-
1
-
-
0037451929
-
The epidemiology of sepsis in the United States from 1979 through 2000
-
Martin GS, Mannino DM, Eaton S, Moss M: The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med 2003, 348:1546-1554.
-
(2003)
N Engl J Med
, vol.348
, pp. 1546-1554
-
-
Martin, G.S.1
Mannino, D.M.2
Eaton, S.3
Moss, M.4
-
2
-
-
0028965644
-
Receptor-dependent mechanisms of cell stimulation by bacterial endotoxin
-
Ulevitch RJ, Tobias PS: Receptor-dependent mechanisms of cell stimulation by bacterial endotoxin. Annu Rev Immunol 1995, 13:437-457.
-
(1995)
Annu Rev Immunol
, vol.13
, pp. 437-457
-
-
Ulevitch, R.J.1
Tobias, P.S.2
-
3
-
-
0031906550
-
Signal transduction through NF-kappa B
-
May MJ, Ghosh S: Signal transduction through NF-kappa B. Immunol Today 1998, 19:80-88.
-
(1998)
Immunol Today
, vol.19
, pp. 80-88
-
-
May, M.J.1
Ghosh, S.2
-
4
-
-
0028986075
-
Control of I kappa B-alpha proteolysis by site-specific, signal-induced phosphorylation
-
Brown K, Gerstberger S, Carlson L, Franzoso G, Siebenlist U: Control of I kappa B-alpha proteolysis by site-specific, signal-induced phosphorylation. Science 1995, 267:1485-1488.
-
(1995)
Science
, vol.267
, pp. 1485-1488
-
-
Brown, K.1
Gerstberger, S.2
Carlson, L.3
Franzoso, G.4
Siebenlist, U.5
-
5
-
-
0029146930
-
Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway
-
Chen Z, Hagler J, Palombella VJ, Melandri F, Scherer D, Ballard D, Maniatis T: Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway. Genes Dev 1995, 9:1586-1597.
-
(1995)
Genes Dev
, vol.9
, pp. 1586-1597
-
-
Chen, Z.1
Hagler, J.2
Palombella, V.J.3
Melandri, F.4
Scherer, D.5
Ballard, D.6
Maniatis, T.7
-
6
-
-
0029670083
-
Mapping of the inducible IkappaB phosphorylation sites that signal its ubiquitination and degradation
-
DiDonato J, Mercurio F, Rosette C, Wu-Li J, Suyang H, Ghosh S, Karin M: Mapping of the inducible IkappaB phosphorylation sites that signal its ubiquitination and degradation. Mol Cell Biol 1996, 16:1295-1304.
-
(1996)
Mol Cell Biol
, vol.16
, pp. 1295-1304
-
-
DiDonato, J.1
Mercurio, F.2
Rosette, C.3
Wu-Li, J.4
Suyang, H.5
Ghosh, S.6
Karin, M.7
-
7
-
-
0028972488
-
Signal-induced degradation of I kappa B alpha requires site-specific ubiquitination
-
Scherer DC, Brockman JA, Chen Z, Maniatis T, Ballard DW: Signal-induced degradation of I kappa B alpha requires site-specific ubiquitination. Proc Natl Acad Sci U S A 1995, 92:11259-11263.
-
(1995)
Proc Natl Acad Sci U S A
, vol.92
, pp. 11259-11263
-
-
Scherer, D.C.1
Brockman, J.A.2
Chen, Z.3
Maniatis, T.4
Ballard, D.W.5
-
8
-
-
0033517189
-
NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase
-
Ozes ON, Mayo LD, Gustin JA, Pfeffer SR, Pfeffer LM, Donner DB: NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase. Nature 1999, 401:82-85.
