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Volumn 150, Issue , 2015, Pages 143-148

Ror2 as a therapeutic target in cancer

Author keywords

Cancer; Pseudokinase; Receptor tyrosine kinase; Ror2; Wnt signaling

Indexed keywords

RECEPTOR TYROSINE KINASE LIKE ORPHAN RECEPTOR; RECEPTOR TYROSINE KINASE LIKE ORPHAN RECEPTOR 1; RECEPTOR TYROSINE KINASE LIKE ORPHAN RECEPTOR 2; UNCLASSIFIED DRUG; WNT PROTEIN; ANTINEOPLASTIC AGENT; ROR2 PROTEIN, HUMAN;

EID: 84928380373     PISSN: 01637258     EISSN: 1879016X     Source Type: Journal    
DOI: 10.1016/j.pharmthera.2015.01.010     Document Type: Review
Times cited : (79)

References (80)
  • 1
    • 0038385028 scopus 로고    scopus 로고
    • One gene, two phenotypes: ROR2 mutations in autosomal recessive Robinow syndrome and autosomal dominant brachydactyly type B
    • A.R. Afzal, and S. Jeffery One gene, two phenotypes: ROR2 mutations in autosomal recessive Robinow syndrome and autosomal dominant brachydactyly type B Hum Mutat 22 2003 1 11
    • (2003) Hum Mutat , vol.22 , pp. 1-11
    • Afzal, A.R.1    Jeffery, S.2
  • 2
    • 0034425405 scopus 로고    scopus 로고
    • Recessive Robinow syndrome, allelic to dominant brachydactyly type B, is caused by mutation of ROR2
    • A.R. Afzal, A. Rajab, C.D. Fenske, M. Oldridge, N. Elanko, and E. Ternes-Pereira Recessive Robinow syndrome, allelic to dominant brachydactyly type B, is caused by mutation of ROR2 Nat Genet 25 2000 419 422
    • (2000) Nat Genet , vol.25 , pp. 419-422
    • Afzal, A.R.1    Rajab, A.2    Fenske, C.D.3    Oldridge, M.4    Elanko, N.5    Ternes-Pereira, E.6
  • 3
    • 46749088657 scopus 로고    scopus 로고
    • The deleted in brachydactyly B domain of ROR2 is required for receptor activation by recruitment of Src
    • S. Akbarzadeh, L.M. Wheldon, S.M. Sweet, S. Talma, F.K. Mardakheh, and J.K. Heath The deleted in brachydactyly B domain of ROR2 is required for receptor activation by recruitment of Src PLoS One 3 2008 e1873
    • (2008) PLoS One , vol.3 , pp. e1873
    • Akbarzadeh, S.1    Wheldon, L.M.2    Sweet, S.M.3    Talma, S.4    Mardakheh, F.K.5    Heath, J.K.6
  • 4
    • 0034838873 scopus 로고    scopus 로고
    • Expression of the Ror1 and Ror2 receptor tyrosine kinase genes during mouse development
    • R. Al-Shawi, S.V. Ashton, C. Underwood, and J.P. Simons Expression of the Ror1 and Ror2 receptor tyrosine kinase genes during mouse development Dev Genes Evol 211 2001 161 171
    • (2001) Dev Genes Evol , vol.211 , pp. 161-171
    • Al-Shawi, R.1    Ashton, S.V.2    Underwood, C.3    Simons, J.P.4
  • 5
    • 84869051908 scopus 로고    scopus 로고
    • Assessing the range of kinase autoinhibition mechanisms in the insulin receptor family
    • S.C. Artim, J.M. Mendrola, and M.A. Lemmon Assessing the range of kinase autoinhibition mechanisms in the insulin receptor family Biochem J 448 2012 213 220
    • (2012) Biochem J , vol.448 , pp. 213-220
    • Artim, S.C.1    Mendrola, J.M.2    Lemmon, M.A.3
  • 7
    • 0029994517 scopus 로고    scopus 로고
    • A new member of the frizzled family from Drosophila functions as a Wingless receptor
    • P. Bhanot, M. Brink, C.H. Samos, J.C. Hsieh, Y. Wang, and J.P. Macke A new member of the frizzled family from Drosophila functions as a Wingless receptor Nature 382 1996 225 230
    • (1996) Nature , vol.382 , pp. 225-230
    • Bhanot, P.1    Brink, M.2    Samos, C.H.3    Hsieh, J.C.4    Wang, Y.5    Macke, J.P.6
  • 8
    • 84899496157 scopus 로고    scopus 로고
    • Wnt5a involved in regulation of the biological behavior of hepatocellular carcinoma
    • L. Bi, X. Liu, C. Wang, Y. Cao, R. Mao, and P. Li Wnt5a involved in regulation of the biological behavior of hepatocellular carcinoma Int J Clin Exp Pathol 7 2014 987 995
    • (2014) Int J Clin Exp Pathol , vol.7 , pp. 987-995
    • Bi, L.1    Liu, X.2    Wang, C.3    Cao, Y.4    Mao, R.5    Li, P.6
  • 10
