-
2
-
-
30944459963
-
A systematic search for downstream mediators of tumor suppressor function of p53reveals a major role of BTG2 in suppression of Ras-induced transformation
-
Boiko AD, Porteous S, Razorenova OV, Krivokrysenko VI, Williams BR, Gudkuv AV. (2006). A systematic search for downstream mediators of tumor suppressor function of p53reveals a major role of BTG2 in suppression of Ras-induced transformation. Genes Dev 20: 236-252.
-
(2006)
Genes Dev
, vol.20
, pp. 236-252
-
-
Boiko, A.D.1
Porteous, S.2
Razorenova, O.V.3
Krivokrysenko, V.I.4
Williams, B.R.5
Gudkuv, A.V.6
-
3
-
-
34047272645
-
Enniatin exerts p53-dependent cytostatic and p53-independent cytotoxic activities against human cancer cells
-
Dornetshuber R, Heffeter P, Kamyar MR, Peterbauer T, Berger W, Lemmens-Gruber R. (2007). Enniatin exerts p53-dependent cytostatic and p53-independent cytotoxic activities against human cancer cells. Chem Res Toxicol 20: 465-473.
-
(2007)
Chem Res Toxicol
, vol.20
, pp. 465-473
-
-
Dornetshuber, R.1
Heffeter, P.2
Kamyar, M.R.3
Peterbauer, T.4
Berger, W.5
Lemmens-Gruber, R.6
-
4
-
-
0034689558
-
P53-degradation by HPV-16 E6 preferentially affects the removal of cyclobutane pyrimidine dimmers from non-transcribed strand and sensitizes mammary epithelial cells to UV-irradiation
-
El-Mahdy MA, Hamada FM, Wani MA, Zhu Q, Wani AA. (2000). P53-degradation by HPV-16 E6 preferentially affects the removal of cyclobutane pyrimidine dimmers from non-transcribed strand and sensitizes mammary epithelial cells to UV-irradiation. Mut Res 459: 135-145.
-
(2000)
Mut Res
, vol.459
, pp. 135-145
-
-
El-Mahdy, M.A.1
Hamada, F.M.2
Wani, M.A.3
Zhu, Q.4
Wani, A.A.5
-
5
-
-
0033976110
-
Arrest of G(1)-S progression by the p53-inducible gene PC3is Rb dependent and relies on the inhibition of cyclin D1 transcription
-
Guardavaccaro D, Corrente G, Covone F, Micheli L, D'Agnano I, Starace G et al. (2000). Arrest of G(1)-S progression by the p53-inducible gene PC3is Rb dependent and relies on the inhibition of cyclin D1 transcription. Mol Cell Biol 20: 1797-1815.
-
(2000)
Mol Cell Biol
, vol.20
, pp. 1797-1815
-
-
Guardavaccaro, D.1
Corrente, G.2
Covone, F.3
Micheli, L.4
D'Agnano, I.5
Starace, G.6
-
6
-
-
0032493870
-
Differential requirement for caspase 9 in apoptotic pathways in vivo
-
Hakem R, Hakem A, Duncan GS, Henderson JT, Woo M, Soengas MS et al. (1998). Differential requirement for caspase 9 in apoptotic pathways in vivo. Cell 94: 339-352.
-
(1998)
Cell
, vol.94
, pp. 339-352
-
-
Hakem, R.1
Hakem, A.2
Duncan, G.S.3
Henderson, J.T.4
Woo, M.5
Soengas, M.S.6
-
9
-
-
0032493910
-
Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9
-
Kuida K, Haydar TF, Kuan CY, Gu Y, Taya C, Karasuyama H et al. (1998). Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9. Cell 94: 325-337.
-
(1998)
Cell
, vol.94
, pp. 325-337
-
-
Kuida, K.1
Haydar, T.F.2
Kuan, C.Y.3
Gu, Y.4
Taya, C.5
Karasuyama, H.6
-
10
-
-
0034694959
-
Primary mouse fibroblasts deficient for c-Fos, p53or both proteins are hypersensitive to UV light and alkylating agent-induced chromosomal breakage and apoptosis
-
Lackinger D, Kaina B. (2000). Primary mouse fibroblasts deficient for c-Fos, p53or both proteins are hypersensitive to UV light and alkylating agent-induced chromosomal breakage and apoptosis. Mut Res 457: 113-123.
-
(2000)
Mut Res
, vol.457
, pp. 113-123
-
-
Lackinger, D.1
Kaina, B.2
-
11
-
-
22144460207
-
Cellular UV damage responses-functions of tumor suppressor p53
-
Latonen L, Laiho M. (2006). Cellular UV damage responses-functions of tumor suppressor p53. Biochim Biophys Acta 1755: 71-89.
