LAMA4, highly expressed in human hepatocellular carcinoma from Chinese patients, is a novel marker of tumor invasion and metastasis

Journal of Cancer Research and Clinical Oncology

Volumn 134, Issue 6, 2008, Pages 705-714

  Huang, Xinghua ^a   Ji, Guoqing ^a   Wu, Yanhua ^a   Wan, Bo ^a   Yu, Long ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

Basement membrane; Hepatocellular carcinoma (HCC) tissue immunofluorescence staining; LAMA4 gene; Reverse transcription polymerase chain reaction (RT PCR)

Indexed keywords

LAMININ ALPHA4; MESSENGER RNA; TUMOR MARKER;

ADULT; AGED; ANGIOGENESIS; ARTICLE; BASEMENT MEMBRANE; BLOOD VESSEL; CANCER INVASION; CANCER PATIENT; CANCER SURGERY; CHI SQUARE TEST; CHINESE; CLINICAL ARTICLE; CORRELATION ANALYSIS; FEMALE; GENE EXPRESSION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE TEST; IN VIVO STUDY; LAMA4 GENE; LIVER; LIVER CELL CARCINOMA; MALE; METASTASIS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; STATISTICAL SIGNIFICANCE; TUMOR GENE; TUMOR VOLUME; TWO TAILED TEST; UPREGULATION; WESTERN BLOTTING;

ADULT; AGED; CARCINOMA, HEPATOCELLULAR; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; LAMININ; LIVER NEOPLASMS; MALE; MIDDLE AGED; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TUMOR MARKERS, BIOLOGICAL;

EID: 41849110225     PISSN: 01715216     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00432-007-0342-6     Document Type: Article

References (21)

1. Burgeson RE, Chiquet M, Deutzmann R, Ekblom P, Engel J, Kleinman H, Martin GR, Meneguzzi G, Paulsson M, Sanes J, et al (1994) A new nomenclature for the laminins. Matrix Biol 14(3):209-211
2. Chen J, Yu L, Li D, Gao Q, Wang JS, Huang XH, Bi G, Zhao SY (2003) Human CRYL1, a novel enzyme-crystallin overexpressed in liver and kidney and downregulated in 58% liver cancer tissues from 60 Chinese patients, and four new homologs from other mammalians. Gene 302:103-113
3. DeHahn KC, Gonzales M, Gonzalez AM, Hopkinson SB, Chandel NS, Brunelle JK, Jones JC (2004) The alpha4 laminin subunit regulates endothelial cell survival. Exp Cell Res 294(1):281-289
4. Hsia CC, Kleiner DE Jr, Axiotis CA, Di Bisceglie A, Nomura AM, Stemmermann GN, Tabor E (1992) Mutations of p53 gene in hepatocellular carcinoma: roles of hepatitis B virus and aflatoxin contamination in the diet. J Natl Cancer Inst 84:1638-1641
5. Hsu IC, Metcalf RA, Sun T, Welsh JA, Wang NJ, Harris CC (1991) Mutational hotspot in the p53 gene in human hepatocellular carcinoma. Nature 350:427-428
6. Huang XH, Sun LH, Lu DD, Sun Y, Ma LJ, Zhang XR, Huang J, Yu L (2003) Codon 249 mutation in exon 7 of p53 gene in plasma DNA: maybe a new early diagnostic marker of hepatocellular carcinoma in Qidong risk area, China. World J Gastroenterol 9(4):692-695
7. Huang XH, Lu DD, Ji GQ, Sun Y, Ma LJ, Chen Z, Zhang LS, Huang J, Yu L (2004) Hepatitis B virus (HBV) vaccine-induced escape mutants of HBV S gene among children from Qidong area, China. Virus Res 99:63-68
8. Iivanainen A, Sainio K, Sariola H, Tryggvason K (1995) Primary structure and expression of a novel human laminin alpha 4 chain. FEBS Lett 365(2-3):183-188
9. Jackson PE, Groopman JD (1999) Aflatoxin and liver cancer. Baillieres Best Pract Res Clin Gastroenterol 13:545-555
10. Jackson PE, Qian GS, Friesen MD, Zhu YR, Lu P, Wang JB, Wu Y, Kensler TW, Vogelstein B, Groopman JD (2001) Specific p53 mutations detected in plasma and tumors of hepatocellular carcinoma patients by electrospray ionization mass spectrometry. Cancer Res 61:33-35
11. Jan F Talts, Takako S, Nicolai M, Walter G, Karlheinz M, Richard M, Rupert T (2000) Structure and functional analysis of the recombinant G domain of the laminin a4 chain and its proteolytic processing in tissues. J Biol Chem 275(45):35192-35199
12. Jiang JM, Yu L, Huang XH, Chen XS, Gao J, Zhang YZ, Tang LS, Zhao SY (2001) Identification of two novel human dynein light chain genes, DNLC2A and DNLC2B, and their expression changes in HCC tissues from 68 Chinese patients. Gene 281:103-113
13. Khazenzon NM, Ljubimov AV, Lakhter AJ, Fujita M, Fujiwara H, Sekiguchi K, Sorokin LM, Petajaniemi N, Virtanen I, Black KL, Ljubimova JY (2003) Antisense inhibition of laminin-8 expression reduces invasion of human gliomas in vitro. Mol Cancer Ther 2(10):985-994
14. Lian J, Dai X, Li X, He F (2006) Identification of an active site on the laminin alpha4 chain globular domain that binds to alphavbeta3 integrin and promotes angiogenesis. Biochem Biophys Res Commun 347(1):248-253
15. Ljubimova JY, Fujita M, Khazenzon NM, Ljubimov AV, Black KL (2006) Changes in laminin isoforms associated with brain tumor invasion and angiogenesis. Front Biosci 11:81-88
16. Lunn RM, Zhang YJ, Wang LY, Chen CJ, Lee PH, Lee CS, Tsai WY, Santella RM (1997) p53 mutations, chronic hepatitis B virus infection, and aflatoxin exposure in hepatocellular carcinoma in Taiwan. Cancer Res 57:3471-3477
17. Nagato S, Nakagawa K, Harada H, Kohno S, Fujiwara H, Sekiguchi K, Ohue S, Iwata S, Ohnishi T (2005) Downregulation of laminin alpha4 chain expression inhibits glioma invasion in vitro and in vivo. Int J Cancer 117(1):41-50
18. Ozaki I, Mizuta T, Zhao G, Yotsumoto H, Hara T, Kajihara S, Hisatomi A, Sakai T, Yamamoto K (2000) Involvement of the Ets-1 gene in overexpression of matrilysin in human hepatocellular carcinoma. Cancer Res 60:6519-6525
19. Richards A, Al-Imara L, Carter NP, Lloyd JC, Leversha MA, Pope FM (1994) Localization of the gene (LAMA4) to chromosome 6q21 and isolation of a partial cDNA encoding a variant laminin A chain. Genomics 22(1):237-239
20. Richards A, Al-Imara L, Pope FM (1996) The complete cDNA sequence of laminin alpha 4 and its relationship to the other human laminin alpha chains. Eur J Biochem 238(3):813-821
21. Richards A, Luccarini C, Pope FM (1997) The structural organisation of LAMA4, the gene encoding laminin alpha4. Eur J Biochem 248(1):15-23