. doi:10.4049/jimmunol.0803446 PMID: 19342690.
15. Sanchez C, Escrieut C, Clerc P, Gigoux V, Waser B, Reubi JC, et al. Characterization of a novel fivetransmembrane domain cholecystokinin-2 receptor splice variant identified in human tumors. Mol Cell Endocrinol. 2012; 349(2):170-9. doi:10.1016/j.mce.2011.10.010 PMID: 22040601.
16. Fino KK, Matters GL, McGovern CO, Gilius EL, Smith JP. Downregulation of the CCK-B receptor in pancreatic cancer cells blocks proliferation and promotes apoptosis. Am J PhysiolGastrointest Liver Physiol. 2012; 302(11):G1244-52.
17. Gu X, Zhang W, Xu L, Cai D. Quantitative assessment of the influence of prostate stem cell antigen polymorphisms on gastric cancer risk. Tumour Biol. 2014; 35(3):2167-74. doi:10.1007/s13277-013-1287-9 PMID: 24146278.
18. Rizzato C, Kato I, Plummer M, Muñoz N, Canzian F. Genetic variation in PSCA and risk of gastric advanced preneoplastic lesions and cancer in relation to Helicobacter pylori infection. PLoS One. 2013; 8 (9):e73100. doi:10.1371/journal.pone.0073100 PMID: 24023815.
19. Li H, Wang J, Xu H, Xing R, Pan Y, Li W, et al. Decreased fructose-1, 6-bisphosphatase-2 expression promotes glycolysis and growth in gastric cancer cells. Mol Cancer. 2013; 12(1):110. doi:10.1186/1476-4598-12-110 PMID: 24063558.
20. Planque C, Choi YH, Guyetant S, Heuzé-Vourc'h N, Briollais L, Courty Y. Alternative splicing variant of kallikrein-related peptidase 8 as an independent predictor of unfavorable prognosis in lung cancer. Clin Chem. 2010; 56(6):987-97. doi:10.1373/clinchem.2009.138917 PMID: 20360129.
21. Ford CE, Jary E, Ma SS, Nixdorf S, Heinzelmann Schwarz VA, Ward RL. The Wnt gatekeeper SFRP4 modulates EMT, cell migration and downstream Wntsignalling in serous ovarian cancer cells. PLoS One. 2013; 8(1):e54362.
22. Feng Han Q1, Zhao W, Bente J, Shearwood AM, Zeps N, Joseph D, Iacopetta B, Dharmarajan A. Expression of sFRP-4 and beta-catenin in human colorectal carcinoma. Cancer Lett. 2006;231(1):129-37. doi:10.1371/journal.pone.0054362 PMID: 23326605.
23. Oshima T, Yoshihara K, Aoyama T, Hasegawa S, Sato T, Yamamoto N, et al. Relation of INHBA gene expression to outcomes in gastric cancer after curative surgery. Anticancer Res. 2014; 34(5):2303-9. PMID: 24778035.
24. Okano M, Yamamoto H, Ohkuma H, Kano Y, Kim H, Nishikawa S, et al. Significance of INHBA expression in human colorectal cancer. Oncol Rep. 2013; 30(6):2903-8. doi:10.3892/or.2013.2761 PMID: 24085226.
25. Czekierdowski A, Czekierdowska S, Danilos J, Czuba B, Sodowski K, Sodowska H, et al. Microvessel density and CpG island methylation of the THBS2 gene in malignant ovarian tumors. J PhysiolPharmacol. 2008; 59 Suppl 4:53-65. PMID: 18955754.
26. Ohlsson L, Lindmark G, Israelsson A, Palmqvist R, Öberg Å, Hammarström ML, et al. Lymph node tissue kallikrein-related peptidase 6 mRNA: A progression marker for colorectal cancer. Br J Cancer. 2012; 107(1):150-7. doi:10.1038/bjc.2012.220 PMID: 22699826.
27. Seiz L, Dorn J, Kotzsch M, Walch A, Grebenchtchikov NI, Gkazepis A, et al. Stromal cell-associated expression of kallikrein-related peptidase 6 (KLK6) indicates poor prognosis of ovarian cancer patients. Biol Chem. 2012; 393(5):391-401. doi:10.1515/hsz-2011-0264 PMID: 22505521.
28. Eftang LL, Esbensen Y, Tannæs TM, Blom GP, Bukholm IR, Bukholm G. Up-regulation of CLDN1 in gastric cancer is correlated with reduced survival. BMC Cancer. 2013; 13:586. doi:10.1186/1471-2407-13-586 PMID: 24321518.
29. Shibutani M, Noda E, Maeda K, Nagahara H, Ohtani H, Hirakawa K. Low expression of claudin-1 and presence of poorly-differentiated tumor clusters correlate with poor prognosis in colorectal cancer. Anticancer Res. 2013; 33(8):3301-6. PMID: 23898096.
