Development and characterization of a novel membrane assay for full-length BACE-1 at pH 6.0

Journal of Biomolecular Screening

Volumn 18, Issue 3, 2013, Pages 277-285

  Saric, Arman ^a   Brügge, Lars Zur ^b   Müller Pompalla, Dirk ^b   Rysiok, Thomas ^b   Ousson, Solenne ^a   Permanne, Bruno ^a   Quattropani, Anna ^a   Busch, Michael ^b   Beher, Dirk ^a   Hussain, Ishrut ^a  

^a MERCK SERONO S A   (Switzerland)

^b Merck Serono GmbH   (Germany)

Author keywords

Alzheimer's disease; amyloid ; BACE 1

Indexed keywords

ASPARTIC PROTEINASE; BETA SITE AMYLOID PRECURSOR PROTEIN CLEAVING ENZYME I; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL ANALYSIS; EMBRYO; ENZYME ASSAY; GEL ELECTROPHORESIS; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; PH; PRIORITY JOURNAL; SCREENING TEST; WESTERN BLOTTING;

ALZHEIMER DISEASE; AMYLOID PRECURSOR PROTEIN SECRETASES; ASPARTIC ACID ENDOPEPTIDASES; CATALYTIC DOMAIN; CELL MEMBRANE; HEK293 CELLS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; HYDROGEN-ION CONCENTRATION; RECOMBINANT PROTEINS;

EID: 84873656989     PISSN: 10870571     EISSN: 1552454X     Source Type: Journal    
DOI: 10.1177/1087057112462237     Document Type: Article

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