Kinetics of ligand binding to membrane receptors from equilibrium fluctuation analysis of single binding events

Journal of the American Chemical Society

Volumn 133, Issue 38, 2011, Pages 14852-14855

  Gunnarsson, Anders ^a   Dexlin, Linda ^b   Wallin, Patric ^a   Svedhem, Sofia ^a   Jönsson, Peter ^a   Wingren, Christer ^b   Höök, Fredrik ^a  

^a CHALMERS UNIVERSITY OF TECHNOLOGY   (Sweden)

^b LUND UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY FRAGMENT; BINDING EVENTS; BINDING KINETICS; DISSOCIATION RATE CONSTANT; DRUG-SCREENING; EQUILIBRIUM FLUCTUATION; LIGAND BINDING; LIGAND INTERACTIONS; MEMBRANE PROTEINS; MEMBRANE RECEPTORS; SINGLE-MOLECULE SENSITIVITY; TIME-DEPENDENT; TOTAL INTERNAL REFLECTION FLUORESCENCE;

CELL MEMBRANES; CYTOLOGY; DISSOCIATION; LIGANDS; LIPOSOMES; MEMBRANES; PHOSPHOLIPIDS; RATE CONSTANTS; REFRACTIVE INDEX;

ANTIBODIES;

CELL MEMBRANE PROTEIN; LIPOSOME; MEMBRANE RECEPTOR;

ARTICLE; B LYMPHOCYTE; BINDING AFFINITY; BINDING KINETICS; CELL MEMBRANE; CELL SURFACE; CONTROLLED STUDY; DISSOCIATION CONSTANT; EQUILIBRIUM CONSTANT; FLUORESCENCE; FLUORESCENCE ACTIVATED CELL SORTING; HUMAN; HUMAN CELL; IMMOBILIZED CELL; LIGAND BINDING; MEAN RESIDENCE TIME; MEMBRANE BINDING; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN INTERACTION; SENSITIVITY ANALYSIS; TOTAL INTERNAL REFLECTION FLUORESCENCE;

B-LYMPHOCYTES; BINDING SITES; CELL MEMBRANE; HUMANS; KINETICS; LIGANDS; LIPOSOMES; MICROSCOPY, FLUORESCENCE; RECEPTORS, CELL SURFACE; SINGLE-CHAIN ANTIBODIES; STRUCTURE-ACTIVITY RELATIONSHIP; SURFACE PROPERTIES; THERMODYNAMICS; TIME FACTORS;

EID: 80053084242     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja2047039     Document Type: Article

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