30. Choi EH, Kim JT, Kim JH, Kim SY, Song EY, Kim JW, et al. Upregulation of the cysteine protease inhibitor, cystatin SN, contributes to cell proliferation and cathepsin inhibition in gastric cancer. ClinChimActa. 2009; 406(1-2):45-51.
31. Wang RF, Zhang LH, Shan LH, Sun WG, Chai CC, Wu HM, et al. Effects of the fibroblast activation protein on the invasion and migration of gastric cancer. ExpMolPathol. 2013; 95(3):350-56.
32. Junnila S, Kokkola A, Mizuguchi T, Hirata K, Karjalainen-Lindsberg ML, Puolakkainen P, et al. Gene expression analysis identifies over-expression of CXCL1, SPARC, SPP1, and SULF1 in gastric cancer. Genes Chromosomes Cancer. 2010; 49(1):28-39. doi:10.1002/gcc.20715 PMID: 19780053.
33. Luo Z, Zhang Q, Zhao Z, Li B, Chen J, Wang Y. OLFM4 is associated with lymph node metastasis and poor prognosis in patients with gastric cancer. J Cancer Res ClinOncol. 2011; 137(11):1713-20. doi:10.1007/s00432-011-1042-9 PMID: 21904905.
34. Wang YF, Lang HY, Yuan J, Wang J, Wang R, Zhang XH, et al. Overexpression of keratin 17 is associated with poor prognosis in epithelial ovarian cancer. Tumour Biol. 2013; 34(3):1685-9. doi:10.1007/s13277-013-0703-5 PMID: 23430585.
35. Okugawa T, Oshima T, Chen X, Hori K, Tomita T, Fukui H, et al. Down-regulation of claudin-3 is associated with proliferative potential in early gastric cancers. Dig Dis Sci. 2012; 57(6):1562-7. doi:10.1007/s10620-012-2043-5 PMID: 22290341.
36. Sha S, Gu Y, Xu B, Hu H, Yang Y, Kong X, et al. Decreased expression of HOXB9 is related to poor overall survival in patients with gastric carcinoma. Dig Liver Dis. 2013; 45(5):422-9. doi:10.1016/j.dld.2012.12.004 PMID: 23332081.
37. Li H, Yu B, Li J, Su L, Yan M, Zhu Z, et al. Overexpression of lncRNA H19 enhances carcinogenesis and metastasis of gastric cancer. Oncotarget. 2014; 5(8):2318-29. PMID: 24810858.
38. Guo G, Kang Q, Chen Q, Chen Z, Wang J, Tan L, et al. High expression of long non-coding RNA H19 is required for efficient tumorigenesis induced by Bcr-Abl oncogene. FEBS Lett. 2014; 588(9):1780-6. doi:10.1016/j.febslet.2014.03.038 PMID: 24685695.
39. Behrends S, Vehse K. The beta(2) subunit of soluble guanylyl cyclase contains a human-specific frameshift and is expressed in gastric carcinoma. BiochemBiophys Res Commun. 2000; 271(1):64-9. PMID: 10777682.
40. Sun M, Xia R, Jin F, Xu T, Liu Z, De W, et al. Downregulated long noncoding RNA MEG3 is associated with poor prognosis and promotes cell proliferation in gastric cancer. Tumour Biol. 2014; 35(2):1065- 73. doi:10.1007/s13277-013-1142-z PMID: 24006224.
41. Yan J, Guo X, Xia J, Shan T, Gu C, Liang Z, et al. MiR-148a regulates MEG3 in gastric cancer by targeting DNA methyltransferase 1. Med Oncol. 2014; 31(3):879. doi:10.1007/s12032-014-0879-6 PMID: 24515776.
42. Praml C, Savelyeva L, Schwab M. Aflatoxin B1 aldehyde reductase (AFAR) genes cluster at 1p35- 1p36.1 in a region frequently altered in human tumour cells. Oncogene. 2003; 22(30):4765-73. PMID: 12879023.
43. Laborde E. Glutathione transferases as mediators of signaling pathways involved in cell proliferation and cell death. Cell Death Differ. 2010; 17(9):1373-80. doi:10.1038/cdd.2010.80 PMID: 20596078.
44. Tomas A, Futter CE, Eden ER. EGF receptor trafficking: consequences for signaling and cancer. Trends Cell Biol. 2014; 24(1):26-34. doi:10.1016/j.tcb.2013.11.002 PMID: 24295852.
45. Fukuda MN, Sugihara K. Trophinin in cell adhesion and signal transduction. Front Biosci (Elite Ed). 2012; 4:342-50. PMID: 22201876.
46. Vallon M, Rohde F, Janssen KP, Essler M. Tumor endothelial marker 5 expression in endothelial cells during capillary morphogenesis is induced by the small GTPaseRac and mediates contact inhibition of cell proliferation. Exp Cell Res. 2010; 316(3):412-21. doi:10.1016/j.yexcr.2009.10.013 PMID: 19853600.
47. Thang NM, Kumasawa K, Tsutsui T, Nakamura H, Masaki H, Ono T, et al. Overexpression of endogenous TIMP-2 increases the proliferation of BeWochoriocarcinoma cells through the MAPK-signaling pathway. Reprod Sci. 2013; 20(10):1184-92. doi:10.1177/1933719113477485 PMID: 23427184.
