Concise review: Induced pluripotency by defined factors: Prey of oxidative stress

Stem Cells

Volumn 33, Issue 5, 2015, Pages 1371-1376

  Qi, Suxia ^a   Fang, Zhi ^a,b   Wang, Danli ^a   Menendez, Pablo ^c,d   Yao, Ke ^b   Ji, Junfeng ^a,e  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b THE SECOND AFFILIATED HOSPITAL OF ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^c UNIVERSITY OF BARCELONA   (Spain)

^d INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS ICREA   (Spain)

^e Zhejiang Provincial Key Laboratory of Tissue Engineering and Regenerative Medicine   (China)

Author keywords

Cellular reprogramming; Genomic aberrations; Induced pluripotent stem cells; Oxidative stress

Indexed keywords

ANTIOXIDANT; DOUBLE STRANDED DNA;

AEROBIC METABOLISM; ARTICLE; CELL STRUCTURE; CHROMOSOME ABERRATION; DNA DAMAGE; DNA END JOINING REPAIR; GENOMIC INSTABILITY; HOMOLOGOUS RECOMBINATION; HUMAN; NONHUMAN; NUCLEAR REPROGRAMMING; OXIDATIVE PHOSPHORYLATION; OXIDATIVE STRESS; PLURIPOTENT STEM CELL; POINT MUTATION; ANIMAL; GENOME; INDUCED PLURIPOTENT STEM CELL; PATHOLOGY;

ANIMALS; CELLULAR REPROGRAMMING; CHROMOSOME ABERRATIONS; GENOME; HUMANS; INDUCED PLURIPOTENT STEM CELLS; OXIDATIVE STRESS;

EID: 84928534190     PISSN: 10665099     EISSN: 15494918     Source Type: Journal    
DOI: 10.1002/stem.1946     Document Type: Article

References (64)