-
(1999)
Nature
, vol.401
, pp. 82-85
-
-
Ozes, O.N.1
Mayo, L.D.2
Gustin, J.A.3
Pfeffer, S.R.4
Pfeffer, L.M.5
Donner, D.B.6
-
9
-
-
0033517190
-
NF-kappaB is a target of AKT in antiapoptotic PDGF signalling
-
Romashkova JA, Makarov SS: NF-kappaB is a target of AKT in antiapoptotic PDGF signalling. Nature 1999, 401:86-90.
-
(1999)
Nature
, vol.401
, pp. 86-90
-
-
Romashkova, J.A.1
Makarov, S.S.2
-
10
-
-
0033038491
-
Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-kappaB p65/RelA subunit
-
Sizemore N, Leung S, Stark GR: Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-kappaB p65/RelA subunit. Mol Cell Biol 1999, 19:4798-4805.
-
(1999)
Mol Cell Biol
, vol.19
, pp. 4798-4805
-
-
Sizemore, N.1
Leung, S.2
Stark, G.R.3
-
11
-
-
0033519453
-
Induction of NF-kappaB by the Akt/PKB kinase
-
Kane LP, Shapiro VS, Stokoe D, Weiss A: Induction of NF-kappaB by the Akt/PKB kinase. Curr Biol 1999, 9:601-604.
-
(1999)
Curr Biol
, vol.9
, pp. 601-604
-
-
Kane, L.P.1
Shapiro, V.S.2
Stokoe, D.3
Weiss, A.4
-
12
-
-
0033961280
-
Akt suppresses apoptosis by stimulating the transactivation potential of the RelA/p65 subunit of NF-kappaB
-
Madrid LV, Wang CY, Guttridge DC, Schottelius AJ, Baldwin AS Jr, Mayo MW: Akt suppresses apoptosis by stimulating the transactivation potential of the RelA/p65 subunit of NF-kappaB. Mol Cell Biol 2000, 20:1626-1638.
-
(2000)
Mol Cell Biol
, vol.20
, pp. 1626-1638
-
-
Madrid, L.V.1
Wang, C.Y.2
Guttridge, D.C.3
Schottelius, A.J.4
Baldwin A.S, Jr.5
Mayo, M.W.6
-
13
-
-
33744972277
-
APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function
-
Mao X, Kikani CK, Riojas RA, Langlais P, Wang L, Ramos FJ, Fang Q, Christ- Roberts CY, Hong JY, Kim RY, Liu F, Dong LQ: APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function. Nat Cell Biol 2006, 8:516-523.
-
(2006)
Nat Cell Biol
, vol.8
, pp. 516-523
-
-
Mao, X.1
Kikani, C.K.2
Riojas, R.A.3
Langlais, P.4
Wang, L.5
Ramos, F.J.6
Fang, Q.7
Christ-Roberts, C.Y.8
Hong, J.Y.9
Kim, R.Y.10
Liu, F.11
Dong, L.Q.12
-
14
-
-
85047689168
-
Signaling mechanisms underlying the insulin-sensitizing effects of adiponectin
-
Cheng KK, Lam KS, Wang B, Xu A: Signaling mechanisms underlying the insulin-sensitizing effects of adiponectin. Best Pract Res Clin Endocrinol Metab 2014, 28:3-13.
-
(2014)
Best Pract Res Clin Endocrinol Metab
, vol.28
, pp. 3-13
-
-
Cheng, K.K.1
Lam, K.S.2
Wang, B.3
Xu, A.4
-
15
-
-
34248147538
-
Adiponectin-induced endothelial nitric oxide synthase activation and nitric oxide production are mediated by APPL1 in endothelial cells
-
Cheng KK, Lam KS, Wang Y, Huang Y, Carling D, Wu D, Wong C, Xu A: Adiponectin-induced endothelial nitric oxide synthase activation and nitric oxide production are mediated by APPL1 in endothelial cells. Diabetes 2007, 56:1387-1394.