48. Liu C, Shao ZM, Zhang L, Beatty P, Sartippour M, Lane T, et al. Human endomucin is an endothelial marker. BiochemBiophys Res Commun. 2001; 288(1):129-36. PMID: 11594763.
49. Schubert T, Denk AE, Ruedel A, Kaufmann S, Hustert E, Bastone P, et al. Fragments of SLIT3 inhibit cellular migration. Int J Mol Med. 2012; 30(5):1133-7. doi:10.3892/ijmm.2012.1098 PMID: 22922792.
50. Lorenzi T, Lorenzi M, Altobelli E, Marzioni D, Mensà E, Quaranta A, et al. HtrA1 in human urothelial bladder cancer: A secreted protein and a potential novel biomarker. Int J Cancer. 2013; 133 (11):2650-61. doi:10.1002/ijc.28280 PMID: 23712470.
51. Sato T, Oshima T, Yamamoto N, Yamada T, Hasegawa S, Yukawa N, et al. Clinical significance of SPARC gene expression in patients with gastric cancer. J SurgOncol. 2013; 108(6):364-8. doi:10.1002/jso.23425 PMID: 24018911.
52. Azim HA Jr, Singhal S, Ignatiadis M, Desmedt C, Fumagalli D, Veys I, et al. Association between SPARC mRNA expression, prognosis and response to neoadjuvant chemotherapy in early breast cancer: A pooled in-silico analysis. PLoS One. 2013; 8(4):e62451. doi:10.1371/journal.pone.0062451 PMID: 23638089.
53. Huang X, Ji G, Wu Y, Wan B, Yu L. LAMA4, highly expressed in human hepatocellular carcinoma from Chinese patients, is a novel marker of tumor invasion and metastasis. J Cancer Res ClinOncol. 2008; 134(6):705-14. PMID: 18084776.
54. Vainionpää N, Lehto VP, Tryggvason K, Virtanen I. Alpha4 chain laminins are widely expressed in renal cell carcinomas and have a de-adhesive function. Lab Invest. 2007; 87(8):780-91. PMID: 17533363.
55. Gorski DH, Leal AJ. Inhibition of endothelial cell activation by the homeobox gene Gax. J Surg Res. 2003; 111(1):91-9. PMID: 12842453.
56. Wei M, Liu B, Su L, Li J, Zhang J, Yu Y, et al. A novel plant homeodomain finger 10-mediated antiapoptotic mechanism involving repression of caspase-3 in gastric cancer cells. Mol Cancer Ther. 2010; 9 (6):1764-74. doi:10.1158/1535-7163.MCT-09-1162 PMID: 20530714.
57. Zhang Y, Zang M, Li J, Ji J, Zhang J, Liu X, et al. CEACAM6 promotes tumor migration, invasion, and metastasis in gastric cancer. Acta Biochim Biophys Sin (Shanghai). 2014; 46(4):283-90. doi:10.1093/abbs/gmu001 PMID: 24492534.
58. Qu Y, Ray PS, Li J, Cai Q, Bagaria SP, Moran C, et al. High levels of secreted frizzled-related protein 1 correlate with poor prognosis and promote tumourigenesis in gastric cancer. Eur J Cancer. 2013; 49 (17):3718-28. doi:10.1016/j.ejca.2013.07.011 PMID: 23927957.
59. Qu Y, Zhou C, Zhang J, Cai Q, Li J, Du T, et al. The metastasis suppressor SOX11 is an independent prognostic factor for improved survival in gastric cancer. Int J Oncol. 2014; 44(5):1512-20. doi:10.3892/ijo.2014.2328 PMID: 24604109.
60. Huang J, Li J, Qu Y, Zhang J, Zhang L, Chen X, et al. The expression of claudin 1 correlates with β- catenin and is a prognostic factor of poor outcome in gastric cancer. Int J Oncol. 2014; 44(4):1293-301. doi:10.3892/ijo.2014.2298 PMID: 24535143.
61. Cui J, Chen Y, Chou WC, Sun L, Chen L, Suo J, et al. An integrated transcriptomic and computational analysis for biomarker identification in gastric cancer. Nucleic Acids Res. 2011; 39(4):1197-207. doi:10.1093/nar/gkq960 PMID: 20965966.
62. Takeno A, Takemasa I, Doki Y, Yamasaki M, Miyata H, Takiguchi S, et al. Integrative approach for differentially overexpressed genes in gastric cancer by combining large-scale gene expression profiling and network analysis. Br J Cancer. 2008; 99(8):1307-15. doi:10.1038/sj.bjc.6604682 PMID: 18827816.
63. Cui J, Li F, Wang G, Fang X, Puett JD, Xu Y. Gene-expression signatures can distinguish gastric cancer grades and stages. PLoS One. 2011; 6(3):e17819. doi:10.1371/journal.pone.0017819 PMID: 21445269.