Endothelial nitric oxide synthase-enhancing G-protein coupled receptor antagonist inhibits pulmonary artery hypertension by endothelin-1-dependent and endothelin-1-independent pathways in a monocrotaline model

Kaohsiung Journal of Medical Sciences

Volumn 30, Issue 6, 2014, Pages 267-278

  Liu, Chung Pin ^a   Dai, Zen Kong ^b,c   Huang, Chein Heng ^d   Yeh, Jwu Lai ^b,d   Wu, Bin Nan ^b,d   Wu, Jiunn Ren ^b,c   Chen, Ing Jun ^b,d  

^a YUAN'S GENERAL HOSPITAL   (Taiwan)

^b KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^c KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^d KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Endothelial nitric oxide synthase; Endothelin 1; G protein coupled receptors; Pulmonary artery hypertension; RhoA Rho kinase

Indexed keywords

ANTIHYPERTENSIVE AGENT; CYCLIC GMP DEPENDENT PROTEIN KINASE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; ENDOTHELIN 1; GUANYLATE CYCLASE; KMUP 1; MONOCROTALINE; N(G) NITROARGININE METHYL ESTER; PROPYLENE GLYCOL; RHO KINASE; RHO KINASE 2; SILDENAFIL; UNCLASSIFIED DRUG; XANTHINE DERIVATIVE; CELL RECEPTOR; G PROTEIN COUPLED RECEPTOR; PIPERAZINE DERIVATIVE; PIPERIDINE DERIVATIVE; PURINE DERIVATIVE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SOLUBLE GUANYLYL CYCLASE; SULFONAMIDE;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIAL PRESSURE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DRUG BLOOD LEVEL; HEART MUSCLE CONTRACTILITY; HEART RATE; HEART RIGHT VENTRICLE HYPERTROPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LUNG ARTERY PRESSURE; LUNG PARENCHYMA; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PULMONARY HYPERTENSION; RAT; SMOOTH MUSCLE FIBER; ANIMAL; ANTAGONISTS AND INHIBITORS; BLOOD; BLOOD PRESSURE; COMPLICATION; DISEASE MODEL; DRUG EFFECTS; ENZYMOLOGY; IN VITRO STUDY; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PULMONARY ARTERY; SIGNAL TRANSDUCTION; VASOCONSTRICTION; WISTAR RAT;

ANIMALS; BLOOD PRESSURE; BODY WEIGHT; CYCLIC GMP-DEPENDENT PROTEIN KINASES; DISEASE MODELS, ANIMAL; ENDOTHELIN-1; GUANYLATE CYCLASE; HEART RATE; HYPERTENSION, PULMONARY; HYPERTROPHY, RIGHT VENTRICULAR; IN VITRO TECHNIQUES; MALE; MONOCROTALINE; NITRIC OXIDE SYNTHASE TYPE III; PIPERAZINES; PIPERIDINES; PULMONARY ARTERY; PURINES; RATS, WISTAR; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, G-PROTEIN-COUPLED; RHO-ASSOCIATED KINASES; RHOA GTP-BINDING PROTEIN; SIGNAL TRANSDUCTION; SULFONAMIDES; VASOCONSTRICTION; XANTHINES;

EID: 84900484441     PISSN: 1607551X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.kjms.2014.02.014     Document Type: Article

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