Cell cycle phase regulates glucocorticoid receptor function

PLoS ONE

Volumn 6, Issue 7, 2011, Pages

  Matthews, Laura ^a   Johnson, James ^b   Berry, Andrew ^a   Trebble, Peter ^a   Cookson, Ann ^a   Spiller, Dave ^a,b   Rivers, Caroline ^c   Norman, Michael ^c   White, Mike ^a,b   Ray, David ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNIVERSITY OF LIVERPOOL   (United Kingdom)

^c UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE; DUAL SPECIFICITY PHOSPHATASE 6; GLUCOCORTICOID RECEPTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PYRUVATE DEHYDROGENASE KINASE 4; SERINE; WNT1 PROTEIN; DEXAMETHASONE; MESSENGER RNA;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL CYCLE; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CONSENSUS SEQUENCE; CONTROLLED STUDY; DNA TEMPLATE; ENZYME ACTIVATION; HUMAN; HUMAN CELL; INTERPHASE; LIGAND BINDING; MITOSIS; MITOSIS INDEX; NUCLEAR LOCALIZATION SIGNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN MODIFICATION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; PROTEIN TRANSPORT; TRANSACTIVATION; CELL NUCLEUS; DRUG EFFECT; FLUORESCENT ANTIBODY TECHNIQUE; GENETIC TRANSCRIPTION; GENETICS; HELA CELL; IMMUNOPRECIPITATION; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SITE DIRECTED MUTAGENESIS; WESTERN BLOTTING;

BLOTTING, WESTERN; CELL CYCLE; CELL NUCLEUS; DEXAMETHASONE; FLUORESCENT ANTIBODY TECHNIQUE; HELA CELLS; HUMANS; IMMUNOPRECIPITATION; MITOSIS; MUTAGENESIS, SITE-DIRECTED; NUCLEAR LOCALIZATION SIGNALS; PHOSPHORYLATION; RECEPTORS, GLUCOCORTICOID; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANSCRIPTION, GENETIC;

EID: 79960928936     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0022289     Document Type: Article

References (45)

