메뉴 건너뛰기




Volumn 19, Issue 5, 2015, Pages 605-615

The potential of targeting indoleamine 2,3-dioxygenase for cancer treatment

Author keywords

Anti inflammatory; Antiproliferative; GTP cyclohydrolase; Immunosuppressive; Indoleamine 2,3 dioxygenase; Kynurenine; Neopterin; Tolerance; Tryptophan; Tumor

Indexed keywords

4 AMINO N (3 CHLORO 4 FLUOROPHENYL) N' HYDROXY 1,2,5 OXADIAZOLE 3 CARBOXIMIDAMIDE; ACENOCOUMAROL; ACETYLSALICYLIC ACID; ANTIOXIDANT; CHLOROQUINE; CYCLOSPORIN A; IMIDAZOLE; INDOLEAMINE 2,3 DIOXYGENASE; INDOLEAMINE 2,3 DIOXYGENASE INHIBITOR; KYNURENINE; METHYLPREDNISOLONE; PLANT MEDICINAL PRODUCT; RAPAMYCIN; TACROLIMUS; TRYPTOPHAN; TRYPTOPHAN 2,3 DIOXYGENASE;

EID: 84928499088     PISSN: 14728222     EISSN: 17447631     Source Type: Journal    
DOI: 10.1517/14728222.2014.995092     Document Type: Review
Times cited : (34)

References (113)
  • 2
    • 0034466503 scopus 로고    scopus 로고
    • Antioxidant activities and redox regulation of interferon-gamma-induced tryptophan metabolism in human monocytes and macrophages
    • Thomas SR, Stocker R. Antioxidant activities and redox regulation of interferon-gamma-induced tryptophan metabolism in human monocytes and macrophages. Adv Exp Med Biol 1999;467:541-52
    • (1999) Adv Exp Med Biol , vol.467 , pp. 541-552
    • Thomas, S.R.1    Stocker, R.2
  • 3
    • 84875261622 scopus 로고    scopus 로고
    • Indoleamine 2,3 dioxygenase and metabolic control of immune responses
    • Munn DH, Mellor AL. Indoleamine 2,3 dioxygenase and metabolic control of immune responses. Trends Immunol 2013;34:137-43
    • (2013) Trends Immunol , vol.34 , pp. 137-143
    • Munn, D.H.1    Mellor, A.L.2
  • 4
    • 33644649659 scopus 로고    scopus 로고
    • Indoleamine 2,3-dioxygenase, tumor-induced tolerance and counter-regulation
    • Munn DH. Indoleamine 2,3-dioxygenase, tumor-induced tolerance and counter-regulation. Curr Opin Immunol 2006;18:220-5
    • (2006) Curr Opin Immunol , vol.18 , pp. 220-225
    • Munn, D.H.1
  • 5
    • 33747179266 scopus 로고    scopus 로고
    • Antitumoral activity of interferon-gamma involved in impaired immune function in cancer patients
    • Brandacher G, Winkler C, Schroecksnadel K, et al. Antitumoral activity of interferon-gamma involved in impaired immune function in cancer patients. Curr Drug Metab 2006;7:599-612
    • (2006) Curr Drug Metab , vol.7 , pp. 599-612
    • Brandacher, G.1    Winkler, C.2    Schroecksnadel, K.3
  • 6
    • 84859833114 scopus 로고    scopus 로고
    • IDO-mediated tryptophan degradation in the pathogenesis of malignant tumor disease
    • Sucher R, Kurz K, Weiss G, et al. IDO-mediated tryptophan degradation in the pathogenesis of malignant tumor disease. Int J Tryptophan Res 2010;3:113-20
    • (2010) Int J Tryptophan Res , vol.3 , pp. 113-120
    • Sucher, R.1    Kurz, K.2    Weiss, G.3
  • 8
    • 34249295962 scopus 로고    scopus 로고
    • Characterization of an indoleamine 2,3-dioxygenase-like protein found in humans and mice
    • Ball HJ, Sanchez-Perez A, Weiser S, et al. Characterization of an indoleamine 2,3-dioxygenase-like protein found in humans and mice. Gene 2007;396:203-13
    • (2007) Gene , vol.396 , pp. 203-213
    • Ball, H.J.1    Sanchez-Perez, A.2    Weiser, S.3
  • 9
    • 73249121300 scopus 로고    scopus 로고
    • Kynurenine pathway metabolites in humans: Disease and healthy States
    • Chen Y, Guillemin GJ. Kynurenine pathway metabolites in humans: disease and healthy States. Int J Tryptophan Res 2009;2:1-19
    • (2009) Int J Tryptophan Res , vol.2 , pp. 1-19
    • Chen, Y.1    Guillemin, G.J.2
  • 10
    • 0023276687 scopus 로고
    • Human macrophages degrade tryptophan upon induction by interferon-gamma
    • Werner ER, Bitterlich G, Fuchs D, et al. Human macrophages degrade tryptophan upon induction by interferon-gamma. Life Sci 1987;41:273-80
    • (1987) Life Sci , vol.41 , pp. 273-280
    • Werner, E.R.1    Bitterlich, G.2    Fuchs, D.3
  • 11
    • 0024460738 scopus 로고
    • Tumour necrosis factoralpha and lipopolysaccharide enhance interferon-induced tryptophan degradation and pteridine synthesis in human cells
    • Werner-Felmayer G, Werner ER, Fuchs D, et al. Tumour necrosis factoralpha and lipopolysaccharide enhance interferon-induced tryptophan degradation and pteridine synthesis in human cells. Biol Chem Hoppe Seyler 1989;370:1063-9
    • (1989) Biol Chem Hoppe Seyler , vol.370 , pp. 1063-1069
    • Werner-Felmayer, G.1    Werner, E.R.2    Fuchs, D.3
  • 12
    • 0022452997 scopus 로고
    • Induction of tryptophan degradation in vitro and in vivo: A gamma-interferon-stimulated activity
    • Byrne GI, Lehmann LK, Kirschbaum JG, et al. Induction of tryptophan degradation in vitro and in vivo: a gamma-interferon-stimulated activity. J Interferon Res 1986;6:389-96
    • (1986) J Interferon Res , vol.6 , pp. 389-396
    • Byrne, G.I.1    Lehmann, L.K.2    Kirschbaum, J.G.3
  • 13
    • 1842507880 scopus 로고    scopus 로고
    • Indoleamine 2,3-dioxygenase: Distribution and function in the developing human placenta
    • Kudo Y, Boyd CA, Spyropoulou I, et al. Indoleamine 2,3-dioxygenase: distribution and function in the developing human placenta. J Reprod Immunol 2004;61:87-98
    • (2004) J Reprod Immunol , vol.61 , pp. 87-98
    • Kudo, Y.1    Boyd, C.A.2    Spyropoulou, I.3
  • 14
    • 0043076307 scopus 로고
    • Induction of pulmonary indoleamine 2,3-dioxygenase by interferon
    • Yoshida R, Imanishi J, Oku T, et al. Induction of pulmonary indoleamine 2,3-dioxygenase by interferon. Proc Natl Acad Sci USA 1981;78:129-32
