Loss of glucocorticoid receptor expression by DNA methylation prevents glucocorticoid induced apoptosis in human small cell lung cancer cells

PLoS ONE

Volumn 6, Issue 10, 2011, Pages

  Kay, Paul ^a   Schlossmacher, George ^b   Matthews, Laura ^a   Sommer, Paula ^a,c   Singh, Dave ^a   White, Anne ^a,b   Ray, David ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

^c UNIVERSITY OF KWAZULU NATAL   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; CASPASE 3; GENOMIC DNA; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; MESSENGER RNA; PROTEIN BCL 2; AZACITIDINE; ENZYME INHIBITOR;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL DEATH; CONTROLLED STUDY; DNA METHYLATION; EMBRYO; ENZYME ACTIVATION; ENZYME ACTIVITY; FEMALE; GENE EXPRESSION REGULATION; GENE LOSS; GLUCOCORTICOID RECEPTOR GENE; HUMAN; HUMAN CELL; LUNG NON SMALL CELL CANCER; LUNG SMALL CELL CANCER; PROMOTER REGION; PROTEIN CLEAVAGE; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; RECEPTOR GENE; TRANSACTIVATION; CELL STRAIN HEK293; CPG ISLAND; DRUG EFFECT; GENETICS; LUNG TUMOR; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PATHOLOGY; TRANSGENE; TUMOR CELL LINE;

APOPTOSIS; AZACITIDINE; BASE SEQUENCE; CASPASE 3; CELL LINE, TUMOR; CPG ISLANDS; DNA METHYLATION; ENZYME INHIBITORS; GLUCOCORTICOIDS; HEK293 CELLS; HUMANS; LUNG NEOPLASMS; MOLECULAR SEQUENCE DATA; PROMOTER REGIONS, GENETIC; PROTO-ONCOGENE PROTEINS C-BCL-2; RECEPTORS, GLUCOCORTICOID; SMALL CELL LUNG CARCINOMA; TRANSGENES;

EID: 80053457669     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0024839     Document Type: Article

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