1. McMaster A, Ray DW, (2008) Drug insight: selective agonists and antagonists of the glucocorticoid receptor. Nat Clin Pract Endocrinol Metab 4: 91-101.
2. Donn R, Payne D, Ray D, (2007) Glucocorticoid receptor gene polymorphisms and susceptibility to rheumatoid arthritis. Clin Endocrinol (Oxf) 67: 342-345.
3. Donn R, Berry A, Stevens A, Farrow S, Betts J, et al. (2007) Use of gene expression profiling to identify a novel glucocorticoid sensitivity determining gene, BMPRII. FASEB J 21: 402-414.
4. Stevens A, Ray DW, Zeggini E, John S, Richards HL, et al. (2004) Glucocorticoid sensitivity is determined by a specific glucocorticoid receptor haplotype. J Clin Endocrinol Metab 89: 892-897.
5. Rhen T, Cidlowski JA, (2005) Antiinflammatory action of glucocorticoids-new mechanisms for old drugs. N Engl J Med 353: 1711-1723.
6. Bookout AL, Jeong Y, Downes M, Yu RT, Evans RM, et al. (2006) Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network. Cell 126: 789-799.
7. Margolis RN, Evans RM, O'Malley BW, (2005) The Nuclear Receptor Signaling Atlas: development of a functional atlas of nuclear receptors. Mol Endocrinol 19: 2433-2436.
8. Evans RM, (2005) The nuclear receptor superfamily: a rosetta stone for physiology. Mol Endocrinol 19: 1429-1438.
9. Stavreva DA, Muller WG, Hager GL, Smith CL, McNally JG, (2004) Rapid glucocorticoid receptor exchange at a promoter is coupled to transcription and regulated by chaperones and proteasomes. Mol Cell Biol 24: 2682-2697.
10. Johnson TA, Elbi C, Parekh BS, Hager GL, John S, (2008) Chromatin Remodeling Complexes Interact Dynamically with a Glucocorticoid Receptor-regulated Promoter. Mol Biol Cell 19: 3308-3322.
11. John S, Sabo PJ, Johnson TA, Sung MH, Biddie SC, et al. (2008) Interaction of the glucocorticoid receptor with the chromatin landscape. Mol Cell 29: 611-624.
12. Nagaich AK, Rayasam GV, Martinez ED, Becker M, Qiu Y, et al. (2004) Subnuclear trafficking and gene targeting by steroid receptors. Ann N Y Acad Sci 1024: 213-220.
13. So AY, Chaivorapol C, Bolton EC, Li H, Yamamoto KR, (2007) Determinants of cell- and gene-specific transcriptional regulation by the glucocorticoid receptor. PLoS Genet 3: e94.
14. Luecke HF, Yamamoto KR, (2005) The glucocorticoid receptor blocks P-TEFb recruitment by NFkappaB to effect promoter-specific transcriptional repression. Genes Dev 19: 1116-1127.
15. Hache RJ, Tse R, Reich T, Savory JG, Lefebvre YA, (1999) Nucleocytoplasmic trafficking of steroid-free glucocorticoid receptor. J Biol Chem 274: 1432-1439.
16. Oakley RH, Webster JC, Jewell CM, Sar M, Cidlowski JA, (1999) Immunocytochemical analysis of the glucocorticoid receptor alpha isoform (GRalpha) using GRalpha-specific antibody. Steroids 64: 742-751.
17. Usmani OS, Ito K, Maneechotesuwan K, Ito M, Johnson M, et al. (2005) Glucocorticoid receptor nuclear translocation in airway cells after inhaled combination therapy. Am J Respir Crit Care Med 172: 704-712.
18. Matthews JG, Ito K, Barnes PJ, Adcock IM, (2004) Defective glucocorticoid receptor nuclear translocation and altered histone acetylation patterns in glucocorticoid-resistant patients. J Allergy Clin Immunol 113: 1100-1108.
19. Matthews L, Berry A, Tersigni M, D'Acquisto F, Ianaro A, et al. (2009) Thiazolidinediones are partial agonists for the glucocorticoid receptor. Endocrinology 150: 75-86.
20. Echeverria PC, Mazaira G, Erlejman A, Gomez-Sanchez C, Piwien PG, et al. (2009) Nuclear import of the glucocorticoid receptor-hsp90 complex through the nuclear pore complex is mediated by its interaction with Nup62 and importin beta. Mol Cell Biol 29: 4788-4797.
21. Carrigan A, Walther RF, Salem HA, Wu D, Atlas E, et al. (2007) An active nuclear retention signal in the glucocorticoid receptor functions as a strong inducer of transcriptional activation. J Biol Chem 282: 10963-10971.
22. Rogatsky I, Trowbridge JM, Garabedian MJ, (1997) Glucocorticoid receptor-mediated cell cycle arrest is achieved through distinct cell-specific transcriptional regulatory mechanisms. Mol Cell Biol 17: 3181-3193.
23. Matthews L, Berry A, Ohanian V, Ohanian J, Garside H, et al. (2008) Caveolin Mediates Rapid Glucocorticoid Effects, and Couples Glucocorticoid Action to the Antiproliferative Programme. Mol Endocrinol 22: 1320-1330.
