메뉴 건너뛰기




Volumn 106, Issue 4, 2015, Pages 337-343

Clinical significance of estrogen receptor β in breast and prostate cancer from biological aspects

Author keywords

Breast cancer; Estrogen receptor alpha; Estrogen receptor beta; Hormone therapy; Prostate cancer

Indexed keywords

ANDROGEN; ANDROGEN RECEPTOR; ESTRADIOL; ESTROGEN; ESTROGEN RECEPTOR; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; ESTROGEN RECEPTOR BETA 2; MESSENGER RNA; TRANSCRIPTION FACTOR SP1; UNCLASSIFIED DRUG; ESTROGEN RECEPTOR ALPHA, HUMAN;

EID: 84928048056     PISSN: 13479032     EISSN: 13497006     Source Type: Journal    
DOI: 10.1111/cas.12613     Document Type: Review
Times cited : (89)

References (76)
  • 1
    • 35348931001 scopus 로고    scopus 로고
    • 5alpha-Androstane-3beta,17beta-diol (3beta-diol), an estrogenic metabolite of 5alpha-dihydrotestosterone, is a potent modulator of estrogen receptor ERbeta expression in the ventral prostrate of adult rats
    • Oliveira AG, Coelho PH, Guedes FD, Mahecha GA, Hess RA, Oliveira CA. 5alpha-Androstane-3beta, 17beta-diol (3beta-diol), an estrogenic metabolite of 5alpha-dihydrotestosterone, is a potent modulator of estrogen receptor ERbeta expression in the ventral prostrate of adult rats. Steroids 2007; 72: 914-22.
    • (2007) Steroids , vol.72 , pp. 914-922
    • Oliveira, A.G.1    Coelho, P.H.2    Guedes, F.D.3    Mahecha, G.A.4    Hess, R.A.5    Oliveira, C.A.6
  • 2
    • 0037109138 scopus 로고    scopus 로고
    • An endocrine pathway in the prostate, ERbeta, AR, 5alpha-androstane-3beta,17beta-diol, and CYP7B1, regulates prostate growth
    • Weihua Z, Lathe R, Warner M, Gustafsson JA. An endocrine pathway in the prostate, ERbeta, AR, 5alpha-androstane-3beta, 17beta-diol, and CYP7B1, regulates prostate growth. Proc Natl Acad Sci U S A 2002; 99: 13589-94.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 13589-13594
    • Weihua, Z.1    Lathe, R.2    Warner, M.3    Gustafsson, J.A.4
  • 3
    • 0027521287 scopus 로고
    • Transcriptional activation by the estrogen receptor requires a conformational change in the ligand binding domain
    • Beekman JM, Allan GF, Tsai SY, Tsai MJ, O'Malley BW. Transcriptional activation by the estrogen receptor requires a conformational change in the ligand binding domain. Mol Endocrinol 1993; 7: 1266-74.
    • (1993) Mol Endocrinol , vol.7 , pp. 1266-1274
    • Beekman, J.M.1    Allan, G.F.2    Tsai, S.Y.3    Tsai, M.J.4    O'Malley, B.W.5
  • 4
  • 6
    • 0030848501 scopus 로고    scopus 로고
    • Functional synergy between the transcription factor Sp1 and the estrogen receptor
    • Porter W, Saville B, Hoivik D, Safe S. Functional synergy between the transcription factor Sp1 and the estrogen receptor. Mol Endocrinol 1997; 11: 1569-80.
    • (1997) Mol Endocrinol , vol.11 , pp. 1569-1580
    • Porter, W.1    Saville, B.2    Hoivik, D.3    Safe, S.4
  • 7
    • 0026095725 scopus 로고
    • Hormone-dependent transcriptional regulation and cellular transformation by Fos-steroid receptor fusion proteins
    • Superti-Furga G, Bergers G, Picard D, Busslinger M. Hormone-dependent transcriptional regulation and cellular transformation by Fos-steroid receptor fusion proteins. Proc Natl Acad Sci U S A 1991; 88: 5114-8.
    • (1991) Proc Natl Acad Sci U S A , vol.88 , pp. 5114-5118
    • Superti-Furga, G.1    Bergers, G.2    Picard, D.3    Busslinger, M.4
  • 8
    • 0030801841 scopus 로고    scopus 로고
    • Differential ligand activation of estrogen receptors ERalpha and ERbeta at AP1 sites
    • Paech K, Webb P, Kuiper GG et al. Differential ligand activation of estrogen receptors ERalpha and ERbeta at AP1 sites. Science 1997; 277: 1508-10.
