The proteasome inhibitor bortezomib induces testicular toxicity by upregulation of oxidative stress, AMP-activated protein kinase (AMPK) activation and deregulation of germ cell development in adult murine testis

Toxicology and Applied Pharmacology

Volumn 285, Issue 2, 2015, Pages 98-109

  Li, Wei ^a   Fu, Jianfang ^b   Zhang, Shun ^c   Zhao, Jie ^a   Xie, Nianlin ^c   Cai, Guoqing ^b  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^c FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

AMP activated protein kinase; Anchoring junction; Apoptosis; Bortezomib; Oxidative stress; Testis

Indexed keywords

BORTEZOMIB; FOLLITROPIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; LUTEINIZING HORMONE; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; ANTINEOPLASTIC AGENT; BORONIC ACID DERIVATIVE; PROTEASOME; PYRAZINE DERIVATIVE; SEX HORMONE;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CELL INTERACTION; CELL MATURATION; CONTROLLED STUDY; DESQUAMATION; ENVIRONMENTAL STRESS; ENZYME ACTIVATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FERTILITY PRESERVATION; FOLLITROPIN BLOOD LEVEL; GERM CELL; HORMONE DETERMINATION; IMMUNOHISTOCHEMISTRY; INTRINSIC ACTIVITY; LUTEINIZING HORMONE BLOOD LEVEL; MALE; MALE FERTILITY; MOUSE; NONHUMAN; OXIDATIVE STRESS; PACHYTENE; PARACRINE SIGNALING; REPRODUCTIVE TOXICITY; SEMINIFEROUS TUBULE; SERTOLI CELL; SIGNAL TRANSDUCTION; SPERM PRESERVATION; SPERMATID; SPERMATOCYTE; SPERMATOGENESIS; SPERMATOGONIUM; SPERMATOZOON DENSITY; TESTICULAR TOXICITY; TESTIS ATROPHY; TUNEL ASSAY; UPREGULATION; WESTERN BLOTTING; ANIMAL; BLOOD; C57BL MOUSE; CHEMICALLY INDUCED; DRUG EFFECTS; FERTILITY; METABOLISM; PATHOLOGY; TESTIS; TESTIS DISEASE;

MURINAE; MUS;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BORONIC ACIDS; ENZYME ACTIVATION; FERTILITY; GERM CELLS; GONADAL STEROID HORMONES; MALE; MICE; MICE, INBRED C57BL; OXIDATIVE STRESS; PROTEASOME ENDOPEPTIDASE COMPLEX; PYRAZINES; SERTOLI CELLS; SPERMATOGENESIS; TESTICULAR DISEASES; TESTIS; UP-REGULATION;

EID: 84928170536     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2015.04.001     Document Type: Article

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