Decreased expression of HOXB9 is related to poor overall survival in patients with gastric carcinoma

Digestive and Liver Disease

Volumn 45, Issue 5, 2013, Pages 422-429

  Sha, Sumei ^a   Gu, Yong ^a,b   Xu, Bin ^a   Hu, Hao ^a   Yang, Yan ^a   Kong, Xiangyun ^a,c   Wu, Kaichun ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b Shanxi Provincial Corps Hospital of Chinese People's Armed Police Forces   (China)

^c XI AN NO 1 HOSPITAL   (China)

Author keywords

Gastric carcinoma; HOXB9; Prognosis; Tumour marker

Indexed keywords

HOXB9 PROTEIN; MESSENGER RNA; PROTEIN; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CELL NUCLEUS; CELLULAR DISTRIBUTION; FEMALE; FOLLOW UP; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; LYMPH NODE METASTASIS; MALE; OVERALL SURVIVAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; STOMACH CARCINOMA; SURVIVAL RATE; WESTERN BLOTTING;

BLOTTING, WESTERN; CARCINOMA; CELL LINE, TUMOR; FEMALE; HOMEODOMAIN PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MICROSCOPY, CONFOCAL; MIDDLE AGED; PROGNOSIS; REAL-TIME POLYMERASE CHAIN REACTION; STOMACH NEOPLASMS; SURVIVAL ANALYSIS; TISSUE ARRAY ANALYSIS; TUMOR MARKERS, BIOLOGICAL;

EID: 84876742559     PISSN: 15908658     EISSN: 18783562     Source Type: Journal    
DOI: 10.1016/j.dld.2012.12.004     Document Type: Article

References (38)

