Upregulation of the cysteine protease inhibitor, cystatin SN, contributes to cell proliferation and cathepsin inhibition in gastric cancer

Clinica Chimica Acta

Volumn 406, Issue 1-2, 2009, Pages 45-51

  Choi, Eun Hwa ^a,c   Kim, Jong Tae ^a   Kim, Joo Heon ^b   Kim, Soo Young ^b   Song, Eun Young ^a   Kim, Jae Wha ^a   Kim, Seon Young ^a   Yeom, Young Il ^a   Kim, Ik Hwan ^c   Lee, Hee Gu ^a  

^a Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^b Eulji University School of Medicine   (South Korea)

^c Korea University   (South Korea)

Author keywords

Cathepsin; CST1; Cystatin SN; Gastric cancer; Proliferation

Indexed keywords

CATHEPSIN; CYSTATIN SN; CYSTEINE PROTEINASE; CYSTEINE PROTEINASE INHIBITOR; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ARTICLE; BODY FLUID; CANCER CELL CULTURE; CANCER STAGING; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVE SITE; GENE EXPRESSION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; INHIBITION KINETICS; MICROARRAY ANALYSIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FAMILY; PROTEIN LOCALIZATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STOMACH CANCER; STOMACH CARCINOGENESIS; UPREGULATION;

CATHEPSINS; CELL LINE, TUMOR; CELL PROLIFERATION; CYSTEINE PROTEINASE INHIBITORS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOHISTOCHEMISTRY; LITHIUM CHLORIDE; MALE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SALIVARY CYSTATINS; STOMACH NEOPLASMS; UP-REGULATION;

EID: 67650266282     PISSN: 00098981     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cca.2009.05.008     Document Type: Article

References (39)