    • (1981) Proc Natl Acad Sci USA , vol.78 , pp. 129-132
    • Yoshida, R.1    Imanishi, J.2    Oku, T.3
  • 15
    • 58149308592 scopus 로고    scopus 로고
    • Indoleamine 2,3-dioxygenase-2; A new enzyme in the kynurenine pathway
    • Ball HJ, Yuasa HJ, Austin CJ, et al. Indoleamine 2,3-dioxygenase-2; a new enzyme in the kynurenine pathway. Int J Biochem Cell Biol 2009;41:467-71
    • (2009) Int J Biochem Cell Biol , vol.41 , pp. 467-471
    • Ball, H.J.1    Yuasa, H.J.2    Austin, C.J.3
  • 16
    • 84906310566 scopus 로고    scopus 로고
    • Human indoleamine 2,3-dioxygenase- 2 has substrate specificity and inhibition characteristics distinct from those of indoleamine 2,3-dioxygenase-1
    • Pantouris G, Serys M, Yuasa HJ, et al. Human indoleamine 2,3-dioxygenase- 2 has substrate specificity and inhibition characteristics distinct from those of indoleamine 2,3-dioxygenase-1. Amino Acids 2014;46:2155-63
    • (2014) Amino Acids , vol.46 , pp. 2155-2163
    • Pantouris, G.1    Serys, M.2    Yuasa, H.J.3
  • 17
    • 54849418903 scopus 로고    scopus 로고
    • IDO1 and IDO2 are expressed in human tumors: Levo- but not dextro-1-methyl tryptophan inhibits tryptophan catabolism
    • Lob S, Konigsrainer A, Zieker D, et al. IDO1 and IDO2 are expressed in human tumors: levo- but not dextro-1-methyl tryptophan inhibits tryptophan catabolism. Cancer Immunol Immunother 2009;58:153-7
    • (2009) Cancer Immunol Immunother , vol.58 , pp. 153-157
    • Lob, S.1    Konigsrainer, A.2    Zieker, D.3
  • 18
    • 84896516675 scopus 로고    scopus 로고
    • IDO2 is critical for IDO1-mediated T-cell regulation and exerts a nonredundant function in inflammation
    • Metz R, Smith C, DuHadaway JB, et al. IDO2 is critical for IDO1-mediated T-cell regulation and exerts a nonredundant function in inflammation. Int Immunol 2014;26:357-67
    • (2014) Int Immunol , vol.26 , pp. 357-367
    • Metz, R.1    Smith, C.2    Duhadaway, J.B.3
  • 19
    • 84896502247 scopus 로고    scopus 로고
    • IDO2 is a critical mediator of autoantibody production and inflammatory pathogenesis in a mouse model of autoimmune arthritis
    • Merlo LM, Pigott E, DuHadaway JB, et al. IDO2 is a critical mediator of autoantibody production and inflammatory pathogenesis in a mouse model of autoimmune arthritis. J Immunol 2014;192:2082-90
    • (2014) J Immunol , vol.192 , pp. 2082-2090
    • Merlo, L.M.1    Pigott, E.2    Duhadaway, J.B.3
  • 20
    • 0013997391 scopus 로고
    • The regulation of tryptophan pyrrolase activity by tryptophan
    • Knox WE. The regulation of tryptophan pyrrolase activity by tryptophan. Adv Enzyme Regul 1966;4:287-97
    • (1966) Adv Enzyme Regul , vol.4 , pp. 287-297
    • Knox, W.E.1
  • 21
    • 0013864538 scopus 로고
    • Induction of tryptophan pyrrolase in rat liver by physiological amounts of hydrocortisone and secreted glucocorticoids
    • Knox WE, Piras MM, Tokuyama K. Induction of tryptophan pyrrolase in rat liver by physiological amounts of hydrocortisone and secreted glucocorticoids. Enzymol Biol Clin (Basel) 1966;7:1-10
    • (1966) Enzymol Biol Clin (Basel) , vol.7 , pp. 1-10
    • Knox, W.E.1    Piras, M.M.2    Tokuyama, K.3
  • 22
    • 0016007501 scopus 로고
    • The effect of hormones and vitamin B6 on urinary excretion of metabolites of the kynurenine pathway
    • Wolf H. The effect of hormones and vitamin B6 on urinary excretion of metabolites of the kynurenine pathway. Scand J Clin Lab Invest Suppl 1974;136:1-186
    • (1974) Scand J Clin Lab Invest Suppl , vol.136 , pp. 1-186
    • Wolf, H.1
  • 23
    • 0029670778 scopus 로고    scopus 로고
    • Ltryptophan: Biochemical, nutritional and pharmacological aspects
    • Sainio EL, Pulkki K, Young SN. Ltryptophan: biochemical, nutritional and pharmacological aspects. Amino Acids 1996;10:21-47
    • (1996) Amino Acids , vol.10 , pp. 21-47
    • Sainio, E.L.1    Pulkki, K.2    Young, S.N.3
  • 24
    • 0003068068 scopus 로고
    • Formation of indole-3-acetic acid and tryptamine in animals: A method for estimation of indole-3-acetic acid in tissues
    • Weissbach H, King W, Sjoerdsma A, Udenfriend S. Formation of indole-3-acetic acid and tryptamine in animals: a method for estimation of indole-3-acetic acid in tissues. J Biol Chem 1959;234:81-6
    • (1959) J Biol Chem , vol.234 , pp. 81-86
    • Weissbach, H.1    King, W.2    Sjoerdsma, A.3    Udenfriend, S.4
  • 25
    • 0028593424 scopus 로고
    • Human indoleamine 2,3-dioxygenase inhibits toxoplasma gondii growth in fibroblast cells
    • Dai W, Pan H, Kwok O, Dubey JP. Human indoleamine 2,3-dioxygenase inhibits toxoplasma gondii growth in fibroblast cells. J Interferon Res 1994;14:313-17
    • (1994) J Interferon Res , vol.14 , pp. 313-317
    • Dai, W.1    Pan, H.2    Kwok, O.3    Dubey, J.P.4
  • 26
    • 0025944659 scopus 로고
    • Relationship between interferon-gamma, indoleamine 2,3-dioxygenase, and tryptophan catabolism
    • Taylor MW, Feng GS. Relationship between interferon-gamma, indoleamine 2,3-dioxygenase, and tryptophan catabolism. FASEB J 1991;5:2516-22
    • (1991) FASEB J , vol.5 , pp. 2516-2522
    • Taylor, M.W.1    Feng, G.S.2
  • 27
    • 0020502358 scopus 로고
    • Identification of interferongamma as the lymphokine that activates human macrophage oxidative metabolism and antimicrobial activity
    • Nathan CF, Murray HW, Wiebe ME, Rubin BY. Identification of interferongamma as the lymphokine that activates human macrophage oxidative metabolism and antimicrobial activity. J Exp Med 1983;158:670-89