    • 0035902180 scopus 로고    scopus 로고
    • Oncogenic kinase signalling
    • P. Blume-Jensen, and T. Hunter Oncogenic kinase signalling Nature 411 2001 355 365
    • (2001) Nature , vol.411 , pp. 355-365
    • Blume-Jensen, P.1    Hunter, T.2
  • 11
    • 80555146643 scopus 로고    scopus 로고
    • A switch from canonical to noncanonical Wnt signaling mediates drug resistance in colon cancer cells
    • M. Bordonaro, S. Tewari, C.E. Cicco, W. Atamna, and D.L. Lazarova A switch from canonical to noncanonical Wnt signaling mediates drug resistance in colon cancer cells PLoS One 6 2001 e27308
    • (2001) PLoS One , vol.6 , pp. e27308
    • Bordonaro, M.1    Tewari, S.2    Cicco, C.E.3    Atamna, W.4    Lazarova, D.L.5
  • 13
    • 84904816257 scopus 로고    scopus 로고
    • Appropriate crypt formation in the uterus for embryo homing and implantation requires Wnt5a-ROR signaling
    • J. Cha, A. Bartos, C. Park, X. Sun, Y. Li, and S.W. Cha Appropriate crypt formation in the uterus for embryo homing and implantation requires Wnt5a-ROR signaling Cell Rep 8 2014 382 392
    • (2014) Cell Rep , vol.8 , pp. 382-392
    • Cha, J.1    Bartos, A.2    Park, C.3    Sun, X.4    Li, Y.5    Cha, S.W.6
  • 14
    • 67449150167 scopus 로고    scopus 로고
    • A Wnt survival guide: From flies to human disease
    • A.J. Chien, W.H. Conrad, and R.T. Moon A Wnt survival guide: From flies to human disease J Invest Dermatol 129 2009 1614 1627
    • (2009) J Invest Dermatol , vol.129 , pp. 1614-1627
    • Chien, A.J.1    Conrad, W.H.2    Moon, R.T.3
  • 15
    • 53249090604 scopus 로고    scopus 로고
    • WNT5A expression increases during melanoma progression and correlates with outcome
    • P.D. Da Forno, J.H. Pringle, P. Hutchinson, J. Osborn, Q. Huang, and L. Potter WNT5A expression increases during melanoma progression and correlates with outcome Clin Res 14 2008 5825 5832
    • (2008) Clin Res , vol.14 , pp. 5825-5832
    • Da Forno, P.D.1    Pringle, J.H.2    Hutchinson, P.3    Osborn, J.4    Huang, Q.5    Potter, L.6
  • 16
    • 84862808809 scopus 로고    scopus 로고
    • ROR2 is a novel prognostic biomarker and a potential therapeutic target in leiomyosarcoma and gastrointestinal stromal tumour
    • B. Edris, I. Espinosa, T. Muhlenberg, A. Mikels, C.H. Lee, and S.E. Steigen ROR2 is a novel prognostic biomarker and a potential therapeutic target in leiomyosarcoma and gastrointestinal stromal tumour J Pathol 227 2012 223 233
    • (2012) J Pathol , vol.227 , pp. 223-233
    • Edris, B.1    Espinosa, I.2    Muhlenberg, T.3    Mikels, A.4    Lee, C.H.5    Steigen, S.E.6
  • 19
    • 84878881838 scopus 로고    scopus 로고
    • The dual role of the novel Wnt receptor tyrosine kinase, ROR2, in human carcinogenesis
    • C.E. Ford, S.S. Qian Ma, A. Quadir, and R.L. Ward The dual role of the novel Wnt receptor tyrosine kinase, ROR2, in human carcinogenesis Int J Cancer 133 2013 779 787
    • (2013) Int J Cancer , vol.133 , pp. 779-787
    • Ford, C.E.1    Qian Ma, S.S.2    Quadir, A.3    Ward, R.L.4
  • 20
    • 0036159121 scopus 로고    scopus 로고
    • The Ror receptor tyrosine kinase family
    • W.C. Forrester The Ror receptor tyrosine kinase family Cell Mol Life Sci 59 2002 83 96
    • (2002) Cell Mol Life Sci , vol.59 , pp. 83-96
    • Forrester, W.C.1
  • 21
    • 84859061223 scopus 로고    scopus 로고
    • Loss of Wnt5a and Ror2 protein in hepatocellular carcinoma associated with poor prognosis
    • M. Geng, Y.C. Cao, Y.J. Chen, H. Jiang, L.Q. Bi, and X.H. Liu Loss of Wnt5a and Ror2 protein in hepatocellular carcinoma associated with poor prognosis World J Gastroenterol 18 2012 1328 1338
    • (2012) World J Gastroenterol , vol.18 , pp. 1328-1338
    • Geng, M.1    Cao, Y.C.2    Chen, Y.J.3    Jiang, H.4    Bi, L.Q.5    Liu, X.H.6
  • 22
  • 23
    • 0030941498 scopus 로고    scopus 로고
    • A member of the Frizzled protein family mediating axis induction by Wnt-5A