1. Wilmut I, Schnieke AE, McWhir J, et al. Viable offspring derived from fetal and adult mammalian cells. Nature 1997; 385: 810-813.
2. Takahashi K, Yamanaka S,. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006; 126: 663-676.
3. Takahashi K, Tanabe K, Ohnuki M, et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 2007; 131: 861-872.
4. Buganim Y, Faddah DA, Jaenisch R,. Mechanisms and models of somatic cell reprogramming. Nat Rev Genet 2013; 14: 427-439.
5. Rossant J, Tam PP,. Blastocyst lineage formation, early embryonic asymmetries and axis patterning in the mouse. Development 2009; 136: 701-713.
6. Ng HH, Surani MA,. The transcriptional and signalling networks of pluripotency. Nat Cell Biol 2011; 13: 490-496.
7. Tee WW, Reinberg D,. Chromatin features and the epigenetic regulation of pluripotency states in ESCs. Development 2014; 141: 2376-2390.
8. Papp B, Plath K,. Epigenetics of reprogramming to induced pluripotency. Cell 2013; 152: 1324-1343.
9. Huangfu D, Maehr R, Guo W, et al. Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds. Nat Biotechnol 2008; 26: 795-797.
10. Mikkelsen TS, Hanna J, Zhang X, et al. Dissecting direct reprogramming through integrative genomic analysis. Nature 2008; 454: 49-55.
11. Mansour AA, Gafni O, Weinberger L, et al. The H3K27 demethylase Utx regulates somatic and germ cell epigenetic reprogramming. Nature 2012; 488: 409-413.
12. Rais Y, Zviran A, Geula S, et al. Deterministic direct reprogramming of somatic cells to pluripotency. Nature 2013; 502: 65-70.
13. Feng B, Ng JH, Heng JC, et al. Molecules that promote or enhance reprogramming of somatic cells to induced pluripotent stem cells. Cell Stem Cell 2009; 4: 301-312.
14. Ho R, Papp B, Hoffman JA, et al. Stage-specific regulation of reprogramming to induced pluripotent stem cells by Wnt signaling and T cell factor proteins. Cell Rep 2013; 3: 2113-2126.
15. Zhang P, Chang WH, Fong B, et al. Regulation of induced pluripotent stem (iPS) cell induction by Wnt/beta-catenin signaling. J Biol Chem 2014; 289: 9221-9232.
16. Ronen D, Benvenisty N,. Genomic stability in reprogramming. Curr Opin Genet Dev 2012; 22: 444-449.
17. Gore A, Li Z, Fung HL, et al. Somatic coding mutations in human induced pluripotent stem cells. Nature 2011; 471: 63-67.
18. Ji J, Ng SH, Sharma V, et al. Elevated coding mutation rate during the reprogramming of human somatic cells into induced pluripotent stem cells. Stem Cells 2012; 30: 435-440.
19. Hussein SM, Batada NN, Vuoristo S, et al. Copy number variation and selection during reprogramming to pluripotency. Nature 2011; 471: 58-62.
20. Laurent LC, Ulitsky I, Slavin I, et al. Dynamic changes in the copy number of pluripotency and cell proliferation genes in human ESCs and iPSCs during reprogramming and time in culture. Cell Stem Cell 2011; 8: 106-118.
21. Liu P, Kaplan A, Yuan B, et al. Passage number is a major contributor to genomic structural variations in mouse iPS cells. Stem Cells 2014; 32: 2657-2667.
22. Esteban MA, Wang T, Qin B, et al. Vitamin C enhances the generation of mouse and human induced pluripotent stem cells. Cell Stem Cell 2010; 6: 71-79.
23. Stadtfeld M, Apostolou E, Ferrari F, et al. Ascorbic acid prevents loss of Dlk1-Dio3 imprinting and facilitates generation of all-iPS cell mice from terminally differentiated B cells. Nat Genet 2012; 44: 398-405, S391-392.
24. Ji J, Sharma V, Qi S, et al. Antioxidant supplementation reduces genomic aberrations in human induced pluripotent stem cells. Stem Cell Reports 2014; 2: 44-51.
25. Chong SJ, Low IC, Pervaiz S,. Mitochondrial ROS and involvement of Bcl-2 as a mitochondrial ROS regulator. Mitochondrion 2014; 19: 39-48.
26. Mailloux RJ, Jin X, Willmore WG,. Redox regulation of mitochondrial function with emphasis on cysteine oxidation reactions. Redox Biol 2013; 2: 123-139.
27. Lu J, Sharma LK, Bai Y,. Implications of mitochondrial DNA mutations and mitochondrial dysfunction in tumorigenesis. Cell Res 2009; 19: 802-815.
28. Amstad P, Cerutti P,. Genetic modulation of the cellular antioxidant defense capacity. Environ Health Perspect 1990; 88: 77-82.
29. Peng C, Wang X, Chen J, et al. Biology of ageing and role of dietary antioxidants. Biomed Res Int 2014; 2014: 831841.
30. Sivaranjani N, Rao SV, Rajeev G,. Role of reactive oxygen species and antioxidants in atopic dermatitis. J Clin Diagn Res 2013; 7: 2683-2685.
31. Vafa O, Wade M, Kern S, et al. c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: A mechanism for oncogene-induced genetic instability. Mol Cell 2002; 9: 1031-1044.
32. Silva JP, Coutinho OP,. Free radicals in the regulation of damage and cell death-Basic mechanisms and prevention. Drug Discov Ther 2010; 4: 144-167.
33. Ramos-Mejia V, Fraga MF, Menendez P,. iPSCs from cancer cells: Challenges and opportunities. Trends Mol Med 2012; 18: 245-247.