    • (1983) J Exp Med , vol.158 , pp. 670-689
    • Nathan, C.F.1    Murray, H.W.2    Wiebe, M.E.3    Rubin, B.Y.4
  • 28
    • 0024317795 scopus 로고
    • Parallel induction of tetrahydrobiopterin biosynthesis and indoleamine 2,3-dioxygenase activity in human cells and cell lines by interferon-gamma
    • Werner ER, Werner-Felmayer G, Fuchs D, et al. Parallel induction of tetrahydrobiopterin biosynthesis and indoleamine 2,3-dioxygenase activity in human cells and cell lines by interferon-gamma. Biochem J 1989;262:861-6
    • (1989) Biochem J , vol.262 , pp. 861-866
    • Werner, E.R.1    Werner-Felmayer, G.2    Fuchs, D.3
  • 30
    • 0025236440 scopus 로고
    • Tetrahydrobiopterin biosynthetic activities in human macrophages, fibroblasts, THP-1, and T 24 cells. GTP-cyclohydrolase i is stimulated by interferon-gamma, and 6- pyruvoyl tetrahydropterin synthase and sepiapterin reductase are constitutively present
    • Werner ER, Werner-Felmayer G, Fuchs D, et al. Tetrahydrobiopterin biosynthetic activities in human macrophages, fibroblasts, THP-1, and T 24 cells. GTP-cyclohydrolase I is stimulated by interferon-gamma, and 6- pyruvoyl tetrahydropterin synthase and sepiapterin reductase are constitutively present. J Biol Chem 1990;265:3189-92
    • (1990) J Biol Chem , vol.265 , pp. 3189-3192
    • Werner, E.R.1    Werner-Felmayer, G.2    Fuchs, D.3
  • 31
    • 0027175225 scopus 로고
    • Nitric oxide synthase is not a constituent of the antimicrobial armature of human mononuclear phagocytes
    • Schneemann M, Schoedon G, Hofer S, et al. Nitric oxide synthase is not a constituent of the antimicrobial armature of human mononuclear phagocytes. J Infect Dis 1993;167:1358-63
    • (1993) J Infect Dis , vol.167 , pp. 1358-1363
    • Schneemann, M.1    Schoedon, G.2    Hofer, S.3
  • 32
    • 84928472315 scopus 로고    scopus 로고
    • Comparison of ELISA and HPLC assays to determine blood kynurenine concentrations in men and mice
    • Haara A, Geisler S, Becker K, et al. Comparison of ELISA and HPLC assays to determine blood kynurenine concentrations in men and mice. Pteridines 2014;25:19
    • (2014) Pteridines , vol.25 , pp. 19
    • Haara, A.1    Geisler, S.2    Becker, K.3
  • 34
    • 58349087544 scopus 로고    scopus 로고
    • Antioxidants suppress Th1-type immune response in vitro
    • Schroecksnadel K, Fischer B, Schennach H, et al. Antioxidants suppress Th1-type immune response in vitro. Drug Metab Lett 2007;1:166-71
    • (2007) Drug Metab Lett , vol.1 , pp. 166-171
    • Schroecksnadel, K.1    Fischer, B.2    Schennach, H.3
  • 35
    • 79951725595 scopus 로고    scopus 로고
    • In vitro testing for anti-inflammatory properties of compounds employing peripheral blood mononuclear cells freshly isolated from healthy donors
    • Jenny M, Klieber M, Zaknun D, et al. In vitro testing for anti-inflammatory properties of compounds employing peripheral blood mononuclear cells freshly isolated from healthy donors. Inflamm Res 2011;60:127-35
    • (2011) Inflamm Res , vol.60 , pp. 127-135
    • Jenny, M.1    Klieber, M.2    Zaknun, D.3
  • 36
    • 84895105024 scopus 로고    scopus 로고
    • Immunoregulatory impact of food antioxidants
    • Gostner J, Ciardi C, Becker K, et al. Immunoregulatory impact of food antioxidants. Curr Pharm Des 2014;20:840-9
    • (2014) Curr Pharm des , vol.20 , pp. 840-849
    • Gostner, J.1    Ciardi, C.2    Becker, K.3
  • 37
    • 0032555614 scopus 로고    scopus 로고
    • Prevention of allogeneic fetal rejection by tryptophan catabolism
    • Munn DH, Zhou M, Attwood JT, et al. Prevention of allogeneic fetal rejection by tryptophan catabolism. Science 1998;281:1191-3
    • (1998) Science , vol.281 , pp. 1191-1193
    • Munn, D.H.1    Zhou, M.2    Attwood, J.T.3
  • 38
    • 0034466557 scopus 로고    scopus 로고
    • An HPLC method to determine tryptophan and kynurenine in serum simultaneously
    • Widner B, Werner ER, Schennach H, Fuchs D. An HPLC method to determine tryptophan and kynurenine in serum simultaneously. Adv Exp Med Biol 1999;467:827-32
    • (1999) Adv Exp Med Biol , vol.467 , pp. 827-832
    • Widner, B.1    Werner, E.R.2    Schennach, H.3    Fuchs, D.4
  • 39
    • 0025819142 scopus 로고
    • Increased endogenous interferongamma and neopterin correlate with increased degradation of tryptophan in human immunodeficiency virus type 1 infection
    • Fuchs D, Moller AA, Reibnegger G, et al. Increased endogenous interferongamma and neopterin correlate with increased degradation of tryptophan in human immunodeficiency virus type 1 infection. Immunol Lett 1991;28:207-11
    • (1991) Immunol Lett , vol.28 , pp. 207-211
    • Fuchs, D.1    Moller, A.A.2    Reibnegger, G.3
  • 41
    • 33845920042 scopus 로고    scopus 로고
    • Decreased serum tryptophan concentration predicts poor prognosis in malignant melanoma patients
    • Weinlich G, Murr C, Richardsen L, et al. Decreased serum tryptophan concentration predicts poor prognosis in malignant melanoma patients. Dermatology 2007;214:8-14
    • (2007) Dermatology , vol.214 , pp. 8-14
    • Weinlich, G.1    Murr, C.2    Richardsen, L.3
  • 42
    • 16044371586 scopus 로고    scopus 로고
    • Differential patterns of serum biomarkers of immune activation in human T-cell lymphotropic virus type Iassociated myelopathy/tropical spastic paraparesis, and adult T-cell leukemia/ lymphoma