    • X. He, J.P. Saint-Jeannet, Y. Wang, J. Nathans, I. Dawid, and H. Varmus A member of the Frizzled protein family mediating axis induction by Wnt-5A Science 275 1997 1652 1654
    • (1997) Science , vol.275 , pp. 1652-1654
    • He, X.1    Saint-Jeannet, J.P.2    Wang, Y.3    Nathans, J.4    Dawid, I.5    Varmus, H.6
  • 24
    • 84921022827 scopus 로고    scopus 로고
    • Expression of the novel Wnt receptor ROR2 is increased in breast cancer and may regulate both beta-catenin dependent and independent Wnt signalling
    • C. Henry, A. Quadir, N.J. Hawkins, E. Jary, E. Llamosas, and D. Kumar Expression of the novel Wnt receptor ROR2 is increased in breast cancer and may regulate both beta-catenin dependent and independent Wnt signalling J Cancer Res Clin Oncol 141 2015 243 245
    • (2015) J Cancer Res Clin Oncol , vol.141 , pp. 243-245
    • Henry, C.1    Quadir, A.2    Hawkins, N.J.3    Jary, E.4    Llamosas, E.5    Kumar, D.6
  • 25
    • 84907443858 scopus 로고    scopus 로고
    • Small-molecule inhibitors of the receptor tyrosine kinases: Promising tools for targeted cancer therapies
    • M. Hojjat-Farsangi Small-molecule inhibitors of the receptor tyrosine kinases: Promising tools for targeted cancer therapies Int J Mol Sci 15 2014 13768 13801
    • (2014) Int J Mol Sci , vol.15 , pp. 13768-13801
    • Hojjat-Farsangi, M.1
  • 27
    • 84903819390 scopus 로고    scopus 로고
    • A new mutation in the gene ROR2 causes brachydactyly type B1
    • D. Huang, S. Jiang, Y. Zhang, X. Liu, J. Zhang, and R. He A new mutation in the gene ROR2 causes brachydactyly type B1 Gene 547 2014 106 110
    • (2014) Gene , vol.547 , pp. 106-110
    • Huang, D.1    Jiang, S.2    Zhang, Y.3    Liu, X.4    Zhang, J.5    He, R.6
  • 28
    • 0028582185 scopus 로고
    • Crystal structure of the tyrosine kinase domain of the human insulin receptor
    • S.R. Hubbard, L. Wei, L. Ellis, and W.A. Hendrickson Crystal structure of the tyrosine kinase domain of the human insulin receptor Nature 372 1994 746 754
    • (1994) Nature , vol.372 , pp. 746-754
    • Hubbard, S.R.1    Wei, L.2    Ellis, L.3    Hendrickson, W.A.4
  • 29
    • 9644290911 scopus 로고    scopus 로고
    • The receptor tyrosine kinase Ror2 associates with and is activated by casein kinase Iepsilon
    • S. Kani, I. Oishi, H. Yamamoto, A. Yoda, H. Suzuki, and A. Nomachi The receptor tyrosine kinase Ror2 associates with and is activated by casein kinase Iepsilon J Biol Chem 279 2004 50102 50109
    • (2004) J Biol Chem , vol.279 , pp. 50102-50109
    • Kani, S.1    Oishi, I.2    Yamamoto, H.3    Yoda, A.4    Suzuki, H.5    Nomachi, A.6
  • 30
    • 34547107319 scopus 로고    scopus 로고
    • WNT signaling pathway and stem cell signaling network
    • M. Katoh, and M. Katoh WNT signaling pathway and stem cell signaling network Clin Res 13 2007 4042 4045
    • (2007) Clin Res , vol.13 , pp. 4042-4045
    • Katoh, M.1    Katoh, M.2
  • 32
    • 84869416805 scopus 로고    scopus 로고
    • Ror2-Src signaling in metastasis of mouse melanoma cells is inhibited by NRAGE
    • S.S. Lai, B. Xue, Y. Yang, L. Zhao, C.S. Chu, and J.Y. Hao Ror2-Src signaling in metastasis of mouse melanoma cells is inhibited by NRAGE Cancer Genet 205 2012 552 562
    • (2012) Cancer Genet , vol.205 , pp. 552-562
    • Lai, S.S.1    Xue, B.2    Yang, Y.3    Zhao, L.4    Chu, C.S.5    Hao, J.Y.6
  • 35
    • 84879205263 scopus 로고    scopus 로고
    • Prognostic significance of Ror2 and Wnt5a expression in medulloblastoma
    • S.E. Lee, S.D. Lim, S.Y. Kang, S.B. Suh, and Y.L. Suh Prognostic significance of Ror2 and Wnt5a expression in medulloblastoma Brain Pathol 23 2013 445 453
    • (2013) Brain Pathol , vol.23 , pp. 445-453
    • Lee, S.E.1    Lim, S.D.2    Kang, S.Y.3    Suh, S.B.4    Suh, Y.L.5
  • 36
    • 77953896432 scopus 로고    scopus 로고
    • Cell signaling by receptor tyrosine kinases
