Identifying panaxynol, a natural activator of nuclear factor erythroid-2 related factor 2 (Nrf2) from American ginseng as a suppressor of inflamed macrophage-induced cardiomyocyte hypertrophy

Journal of Ethnopharmacology

Volumn 168, Issue , 2015, Pages 326-336

  Qu, Chen ^a,b   Li, Bin ^c,d   Lai, Yimu ^b   Li, Hechu ^b   Windust, Anthony ^e   Hofseth, Lorne J ^f   Nagarkatti, Mitzi ^b   Nagarkatti, Prakash ^b   Wang, Xing Li ^c   Tang, Dongqi ^c   Janicki, Joseph S ^b   Tian, Xingsong ^a   Cui, Taixing ^b,c  

^a SHANDONG PROVINCIAL HOSPITAL AFFILIATED TO SHANDONG UNIVERSITY   (China)

^b UNIVERSITY OF SOUTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c SHANDONG UNIVERSITY   (China)

^d LINYI PEOPLE'S HOSPITAL   (China)

^e NATIONAL RESEARCH COUNCIL CANADA   (Canada)

^f University of South Carolina   (United States)

Author keywords

American ginseng; Cardiomyocytes; Inflammation; Macrophages; Nrf2; Panaxynol

Indexed keywords

ENZYME ACTIVATOR; HEXANE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; KELCH LIKE ECH ASSOCIATED PROTEIN 1; PANAXYNOL; POLYACETYLENE DERIVATIVE; TRANSCRIPTION FACTOR NRF2; ALKYNE DERIVATIVE; ANTIINFLAMMATORY AGENT; CYTOKINE; FATTY ALCOHOL; INDUCIBLE NITRIC OXIDE SYNTHASE; NOS2 PROTEIN, MOUSE; PLANT EXTRACT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; HEART MUSCLE CELL; HEART VENTRICLE HYPERTROPHY; LIQUID CHROMATOGRAPHY; MACROPHAGE; MASS SPECTROMETRY; MOUSE; NONHUMAN; PANAX QUINQUEFOLIUS; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN EXPRESSION; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ULTRAVIOLET SPECTROSCOPY; ANIMAL; CARDIAC MUSCLE CELL; CELL LINE; CHEMISTRY; DRUG EFFECTS; FEMALE; HYPERTROPHY; ISOLATION AND PURIFICATION; KNOCKOUT MOUSE; MALE; METABOLISM; PANAX; PATHOLOGY; RAT;

PANAX QUINQUEFOLIUS;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CELL LINE; CYTOKINES; DIYNES; FATTY ALCOHOLS; FEMALE; HYPERTROPHY; MACROPHAGES; MALE; MICE, KNOCKOUT; MYOCYTES, CARDIAC; NF-E2-RELATED FACTOR 2; NITRIC OXIDE SYNTHASE TYPE II; PANAX; PLANT EXTRACTS; RATS;

EID: 84928577905     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2015.04.004     Document Type: Article

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