    • (1997) Science , vol.277 , pp. 1508-1510
    • Paech, K.1    Webb, P.2    Kuiper, G.G.3
  • 9
    • 0033305431 scopus 로고    scopus 로고
    • The estrogen receptor enhances AP-1 activity by two distinct mechanisms with different requirements for receptor transactivation functions
    • Webb P, Nguyen P, Valentine C et al. The estrogen receptor enhances AP-1 activity by two distinct mechanisms with different requirements for receptor transactivation functions. Mol Endocrinol 1999; 13: 1672-85.
    • (1999) Mol Endocrinol , vol.13 , pp. 1672-1685
    • Webb, P.1    Nguyen, P.2    Valentine, C.3
  • 10
    • 0032145924 scopus 로고    scopus 로고
    • Molecular cloning and characterization of human estrogen receptor betacx: a potential inhibitor ofestrogen action in human
    • Ogawa S, Inoue S, Watanabe T et al. Molecular cloning and characterization of human estrogen receptor betacx: a potential inhibitor ofestrogen action in human. Nucleic Acids Res 1998; 26: 3505-12.
    • (1998) Nucleic Acids Res , vol.26 , pp. 3505-3512
    • Ogawa, S.1    Inoue, S.2    Watanabe, T.3
  • 11
    • 0030931842 scopus 로고    scopus 로고
    • Identification of a splice variant of the rat estrogen receptor beta gene
    • Chu S, Fuller PJ. Identification of a splice variant of the rat estrogen receptor beta gene. Mol Cell Endocrinol 1997; 132: 195-9.
    • (1997) Mol Cell Endocrinol , vol.132 , pp. 195-199
    • Chu, S.1    Fuller, P.J.2
  • 12
    • 0031791153 scopus 로고    scopus 로고
    • Identification of estrogen receptor beta2, a functional variant of estrogen receptor beta expressed in normal rat tissues
    • Petersen DN, Tkalcevic GT, Koza-Taylor PH, Turi TG, Brown TA. Identification of estrogen receptor beta2, a functional variant of estrogen receptor beta expressed in normal rat tissues. Endocrinology 1998; 139: 1082-92.
    • (1998) Endocrinology , vol.139 , pp. 1082-1092
    • Petersen, D.N.1    Tkalcevic, G.T.2    Koza-Taylor, P.H.3    Turi, T.G.4    Brown, T.A.5
  • 13
    • 0042388370 scopus 로고    scopus 로고
    • Estrogen receptor (ER) beta1 and ERbetacx/beta2 inhibit ERalpha function differently in breast cancer cell line MCF7
    • Omoto Y, Eguchi H, Yamamoto-Yamaguchi Y, Hayashi S. Estrogen receptor (ER) beta1 and ERbetacx/beta2 inhibit ERalpha function differently in breast cancer cell line MCF7. Oncogene 2003; 22: 5011-20.
    • (2003) Oncogene , vol.22 , pp. 5011-5020
    • Omoto, Y.1    Eguchi, H.2    Yamamoto-Yamaguchi, Y.3    Hayashi, S.4
  • 14
    • 1642398054 scopus 로고    scopus 로고
    • Estrogen receptors ER alpha and ER beta in proliferation in the rodent mammary gland
    • Cheng G, Weihua Z, Warner M, Gustafsson JA. Estrogen receptors ER alpha and ER beta in proliferation in the rodent mammary gland. Proc Natl Acad Sci U S A 2004; 101: 3739-46.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 3739-3746
    • Cheng, G.1    Weihua, Z.2    Warner, M.3    Gustafsson, J.A.4
  • 15
    • 4444234730 scopus 로고    scopus 로고
    • The expression of oestrogen receptor (ER)-beta and its variants, but not ERalpha, in adult human mammary fibroblasts
    • Palmieri C, Saji S, Sakaguchi H et al. The expression of oestrogen receptor (ER)-beta and its variants, but not ERalpha, in adult human mammary fibroblasts. J Mol Endocrinol 2004; 33: 35-50.
    • (2004) J Mol Endocrinol , vol.33 , pp. 35-50
    • Palmieri, C.1    Saji, S.2    Sakaguchi, H.3
  • 16
    • 0036261086 scopus 로고    scopus 로고
    • Distinct expression patterns of ER alpha and ER beta in normal human mammary gland