    • Giusti RM, Maloney EM, Hanchard B, et al. Differential patterns of serum biomarkers of immune activation in human T-cell lymphotropic virus type Iassociated myelopathy/tropical spastic paraparesis, and adult T-cell leukemia/ lymphoma. Cancer Epidemiol Biomarkers Prev 1996;5:699-704
    • (1996) Cancer Epidemiol Biomarkers Prev , vol.5 , pp. 699-704
    • Giusti, R.M.1    Maloney, E.M.2    Hanchard, B.3
  • 43
    • 19344369437 scopus 로고    scopus 로고
    • Tryptophan degradation in patients with gynecological cancer correlates with immune activation
    • Schroecksnadel K, Winkler C, Fuith LC, Fuchs D. Tryptophan degradation in patients with gynecological cancer correlates with immune activation. Cancer Lett 2005;223:323-9
    • (2005) Cancer Lett , vol.223 , pp. 323-329
    • Schroecksnadel, K.1    Winkler, C.2    Fuith, L.C.3    Fuchs, D.4
  • 44
    • 0037024439 scopus 로고    scopus 로고
    • Serum tryptophan decrease correlates with immune activation and impaired quality of life in colorectal cancer
    • Huang A, Fuchs D, Widner B, et al. Serum tryptophan decrease correlates with immune activation and impaired quality of life in colorectal cancer. Br J Cancer 2002;86:1691-6
    • (2002) Br J Cancer , vol.86 , pp. 1691-1696
    • Huang, A.1    Fuchs, D.2    Widner, B.3
  • 45
    • 0027402767 scopus 로고
    • Weight loss in patients with hematological neoplasias is associated with immune system stimulation
    • Denz H, Orth B, Weiss G, et al. Weight loss in patients with hematological neoplasias is associated with immune system stimulation. Clin Investig 1993;71:37-41
    • (1993) Clin Investig , vol.71 , pp. 37-41
    • Denz, H.1    Orth, B.2    Weiss, G.3
  • 46
    • 79957936035 scopus 로고    scopus 로고
    • Indoleamine 2,3- dioxygenase, Tregs and cancer
    • Munn DH. Indoleamine 2,3- dioxygenase, Tregs and cancer. Curr Med Chem 2011;18:2240-6
    • (2011) Curr Med Chem , vol.18 , pp. 2240-2246
    • Munn, D.H.1
  • 47
    • 79957959848 scopus 로고    scopus 로고
    • Using an ancient tool for igniting and propagating immune tolerance: IDO as an inducer and amplifier of regulatory T cell functions
    • Fallarino F, Grohmann U. Using an ancient tool for igniting and propagating immune tolerance: IDO as an inducer and amplifier of regulatory T cell functions. Curr Med Chem 2011;18:2215-21
    • (2011) Curr Med Chem , vol.18 , pp. 2215-2221
    • Fallarino, F.1    Grohmann, U.2
  • 48
    • 70149101645 scopus 로고    scopus 로고
    • IDO activates regulatory T cells and blocks their conversion into Th17- like T cells
    • Baban B, Chandler PR, Sharma MD, et al. IDO activates regulatory T cells and blocks their conversion into Th17- like T cells. J Immunol 2009;183:2475-83
    • (2009) J Immunol , vol.183 , pp. 2475-2483
    • Baban, B.1    Chandler, P.R.2    Sharma, M.D.3
  • 49
    • 84874940388 scopus 로고    scopus 로고
    • CTLA4-Ig immunosuppressive activity at the level of dendritic cell/T cell crosstalk
    • Mayer E, Holzl M, Ahmadi S, et al. CTLA4-Ig immunosuppressive activity at the level of dendritic cell/T cell crosstalk. Int Immunopharmacol 2013;15:638-45
    • (2013) Int Immunopharmacol , vol.15 , pp. 638-645
    • Mayer, E.1    Holzl, M.2    Ahmadi, S.3
  • 50
    • 5044250291 scopus 로고    scopus 로고
    • Specific subsets of murine dendritic cells acquire potent T cell regulatory functions following CTLA4-mediated induction of indoleamine 2,3 dioxygenase
    • Mellor AL, Chandler P, Baban B, Specific subsets of murine dendritic cells acquire potent T cell regulatory functions following CTLA4-mediated induction of indoleamine 2,3 dioxygenase. Int Immunol 2004;16:1391-401
    • (2004) Int Immunol , vol.16 , pp. 1391-1401
    • Mellor, A.L.1    Chandler, P.2    Baban, B.3
  • 51
    • 77950950894 scopus 로고    scopus 로고
    • Macrophage diversity enhances tumor progression and metastasis
    • Qian BZ, Pollard JW. Macrophage diversity enhances tumor progression and metastasis. Cell 2010;141:39-51
    • (2010) Cell , vol.141 , pp. 39-51
    • Qian, B.Z.1    Pollard, J.W.2
  • 53
    • 77955012431 scopus 로고    scopus 로고
    • Tryptophan metabolite 3-hydroxyanthranilic acid selectively induces activated T cell death via intracellular GSH depletion
    • Lee SM, Lee YS, Choi JH, Tryptophan metabolite 3-hydroxyanthranilic acid selectively induces activated T cell death via intracellular GSH depletion. Immunol Lett 2010;132:53-60
    • (2010) Immunol Lett , vol.132 , pp. 53-60
    • Lee, S.M.1    Lee, Y.S.2    Choi, J.H.3
  • 54
    • 36749044869 scopus 로고    scopus 로고
    • 3-Hydroxyanthranilic acid inhibits PDK1 activation and suppresses experimental asthma by inducing T cell apoptosis
    • Hayashi T, Mo JH, Gong X, et al. 3-Hydroxyanthranilic acid inhibits PDK1 activation and suppresses experimental asthma by inducing T cell apoptosis. Proc Natl Acad Sci USA 2007;104:18619-24
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 18619-18624
    • Hayashi, T.1    Mo, J.H.2    Gong, X.3
  • 55
    • 42649095378 scopus 로고    scopus 로고
    • Control of T(reg) and T(H)17 cell differentiation by the aryl hydrocarbon receptor
    • Quintana FJ, Basso AS, Iglesias AH, et al. Control of T(reg) and T(H)17 cell differentiation by the aryl hydrocarbon receptor. Nature 2008;453:65-71
    • (2008) Nature , vol.453 , pp. 65-71
    • Quintana, F.J.1    Basso, A.S.2    Iglesias, A.H.3
  • 56
    • 42649106556 scopus 로고    scopus 로고
    • The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins
    • Veldhoen M, Hirota K, Westendorf AM, et al. The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins. Nature 2008;453:106-9
    • (2008) Nature , vol.453 , pp. 106-109
    • Veldhoen, M.1    Hirota, K.2    Westendorf, A.M.3
  • 57
    • 78649880396 scopus 로고    scopus 로고
    • An interaction between kynurenine and the aryl hydrocarbon receptor can generate regulatory T cells
    • Mezrich JD, Fechner JH, Zhang X, An interaction between kynurenine and the aryl hydrocarbon receptor can generate regulatory T cells. J Immunol 2010;185:3190-8
    • (2010) J Immunol , vol.185 , pp. 3190-3198
    • Mezrich, J.D.1    Fechner, J.H.2    Zhang, X.3
  • 58
    • 84904216760 scopus 로고    scopus 로고
    • Aryl hydrocarbon receptor control of a disease tolerance defence pathway
    • Bessede A, Gargaro M, Pallotta MT, et al. Aryl hydrocarbon receptor control of a disease tolerance defence pathway. Nature 2014;511:184-90
    • (2014) Nature , vol.511 , pp. 184-190
    • Bessede, A.1    Gargaro, M.2    Pallotta, M.T.3
  • 59
    • 37249004668 scopus 로고    scopus 로고
    • The Gcn2 kinase as a cell cycle regulator
    • Grallert B, Boye E. The Gcn2 kinase as a cell cycle regulator. Cell Cycle 2007;6:2768-72
    • (2007) Cell Cycle , vol.6 , pp. 2768-2772
    • Grallert, B.1    Boye, E.2
  • 60
    • 19344377474 scopus 로고    scopus 로고
    • GCN2 kinase in T cells mediates proliferative arrest and anergy induction in response to indoleamine 2,3- dioxygenase
    • Munn DH, Sharma MD, Baban B, et al. GCN2 kinase in T cells mediates proliferative arrest and anergy induction in response to indoleamine 2,3- dioxygenase. Immunity 2005;22:633-42
    • (2005) Immunity , vol.22 , pp. 633-642
    • Munn, D.H.1    Sharma, M.D.2    Baban, B.3
  • 62
    • 84870222809 scopus 로고    scopus 로고
    • New functions of protein kinase Gcn2 in yeast and mammals
    • Murguia JR, Serrano R. New functions of protein kinase Gcn2 in yeast and mammals. IUBMB Life 2012;64:971-4
    • (2012) IUBMB Life , vol.64 , pp. 971-974
    • Murguia, J.R.1    Serrano, R.2
  • 63
    • 77953565102 scopus 로고    scopus 로고
    • The GCN2-ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation
    • Ye J, Kumanova M, Hart LS, et al. The GCN2-ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation. EMBO J 2010;29:2082-96
    • (2010) EMBO J , vol.29 , pp. 2082-2096
    • Ye, J.1    Kumanova, M.2    Hart, L.S.3
  • 64
    • 0142137237 scopus 로고    scopus 로고
    • Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase
    • Uyttenhove C, Pilotte L, Theate I, et al. Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase. Nat Med 2003;9:1269-74
    • (2003) Nat Med , vol.9 , pp. 1269-1274
    • Uyttenhove, C.1    Pilotte, L.2    Theate, I.3
  • 65
    • 84901239041 scopus 로고    scopus 로고
    • Indoleamine 2,3-dioxygenase (IDO) is frequently expressed in stromal cells of Hodgkin lymphoma and is associated with adverse clinical features: A retrospective cohort study
    • Choe JY, Yun JY, Jeon YK, et al. Indoleamine 2,3-dioxygenase (IDO) is frequently expressed in stromal cells of Hodgkin lymphoma and is associated with adverse clinical features: a retrospective cohort study. BMC Cancer 2014;14:335
    • (2014) BMC Cancer , vol.14 , pp. 335
    • Choe, J.Y.1    Yun, J.Y.2    Jeon, Y.K.3
  • 66
    • 81255138408 scopus 로고    scopus 로고
    • Indoleamine 2,3-dioxygenase expression in human cancers: Clinical and immunologic perspectives
    • Godin-Ethier J, Hanafi LA, Piccirillo CA, Lapointe R. Indoleamine 2,3-dioxygenase expression in human cancers: clinical and immunologic perspectives. Clin Cancer Res 2011;17:6985-91
    • (2011) Clin Cancer Res , vol.17 , pp. 6985-6991
    • Godin-Ethier, J.1    Hanafi, L.A.2    Piccirillo, C.A.3    Lapointe, R.4
  • 67
    • 67649356699 scopus 로고    scopus 로고
    • Expression of indoleamine 2,3- dioxygenase in metastatic malignant melanoma recruits regulatory T cells to avoid immune detection and affects survival
    • Brody JR, Costantino CL, Berger AC, et al. Expression of indoleamine 2,3- dioxygenase in metastatic malignant melanoma recruits regulatory T cells to avoid immune detection and affects survival. Cell Cycle 2009;8:1930-4
    • (2009) Cell Cycle , vol.8 , pp. 1930-1934
    • Brody, J.R.1    Costantino, C.L.2    Berger, A.C.3
  • 68
    • 57349164479 scopus 로고    scopus 로고
    • High INDO (indoleamine 2,3-dioxygenase) mRNA level in blasts of acute myeloid leukemic patients predicts poor clinical outcome
    • Chamuleau ME, van de Loosdrecht AA, Hess CJ, et al. High INDO (indoleamine 2,3-dioxygenase) mRNA level in blasts of acute myeloid leukemic patients predicts poor clinical outcome. Haematologica 2008;93:1894-8
    • (2008) Haematologica , vol.93 , pp. 1894-1898
    • Chamuleau, M.E.1    Van De Loosdrecht, A.A.2    Hess, C.J.3
  • 69
    • 33845246900 scopus 로고    scopus 로고
    • Indoleamine 2,3-dioxygenase is a novel prognostic indicator for endometrial cancer
    • Ino K, Yoshida N, Kajiyama H, et al. Indoleamine 2,3-dioxygenase is a novel prognostic indicator for endometrial cancer. Br J Cancer 2006;95:1555-61
    • (2006) Br J Cancer , vol.95 , pp. 1555-1561
    • Ino, K.1    Yoshida, N.2    Kajiyama, H.3
  • 70
    • 71849101405 scopus 로고    scopus 로고
    • Prognostic value of indoleamine 2,3-dioxygenase expression in high grade osteosarcoma
    • Urakawa H, Nishida Y, Nakashima H, et al. Prognostic value of indoleamine 2,3-dioxygenase expression in high grade osteosarcoma. Clin Exp Metastasis 2009;26:1005-12