-
(2007)
Diabetes
, vol.56
, pp. 1387-1394
-
-
Cheng, K.K.1
Lam, K.S.2
Wang, Y.3
Huang, Y.4
Carling, D.5
Wu, D.6
Wong, C.7
Xu, A.8
-
16
-
-
84857032455
-
Adiponectin-AdipoR1/2-APPL1 signaling axis suppresses human foam cell formation: differential ability of AdipoR1 and AdipoR2 to regulate inflammatory cytokine responses
-
Tian L, Luo N, Zhu X, Chung BH, Garvey WT, Fu Y: Adiponectin-AdipoR1/2-APPL1 signaling axis suppresses human foam cell formation: differential ability of AdipoR1 and AdipoR2 to regulate inflammatory cytokine responses. Atherosclerosis 2012, 221:66-75.
-
(2012)
Atherosclerosis
, vol.221
, pp. 66-75
-
-
Tian, L.1
Luo, N.2
Zhu, X.3
Chung, B.H.4
Garvey, W.T.5
Fu, Y.6
-
17
-
-
17844396206
-
Adiponectin inhibits LPS-induced NF-kappaB activation and IL-6 production and increases PPARgamma2 expression in adipocytes
-
Ajuwon KM, Spurlock ME: Adiponectin inhibits LPS-induced NF-kappaB activation and IL-6 production and increases PPARgamma2 expression in adipocytes. Am J Physiol Regul Integr Comp Physiol 2005, 288:R1220-R1225.
-
(2005)
Am J Physiol Regul Integr Comp Physiol
, vol.288
, pp. R1220-R1225
-
-
Ajuwon, K.M.1
Spurlock, M.E.2
-
18
-
-
0034641647
-
Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-kappaB signaling through a cAMPdependent pathway
-
Ouchi N, Kihara S, Arita Y, Okamoto Y, Maeda K, Kuriyama H, Hotta K, Nishida M, Takahashi M, Muraguchi M, Ohmoto Y, Nakamura T, Yamashita S, Funahashi T, Matsuzawa Y: Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-kappaB signaling through a cAMPdependent pathway. Circulation 2000, 102:1296-1301.
-
(2000)
Circulation
, vol.102
, pp. 1296-1301
-
-
Ouchi, N.1
Kihara, S.2
Arita, Y.3
Okamoto, Y.4
Maeda, K.5
Kuriyama, H.6
Hotta, K.7
Nishida, M.8
Takahashi, M.9
Muraguchi, M.10
Ohmoto, Y.11
Nakamura, T.12
Yamashita, S.13
Funahashi, T.14
Matsuzawa, Y.15
-
19
-
-
33847381993
-
Globular adiponectin activates nuclear factor-kappaB and activating protein-1 and enhances angiotensin II-induced proliferation in cardiac fibroblasts
-
Hattori Y, Hattori S, Akimoto K, Nishikimi T, Suzuki K, Matsuoka H, Kasai K: Globular adiponectin activates nuclear factor-kappaB and activating protein-1 and enhances angiotensin II-induced proliferation in cardiac fibroblasts. Diabetes 2007, 56:804-808.
-
(2007)
Diabetes
, vol.56
, pp. 804-808
-
-
Hattori, Y.1
Hattori, S.2
Akimoto, K.3
Nishikimi, T.4
Suzuki, K.5
Matsuoka, H.6
Kasai, K.7
-
20
-
-
38449089987
-
Adiponectin enhances IL-6 production in human synovial fibroblast via an AdipoR1 receptor, AMPK, p38, and NF-kappa B pathway
-
Tang CH, Chiu YC, Tan TW, Yang RS, Fu WM: Adiponectin enhances IL-6 production in human synovial fibroblast via an AdipoR1 receptor, AMPK, p38, and NF-kappa B pathway. J Immunol 2007, 179:5483-5492.
