Heme-assisted S-nitrosation desensitizes ferric soluble guanylate cyclase to nitric oxide

Journal of Biological Chemistry

Volumn 287, Issue 51, 2012, Pages 43053-43062

  Fernhoff, Nathaniel B ^a   Derbyshire, Emily R ^a   Underbakke, Eric S ^a,b   Marletta, Michael A ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARDIO-VASCULAR DISEASE; CONFORMATIONAL CHANGE; GUANYLATE CYCLASE; HEME COFACTOR; KEY PROCESS; MOLECULAR MECHANISM; NITROSOTHIOLS; NO SENSOR; OXIDATION STATE; PLATELET AGGREGATION; REDUCTIVE NITROSYLATION; S-NITROSATION; SECOND MESSENGER; SOLUBLE GUANYLATE CYCLASE (SGC); THERAPEUTIC TARGETS;

AMINO ACIDS; CHEMICAL REACTIONS; DISEASES; MAMMALS; NITRIC OXIDE; SIGNAL TRANSDUCTION;

PORPHYRINS;

CYSTEINE; FERRIC HEME; FERRIC SOLUBLE GUANYLATE CYCLASE; GUANYLATE CYCLASE; HEME; NITRIC OXIDE; UNCLASSIFIED DRUG;

ABSORPTION SPECTROSCOPY; ALKYLATION; ARTICLE; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME MECHANISM; HEME SYNTHESIS; HUMAN; LIGAND BINDING; MOLECULAR DYNAMICS; NITROSATION; NITROSYLATION; NONHUMAN; OXIDATION KINETICS; OXIDATION REDUCTION REACTION; OXIDATION REDUCTION STATE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN MODIFICATION; RAT; REDUCTION KINETICS;

ALKYLATION; ANIMALS; CATALYTIC DOMAIN; CYSTEINE; GUANYLATE CYCLASE; HEME; HUMANS; HYDROXIDES; IRON; KINETICS; MUTANT PROTEINS; NITRIC OXIDE; NITROSATION; NUCLEOTIDES; OXIDATION-REDUCTION; PROTEIN BINDING; RATS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; SULFHYDRYL COMPOUNDS;

MAMMALIA;

EID: 84871140335     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.393892     Document Type: Article

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