    • M.A. Lemmon, and J. Schlessinger Cell signaling by receptor tyrosine kinases Cell 141 2010 1117 1134
    • (2010) Cell , vol.141 , pp. 1117-1134
    • Lemmon, M.A.1    Schlessinger, J.2
  • 37
    • 36849046794 scopus 로고    scopus 로고
    • Homodimerization of Ror2 tyrosine kinase receptor induces 14-3-3(beta) phosphorylation and promotes osteoblast differentiation and bone formation
    • Y. Liu, J.F. Ross, P.V. Bodine, and J. Billiard Homodimerization of Ror2 tyrosine kinase receptor induces 14-3-3(beta) phosphorylation and promotes osteoblast differentiation and bone formation Mol Endocrinol 21 2007 3050 3061
    • (2007) Mol Endocrinol , vol.21 , pp. 3050-3061
    • Liu, Y.1    Ross, J.F.2    Bodine, P.V.3    Billiard, J.4
  • 38
    • 54249096215 scopus 로고    scopus 로고
    • Wnt5a induces homodimerization and activation of Ror2 receptor tyrosine kinase
    • Y. Liu, B. Rubin, P.V. Bodine, and J. Billiard Wnt5a induces homodimerization and activation of Ror2 receptor tyrosine kinase J Cell Biochem 105 2008 497 502
    • (2008) J Cell Biochem , vol.105 , pp. 497-502
    • Liu, Y.1    Rubin, B.2    Bodine, P.V.3    Billiard, J.4
  • 39
    • 84858007236 scopus 로고    scopus 로고
    • Wnt5a-Ror2 signaling between osteoblast-lineage cells and osteoclast precursors enhances osteoclastogenesis
    • K. Maeda, Y. Kobayashi, N. Udagawa, S. Uehara, A. Ishihara, and T. Mizoguchi Wnt5a-Ror2 signaling between osteoblast-lineage cells and osteoclast precursors enhances osteoclastogenesis Nat Med 18 2012 405 412
    • (2012) Nat Med , vol.18 , pp. 405-412
    • Maeda, K.1    Kobayashi, Y.2    Udagawa, N.3    Uehara, S.4    Ishihara, A.5    Mizoguchi, T.6
  • 41
    • 0027074850 scopus 로고
    • A novel family of cell surface receptors with tyrosine kinase-like domain
    • P. Masiakowski, and R.D. Carroll A novel family of cell surface receptors with tyrosine kinase-like domain J Biol Chem 267 1992 26181 26190
    • (1992) J Biol Chem , vol.267 , pp. 26181-26190
    • Masiakowski, P.1    Carroll, R.D.2
  • 42
    • 0034948866 scopus 로고    scopus 로고
    • Expression of the receptor tyrosine kinase genes, Ror1 and Ror2, during mouse development
    • T. Matsuda, M. Nomi, M. Ikeya, S. Kani, I. Oishi, and T. Terashima Expression of the receptor tyrosine kinase genes, Ror1 and Ror2, during mouse development Mech Dev 105 2001 153 156
    • (2001) Mech Dev , vol.105 , pp. 153-156
    • Matsuda, T.1    Nomi, M.2    Ikeya, M.3    Kani, S.4    Oishi, I.5    Terashima, T.6
  • 43
    • 84909993088 scopus 로고    scopus 로고
    • High expression of ROR2 in cancer cell correlates with unfavorable prognosis in colorectal cancer
    • H. Mei, S. Lian, S. Zhang, W. Wang, Q. Mao, and H. Wang High expression of ROR2 in cancer cell correlates with unfavorable prognosis in colorectal cancer Biochem Biophys Res Commun 453 2014 703 709
    • (2014) Biochem Biophys Res Commun , vol.453 , pp. 703-709
    • Mei, H.1    Lian, S.2    Zhang, S.3    Wang, W.4    Mao, Q.5    Wang, H.6
  • 44
    • 84880549135 scopus 로고    scopus 로고
    • Receptor tyrosine kinases with intracellular pseudokinase domains
    • J.M. Mendrola, F. Shi, J.H. Park, and M.A. Lemmon Receptor tyrosine kinases with intracellular pseudokinase domains Biochem Soc Trans 41 2013 1029 1036
    • (2013) Biochem Soc Trans , vol.41 , pp. 1029-1036
    • Mendrola, J.M.1    Shi, F.2    Park, J.H.3    Lemmon, M.A.4
  • 45
    • 71049147900 scopus 로고    scopus 로고
    • Ror2 receptor requires tyrosine kinase activity to mediate Wnt5A signaling
    • A. Mikels, Y. Minami, and R. Nusse Ror2 receptor requires tyrosine kinase activity to mediate Wnt5A signaling J Biol Chem 284 2009 30167 30176
    • (2009) J Biol Chem , vol.284 , pp. 30167-30176
    • Mikels, A.1    Minami, Y.2    Nusse, R.3
  • 46
    • 73949156925 scopus 로고    scopus 로고
    • Ror-family receptor tyrosine kinases in noncanonical Wnt signaling: Their implications in developmental morphogenesis and human diseases