-
(2007)
J Immunol
, vol.179
, pp. 5483-5492
-
-
Tang, C.H.1
Chiu, Y.C.2
Tan, T.W.3
Yang, R.S.4
Fu, W.M.5
-
21
-
-
84869099031
-
APPL1 regulates basal NF-kappaB activity by stabilizing NIK
-
Hupalowska A, Pyrzynska B, Miaczynska M: APPL1 regulates basal NF-kappaB activity by stabilizing NIK. J Cell Sci 2012, 125:4090-4102.
-
(2012)
J Cell Sci
, vol.125
, pp. 4090-4102
-
-
Hupalowska, A.1
Pyrzynska, B.2
Miaczynska, M.3
-
22
-
-
84884946232
-
APPL1 transgenic mice are protected from high-fat diet-induced cardiac dysfunction
-
Park M, Wu D, Park T, Choi CS, Li RK, Cheng KK, Xu A, Sweeney G: APPL1 transgenic mice are protected from high-fat diet-induced cardiac dysfunction. Am J Physiol Endocrinol Metab 2013, 305:E795-E804.
-
(2013)
Am J Physiol Endocrinol Metab
, vol.305
, pp. E795-E804
-
-
Park, M.1
Wu, D.2
Park, T.3
Choi, C.S.4
Li, R.K.5
Cheng, K.K.6
Xu, A.7
Sweeney, G.8
-
23
-
-
77949900267
-
Appl1 is dispensable for mouse development, and loss of Appl1 has growth factor-selective effects on Akt signaling in murine embryonic fibroblasts
-
Tan Y, You H, Wu C, Altomare DA, Testa JR: Appl1 is dispensable for mouse development, and loss of Appl1 has growth factor-selective effects on Akt signaling in murine embryonic fibroblasts. J Biol Chem 2010, 285:6377-6389.
-
(2010)
J Biol Chem
, vol.285
, pp. 6377-6389
-
-
Tan, Y.1
You, H.2
Wu, C.3
Altomare, D.A.4
Testa, J.R.5
-
24
-
-
70450265225
-
Yin-Yang regulation of adiponectin signaling by APPL isoforms in muscle cells
-
Wang C, Xin X, Xiang R, Ramos FJ, Liu M, Lee HJ, Chen H, Mao X, Kikani CK, Liu F, Dong LQ: Yin-Yang regulation of adiponectin signaling by APPL isoforms in muscle cells. J Biol Chem 2009, 284:31608-31615.
-
(2009)
J Biol Chem
, vol.284
, pp. 31608-31615
-
-
Wang, C.1
Xin, X.2
Xiang, R.3
Ramos, F.J.4
Liu, M.5
Lee, H.J.6
Chen, H.7
Mao, X.8
Kikani, C.K.9
Liu, F.10
Dong, L.Q.11
-
25
-
-
84925032273
-
Association of genetic variation in adaptor protein APPL1/APPL2 loci with non-alcoholic fatty liver disease
-
Barbieri M, Esposito A, Angellotti E, Rizzo MR, Marfella R, Paolisso G: Association of genetic variation in adaptor protein APPL1/APPL2 loci with non-alcoholic fatty liver disease. PLoS One 2013, 8:e71391.
-
(2013)
PLoS One
, vol.8
-
-
Barbieri, M.1
Esposito, A.2
Angellotti, E.3
Rizzo, M.R.4
Marfella, R.5
Paolisso, G.6
-
26
-
-
67149121074
-
TLR4/MyD88/PI3K interactions regulate TLR4 signaling
-
Laird MH, Rhee SH, Perkins DJ, Medvedev AE, Piao W, Fenton MJ, Vogel SN: TLR4/MyD88/PI3K interactions regulate TLR4 signaling. J Leukoc Biol 2009, 85:966-977.
-
(2009)
J Leukoc Biol
, vol.85
, pp. 966-977
-
-
Laird, M.H.1
Rhee, S.H.2
Perkins, D.J.3
Medvedev, A.E.4
Piao, W.5
Fenton, M.J.6
Vogel, S.N.7
-
27
-
-
77957769313
-
Adiponectin receptor binding proteins-recent advances in elucidating adiponectin signalling pathways
-
Buechler C, Wanninger J, Neumeier M: Adiponectin receptor binding proteins-recent advances in elucidating adiponectin signalling pathways. FEBS Lett 2010, 584:4280-4286.