    • (2009) Clin Exp Metastasis , vol.26 , pp. 1005-1012
    • Urakawa, H.1    Nishida, Y.2    Nakashima, H.3
  • 71
    • 53749088471 scopus 로고    scopus 로고
    • Expression and prognosis role of indoleamine 2,3-dioxygenase in hepatocellular carcinoma
    • Pan K, Wang H, Chen MS, et al. Expression and prognosis role of indoleamine 2,3-dioxygenase in hepatocellular carcinoma. J Cancer Res Clin Oncol 2008;134:1247-53
    • (2008) J Cancer Res Clin Oncol , vol.134 , pp. 1247-1253
    • Pan, K.1    Wang, H.2    Chen, M.S.3
  • 72
    • 37249048334 scopus 로고    scopus 로고
    • Expression of indoleamine 2,3- dioxygenase in tumor endothelial cells correlates with long-term survival of patients with renal cell carcinoma
    • Riesenberg R, Weiler C, Spring O, et al. Expression of indoleamine 2,3- dioxygenase in tumor endothelial cells correlates with long-term survival of patients with renal cell carcinoma. Clin Cancer Res 2007;13:6993-7002
    • (2007) Clin Cancer Res , vol.13 , pp. 6993-7002
    • Riesenberg, R.1    Weiler, C.2    Spring, O.3
  • 73
    • 80155156932 scopus 로고    scopus 로고
    • High expression of indoleamine 2,3- dioxygenase in the tumour is associated with medullary features and favourable outcome in basal-like breast carcinoma
    • Jacquemier J, Bertucci F, Finetti P, et al. High expression of indoleamine 2,3- dioxygenase in the tumour is associated with medullary features and favourable outcome in basal-like breast carcinoma. Int J Cancer 2012;130:96-104
    • (2012) Int J Cancer , vol.130 , pp. 96-104
    • Jacquemier, J.1    Bertucci, F.2    Finetti, P.3
  • 74
    • 84897374481 scopus 로고    scopus 로고
    • Constitutive IDO expression in human cancer is sustained by an autocrine signaling loop involving IL-6, STAT3 and the AHR
    • Litzenburger UM, Opitz CA, Sahm F, et al. Constitutive IDO expression in human cancer is sustained by an autocrine signaling loop involving IL-6, STAT3 and the AHR. Oncotarget 2014;5:1038-51
    • (2014) Oncotarget , vol.5 , pp. 1038-1051
    • Litzenburger, U.M.1    Opitz, C.A.2    Sahm, F.3
  • 75
    • 84874594968 scopus 로고    scopus 로고
    • The aryl hydrocarbon receptor in tumor immunity
    • Platten M, Litzenburger U, Wick W. The aryl hydrocarbon receptor in tumor immunity. Oncoimmunology 2012;1:396-7
    • (2012) Oncoimmunology , vol.1 , pp. 396-397
    • Platten, M.1    Litzenburger, U.2    Wick, W.3
  • 76
    • 80054041992 scopus 로고    scopus 로고
    • An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor
    • Opitz CA, Litzenburger UM, Sahm F. An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor. Nature 2011;478:197-203
    • (2011) Nature , vol.478 , pp. 197-203
    • Opitz, C.A.1    Litzenburger, U.M.2    Sahm, F.3
  • 77
    • 84857136779 scopus 로고    scopus 로고
    • Reversal of tumoral immune resistance by inhibition of tryptophan 2,3- dioxygenase
    • Pilotte L, Larrieu P, Stroobant V, et al. Reversal of tumoral immune resistance by inhibition of tryptophan 2,3- dioxygenase. Proc Natl Acad Sci USA 2012;109:2497-502
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 2497-2502
    • Pilotte, L.1    Larrieu, P.2    Stroobant, V.3
  • 78
    • 37849002571 scopus 로고    scopus 로고
    • Human tryptophan dioxygenase: A comparison to indoleamine 2,3-dioxygenase
    • Batabyal D, Yeh SR. Human tryptophan dioxygenase: a comparison to indoleamine 2,3-dioxygenase. J Am Chem Soc 2007;129:15690-701
    • (2007) J Am Chem Soc , vol.129 , pp. 15690-15701
    • Batabyal, D.1    Yeh, S.R.2
  • 79
    • 0023926018 scopus 로고
    • Mechanism of interferon-gamma action. Characterization of indoleamine 2,3-dioxygenase in cultured human cells induced by interferon-gamma and evaluation of the enzyme-mediated tryptophan degradation in its anticellular activity
    • Takikawa O, Kuroiwa T, Yamazaki F, Kido R. Mechanism of interferon-gamma action. Characterization of indoleamine 2,3-dioxygenase in cultured human cells induced by interferon-gamma and evaluation of the enzyme-mediated tryptophan degradation in its anticellular activity. J Biol Chem 1988;263:2041-8
    • (1988) J Biol Chem , vol.263 , pp. 2041-2048
    • Takikawa, O.1    Kuroiwa, T.2    Yamazaki, F.3    Kido, R.4
  • 80
    • 57749111596 scopus 로고    scopus 로고
    • Nutrient transporters in cancer: Relevance to Warburg hypothesis and beyond
    • Ganapathy V, Thangaraju M, Prasad PD. Nutrient transporters in cancer: relevance to Warburg hypothesis and beyond. Pharmacol Ther 2009;121:29-40
    • (2009) Pharmacol Ther , vol.121 , pp. 29-40
    • Ganapathy, V.1    Thangaraju, M.2    Prasad, P.D.3
  • 81
    • 84862292292 scopus 로고    scopus 로고
    • Oxidative stress, tumor microenvironment, and metabolic reprogramming: A diabolic liaison
    • Fiaschi T, Chiarugi P. Oxidative stress, tumor microenvironment, and metabolic reprogramming: a diabolic liaison. Int J Cell Biol 2012;2012:762825
    • (2012) Int J Cell Biol , vol.2012 , pp. 762825
    • Fiaschi, T.1    Chiarugi, P.2
  • 82
    • 84921736325 scopus 로고    scopus 로고
    • Vitamins B2 and B6 as determinants of kynurenines and related markers of interferon-g-mediated immune activation in the communitybased Hordaland Health Study
    • Theofylaktopoulou D, Ulvik A, Midttun Ø, et al. Vitamins B2 and B6 as determinants of kynurenines and related markers of interferon-g-mediated immune activation in the communitybased Hordaland Health Study. Br J Nutr 2014;112:1065-72
    • (2014) Br J Nutr , vol.112 , pp. 1065-1072