1. Sano T., Sasako M., Yamamoto S., et al. Gastric cancer surgery: morbidity and mortality results from a prospective randomized controlled trial comparing D2 and extended para-aortic lymphadenectomy - Japan Clinical Oncology Group Study 9501. Journal of Clinical Oncology 2004, 22:2767-2773.
2. Brenner H., Rothenbacher D., Arndt V. Epidemiology of stomach cancer. Methods in Molecular Biology 2009, 472:467-477.
3. Winer E., Gralow J., Diller L., et al. Clinical cancer advances 2008: major research advances in cancer treatment, prevention, and screening - a report from the American Society of Clinical Oncology. Journal of Clinical Oncology 2009, 27:812-826.
4. Dicken B.J., Bigam D.L., Cass C., Mackey J.R., Joy A.A., Hamilton S.M. Gastric adenocarcinoma: review and considerations for future directions. Annals of Surgery 2005, 241:27-39.
5. Cho J.Y., Lim J.Y., Cheong J.H., et al. Gene expression signature-based prognostic risk score in gastric cancer. Clinical Cancer Research 2011, 17:1850-1857.
6. Feng W., Brown R.E., Trung C.D., et al. Morphoproteomic profile of mTOR, Ras/Raf kinase/ERK, and NF-kappaB pathways in human gastric adenocarcinoma. Annals of Clinical and Laboratory Science 2008, 38:195-209.
7. Wang K., Liu R., Li J., et al. Quercetin induces protective autophagy in gastric cancer cells: involvement of Akt-mTOR- and hypoxia-induced factor 1alpha-mediated signaling. Autophagy 2011, 7:966-978.
8. Tan I.B., Ivanova T., Lim K.H., et al. Intrinsic subtypes of gastric cancer, based on gene expression pattern, predict survival and respond differently to chemotherapy. Gastroenterology 2011, 141:476-485. 485e1-11.
9. Wang W., Lv L., Pan K., et al. Reduced expression of transcription factor AP-2alpha is associated with gastric adenocarcinoma prognosis. PLoS One 2011, 6:e24897.
10. Wang S., Wu X., Chen Yet al. Prognostic and predictive role of JWA and XRCC1 expressions in gastric cancer. Clinical Cancer Research 2012, 18:2987-2996.
11. Kim J., Min S.Y., Lee H.E., Kim W.H. Aberrant DNA methylation and tumor suppressive activity of the EBF3 gene in gastric carcinoma. International Journal of Cancer 2012, 130:817-826.
12. Garcia-Fernandez J. The genesis and evolution of homeobox gene clusters. Nature Reviews Genetics 2005, 6:881-892.
13. Kelly Z.L., Michael A., Butler-Manuel S., Pandha H.S., Morgan R.G. HOX genes in ovarian cancer. Journal of Ovarian Research 2011, 4:16.
14. Nunes F.D., de Almeida F.C., Tucci R., de Sousa S.C. Homeobox genes: a molecular link between development and cancer. Pesquisa Odontologica Brasileira 2003, 17:94-98.
15. Calvo R., West J., Franklin W., et al. Altered HOX and WNT7A expression in human lung cancer. Proceedings of the National Academy of Sciences of the United States of America 2000, 97:12776-12781.
16. Miller G.J., Miller H.L., van Bokhoven A., et al. Aberrant HOXC expression accompanies the malignant phenotype in human prostate. Cancer Research 2003, 63:5879-5888.
17. Raman V., Martensen S.A., Reisman D., et al. Compromised HOXA5 function can limit p53 expression in human breast tumours. Nature 2000, 405:974-978.
18. Vider B.Z., Zimber A., Hirsch D., et al. Human colorectal carcinogenesis is associated with deregulation of homeobox gene expression. Biochemical and Biophysical Research Communications 1997, 232:742-748.
19. Cantile M., Cindolo L., Napodano G., Altieri V., Cillo C. Hyperexpression of locus C genes in the HOX network is strongly associated in vivo with human bladder transitional cell carcinomas. Oncogene 2003, 22:6462-6468.
20. Cheng W., Liu J., Yoshida H., Rosen D., Naora H. Lineage infidelity of epithelial ovarian cancers is controlled by HOX genes that specify regional identity in the reproductive tract. Nature Medicine 2005, 11:531-537.
21. Hatzis P., van der Flier L.G., van Driel M.A., et al. Genome-wide pattern of TCF7L2/TCF4 chromatin occupancy in colorectal cancer cells. Molecular and Cellular Biology 2008, 28:2732-2744.
22. Abate-Shen C. Deregulated homeobox gene expression in cancer: cause or consequence?. Nature Reviews Cancer 2002, 2:777-785.
23. Chiba N., Comaills V., Shiotani B., et al. Homeobox B9 induces epithelial-to-mesenchymal transition-associated radioresistance by accelerating DNA damage responses. Proceedings of the National Academy of Sciences of the United States of America 2012, 109:2760-2765.
24. Hayashida T., Takahashi F., Chiba N., et al. HOXB9, a gene overexpressed in breast cancer, promotes tumorigenicity and lung metastasis. Proceedings of the National Academy of Sciences of the United States of America 2010, 107:1100-1105.
25. Seki H., Hayashida T., Jinno H., et al. HOXB9 expression promoting tumor cell proliferation and angiogenesis is associated with clinical outcomes in breast cancer patients. Annals of Surgical Oncology 2012, 19:1831-1840.
26. Sinicrope F.A., Ruan S.B., Cleary K.R., Stephens L.C., Lee J.J., Levin B. bcl-2 and p53 oncoprotein expression during colorectal tumorigenesis. Cancer Research 1995, 55:237-241.
27. Parkin D.M., Bray F., Ferlay J., Pisani P. Global cancer statistics, 2002. CA: A Cancer Journal for Clinicians 2005, 55:74-108.
28. Crew K.D., Neugut A.I. Epidemiology of gastric cancer. World Journal of Gastroenterology 2006, 12:354-362.
29. Leung W.K., Wu M.S., Kakugawa Y., et al. Screening for gastric cancer in Asia: current evidence and practice. Lancet Oncology 2008, 9:279-287.
30. Hundahl S.A., Phillips J.L., Menck H.R. The National Cancer Data Base Report on poor survival of U.S. gastric carcinoma patients treated with gastrectomy: Fifth Edition American Joint Committee on Cancer staging, proximal disease, and the " different disease" hypothesis. Cancer 2000, 88:921-932.
31. Liu X., Xu Y., Long Z., Zhu H., Wang Y. Prognostic significance of tumor size in T3 gastric cancer. Annals of Surgical Oncology 2009, 16:1875-1882.
32. Liu X., Cai H., Huang H., Long Z., Shi Y., Wang Y. The prognostic significance of apoptosis-related biological markers in Chinese gastric cancer patients. PLoS One 2011, 6:e29670.
33. Kapur R.P., Gershon M.D., Milla P.J., Pachnis V. The influence of Hox genes and three intercellular signalling pathways on enteric neuromuscular development. Neurogastroenterology and Motility 2004, 16(Suppl. 1):8-13.
34. Cantile M., Schiavo G., Terracciano L., Cillo C. Homeobox genes in normal and abnormal vasculogenesis. Nutrition, Metabolism and Cardiovascular Diseases 2008, 18:651-658.
35. Duboule D. The rise and fall of Hox gene clusters. Development 2007, 134:2549-2560.
36. Danen-van Oorschot A.A., Kuipers J.E., Arentsen-Peters S., et al. Differentially expressed miRNAs in cytogenetic and molecular subtypes of pediatric acute myeloid leukemia. Pediatric Blood and Cancer 2012, 58:715-721.
37. Nagel S., Burek C., Venturini L., et al. Comprehensive analysis of homeobox genes in Hodgkin lymphoma cell lines identifies dysregulated expression of HOXB9 mediated via ERK5 signaling and BMI1. Blood 2007, 109:3015-3023.
38. Takahashi Y., Hamada J., Murakawa K., et al. Expression profiles of 39 HOX genes in normal human adult organs and anaplastic thyroid cancer cell lines by quantitative real-time RT-PCR system. Experimental Cell Research 2004, 293:144-153.