24. Chen W, Dang T, Blind RD, Wang Z, Cavasotto CN, et al. (2008) Glucocorticoid receptor phosphorylation differentially affects target gene expression. Mol Endocrinol 22: 1754-1766.
25. Wang Z, Chen W, Kono E, Dang T, Garabedian MJ, (2007) Modulation of glucocorticoid receptor phosphorylation and transcriptional activity by a C-terminal-associated protein phosphatase. Mol Endocrinol 21: 625-634.
26. Hsu SC, DeFranco DB, (1995) Selectivity of cell cycle regulation of glucocorticoid receptor function. J Biol Chem 270: 3359-3364.
27. Hsu SC, Qi M, DeFranco DB, (1992) Cell cycle regulation of glucocorticoid receptor function. EMBO J 11: 3457-3468.
28. Abel GA, Wochnik GM, Ruegg J, Rouyer A, Holsboer F, et al. (2002) Activity of the GR in G2 and mitosis. Mol Endocrinol 16: 1352-1366.
29. Krstic MD, Rogatsky I, Yamamoto KR, Garabedian MJ, (1997) Mitogen-activated and cyclin-dependent protein kinases selectively and differentially modulate transcriptional enhancement by the glucocorticoid receptor. Mol Cell Biol 17: 3947-3954.
30. Berry A, Matthews L, Jangani M, Plumb J, Farrow S, et al. (2010) Interferon-inducible factor 16 is a novel modulator of glucocorticoid action. FASEB J 24: 1700-1713.
31. Iniguez-Lluhi JA, Pearce D, (2000) A common motif within the negative regulatory regions of multiple factors inhibits their transcriptional synergy. Mol Cell Biol 20: 6040-6050.
32. Fanger BO, Currie RA, Cidlowski JA, (1986) Regulation of epidermal growth factor receptors by glucocorticoids during the cell cycle in HeLa S3 cells. Arch Biochem Biophys 249: 116-125.
33. Cidlowski JA, Michaels GA, (1977) Alteration in glucocorticoid binding site number during the cell cycle in HeLa cells. Nature 266: 643-645.
34. Distelhorst CW, Benutto BM, Bergamini RA, (1984) Effect of cell cycle position on dexamethasone binding by mouse and human lymphoid cell lines: correlation between an increase in dexamethasone binding during S phase and dexamethasone sensitivity. Blood 63: 105-113.
35. Hu JM, Bodwell JE, Munck A, (1994) Cell cycle-dependent glucocorticoid receptor phosphorylation and activity. Mol Endocrinol 8: 1709-1713.
36. Bodwell JE, Webster JC, Jewell CM, Cidlowski JA, Hu JM, et al. (1998) Glucocorticoid receptor phosphorylation: overview, function and cell cycle-dependence. J Steroid Biochem Mol Biol 65: 91-99.
37. Martin D Jr, Tomkins GM, Granner D, (1969) Synthesis and induction of tyrosine aminotransferase in synchronized hepatoma cells in culture. Proc Natl Acad Sci U S A 62: 248-255.
38. Griffin MJ, Ber R, (1969) Cell cycle events in the hydrocortisone regulation of alkaline phosphatase in HeLa S3 cells. J Cell Biol 40: 297-304.
39. Kayahara M, Ohanian J, Ohanian V, Berry A, Vadlamudi R, et al. (2008) MNAR functionally interacts with both NH2- and COOH-terminal GR domains to modulate transactivation. Am J Physiol Endocrinol Metab 295: E1047-E1055.
40. Waters CE, Stevens A, White A, Ray DW, (2004) Analysis of co-factor function in a glucocorticoid-resistant small cell carcinoma cell line. J Endocrinol 183: 375-383.
41. Miller AL, Webb MS, Copik AJ, Wang Y, Johnson BH, et al. (2005) p38 Mitogen-activated protein kinase (MAPK) is a key mediator in glucocorticoid-induced apoptosis of lymphoid cells: correlation between p38 MAPK activation and site-specific phosphorylation of the human glucocorticoid receptor at serine 211. Mol Endocrinol 19: 1569-1583.
42. Wang Z, Frederick J, Garabedian MJ, (2002) Deciphering the phosphorylation "code" of the glucocorticoid receptor in vivo. J Biol Chem 277: 26573-26580.
43. Chen W, Rogatsky I, Garabedian MJ, (2006) MED14 and MED1 differentially regulate target-specific gene activation by the glucocorticoid receptor. Mol Endocrinol 20: 560-572.
44. Verhoog NJD, Du Toit A, Avenant C, Hapgood JP, (2011) Glucocorticoid- independent Repression of Tumor Necrosis Factor (TNF) α-stimulated Interleukin (IL)-6 Expression by the Glucocorticoid Receptor J Biol Chem 286: 19297-19310.
45. Elsby LM, Donn R, Alourfi Z, Green LM, Beaulieu E, et al. (2009) Hypoxia and glucocorticoid signaling converge to regulate macrophage migration inhibitory factor gene expression. Arthritis Rheum 60: 2220-2231.