    • Theofylaktopoulou, D.1    Ulvik, A.2    Midttun Ø.3
  • 83
    • 0014096187 scopus 로고
    • Biochemical and physiological changes in vitamin B6 deficiency
    • Linkswiler H. Biochemical and physiological changes in vitamin B6 deficiency. Am J Clin Nutr 1967;20:547-61
    • (1967) Am J Clin Nutr , vol.20 , pp. 547-561
    • Linkswiler, H.1
  • 84
    • 0015261660 scopus 로고
    • Aspects of tryptophan metabolism in health and disease: A review
    • Rose DP. Aspects of tryptophan metabolism in health and disease: a review. J Clin Pathol 1972;25:17-25
    • (1972) J Clin Pathol , vol.25 , pp. 17-25
    • Rose, D.P.1
  • 85
    • 79551606751 scopus 로고    scopus 로고
    • Possible roles of excess tryptophan metabolites in cancer
    • Chung KT, Gadupudi GS. Possible roles of excess tryptophan metabolites in cancer. Environ Mol Mutagen 2011;52:81-104
    • (2011) Environ Mol Mutagen , vol.52 , pp. 81-104
    • Chung, K.T.1    Gadupudi, G.S.2
  • 86
    • 79960278867 scopus 로고    scopus 로고
    • Kynurenic acid synthesis and kynurenine aminotransferases expression in colon derived normal and cancer cells
    • Walczak K, Dabrowski W, Langner E, et al. Kynurenic acid synthesis and kynurenine aminotransferases expression in colon derived normal and cancer cells. Scand J Gastroenterol 2011;46:903-12
    • (2011) Scand J Gastroenterol , vol.46 , pp. 903-912
    • Walczak, K.1    Dabrowski, W.2    Langner, E.3
  • 87
    • 84867577438 scopus 로고    scopus 로고
    • Kynurenic acid in human renal cell carcinoma: Its antiproliferative and antimigrative action on Caki-2 cells
    • Walczak K, Zurawska M, Kis J, et al. Kynurenic acid in human renal cell carcinoma: its antiproliferative and antimigrative action on Caki-2 cells. Amino Acids 2012;43:1663-70
    • (2012) Amino Acids , vol.43 , pp. 1663-1670
    • Walczak, K.1    Zurawska, M.2    Kis, J.3
  • 88
    • 33644775726 scopus 로고    scopus 로고
    • Prognostic value of indoleamine 2,3-dioxygenase expression in colorectal cancer: Effect on tumorinfiltrating T cells
    • Brandacher G, Perathoner A, Ladurner R, et al. Prognostic value of indoleamine 2,3-dioxygenase expression in colorectal cancer: effect on tumorinfiltrating T cells. Clin Cancer Res 2006;12:1144-51
    • (2006) Clin Cancer Res , vol.12 , pp. 1144-1151
    • Brandacher, G.1    Perathoner, A.2    Ladurner, R.3
  • 89
    • 0742269461 scopus 로고    scopus 로고
    • Possible role of cytokine-induced tryptophan degradation in anaemia of inflammation
    • Weiss G, Schroecksnadel K, Mattle V, et al. Possible role of cytokine-induced tryptophan degradation in anaemia of inflammation. Eur J Haematol 2004;72:130-4
    • (2004) Eur J Haematol , vol.72 , pp. 130-134
    • Weiss, G.1    Schroecksnadel, K.2    Mattle, V.3
  • 90
    • 77952553096 scopus 로고    scopus 로고
    • Interferon-gamma-mediated pathways are induced in human CD34(+) haematopoietic stem cells
    • Kurz K, Gluhcheva Y, Zvetkova E, et al. Interferon-gamma-mediated pathways are induced in human CD34(+) haematopoietic stem cells. Immunobiology 2010;215:452-7
    • (2010) Immunobiology , vol.215 , pp. 452-457
    • Kurz, K.1    Gluhcheva, Y.2    Zvetkova, E.3
  • 91
    • 2942595706 scopus 로고    scopus 로고
    • Human bone marrow stromal cells inhibit allogeneic T-cell responses by indoleamine 2,3-dioxygenase-mediated tryptophan degradation
    • Meisel R, Zibert A, Laryea M, et al. Human bone marrow stromal cells inhibit allogeneic T-cell responses by indoleamine 2,3-dioxygenase-mediated tryptophan degradation. Blood 2004;103:4619-21
    • (2004) Blood , vol.103 , pp. 4619-4621
    • Meisel, R.1    Zibert, A.2    Laryea, M.3
  • 93
    • 0027402767 scopus 로고
    • Weight loss in patients with hematological neoplasias is associated with immune system stimulation
    • Denz H, Orth B, Weiss G, et al. Weight loss in patients with hematological neoplasias is associated with immune system stimulation. Clin Investig 1993;71:37-41
    • (1993) Clin Investig , vol.71 , pp. 37-41
    • Denz, H.1    Orth, B.2    Weiss, G.3
  • 94
    • 79851514132 scopus 로고    scopus 로고
    • Association between increased tryptophan degradation and depression in cancer patients
    • Kurz K, Schroecksnadel S, Weiss G, Fuchs D. Association between increased tryptophan degradation and depression in cancer patients. Curr Opin Clin Nutr Metab Care 2011;14:49-56
    • (2011) Curr Opin Clin Nutr Metab Care , vol.14 , pp. 49-56
    • Kurz, K.1    Schroecksnadel, S.2    Weiss, G.3    Fuchs, D.4
  • 97
    • 84856111463 scopus 로고    scopus 로고
    • Psychoneuroimmunology meets neuropsychopharmacology: Translational implications of the impact of inflammation on behavior
    • Haroon E, Raison CL, Miller AH. Psychoneuroimmunology meets neuropsychopharmacology: translational implications of the impact of inflammation on behavior. Neuropsychopharmacology 2012;37:137-62
    • (2012) Neuropsychopharmacology , vol.37 , pp. 137-162
    • Haroon, E.1    Raison, C.L.2    Miller, A.H.3
  • 98
    • 0037293033 scopus 로고    scopus 로고
    • Cytokines and depression: The need for a new paradigm
    • Capuron L, Dantzer R. Cytokines and depression: the need for a new paradigm. Brain Behav Immun 2003;17(Suppl 1):S119-24
    • (2003) Brain Behav Immun , vol.17 , pp. S119-S124
    • Capuron, L.1    Dantzer, R.2
  • 99
    • 0036430419 scopus 로고    scopus 로고
    • Neopterin production, tryptophan degradation, and mental depression - what is the link?