    • Y. Minami, I. Oishi, M. Endo, and M. Nishita Ror-family receptor tyrosine kinases in noncanonical Wnt signaling: Their implications in developmental morphogenesis and human diseases Dev Dyn 239 2010 1 15
    • (2010) Dev Dyn , vol.239 , pp. 1-15
    • Minami, Y.1    Oishi, I.2    Endo, M.3    Nishita, M.4
  • 47
    • 67449103899 scopus 로고    scopus 로고
    • Orphan receptor tyrosine kinase ROR2 as a potential therapeutic target for osteosarcoma
    • K. Morioka, C. Tanikawa, K. Ochi, Y. Daigo, T. Katagiri, and H. Kawano Orphan receptor tyrosine kinase ROR2 as a potential therapeutic target for osteosarcoma Cancer Sci 100 2009 1227 1233
    • (2009) Cancer Sci , vol.100 , pp. 1227-1233
    • Morioka, K.1    Tanikawa, C.2    Ochi, K.3    Daigo, Y.4    Katagiri, T.5    Kawano, H.6
  • 48
    • 77954365864 scopus 로고    scopus 로고
    • Ror2/Frizzled complex mediates Wnt5a-induced AP-1 activation by regulating Dishevelled polymerization
    • M. Nishita, S. Itsukushima, A. Nomachi, M. Endo, Z. Wang, and D. Inaba Ror2/Frizzled complex mediates Wnt5a-induced AP-1 activation by regulating Dishevelled polymerization Mol Cell Biol 30 2010 3610 3619
    • (2010) Mol Cell Biol , vol.30 , pp. 3610-3619
    • Nishita, M.1    Itsukushima, S.2    Nomachi, A.3    Endo, M.4    Wang, Z.5    Inaba, D.6
  • 49
    • 33751215213 scopus 로고    scopus 로고
    • Filopodia formation mediated by receptor tyrosine kinase Ror2 is required for Wnt5a-induced cell migration
    • M. Nishita, S.K. Yoo, A. Nomachi, S. Kani, N. Sougawa, and Y. Ohta Filopodia formation mediated by receptor tyrosine kinase Ror2 is required for Wnt5a-induced cell migration J Cell Biol 175 2006 555 562
    • (2006) J Cell Biol , vol.175 , pp. 555-562
    • Nishita, M.1    Yoo, S.K.2    Nomachi, A.3    Kani, S.4    Sougawa, N.5    Ohta, Y.6
  • 50
    • 54249099723 scopus 로고    scopus 로고
    • Receptor tyrosine kinase Ror2 mediates Wnt5a-induced polarized cell migration by activating c-Jun N-terminal kinase via actin-binding protein filamin A
    • A. Nomachi, M. Nishita, D. Inaba, M. Enomoto, M. Hamasaki, and Y. Minami Receptor tyrosine kinase Ror2 mediates Wnt5a-induced polarized cell migration by activating c-Jun N-terminal kinase via actin-binding protein filamin A J Biol Chem 283 2008 27973 27981
    • (2008) J Biol Chem , vol.283 , pp. 27973-27981
    • Nomachi, A.1    Nishita, M.2    Inaba, D.3    Enomoto, M.4    Hamasaki, M.5    Minami, Y.6
  • 51
    • 33747353254 scopus 로고    scopus 로고
    • An early role for WNT signaling in specifying neural patterns of Cdx and Hox gene expression and motor neuron subtype identity
    • U. Nordstrom, E. Maier, T.M. Jessell, and T. Edlund An early role for WNT signaling in specifying neural patterns of Cdx and Hox gene expression and motor neuron subtype identity PLoS Biol 4 2006 e252
    • (2006) PLoS Biol , vol.4 , pp. e252
    • Nordstrom, U.1    Maier, E.2    Jessell, T.M.3    Edlund, T.4
  • 52
    • 73849123750 scopus 로고    scopus 로고
    • The orphan tyrosine kinase receptor, ROR2, mediates Wnt5A signaling in metastatic melanoma
    • M.P. O'Connell, J.L. Fiori, M. Xu, A.D. Carter, B.P. Frank, and T.C. Camilli The orphan tyrosine kinase receptor, ROR2, mediates Wnt5A signaling in metastatic melanoma Oncogene 29 2010 34 44
    • (2010) Oncogene , vol.29 , pp. 34-44
    • O'Connell, M.P.1    Fiori, J.L.2    Xu, M.3    Carter, A.D.4    Frank, B.P.5    Camilli, T.C.6
  • 53
    • 70350100352 scopus 로고    scopus 로고
    • Hear the Wnt Ror: How melanoma cells adjust to changes in Wnt
    • M.P. O'Connell, and A.T. Weeraratna Hear the Wnt Ror: How melanoma cells adjust to changes in Wnt Pigment Cell Melanoma Res 22 2009 724 739
    • (2009) Pigment Cell Melanoma Res , vol.22 , pp. 724-739
    • O'Connell, M.P.1    Weeraratna, A.T.2
  • 54
    • 0030999606 scopus 로고    scopus 로고
