Tumor endothelial marker 5 expression in endothelial cells during capillary morphogenesis is induced by the small GTPase Rac and mediates contact inhibition of cell proliferation

Experimental Cell Research

Volumn 316, Issue 3, 2010, Pages 412-421

  Vallon, Mario ^a   Rohde, Franziska ^a   Janssen, Klaus Peter ^a   Essler, Markus ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

Capillary morphogenesis; Contact inhibition; Endothelial cells; Proliferation; Rac; TEM5

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR; COLLAGEN TYPE 1; GLYCOPROTEIN; MATRIGEL; RAC PROTEIN; TUMOR ENDOTHELIAL MARKER 5; UNCLASSIFIED DRUG; VASCULOTROPIN;

ARTICLE; CAPILLARY DENSITY; CAPILLARY PROLIFERATION; CELL PROLIFERATION; CONTACT INHIBITION; CONTROLLED STUDY; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; MORPHOGENESIS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; UPREGULATION;

CLOSTRIDIUM BOTULINUM; CLOSTRIDIUM DIFFICILE;

EID: 72149109281     PISSN: 00144827     EISSN: 10902422     Source Type: Journal    
DOI: 10.1016/j.yexcr.2009.10.013     Document Type: Article

References (28)

1. Folkman J. Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat. Med. 1 (1995) 27-31
2. Bazzoni G., and Dejana E. Endothelial cell-to-cell junctions: molecular organization and role in vascular homeostasis. Physiol. Rev. 84 (2004) 869-901
3. Caveda L., Martin-Padura I., Navarro P., Breviario F., Corada M., Gulino D., Lampugnani M.G., and Dejana E. Inhibition of cultured cell growth by vascular endothelial cadherin (cadherin-5/VE-cadherin). J. Clin. Invest. 98 (1996) 886-893
4. Grazia Lampugnani M., Zanetti A., Corada M., Takahashi T., Balconi G., Breviario F., Orsenigo F., Cattelino A., Kemler R., Daniel T.O., and Dejana E. Contact inhibition of VEGF- induced proliferation requires vascular endothelial cadherin, beta-catenin, and the phosphatase DEP-1/CD148. J. Cell Biol. 161 (2003) 793-804
5. Lampugnani M.G., Zanetti A., Breviario F., Balconi G., Orsenigo F., Corada M., Spagnuolo R., Betson M., Braga V., and Dejana E. VE-cadherin regulates endothelial actin activating Rac and increasing membrane association of Tiam. Mol. Biol. Cell. 13 (2002) 1175-1189
6. Bryan B.A., and D'Amore P.A. What tangled webs they weave: Rho-GTPase control of angiogenesis. Cell. Mol. Life Sci. 64 (2007) 2053-2065
7. Vega F.M., and Ridley A.J. Rho GTPases in cancer cell biology. FEBS Lett. 582 (2008) 2093-2101
8. Voth D.E., and Ballard J.D. Clostridium difficile toxins: mechanism of action and role in disease. Clin. Microbiol. Rev. 18 (2005) 247-263
9. Wilde C., and Aktories K. The Rho-ADP-ribosylating C3 exoenzyme from Clostridium botulinum and related C3-like transferases. Toxicon 39 (2001) 1647-1660
10. Gao Y., Dickerson J.B., Guo F., Zheng J., and Zheng Y. Rational design and characterization of a Rac GTPase-specific small molecule inhibitor. Proc. Natl. Acad. Sci. U. S. A. 101 (2004) 7618-7623
11. St B., Croix C., Rago V., Velculescu G., Traverso K.E., Romans E., Montgomery A., Lal G.J., Riggins C., Lengauer B., and Vogelstein K.W. Kinzler, Genes expressed in human tumor endothelium. Science 289 (2000) 1197-1202
12. Carson-Walter E.B., Watkins D.N., Nanda A., Vogelstein B., Kinzler K.W., and Croix B.St. Cell surface tumor endothelial markers are conserved in mice and humans. Cancer Res. 61 (2001) 6649-6655