    • Widner B, Laich A, Sperner-Unterweger B, et al. Neopterin production, tryptophan degradation, and mental depression - what is the link? Brain Behav Immun 2002;16:590-5
    • (2002) Brain Behav Immun , vol.16 , pp. 590-595
    • Widner, B.1    Laich, A.2    Sperner-Unterweger, B.3
  • 100
    • 84862603083 scopus 로고    scopus 로고
    • Kynurenines in the mammalian brain: When physiology meets pathology
    • Schwarcz R, Bruno JP, Muchowski PJ, Wu HQ. Kynurenines in the mammalian brain: when physiology meets pathology. Nat Rev Neurosci 2012;13:465-77
    • (2012) Nat Rev Neurosci , vol.13 , pp. 465-477
    • Schwarcz, R.1    Bruno, J.P.2    Muchowski, P.J.3    Wu, H.Q.4
  • 101
    • 0026076136 scopus 로고
    • Blood-brain barrier transport of kynurenines: Implications for brain synthesis and metabolism
    • Fukui S, Schwarcz R, Rapoport SI, et al. Blood-brain barrier transport of kynurenines: implications for brain synthesis and metabolism. J Neurochem 1991;56:2007-17
    • (1991) J Neurochem , vol.56 , pp. 2007-2017
    • Fukui, S.1    Schwarcz, R.2    Rapoport, S.I.3
  • 102
    • 77249170294 scopus 로고    scopus 로고
    • Rational design of indoleamine 2,3- dioxygenase inhibitors
    • Rohrig UF, Awad L, Grosdidier A, et al. Rational design of indoleamine 2,3- dioxygenase inhibitors. J Med Chem 2010;53:1172-89
    • (2010) J Med Chem , vol.53 , pp. 1172-1189
    • Rohrig, U.F.1    Awad, L.2    Grosdidier, A.3
  • 103
    • 76149132331 scopus 로고    scopus 로고
    • Inhibitors of indoleamine 2,3-dioxygenase: A review of novel patented lead compounds
    • Di PT, Danese S, De CR, Rutella S. Inhibitors of indoleamine 2,3- dioxygenase: a review of novel patented lead compounds. Expert Opin Ther Pat 2010;20:229-50
    • (2010) Expert Opin Ther Pat , vol.20 , pp. 229-250
    • Di, P.T.1    Danese, S.2    De, C.R.3    Rutella, S.4
  • 104
    • 84921398751 scopus 로고    scopus 로고
    • Trial watch: IDO inhibitors in cancer therapy
    • Vacchelli E, Aranda F, Eggermont A, et al. Trial watch: IDO inhibitors in cancer therapy. OncoImmunology 2014;3:1-10
    • (2014) OncoImmunology , vol.3 , pp. 1-10
    • Vacchelli, E.1    Aranda, F.2    Eggermont, A.3
  • 105
    • 84884545929 scopus 로고    scopus 로고
    • Indoleamine 2,3- dioxygenase inhibitors: A patent review (2008-2012)
    • Dolusic E, Frederick R. Indoleamine 2,3- dioxygenase inhibitors: a patent review (2008-2012). Expert Opin Ther Pat 2013;23:1367-81
    • (2013) Expert Opin Ther Pat , vol.23 , pp. 1367-1381
    • Dolusic, E.1    Frederick, R.2
  • 106
    • 79961217268 scopus 로고    scopus 로고
    • Tryptophan 2,3-dioxygenase (TDO) inhibitors. 3-(2-(pyridyl)ethenyl)indoles as potential anticancer immunomodulators
    • Dolusić E, Larrieu P, Moineaux L, et al. Tryptophan 2,3-dioxygenase (TDO) inhibitors. 3-(2-(pyridyl)ethenyl)indoles as potential anticancer immunomodulators. J Med Chem 2011;54:5320-34
    • (2011) J Med Chem , vol.54 , pp. 5320-5334
    • Dolusić, E.1    Larrieu, P.2    Moineaux, L.3
  • 107
    • 84890857180 scopus 로고    scopus 로고
    • Antitumour agents as inhibitors of tryptophan 2,3- dioxygenase
    • Pantouris G, Mowat CG. Antitumour agents as inhibitors of tryptophan 2,3- dioxygenase. Biochem Biophys Res Commun 2014;443:28-31
    • (2014) Biochem Biophys Res Commun , vol.443 , pp. 28-31
    • Pantouris, G.1    Mowat, C.G.2
  • 108
    • 80052325862 scopus 로고    scopus 로고
    • Influence of immunosuppressive agents on tryptophan degradation and neopterin production in human peripheral blood mononuclear cells
    • Schroecksnadel S, Sucher R, Kurz K, et al. Influence of immunosuppressive agents on tryptophan degradation and neopterin production in human peripheral blood mononuclear cells. Transpl Immunol 2011;25:119-23
    • (2011) Transpl Immunol , vol.25 , pp. 119-123
    • Schroecksnadel, S.1    Sucher, R.2    Kurz, K.3
  • 109
    • 16244393385 scopus 로고    scopus 로고
    • Aspirin downregulates tryptophan degradation in stimulated human peripheral blood mononuclear cells in vitro
    • Schroecksnadel K, Winkler C, Wirleitner B, et al. Aspirin downregulates tryptophan degradation in stimulated human peripheral blood mononuclear cells in vitro. Clin Exp Immunol 2005;140:41-5
    • (2005) Clin Exp Immunol , vol.140 , pp. 41-45
    • Schroecksnadel, K.1    Winkler, C.2    Wirleitner, B.3
  • 110
    • 84867298900 scopus 로고    scopus 로고
    • Antimalarial drug chloroquine counteracts activation of indoleamine (2,3)-dioxygenase activity in human PBMC
    • Gostner JM, Schrocksnadel S, Becker K, et al. Antimalarial drug chloroquine counteracts activation of indoleamine (2,3)-dioxygenase activity in human PBMC. FEBS Open Bio 2012;2:241-5
    • (2012) FEBS Open Bio , vol.2 , pp. 241-245
    • Gostner, J.M.1    Schrocksnadel, S.2    Becker, K.3
  • 111
    • 84878870522 scopus 로고    scopus 로고
    • Immunomodulatory effects in vitro of vitamin K antagonist acenocoumarol
    • Schroecksnadel S, Gostner J, Jenny M, et al. Immunomodulatory effects in vitro of vitamin K antagonist acenocoumarol. Thromb Res 2013;131:e264-9
    • (2013) Thromb Res , vol.131 , pp. e264-e269
    • Schroecksnadel, S.1    Gostner, J.2    Jenny, M.3
  • 112
    • 0034721335 scopus 로고    scopus 로고
    • Mechanism of the combination immunosuppressive effects of rapamycin with either cyclosporine or tacrolimus
    • Khanna AK. Mechanism of the combination immunosuppressive effects of rapamycin with either cyclosporine or tacrolimus. Transplantation 2000;70:690-4
    • (2000) Transplantation , vol.70 , pp. 690-694
    • Khanna, A.K.1
  • 113
    • 0024835226 scopus 로고
    • Endogenous release of interferongamma and diminished response of peripheral blood mononuclear cells to antigenic stimulation
    • Fuchs D, Malkovsky M, Reibnegger G, et al. Endogenous release of interferongamma and diminished response of peripheral blood mononuclear cells to antigenic stimulation. Immunol Lett 1989;23:103-8
    • (1989) Immunol Lett , vol.23 , pp. 103-108
    • Fuchs, D.1    Malkovsky, M.2    Reibnegger, G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.