    • A novel Drosophila receptor tyrosine kinase expressed specifically in the nervous system. Unique structural features and implication in developmental signaling
    • I. Oishi, S. Sugiyama, Z.J. Liu, H. Yamamura, Y. Nishida, and Y. Minami A novel Drosophila receptor tyrosine kinase expressed specifically in the nervous system. Unique structural features and implication in developmental signaling J Biol Chem 272 1997 11916 11923
    • (1997) J Biol Chem , vol.272 , pp. 11916-11923
    • Oishi, I.1    Sugiyama, S.2    Liu, Z.J.3    Yamamura, H.4    Nishida, Y.5    Minami, Y.6
  • 55
    • 10744219743 scopus 로고    scopus 로고
    • The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signalling pathway
    • I. Oishi, H. Suzuki, N. Onishi, R. Takada, S. Kani, and B. Ohkawara The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signalling pathway Genes Cells 8 2003 645 654
    • (2003) Genes Cells , vol.8 , pp. 645-654
    • Oishi, I.1    Suzuki, H.2    Onishi, N.3    Takada, R.4    Kani, S.5    Ohkawara, B.6
  • 57
    • 0034727078 scopus 로고    scopus 로고
    • An LDL-receptor-related protein mediates Wnt signalling in mice
    • K.I. Pinson, J. Brennan, S. Monkley, B.J. Avery, and W.C. Skarnes An LDL-receptor-related protein mediates Wnt signalling in mice Nature 407 2000 535 538
    • (2000) Nature , vol.407 , pp. 535-538
    • Pinson, K.I.1    Brennan, J.2    Monkley, S.3    Avery, B.J.4    Skarnes, W.C.5
  • 58
    • 84883686303 scopus 로고    scopus 로고
    • Receptor tyrosine kinase-like orphan receptor 2 (Ror2) expression creates a poised state of Wnt signaling in renal cancer
    • N.R. Rasmussen, T.M. Wright, S.A. Brooks, K.E. Hacker, Z. Debebe, and A.B. Sendor Receptor tyrosine kinase-like orphan receptor 2 (Ror2) expression creates a poised state of Wnt signaling in renal cancer J Biol Chem 288 2013 26301 26310
    • (2013) J Biol Chem , vol.288 , pp. 26301-26310
    • Rasmussen, N.R.1    Wright, T.M.2    Brooks, S.A.3    Hacker, K.E.4    Debebe, Z.5    Sendor, A.B.6
  • 59
    • 0031569868 scopus 로고    scopus 로고
    • Localization of the human Ror1 gene (NTRKR1) to chromosome 1p31-p32 by fluorescence in situ hybridization and somatic cell hybrid analysis
    • U.R. Reddy, S. Phatak, C. Allen, L.M. Nycum, E.P. Sulman, and P.S. White Localization of the human Ror1 gene (NTRKR1) to chromosome 1p31-p32 by fluorescence in situ hybridization and somatic cell hybrid analysis Genomics 41 1997 283 285
    • (1997) Genomics , vol.41 , pp. 283-285
    • Reddy, U.R.1    Phatak, S.2    Allen, C.3    Nycum, L.M.4    Sulman, E.P.5    White, P.S.6
  • 60
    • 34247876138 scopus 로고    scopus 로고
    • Development trends for monoclonal antibody cancer therapeutics
    • J.M. Reichert, and V.E. Valge-Archer Development trends for monoclonal antibody cancer therapeutics Nat Rev Drug Discov. 6 2007 349 356
    • (2007) Nat Rev Drug Discov. , vol.6 , pp. 349-356
    • Reichert, J.M.1    Valge-Archer, V.E.2
  • 61
    • 36448970568 scopus 로고    scopus 로고
    • WNT5A, a putative tumour suppressor of lymphoid malignancies, is inactivated by aberrant methylation in acute lymphoblastic leukaemia
    • J. Roman-Gomez, A. Jimenez-Velasco, L. Cordeu, A. Vilas-Zornoza, E. San Jose-Eneriz, and L. Garate WNT5A, a putative tumour suppressor of lymphoid malignancies, is inactivated by aberrant methylation in acute lymphoblastic leukaemia Eur J Cancer 43 2007 2736 2746
    • (2007) Eur J Cancer , vol.43 , pp. 2736-2746
    • Roman-Gomez, J.1    Jimenez-Velasco, A.2    Cordeu, L.3    Vilas-Zornoza, A.4    San Jose-Eneriz, E.5    Garate, L.6
  • 62
    • 0031596806 scopus 로고    scopus 로고
    • Identification of a Frizzled-like cysteine rich domain in the extracellular region of developmental receptor tyrosine kinases
    • J. Saldanha, J. Singh, and D. Mahadevan Identification of a Frizzled-like cysteine rich domain in the extracellular region of developmental receptor tyrosine kinases Protein Sci 7 1998 1632 1635