-
(2006)
Biochim Biophys Acta
, vol.1755
, pp. 71-89
-
-
Latonen, L.1
Laiho, M.2
-
12
-
-
33646757232
-
The complexity of p53stabilizatio n and activation
-
Lavin MF, Gueven N. (2006). The complexity of p53stabilizatio n and activation. Cell Death Differ 13: 941-950.
-
(2006)
Cell Death Differ
, vol.13
, pp. 941-950
-
-
Lavin, M.F.1
Gueven, N.2
-
13
-
-
0030715323
-
Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
-
Li P, Nijhawan D, Budihardjo I, Srinivasula SM, Ahmad M, Alnemri ES et al. (1997). Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 91: 479-489.
-
(1997)
Cell
, vol.91
, pp. 479-489
-
-
Li, P.1
Nijhawan, D.2
Budihardjo, I.3
Srinivasula, S.M.4
Ahmad, M.5
Alnemri, E.S.6
-
14
-
-
0035845852
-
P53plays a protective role against UV-and cisplatin-induced apoptosis in transcriptioncoupled repair proficient fibroblasts
-
McKay BC, Becerril C, Ljungman M. (2001). P53plays a protective role against UV-and cisplatin-induced apoptosis in transcriptioncoupled repair proficient fibroblasts. Oncogene 20: 6805-6808.
-
(2001)
Oncogene
, vol.20
, pp. 6805-6808
-
-
McKay, B.C.1
Becerril, C.2
Ljungman, M.3
-
15
-
-
0030050820
-
Tob, a novel protein that interacts with p185ErbB2, is associated with anti-proliferative activity
-
Matsuda S, Tsuzuku J, Ohsugi M, Yoshida M, Emi M, Nakamura Y et al. (1996). Tob, a novel protein that interacts with p185ErbB2, is associated with anti-proliferative activity. Oncogene 12: 705-713.
-
(1996)
Oncogene
, vol.12
, pp. 705-713
-
-
Matsuda, S.1
Tsuzuku, J.2
Ohsugi, M.3
Yoshida, M.4
Emi, M.5
Nakamura, Y.6
-
16
-
-
33846997899
-
Ultraviolet radiation triggers apoptosis of fibroblasts and skin keratinocytes mainly via the BH3-only protein Noxa
-
Naik E, Michalak EM, Villunger A, Adams JM, Strasser A. (2008). Ultraviolet radiation triggers apoptosis of fibroblasts and skin keratinocytes mainly via the BH3-only protein Noxa. J Cell Biol 176: 415-424.
-
(2008)
J Cell Biol
, vol.176
, pp. 415-424
-
-
Naik, E.1
Michalak, E.M.2
Villunger, A.3
Adams, J.M.4
Strasser, A.5
-
17
-
-
2342459790
-
DNA damage-induced apoptosis
-
Norbury CJ, Zhivotovsky B. (2004). DNA damage-induced apoptosis. Oncogene 23: 2797-2808.
-
(2004)
Oncogene
, vol.23
, pp. 2797-2808
-
-
Norbury, C.J.1
Zhivotovsky, B.2
-
18
-
-
0032570562
-
Ultraviolet radiation-induced ubiquitination and proteasomal degradation of the large subunit of RNA polymerase II
-
Ratner JN, Balasubramanian B, Corden J, Warren SL, Bregman DB. (1998). Ultraviolet radiation-induced ubiquitination and proteasomal degradation of the large subunit of RNA polymerase II. J Biol Chem 273: 5184-5189.
-
(1998)
J Biol Chem
, vol.273
, pp. 5184-5189
-
-
Ratner, J.N.1
Balasubramanian, B.2
Corden, J.3
Warren, S.L.4
Bregman, D.B.5
-
19
-
-
16144362452
-
Identification of BTG2, an antiproliferative p53-dependent component of the DNA damage cellular response pathway
-
Rouault JP, Falette N, Guehenneux F, Rimokh R, Wang Q, Berthet C et al. (1996). Identification of BTG2, an antiproliferative p53-dependent component of the DNA damage cellular response pathway. Nat Genet 14: 482-486.
-
(1996)
Nat Genet
, vol.14
, pp. 482-486
-
-
Rouault, J.P.1
Falette, N.2
Guehenneux, F.3
Rimokh, R.4
Wang, Q.5
Berthet, C.6
-
20
-
-
0037281153
-
Nicotinamine-and caspase mediated inhibition of poly(ADP-ribose) polymerase are associated with p53-independent cell cycle (G2) arrest and apoptosis
-
Saldeen J, Tillmar L, Karlsson E, Welsh N. (2003). Nicotinamine-and caspase mediated inhibition of poly(ADP-ribose) polymerase are associated with p53-independent cell cycle (G2) arrest and apoptosis. Mol Cell Biochem 243: 113-122.