34. Nesbit CE, Tersak JM, Prochownik EV,. MYC oncogenes and human neoplastic disease. Oncogene 1999; 18: 3004-3016.
35. Rowland BD, Bernards R, Peeper DS,. The KLF4 tumour suppressor is a transcriptional repressor of p53 that acts as a context-dependent oncogene. Nat Cell Biol 2005; 7: 1074-1082.
36. Hochedlinger K, Yamada Y, Beard C, et al. Ectopic expression of Oct-4 blocks progenitor-cell differentiation and causes dysplasia in epithelial tissues. Cell 2005; 121: 465-477.
37. Bass AJ, Watanabe H, Mermel CH, et al. SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas. Nat Genet 2009; 41: 1238-1242.
38. Boumahdi S, Driessens G, Lapouge G, et al. SOX2 controls tumour initiation and cancer stem-cell functions in squamous-cell carcinoma. Nature 2014; 511: 246-250.
39. Banito A, Rashid ST, Acosta JC, et al. Senescence impairs successful reprogramming to pluripotent stem cells. Genes Dev 2009; 23: 2134-2139.
40. Marion RM, Strati K, Li H, et al. A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity. Nature 2009; 460: 1149-1153.
41. Kawamura T, Suzuki J, Wang YV, et al. Linking the p53 tumour suppressor pathway to somatic cell reprogramming. Nature 2009; 460: 1140-1144.
42. Hong H, Takahashi K, Ichisaka T, et al. Suppression of induced pluripotent stem cell generation by the p53-p21 pathway. Nature 2009; 460: 1132-1135.
43. Chen J, Guo L, Zhang L, et al. Vitamin C modulates TET1 function during somatic cell reprogramming. Nat Genet 2013; 45: 1504-1509.
44. Wang T, Chen K, Zeng X, et al. The histone demethylases Jhdm1a/1b enhance somatic cell reprogramming in a vitamin-C-dependent manner. Cell Stem Cell 2011; 9: 575-587.
45. Romero-Moya D, Bueno C, Montes R, et al. Cord blood-derived CD34+ hematopoietic cells with low mitochondrial mass are enriched in hematopoietic repopulating stem cell function. Haematologica 2013; 98: 1022-1029.
46. Prigione A, Fauler B, Lurz R, et al. The senescence-related mitochondrial/oxidative stress pathway is repressed in human induced pluripotent stem cells. Stem Cells 2010; 28: 721-733.
47. Yoshida Y, Takahashi K, Okita K, et al. Hypoxia enhances the generation of induced pluripotent stem cells. Cell Stem Cell 2009; 5: 237-241.
48. Prigione A, Rohwer N, Hoffmann S, et al. HIF1α modulates cell fate reprogramming through early glycolytic shift and upregulation of PDK1-3 and PKM2. Stem Cells 2014; 32: 364-376.
49. Navas P, Villalba JM, de Cabo R,. The importance of plasma membrane coenzyme Q in aging and stress responses. Mitochondrion 2007;(7 suppl): S34-40.
50. Prigione A, Lichtner B, Kuhl H, et al. Human induced pluripotent stem cells harbor homoplasmic and heteroplasmic mitochondrial DNA mutations while maintaining human embryonic stem cell-like metabolic reprogramming. Stem Cells 2011; 29: 1338-1348.
51. Blasco MA, Serrano M, Fernandez-Capetillo O,. Genomic instability in iPS: Time for a break. EMBO J 2011; 30: 991-993.
52. Hong SG, Dunbar CE, Winkler T,. Assessing the risks of genotoxicity in the therapeutic development of induced pluripotent stem cells. Mol Ther 2013; 21: 272-281.
53. Neeley WL, Essigmann JM,. Mechanisms of formation, genotoxicity, and mutation of guanine oxidation products. Chem Res Toxicol 2006; 19: 491-505.
54. von Zglinicki T,. Oxidative stress shortens telomeres. Trends Biochem Sci 2002; 27: 339-344.
55. Mehta A, Haber JE,. Sources of DNA double-strand breaks and models of recombinational DNA repair. Cold Spring Harb Perspect Biol 2014; 6.
56. Ciccia A, Elledge SJ,. The DNA damage response: Making it safe to play with knives. Mol Cell 2010; 40: 179-204.
57. Müller LU, Milsom MD, Harris CE, et al. Overcoming reprogramming resistance of Fanconi anemia cells. Blood 2012; 119: 5449-5457.
58. Skalka AM, Katz RA,. Retroviral DNA integration and the DNA damage response. Cell Death Differ 2005; 12(suppl 1): 971-978.
59. González F, Georgieva D, Vanoli F, et al. Homologous recombination DNA repair genes play a critical role in reprogramming to a pluripotent state. Cell Rep 2013; 3: 651-660.
60. Prigione A, Hossini AM, Lichtner B, et al. Mitochondrial-associated cell death mechanisms are reset to an embryonic-like state in aged donor-derived iPS cells harboring chromosomal aberrations. PLoS One 2011; 6: e27352.
61. Gorgens H, Muller A, Kruger S, et al. Analysis of the base excision repair genes MTH1, OGG1 and MUTYH in patients with squamous oral carcinomas. Oral Oncol 2007; 43: 791-795.
62. Fujikawa K, Kamiya H, Yakushiji H, et al. Human MTH1 protein hydrolyzes the oxidized ribonucleotide, 2-hydroxy-ATP. Nucleic Acids Res 2001; 29: 449-454.
63. David SS, O'Shea VL, Kundu S,. Base-excision repair of oxidative DNA damage. Nature 2007; 447: 941-950.
64. Zeman MK, Cimprich KA,. Causes and consequences of replication stress. Nat Cell Biol 2014; 16: 2-9.