    • (1998) Protein Sci , vol.7 , pp. 1632-1635
    • Saldanha, J.1    Singh, J.2    Mahadevan, D.3
  • 63
    • 0942287260 scopus 로고    scopus 로고
    • Ror2 knockout mouse as a model for the developmental pathology of autosomal recessive Robinow syndrome
    • G.C. Schwabe, B. Trepczik, K. Suring, N. Brieske, A.S. Tucker, and P.T. Sharpe Ror2 knockout mouse as a model for the developmental pathology of autosomal recessive Robinow syndrome Dev Dyn 229 2004 400 410
    • (2004) Dev Dyn , vol.229 , pp. 400-410
    • Schwabe, G.C.1    Trepczik, B.2    Suring, K.3    Brieske, N.4    Tucker, A.S.5    Sharpe, P.T.6
  • 64
    • 70349980155 scopus 로고    scopus 로고
    • A gradient of ROR2 protein stability and membrane localization confers brachydactyly type B or Robinow syndrome phenotypes
    • W. Schwarzer, F. Witte, A. Rajab, S. Mundlos, and S. Stricker A gradient of ROR2 protein stability and membrane localization confers brachydactyly type B or Robinow syndrome phenotypes Hum Mol Genet 18 2009 4013 4021
    • (2009) Hum Mol Genet , vol.18 , pp. 4013-4021
    • Schwarzer, W.1    Witte, F.2    Rajab, A.3    Mundlos, S.4    Stricker, S.5
  • 65
    • 0036490442 scopus 로고    scopus 로고
    • Smart drugs: Tyrosine kinase inhibitors in cancer therapy
    • L.K. Shawver, D. Slamon, and A. Ullrich Smart drugs: Tyrosine kinase inhibitors in cancer therapy Cancer Cell 1 2002 117 123
    • (2002) Cancer Cell , vol.1 , pp. 117-123
    • Shawver, L.K.1    Slamon, D.2    Ullrich, A.3
  • 66
    • 0028875162 scopus 로고
    • Recognition and specificity in protein tyrosine kinase-mediated signalling
    • Z. Songyang, and L.C. Cantley Recognition and specificity in protein tyrosine kinase-mediated signalling Trends Biochem Sci 20 1995 470 475
    • (1995) Trends Biochem Sci , vol.20 , pp. 470-475
    • Songyang, Z.1    Cantley, L.C.2
  • 67
    • 0028351583 scopus 로고
    • Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav
    • Z. Songyang, S.E. Shoelson, J. McGlade, P. Olivier, T. Pawson, and X.R. Bustelo Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav Mol Cell Biol 14 1994 2777 2785
    • (1994) Mol Cell Biol , vol.14 , pp. 2777-2785
    • Songyang, Z.1    Shoelson, S.E.2    McGlade, J.3    Olivier, P.4    Pawson, T.5    Bustelo, X.R.6
  • 68
    • 33644873184 scopus 로고    scopus 로고
    • Biogrid: A general repository for interaction datasets
    • C. B.B. Stark, T. Reguly, L. Boucher, A. Breitkreutz, and M. Tyers Biogrid: a general repository for interaction datasets Nucleic Acids Res 34 2006 D535 D539 (Database issue)
    • (2006) Nucleic Acids Res , vol.34 , Issue.DATABASE ISSUE , pp. D535-D539
    • Stark, C.B.B.1    Reguly, T.2    Boucher, L.3    Breitkreutz, A.4    Tyers, M.5
  • 69
    • 0025343230 scopus 로고
    • Signal transduction by receptors with tyrosine kinase activity
    • A. Ullrich, and J. Schlessinger Signal transduction by receptors with tyrosine kinase activity Cell 61 1990 203 212
    • (1990) Cell , vol.61 , pp. 203-212
    • Ullrich, A.1    Schlessinger, J.2
  • 70
    • 0034426036 scopus 로고    scopus 로고
    • Mutation of the gene encoding the ROR2 tyrosine kinase causes autosomal recessive Robinow syndrome
    • H. van Bokhoven, J. Celli, H. Kayserili, E. van Beusekom, S. Balci, and W. Brussel Mutation of the gene encoding the ROR2 tyrosine kinase causes autosomal recessive Robinow syndrome Nat Genet 25 2000 423 426
    • (2000) Nat Genet , vol.25 , pp. 423-426
    • Van Bokhoven, H.1    Celli, J.2    Kayserili, H.3    Van Beusekom, E.4    Balci, S.5    Brussel, W.6
  • 71
    • 21544439319 scopus 로고    scopus 로고
    • A Wnt-er wonderland - The complexity of Wnt signaling in melanoma
    • A.T. Weeraratna A Wnt-er wonderland - The complexity of Wnt signaling in melanoma Cancer Metastasis Rev 24 2005 237 250
    • (2005) Cancer Metastasis Rev , vol.24 , pp. 237-250
