Buffered l-ascorbic acid, alone or bound to KMUP-1 or sildenafil, reduces vascular endothelium growth factor and restores endothelium nitric oxide synthase in hypoxic pulmonary artery

Kaohsiung Journal of Medical Sciences

Volumn 31, Issue 5, 2015, Pages 241-254

  Wu, Jiunn Ren ^a   Kao, Li Pin ^b   Wu, Bin Nan ^b   Dai, Zen Kong ^a   Wang, Yi Ya ^b   Chai, Chee Yin ^a   Chen, Ing Jun ^b  

^a KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^b KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Endothelium nitric oxide synthase; Hypoxia; Pulmonary arterial hypertension; Rho kinase II; Vascular endothelium growth factor

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; 7 [2 [4 (2 CHLOROPHENYL)PIPERAZINYL]ETHYL] 1,3 DIMETHYLXANTHINE ASCORBATE; ANTIOXIDANT; ASCORBIC ACID; CYCLIC GMP DEPENDENT PROTEIN KINASE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GUANYLATE CYCLASE; NITRIC OXIDE; PHOSPHODIESTERASE; PHOSPHODIESTERASE 5A; REACTIVE OXYGEN METABOLITE; RHO KINASE; RHO KINASE II; SILDENAFIL ASCORBATE; UNCLASSIFIED DRUG; VASCULOTROPIN; AMIDE; KMUP 1; PIPERIDINE DERIVATIVE; PYRIDINE DERIVATIVE; SILDENAFIL; XANTHINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; HEART LEFT VENTRICLE; HEART RIGHT VENTRICLE HYPERTROPHY; HEART VENTRICLE SEPTUM; HEART WEIGHT; HYPOXIA; IMMUNOHISTOCHEMISTRY; LUNG ARTERY PRESSURE; LUNG PARENCHYMA; MALE; NONHUMAN; PROTEIN EXPRESSION; PULMONARY ARTERY; PULMONARY HYPERTENSION; RAT; ANIMAL; ANOXIA; CHEMISTRY; DRUG EFFECTS; HYPERTENSION, PULMONARY; METABOLISM; VASCULAR ENDOTHELIUM;

AMIDES; ANIMALS; ANOXIA; ASCORBIC ACID; ENDOTHELIUM, VASCULAR; HYPERTENSION, PULMONARY; MALE; NITRIC OXIDE SYNTHASE TYPE III; PIPERIDINES; PULMONARY ARTERY; PYRIDINES; RATS; SILDENAFIL CITRATE; VASCULAR ENDOTHELIAL GROWTH FACTORS; XANTHINES;

EID: 84928705788     PISSN: 1607551X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.kjms.2015.02.005     Document Type: Article

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