Drug discovery at the single molecule level: Inhibition-in-solution assay of membrane-reconstituted β-secretase using single-molecule imaging

Analytical Chemistry

Volumn 87, Issue 8, 2015, Pages 4100-4103

  Gunnarsson, Anders ^a   Snijder, Arjan ^a   Hicks, Jennifer ^a   Gunnarsson, Jenny ^a   Höök, Fredrik ^b   Geschwindner, Stefan ^a  

^a ASTRAZENECA R AND D   (Sweden)

^b CHALMERS UNIVERSITY OF TECHNOLOGY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ASSAYS; BIOLOGICAL MEMBRANES; MOLECULES; PROTEINS;

LIMITED SENSITIVITY; MEMBRANE PROTEINS; ORDERS OF MAGNITUDE; PROTEIN CONCENTRATIONS; SCREENING APPROACHES; SINGLE MOLECULE LEVEL; SINGLE-MOLECULE IMAGING; SMALL MOLECULE INHIBITOR;

SURFACE PLASMON RESONANCE;

ASPARTIC PROTEINASE; BACE1 PROTEIN, HUMAN; ENZYME INHIBITOR; SECRETASE; SOLUTION AND SOLUBILITY;

ANTAGONISTS AND INHIBITORS; CHEMISTRY; DRUG DEVELOPMENT; HUMAN; METABOLISM; MOLECULAR IMAGING; SOLUTION AND SOLUBILITY; STRUCTURE ACTIVITY RELATION; SURFACE PLASMON RESONANCE;

AMYLOID PRECURSOR PROTEIN SECRETASES; ASPARTIC ACID ENDOPEPTIDASES; DRUG DISCOVERY; ENZYME INHIBITORS; HUMANS; MOLECULAR IMAGING; SOLUTIONS; STRUCTURE-ACTIVITY RELATIONSHIP; SURFACE PLASMON RESONANCE;

EID: 84928309434     PISSN: 00032700     EISSN: 15206882     Source Type: Journal    
DOI: 10.1021/acs.analchem.5b00740     Document Type: Article

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