-
(2003)
Mol Cell Biochem
, vol.243
, pp. 113-122
-
-
Saldeen, J.1
Tillmar, L.2
Karlsson, E.3
Welsh, N.4
-
21
-
-
0036375529
-
Antiproliferative proteins of the BTG/Tob family are degraded by the ubiquitinproteasome system
-
Sasajima H, Nakagawa K, Yokosawa H. (2002). Antiproliferative proteins of the BTG/Tob family are degraded by the ubiquitinproteasome system. Eur J Biochem 269: 3596-3604.
-
(2002)
Eur J Biochem
, vol.269
, pp. 3596-3604
-
-
Sasajima, H.1
Nakagawa, K.2
Yokosawa, H.3
-
22
-
-
0034053780
-
P53-mediated DNA repair responces to UV radiation: Studies of mouse cells lacking p53, p21 and/or gadd45 genes
-
Smith ML, Ford JM, Hollander MC, Bortnick RA, Amundson SA, Seo YR et al. (2000). P53-mediated DNA repair responces to UV radiation: studies of mouse cells lacking p53, p21 and/or gadd45 genes. Mol Cell Biol 20: 3705-3714.
-
(2000)
Mol Cell Biol
, vol.20
, pp. 3705-3714
-
-
Smith, M.L.1
Ford, J.M.2
Hollander, M.C.3
Bortnick, R.A.4
Amundson, S.A.5
Seo, Y.R.6
-
23
-
-
0036594619
-
Phosphorylation of three regulatory serines of Tob by Erk1 and Erk2 is required for Ras-mediated cell proliferation and transformation
-
Suzuki T, Tsuzuku J, Ajima R, Nakamura T, Yoshida Y, Yamamoto T. (2002). Phosphorylation of three regulatory serines of Tob by Erk1 and Erk2 is required for Ras-mediated cell proliferation and transformation. Genes Dev 16: 1357-1370.
-
(2002)
Genes Dev
, vol.16
, pp. 1357-1370
-
-
Suzuki, T.1
Tsuzuku, J.2
Ajima, R.3
Nakamura, T.4
Yoshida, Y.5
Yamamoto, T.6
-
24
-
-
0035057256
-
The gene PC3/TIS21/BTG2, prototype member of the PC3/BTG/TOB family: Regulator in control of cell growth, differentiation, and DNA repair?
-
Tirone F. (2001). The gene PC3/TIS21/BTG2, prototype member of the PC3/BTG/TOB family: regulator in control of cell growth, differentiation, and DNA repair? J Cell Physiol 187: 155-165.
-
(2001)
J Cell Physiol
, vol.187
, pp. 155-165
-
-
Tirone, F.1
-
25
-
-
30944454672
-
Apoptosis in UV-C light irradiated p53wild-type, apaf-1 and p53knockout mouse embryonic fibroblasts: Interplay of receptor and mitochondrial pathway
-
Tomicic MT, Christmann M, Kaina B. (2005). Apoptosis in UV-C light irradiated p53wild-type, apaf-1 and p53knockout mouse embryonic fibroblasts: Interplay of receptor and mitochondrial pathway. Apoptosis 10: 1295-1304.
-
(2005)
Apoptosis
, vol.10
, pp. 1295-1304
-
-
Tomicic, M.T.1
Christmann, M.2
Kaina, B.3
-
27
-
-
33845942768
-
c-Jun NH2-terminal kinase promotes apoptosis by down-regulating the transcriptional corepressor CtBP
-
Wang S-Y, Iordanov M, Zhang Q. (2006). c-Jun NH2-terminal kinase promotes apoptosis by down-regulating the transcriptional corepressor CtBP. J Biol Chem 281: 34810-34815.
-
(2006)
J Biol Chem
, vol.281
, pp. 34810-34815
-
-
Wang, S.-Y.1
Iordanov, M.2
Zhang, Q.3
-
28
-
-
0035890085
-
The expanding role of the mitochondria in apoptosis
-
Wang X. (2001). The expanding role of the mitochondria in apoptosis. Genes Dev 15: 2922-2933.
-
(2001)
Genes Dev
, vol.15
, pp. 2922-2933
-
-
Wang, X.1
-
29
-
-
0035957653
-
Proapoptotic BAX and BAK; a requisite gateway to mitochondrial dysfunction and death
-
WeiMC, Zong WX, Cheng EH, Lindstein T, Panoutsakopoulou V, Ross AJ et al. (2001). Proapoptotic BAX and BAK; a requisite gateway to mitochondrial dysfunction and death. Science 292: 727-730.