    • Weeraratna, A.T.1
  • 72
    • 48249092251 scopus 로고    scopus 로고
    • Src family kinases are required for WNT5 signaling through the Derailed/RYK receptor in the Drosophila embryonic central nervous system
    • R.R. Wouda, M.R. Bansraj, A.W. de Jong, J.N. Noordermeer, and L.G. Fradkin Src family kinases are required for WNT5 signaling through the Derailed/RYK receptor in the Drosophila embryonic central nervous system Development 135 2008 2277 2287
    • (2008) Development , vol.135 , pp. 2277-2287
    • Wouda, R.R.1    Bansraj, M.R.2    De Jong, A.W.3    Noordermeer, J.N.4    Fradkin, L.G.5
  • 73
    • 67650429679 scopus 로고    scopus 로고
    • Ror2, a developmentally regulated kinase, promotes tumor growth potential in renal cell carcinoma
    • T.M. Wright, A.R. Brannon, J.D. Gordan, A.J. Mikels, C. Mitchell, and S. Chen Ror2, a developmentally regulated kinase, promotes tumor growth potential in renal cell carcinoma Oncogene 28 2009 2513 2523
    • (2009) Oncogene , vol.28 , pp. 2513-2523
    • Wright, T.M.1    Brannon, A.R.2    Gordan, J.D.3    Mikels, A.J.4    Mitchell, C.5    Chen, S.6
  • 74
    • 77951211765 scopus 로고    scopus 로고
    • Identification of Ror2 as a hypoxia-inducible factor target in von Hippel-Lindau-associated renal cell carcinoma
    • T.M. Wright, and W.K. Rathmell Identification of Ror2 as a hypoxia-inducible factor target in von Hippel-Lindau-associated renal cell carcinoma J Biol Chem 285 2010 12916 12924
    • (2010) J Biol Chem , vol.285 , pp. 12916-12924
    • Wright, T.M.1    Rathmell, W.K.2
  • 76
    • 77950865388 scopus 로고    scopus 로고
    • Wnt5a signaling is involved in the aggressiveness of prostate cancer and expression of metalloproteinase
    • H. Yamamoto, N. Oue, A. Sato, Y. Hasegawa, H. Yamamoto, and A. Matsubara Wnt5a signaling is involved in the aggressiveness of prostate cancer and expression of metalloproteinase Oncogene 29 2010 2036 2046
    • (2010) Oncogene , vol.29 , pp. 2036-2046
    • Yamamoto, H.1    Oue, N.2    Sato, A.3    Hasegawa, Y.4    Yamamoto, H.5    Matsubara, A.6
  • 77
    • 35748986142 scopus 로고    scopus 로고
    • Wnt5a modulates glycogen synthase kinase 3 to induce phosphorylation of receptor tyrosine kinase Ror2
    • H. Yamamoto, S.K. Yoo, M. Nishita, A. Kikuchi, and Y. Minami Wnt5a modulates glycogen synthase kinase 3 to induce phosphorylation of receptor tyrosine kinase Ror2 Genes Cells 12 2007 1215 1223
    • (2007) Genes Cells , vol.12 , pp. 1215-1223
    • Yamamoto, H.1    Yoo, S.K.2    Nishita, M.3    Kikuchi, A.4    Minami, Y.5
  • 78
    • 77954112841 scopus 로고    scopus 로고
    • Epigenetic disruption of the WNT/beta-catenin signaling pathway in human cancers
    • Y. Ying, and Q. Tao Epigenetic disruption of the WNT/beta-catenin signaling pathway in human cancers Epigenetics 4 2009 307 312
    • (2009) Epigenetics , vol.4 , pp. 307-312
    • Ying, Y.1    Tao, Q.2
  • 79
    • 0037237125 scopus 로고    scopus 로고
    • Expression and function of the Ror-family receptor tyrosine kinases during development: Lessons from genetic analyses of nematodes, mice, and humans
    • A. Yoda, I. Oishi, and Y. Minami Expression and function of the Ror-family receptor tyrosine kinases during development: Lessons from genetic analyses of nematodes, mice, and humans J Recept Signal Transduct Res 23 2003 1 15
    • (2003) J Recept Signal Transduct Res , vol.23 , pp. 1-15
    • Yoda, A.1    Oishi, I.2    Minami, Y.3
  • 80
    • 78649642175 scopus 로고    scopus 로고
    • Pseudokinases - Remnants of evolution or key allosteric regulators?
    • E. Zeqiraj, and D.M. van Aalten Pseudokinases - Remnants of evolution or key allosteric regulators? Curr Opin Struct Biol 20 2010 772 781
    • (2010) Curr Opin Struct Biol , vol.20 , pp. 772-781
    • Zeqiraj, E.1    Van Aalten, D.M.2


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