-
(2010)
FEBS Lett
, vol.584
, pp. 4280-4286
-
-
Buechler, C.1
Wanninger, J.2
Neumeier, M.3
-
28
-
-
84855604126
-
LPS induced inflammatory responses in human peripheral blood mononuclear cells is mediated through NOX4 and Gialpha dependent PI-3kinase signalling
-
Ngkelo A, Meja K, Yeadon M, Adcock I, Kirkham PA: LPS induced inflammatory responses in human peripheral blood mononuclear cells is mediated through NOX4 and Gialpha dependent PI-3kinase signalling. J Inflamm (Lond) 2012, 9:1.
-
(2012)
J Inflamm (Lond)
, vol.9
, pp. 1
-
-
Ngkelo, A.1
Meja, K.2
Yeadon, M.3
Adcock, I.4
Kirkham, P.A.5
-
29
-
-
42949092018
-
The endosomal protein Appl1 mediates Akt substrate specificity and cell survival in vertebrate development
-
Schenck A, Goto-Silva L, Collinet C, Rhinn M, Giner A, Habermann B, Brand M, Zerial M: The endosomal protein Appl1 mediates Akt substrate specificity and cell survival in vertebrate development. Cell 2008, 133:486-497.
-
(2008)
Cell
, vol.133
, pp. 486-497
-
-
Schenck, A.1
Goto-Silva, L.2
Collinet, C.3
Rhinn, M.4
Giner, A.5
Habermann, B.6
Brand, M.7
Zerial, M.8
-
30
-
-
84908657614
-
The adaptor protein APPL2 inhibits insulin-stimulated glucose uptake by interacting with TBC1D1 in skeletal muscle
-
1939-327X
-
Cheng KK, Zhu W, Chen B, Wang Y, Wu D, Sweeney G, Wang B, Lam KS, Xu A: The adaptor protein APPL2 inhibits insulin-stimulated glucose uptake by interacting with TBC1D1 in skeletal muscle. Diabetes 2014, 5:1939-327X.
-
(2014)
Diabetes
, vol.5
-
-
Cheng, K.K.1
Zhu, W.2
Chen, B.3
Wang, Y.4
Wu, D.5
Sweeney, G.6
Wang, B.7
Lam, K.S.8
Xu, A.9
-
31
-
-
33751042265
-
Toll-like receptors (TLRs) and immune disorders.
-
Akashi-Takamura S, Miyake K: Toll-like receptors (TLRs) and immune disorders. J Infect Chemother 2006, 12:233-240
-
(2006)
J Infect Chemother
, vol.12
, pp. 233-240
-
-
Akashi-Takamura, S.1
Miyake, K.2
-
32
-
-
20244384395
-
Cutting edge: endotoxin tolerance in mouse peritoneal macrophages correlates with down-regulation of surface toll-like receptor 4 expression
-
Nomura F, Akashi S, Sakao Y, Sato S, Kawai T, Matsumoto M, Nakanishi K, Kimoto M, Miyake K, Takeda K, Akira S: Cutting edge: endotoxin tolerance in mouse peritoneal macrophages correlates with down-regulation of surface toll-like receptor 4 expression. J Immunol 2000, 164:3476-3479.
-
(2000)
J Immunol
, vol.164
, pp. 3476-3479
-
-
Nomura, F.1
Akashi, S.2
Sakao, Y.3
Sato, S.4
Kawai, T.5
Matsumoto, M.6
Nakanishi, K.7
Kimoto, M.8
Miyake, K.9
Takeda, K.10
Akira, S.11
-
33
-
-
0037450737
-
Interleukin 1 receptor dependence of serum transferred arthritis can be circumvented by toll-like receptor 4 signaling
-
Choe JY, Crain B, Wu SR, Corr M: Interleukin 1 receptor dependence of serum transferred arthritis can be circumvented by toll-like receptor 4 signaling. J Exp Med 2003, 197:537-542.