1. Lah T.T., Babnik J., Schiffmann E., Turk V., and Skaleric U. Cysteine proteinases and inhibitors in inflammation: their role in periodontal disease. J Periodontol 64 (1993) 485-491
2. Travis J., and Potempa J. Bacterial proteinases as targets for the development of second-generation antibiotics. Biochim Biophys Acta 1477 (2000) 35-50
3. Koblinski J.E., Ahram M., and Sloane B.F. Unraveling the role of proteases in cancer. Clin Chim Acta 291 (2000) 113-135
4. Dickinson D.P., Thiesse M., Dempsey L.D., and Millar S.J. Genomic cloning, physical mapping, and expression of human type 2 cystatin genes. Crit Rev Oral Biol Med 4 (1993) 573-580
5. Dickinson D.P., Thiesse M., and Hicks M.J. Expression of type 2 cystatin genes CST1-CST5 in adult human tissues and the developing submandibular gland. DNA Cell Biol 21 (2002) 47-65
6. Barrett A.J. The cystatins: a diverse superfamily of cysteine peptidase inhibitors. Biomed Biochim Acta 45 (1986) 1363-1374
7. Lindahl P., Abrahamson M., and Bjork I. Interaction of recombinant human cystatin C with the cysteine proteinases papain and actinidin. Biochem J 281 Pt 1 (1992) 49-55
8. Bobek L.A., and Levine M.J. Cystatins-inhibitors of cysteine proteinases. Crit Rev Oral Biol Med 3 (1992) 307-332
9. Henskens Y.M., Veerman E.C., and Nieuw Amerongen A.V. Cystatins in health and disease. Biol Chem Hoppe Seyler 377 (1996) 71-86
10. Dickinson D.P., Zhao Y., Thiesse M., and Siciliano M.J. Direct mapping of seven genes encoding human type 2 cystatins to a single site located at 20p11.2. Genomics 24 (1994) 172-175
11. Thiesse M., Millar S.J., and Dickinson D.P. The human type 2 cystatin gene family consists of eight to nine members, with at least seven genes clustered at a single locus on human chromosome 20. DNA Cell Biol 13 (1994) 97-116
12. Balbin M., Hall A., Grubb A., Mason R.W., Lopez-Otin C., and Abrahamson M. Structural and functional characterization of two allelic variants of human cystatin D sharing a characteristic inhibition spectrum against mammalian cysteine proteinases. J Biol Chem 269 (1994) 23156-23162
13. Buttle D.J., Burnett D., and Abrahamson M. Levels of neutrophil elastase and cathepsin B activities, and cystatins in human sputum: relationship to inflammation. Scand J Clin Lab Invest 50 (1990) 509-516
14. Bobek L.A., Aguirre A., and Levine M.J. Human salivary cystatin S. Cloning, sequence analysis, hybridization in situ and immunocytochemistry. Biochem J 278 Pt 3 (1991) 627-635
15. Coulibaly S., Schwihla H., Abrahamson M., et al. Modulation of invasive properties of murine squamous carcinoma cells by heterologous expression of cathepsin B and cystatin C. Int J Cancer 83 (1999) 526-531
16. Cox J.L., Sexton P.S., Green T.J., and Darmani N.A. Inhibition of B16 melanoma metastasis by overexpression of the cysteine proteinase inhibitor cystatin C. Melanoma Res 9 (1999) 369-374
17. Kos J., Krasovec M., Cimerman N., Nielsen H.J., Christensen I.J., and Brunner N. Cysteine proteinase inhibitors stefin A, stefin B, and cystatin C in sera from patients with colorectal cancer: relation to prognosis. Clin Cancer Res 6 (2000) 505-511
18. Vigneswaran N., Wu J., and Zacharias W. Upregulation of cystatin M during the progression of oropharyngeal squamous cell carcinoma from primary tumor to metastasis. Oral Oncol 39 (2003) 559-568
19. Haider A.S., Peters S.B., Kaporis H., et al. Genomic analysis defines a cancer-specific gene expression signature for human squamous cell carcinoma and distinguishes malignant hyperproliferation from benign hyperplasia. J Invest Dermatol 126 (2006) 869-881
20. TNM classification of malignant tumors. In: Sobin L.H., and Wittekind C.H. (Eds). International Union Against Cancer (UICC). 5th ed (1997), Wiley, New York 59-62
21. In: Greene F.L., Page D.L., and Fleming I.D. (Eds). American Joint Committee on Cancer (AJCC) Cancer Staging Manual. 6th ed (2002), Springer-Verlag, New York 99-106
22. Kim Y.J., Yoon S.Y., Kim J.T., et al. NDRG2 expression decreases with tumor stages and regulates TCF/β-catenin signaling in human colon carcinoma. Carcinogenesis 30 (2009) 598-605
23. Kim J.H., Bogner P.N., Ramnath N., Park Y., Yu J., and Park Y.M. Elevated peroxiredoxin 1, but not NF-E2-related factor 2, is an independent prognostic factor for disease recurrence and reduced survival in stage I non-small cell lung cancer. Clin Cancer Res 13 (2007) 3875-3882
24. Abrahamson M., Barrett A.J., Salvesen G., and Grubb A. Isolation of six cysteine proteinase inhibitors from human urine. Their physicochemical and enzyme kinetic properties and concentrations in biological fluids. J Biol Chem 261 (1986) 11282-11289
25. Abrahamson M., Olafsson I., Palsdottir A., et al. Structure and expression of the human cystatin C gene. Biochem J 268 (1990) 287-294
26. Baron A., DeCarlo A., and Featherstone J. Functional aspects of the human salivary cystatins in the oral environment. Oral Dis 5 (1999) 234-240
27. Tseng C.C., Tseng C.P., Levine M.J., and Bobek L.A. Differential effect toward inhibition of papain and cathepsin C by recombinant human salivary cystatin SN and its variants produced by a baculovirus system. Arch Biochem Biophys 380 (2000) 133-140
28. Schwartz D.R., Wu R., Kardia S.L., et al. Novel candidate targets of beta-catenin/T-cell factor signaling identified by gene expression profiling of ovarian endometrioid adenocarcinomas. Cancer Res 63 (2003) 2913-2922
29. Saitoh E., Isemura S., Sanada K., and Ohnishi K. Characterization of two members (CST4 and CST5) of the cystatin gene family and molecular evolution of cystatin genes. Agents Actions Suppl 38 Pt 1 (1992) 340-348
30. Freije J.P., Abrahamson M., Olafsson I., Velasco G., Grubb A., and Lopez-Otin C. Structure and expression of the gene encoding cystatin D, a novel human cysteine proteinase inhibitor. J Biol Chem 266 (1991) 20538-20543
31. Morita M., Hara Y., Tamai Y., Arakawa H., and Nishimura S. Genomic construct and mapping of the gene for CMAP (leukocystatin/cystatin F, CST7) and identification of a proximal novel gene, BSCv (C20orf3). Genomics 67 (2000) 87-91
32. Barka T., Asbell P.A., van der Noen H., and Prasad A. Cystatins in human tear fluid. Curr Eye Res 10 (1991) 25-34
33. Barka T., van der Noen H., and Patil S. Cysteine proteinase inhibitor in cultured human medullary thyroid carcinoma cells. Lab Invest 66 (1992) 691-700
34. Mulaomerovic A., Halilbasic A., Cickusic E., Zavasnik-Bergant T., Begic L., and Kos J. Cystatin C as a potential marker for relapse in patients with non-Hodgkin B-cell lymphoma. Cancer Lett 248 (2007) 192-197
35. Sotiropoulou G., Anisowicz A., and Sager R. Identification, cloning, and characterization of cystatin M, a novel cysteine proteinase inhibitor, down-regulated in breast cancer. J Biol Chem 272 (1997) 903-910
36. Schagdarsurengin U., Pfeifer G.P., and Dammann R. Frequent epigenetic inactivation of cystatin M in breast carcinoma. Oncogene 26 (2007) 3089-3094
37. Parle-McDermott A., McWilliam P., Tighe O., Dunican D., and Croke D.T. Serial analysis of gene expression identifies putative metastasis-associated transcripts in colon tumour cell lines. Br J Cancer 83 (2000) 725-728
38. Cegnar M., Kos J., and Kristl J. Intracellular delivery of cysteine protease inhibitor cystatin by polymeric nanoparticles. J Nanosci Nanotechnol 6 (2006) 3087-3094
39. Bell-McGuinn K.M., Garfall A.L., Bogyo M., Hanahan D., and Joyce J.A. Inhibition of cysteine cathepsin protease activity enhances chemotherapy regimens by decreasing tumor growth and invasiveness in a mouse model of multistage cancer. Cancer Res 67 (2007) 7378-7385