13. Bjarnadottir T.K., Fredriksson R., Hoglund P.J., Gloriam D.E., Lagerstrom M.C., and Schioth H.B. The human and mouse repertoire of the adhesion family of G-protein-coupled receptors. Genomics 84 (2004) 23-33
14. Yamamoto Y., Irie K., Asada M., Mino A., Mandai K., and Takai Y. Direct binding of the human homologue of the Drosophila disc large tumor suppressor gene to seven-pass transmembrane proteins, tumor endothelial marker 5 (TEM5), and a novel TEM5-like protein. Oncogene 23 (2004) 3889-3897
15. Vallon M., and Essler M. Proteolytically processed soluble tumor endothelial marker (TEM) 5 mediates endothelial cell survival during angiogenesis by linking integrin alpha(v)beta3 to glycosaminoglycans. J. Biol. Chem. 281 (2006) 34179-34188
16. Davis G.E., and Camarillo C.W. An alpha 2 beta 1 integrin-dependent pinocytic mechanism involving intracellular vacuole formation and coalescence regulates capillary lumen and tube formation in three-dimensional collagen matrix. Exp. Cell Res. 224 (1996) 39-51
17. Ishidate T., Matsumine A., Toyoshima K., and Akiyama T. The APC-hDLG complex negatively regulates cell cycle progression from the G0/G1 to S phase. Oncogene 19 (2000) 365-372
18. Wheelock M.J., and Johnson K.R. Cadherin-mediated cellular signalling. Curr. Opin. Cell. Biol. 15 (2003) 509-514
19. Cascone I., Giraudo E., Caccavari F., Napione L., Bertotti E., Collard J.G., Serini G., and Bussolino F. Temporal and spatial modulation of Rho GTPases during in vitro formation of capillary vascular network. Adherens junctions and myosin light chain as targets of Rac1 and RhoA. J. Biol. Chem. 278 (2003) 50702-50713
20. Koh W., Mahan R.D., and Davis G.E. Cdc42- and Rac1-mediated endothelial lumen formation requires Pak2, Pak4 and Par3, and PKC-dependent signalling. J. Cell Sci. 121 (2008) 989-1001
21. Noren N.K., Niessen C.M., Gumbiner B.M., and Burridge K. Cadherin engagement regulates Rho family GTPases. J. Biol. Chem. 276 (2001) 33305-33308
22. Betson M., Lozano E., Zhang J., and Braga V.M. Rac activation upon cell-cell contact formation is dependent on signaling from the epidermal growth factor receptor. J. Biol. Chem. 277 (2002) 36962-36969
23. Nakagawa M., Fukata M., Yamaga M., Itoh N., and Kaibuchi K. Recruitment and activation of Rac1 by the formation of E-cadherin-mediated cell-cell adhesion sites. J. Cell Sci. 114 (2001) 1829-1838
24. Coso O.A., Chiariello M., Yu J.C., Teramoto H., Crespo P., Xu N., Miki T., and Gutkind J.S. The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway. Cell 81 (1995) 1137-1146
25. Minden A., Lin A., Claret F.X., Abo A., and Karin M. Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs. Cell 81 (1995) 1147-1157
26. Hill C.S., Wynne J., and Treisman R. The Rho family GTPases RhoA, Rac1, and CDC42Hs regulate transcriptional activation by SRF. Cell 81 (1995) 1159-1170
27. Garrett T.A., Van Buul J.D., and Burridge K. VEGF-induced Rac1 activation in endothelial cells is regulated by the guanine nucleotide exchange factor Vav2. Exp. Cell Res. 313 (2007) 3285-3297
28. Laprise P., Viel A., and Rivard N. Human homolog of disc-large is required for adherens junction assembly and differentiation of human intestinal epithelial cells. J. Biol. Chem. 279 (2004) 10157-10166