    • Speirs V, Skliris GP, Burdall SE, Carder PJ. Distinct expression patterns of ER alpha and ER beta in normal human mammary gland. J Clin Pathol 2002; 55: 371-4.
    • (2002) J Clin Pathol , vol.55 , pp. 371-374
    • Speirs, V.1    Skliris, G.P.2    Burdall, S.E.3    Carder, P.J.4
  • 17
    • 1642535535 scopus 로고    scopus 로고
    • Estrogen receptor beta inhibits human breast cancer cell proliferation and tumor formation by causing a G2 cell cycle arrest
    • Paruthiyil S, Parmar H, Kerekatte V, Cunha GR, Firestone GL, Leitman DC. Estrogen receptor beta inhibits human breast cancer cell proliferation and tumor formation by causing a G2 cell cycle arrest. Cancer Res 2004; 64: 423-8.
    • (2004) Cancer Res , vol.64 , pp. 423-428
    • Paruthiyil, S.1    Parmar, H.2    Kerekatte, V.3    Cunha, G.R.4    Firestone, G.L.5    Leitman, D.C.6
  • 18
    • 34547409238 scopus 로고    scopus 로고
    • Loss of tumourigenicity of stably ERbeta-transfected MCF-7 breast cancer cells
    • Behrens D, Gill JH, Fichtner I. Loss of tumourigenicity of stably ERbeta-transfected MCF-7 breast cancer cells. Mol Cell Endocrinol 2007; 274: 19-29.
    • (2007) Mol Cell Endocrinol , vol.274 , pp. 19-29
    • Behrens, D.1    Gill, J.H.2    Fichtner, I.3
  • 19
    • 33845762296 scopus 로고    scopus 로고
    • Estrogen receptor beta inhibits angiogenesis and growth of T47D breast cancer xenografts
    • Hartman J, Lindberg K, Morani A, Inzunza J, Strom A, Gustafsson JA. Estrogen receptor beta inhibits angiogenesis and growth of T47D breast cancer xenografts. Cancer Res 2006; 66: 11207-13.
    • (2006) Cancer Res , vol.66 , pp. 11207-11213
    • Hartman, J.1    Lindberg, K.2    Morani, A.3    Inzunza, J.4    Strom, A.5    Gustafsson, J.A.6
  • 20
    • 55349099465 scopus 로고    scopus 로고
    • Different roles of estrogen receptors alpha and beta in the regulation of E-cadherin protein levels in a mouse mammary epithelial cell line
    • Helguero LA, Lindberg K, Gardmo C, Schwend T, Gustafsson JA, Haldosen LA. Different roles of estrogen receptors alpha and beta in the regulation of E-cadherin protein levels in a mouse mammary epithelial cell line. Cancer Res 2008; 68: 8695-704.
    • (2008) Cancer Res , vol.68 , pp. 8695-8704
    • Helguero, L.A.1    Lindberg, K.2    Gardmo, C.3    Schwend, T.4    Gustafsson, J.A.5    Haldosen, L.A.6
  • 21
    • 34250164212 scopus 로고    scopus 로고
    • Inhibitory effects of estrogen receptor beta on specific hormone-responsive gene expression and association with disease outcome in primary breast cancer
    • Lin CY, Strom A, Li Kong S et al. Inhibitory effects of estrogen receptor beta on specific hormone-responsive gene expression and association with disease outcome in primary breast cancer. Breast Cancer Res 2007; 9: R25.
    • (2007) Breast Cancer Res , vol.9 , pp. R25
    • Lin, C.Y.1    Strom, A.2    Li Kong, S.3
  • 23
    • 0345382876 scopus 로고    scopus 로고
    • Involvement of estrogen receptor beta in terminal differentiation of mammary gland epithelium
    • Forster C, Makela S, Warri A et al. Involvement of estrogen receptor beta in terminal differentiation of mammary gland epithelium. Proc Natl Acad Sci U S A 2002; 99: 15578-83.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 15578-15583
    • Forster, C.1    Makela, S.2    Warri, A.3
  • 24
    • 0035866760 scopus 로고    scopus 로고
    • Decreased expression of estrogen receptor beta protein in proliferative preinvasive mammary tumors
    • Roger P, Sahla ME, Makela S, Gustafsson JA, Baldet P, Rochefort H. Decreased expression of estrogen receptor beta protein in proliferative preinvasive mammary tumors. Cancer Res 2001; 61: 2537-41.