-
(2003)
J Exp Med
, vol.197
, pp. 537-542
-
-
Choe, J.Y.1
Crain, B.2
Wu, S.R.3
Corr, M.4
-
34
-
-
69249176159
-
Toll-like receptor 4 activation increases Akt phosphorylation in colon cancer cells
-
Doan HQ, Bowen KA, Jackson LA, Evers BM: Toll-like receptor 4 activation increases Akt phosphorylation in colon cancer cells. Anticancer Res 2009, 29:2473-2478.
-
(2009)
Anticancer Res
, vol.29
, pp. 2473-2478
-
-
Doan, H.Q.1
Bowen, K.A.2
Jackson, L.A.3
Evers, B.M.4
-
35
-
-
0033517348
-
Identification of a chromosome 3p14.3-21.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2
-
Mitsuuchi Y, Johnson SW, Sonoda G, Tanno S, Golemis EA, Testa JR: Identification of a chromosome 3p14.3-21.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2. Oncogene 1999, 18:4891-4898.
-
(1999)
Oncogene
, vol.18
, pp. 4891-4898
-
-
Mitsuuchi, Y.1
Johnson, S.W.2
Sonoda, G.3
Tanno, S.4
Golemis, E.A.5
Testa, J.R.6
-
36
-
-
84861853310
-
APPL1 potentiates insulin secretion in pancreatic beta cells by enhancing protein kinase Akt-dependent expression of SNARE proteins in mice
-
Cheng KK, Lam KS, Wu D, Wang Y, Sweeney G, Hoo RL, Zhang J, Xu A: APPL1 potentiates insulin secretion in pancreatic beta cells by enhancing protein kinase Akt-dependent expression of SNARE proteins in mice. Proc Natl Acad Sci U S A 2012, 109:8919-8924.
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
, pp. 8919-8924
-
-
Cheng, K.K.1
Lam, K.S.2
Wu, D.3
Wang, Y.4
Sweeney, G.5
Hoo, R.L.6
Zhang, J.7
Xu, A.8
-
37
-
-
0028500365
-
Gene targeting in the mouse
-
Melton DW: Gene targeting in the mouse. Bioessays 1994, 16:633-638.
-
(1994)
Bioessays
, vol.16
, pp. 633-638
-
-
Melton, D.W.1
-
38
-
-
0027257221
-
Gene targeting yields a CD18-mutant mouse for study of inflammation
-
Wilson RW, Ballantyne CM, Smith CW, Montgomery C, Bradley A, O'Brien WE, Beaudet AL: Gene targeting yields a CD18-mutant mouse for study of inflammation. J Immunol 1993, 151:1571-1578.
-
(1993)
J Immunol
, vol.151
, pp. 1571-1578
-
-
Wilson, R.W.1
Ballantyne, C.M.2
Smith, C.W.3
Montgomery, C.4
Bradley, A.5
O'Brien, W.E.6
Beaudet, A.L.7
-
39
-
-
84892364541
-
Enalapril inhibits nuclear factor-kappaB signaling in intestinal epithelial cells and peritoneal macrophages and attenuates experimental colitis in mice
-
Lee C, Chun J, Hwang SW, Kang SJ, Im JP, Kim JS: Enalapril inhibits nuclear factor-kappaB signaling in intestinal epithelial cells and peritoneal macrophages and attenuates experimental colitis in mice. Life Sci 2014, 95:29-39.
-
(2014)
Life Sci
, vol.95
, pp. 29-39
-
-
Lee, C.1
Chun, J.2
Hwang, S.W.3
Kang, S.J.4
Im, J.P.5
Kim, J.S.6
|