-
(2001)
Science
, vol.292
, pp. 727-730
-
-
Wei, M.C.1
Zong, W.X.2
Cheng, E.H.3
Lindstein, T.4
Panoutsakopoulou, V.5
Ross, A.J.6
-
30
-
-
15644364847
-
Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes
-
Woo M, Hakem R, Soengas MS, Duncan DS, Shahinian A, Kagi D et al. (1998). Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes. Genes Dev 12: 806-819.
-
(1998)
Genes Dev
, vol.12
, pp. 806-819
-
-
Woo, M.1
Hakem, R.2
Soengas, M.S.3
Duncan, D.S.4
Shahinian, A.5
Kagi, D.6
-
31
-
-
0032544564
-
Apaf1 is required for mitochondrial pathways of apoptosis and brain development
-
Yoshida H, Kong YY, Yoshida R, Elia AJ, Hakem A, Hakem R et al. (1998). Apaf1 is required for mitochondrial pathways of apoptosis and brain development. Cell 94: 739-750.
-
(1998)
Cell
, vol.94
, pp. 739-750
-
-
Yoshida, H.1
Kong, Y.Y.2
Yoshida, R.3
Elia, A.J.4
Hakem, A.5
Hakem, R.6
-
32
-
-
0037948872
-
Mice lacking a transcriptional corepressor Tob are predisposed to cancer
-
Yoshida Y, Nakamura T, Komoda M, Satoh H, Suzuki T, Tsuzuku J et al. (2003). Mice lacking a transcriptional corepressor Tob are predisposed to cancer. Genes Dev 17: 1201-1206.
-
(2003)
Genes Dev
, vol.17
, pp. 1201-1206
-
-
Yoshida, Y.1
Nakamura, T.2
Komoda, M.3
Satoh, H.4
Suzuki, T.5
Tsuzuku, J.6
-
33
-
-
17744389965
-
Negative regulation of BMP/Smad signaling by Tob in osteoblasts
-
Yoshida Y, Tanaka S, Umemori H, Minowa O, Usui M, Ikematsu N et al. (2000). Negative regulation of BMP/Smad signaling by Tob in osteoblasts. Cell 103: 1085-1097.
-
(2000)
Cell
, vol.103
, pp. 1085-1097
-
-
Yoshida, Y.1
Tanaka, S.2
Umemori, H.3
Minowa, O.4
Usui, M.5
Ikematsu, N.6
-
34
-
-
37849011860
-
Kruppel-like factor 5 modulates p53-independent apoptosis through Pim1 survival kinase in cancer cells
-
Zhao Y, Hamza MS, Leong HS, Lim C-B, Pan Y-F, Cheung E et al. (2008). Kruppel-like factor 5 modulates p53-independent apoptosis through Pim1 survival kinase in cancer cells. Oncogene 27: 1-8.
-
(2008)
Oncogene
, vol.27
, pp. 1-8
-
-
Zhao, Y.1
Hamza, M.S.2
Leong, H.S.3
Lim, C.-B.4
Pan, Y.-F.5
Cheung, E.6
-
35
-
-
0142258245
-
Homeodomain interacting protein kinase 2 promotes apoptosis by downregulating the transcriptional corepressor CtBP
-
Zhang Q, Yoshimatsu Y, Hildebrand J, Frish SM, Goodman RH. (2003). Homeodomain interacting protein kinase 2 promotes apoptosis by downregulating the transcriptional corepressor CtBP. Cell 115: 177-186.
-
(2003)
Cell
, vol.115
, pp. 177-186
-
-
Zhang, Q.1
Yoshimatsu, Y.2
Hildebrand, J.3
Frish, S.M.4
Goodman, R.H.5
-
36
-
-
0034707047
-
The DNA damage response: Putting checkpoints in perspective
-
Zhou BS, Elledge SJ. (2000). The DNA damage response: putting checkpoints in perspective. Nature 408: 433-439.
-
(2000)
Nature
, vol.408
, pp. 433-439
-
-
Zhou, B.S.1
Elledge, S.J.2
-
37
-
-
0035876483
-
BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak
-
Zong WX, Lindstein T, Ross AJ, MacGregor GR, Thompson CB. (2001). BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak. Genes Dev 15: 1481-1486.
-
(2001)
Genes Dev
, vol.15
, pp. 1481-1486
-
-
Zong, W.X.1
Lindstein, T.2
Ross, A.J.3
MacGregor, G.R.4
Thompson, C.B.5
-
38
-
-
0030745646
-
Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3
-
Zou H, Henzel WJ, Liu X, Lutschg A, Wang X. (1997). Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3. Cell 90: 405-413.
-
(1997)
Cell
, vol.90
, pp. 405-413
-
-
Zou, H.1
Henzel, W.J.2
Liu, X.3
Lutschg, A.4
Wang, X.5
|