    • (2001) Cancer Res , vol.61 , pp. 2537-2541
    • Roger, P.1    Sahla, M.E.2    Makela, S.3    Gustafsson, J.A.4    Baldet, P.5    Rochefort, H.6
  • 25
    • 0036161026 scopus 로고    scopus 로고
    • Evaluation of oestrogen receptor beta wild-type and variant protein expression, and relationship with clinicopathological factors in breast cancers
    • Omoto Y, Kobayashi S, Inoue S et al. Evaluation of oestrogen receptor beta wild-type and variant protein expression, and relationship with clinicopathological factors in breast cancers. Eur J Cancer 2002; 38: 380-6.
    • (2002) Eur J Cancer , vol.38 , pp. 380-386
    • Omoto, Y.1    Kobayashi, S.2    Inoue, S.3
  • 26
    • 49249129393 scopus 로고    scopus 로고
    • Clinical importance of estrogen receptor-beta evaluation in breast cancer patients treated with adjuvant tamoxifen therapy
    • Honma N, Horii R, Iwase T et al. Clinical importance of estrogen receptor-beta evaluation in breast cancer patients treated with adjuvant tamoxifen therapy. J Clin Oncol 2008; 26: 3727-34.
    • (2008) J Clin Oncol , vol.26 , pp. 3727-3734
    • Honma, N.1    Horii, R.2    Iwase, T.3
  • 27
    • 84893513998 scopus 로고    scopus 로고
    • Differential expression of estrogen receptor alpha, beta1, and beta2 in lobular and ductal breast cancer
    • Huang B, Omoto Y, Iwase H et al. Differential expression of estrogen receptor alpha, beta1, and beta2 in lobular and ductal breast cancer. Proc Natl Acad Sci U S A 2014; 111: 1933-8.
    • (2014) Proc Natl Acad Sci U S A , vol.111 , pp. 1933-1938
    • Huang, B.1    Omoto, Y.2    Iwase, H.3
  • 28
    • 9344264630 scopus 로고    scopus 로고
    • Low levels of estrogen receptor beta protein predict resistance to tamoxifen therapy in breast cancer
    • Hopp TA, Weiss HL, Parra IS, Cui Y, Osborne CK, Fuqua SA. Low levels of estrogen receptor beta protein predict resistance to tamoxifen therapy in breast cancer. Clin Cancer Res 2004; 10: 7490-9.
    • (2004) Clin Cancer Res , vol.10 , pp. 7490-7499
    • Hopp, T.A.1    Weiss, H.L.2    Parra, I.S.3    Cui, Y.4    Osborne, C.K.5    Fuqua, S.A.6
  • 29
    • 0042326176 scopus 로고    scopus 로고
    • Clinical significance of the expression of estrogen receptors alpha and beta for endocrine therapy of breast cancer
    • Iwase H, Zhang Z, Omoto Y et al. Clinical significance of the expression of estrogen receptors alpha and beta for endocrine therapy of breast cancer. Cancer Chemother Pharmacol 2003; 52 (Suppl 1): S34-8.
    • (2003) Cancer Chemother Pharmacol , vol.52 , pp. S34-S38
    • Iwase, H.1    Zhang, Z.2    Omoto, Y.3
  • 30
    • 17844409085 scopus 로고    scopus 로고
    • Inducible upregulation of oestrogen receptor-beta1 affects oestrogen and tamoxifen responsiveness in MCF7 human breast cancer cells
    • Murphy LC, Peng B, Lewis A et al. Inducible upregulation of oestrogen receptor-beta1 affects oestrogen and tamoxifen responsiveness in MCF7 human breast cancer cells. J Mol Endocrinol 2005; 34: 553-66.
    • (2005) J Mol Endocrinol , vol.34 , pp. 553-566
    • Murphy, L.C.1    Peng, B.2    Lewis, A.3
  • 31
    • 19944429289 scopus 로고    scopus 로고
    • Prospective evaluation of estrogen receptor-beta in predicting response to neoadjuvant antiestrogen therapy in elderly breast cancer patients
    • Cappelletti V, Celio L, Bajetta E et al. Prospective evaluation of estrogen receptor-beta in predicting response to neoadjuvant antiestrogen therapy in elderly breast cancer patients. Endocr Relat Cancer 2004; 11: 761-70.
    • (2004) Endocr Relat Cancer , vol.11 , pp. 761-770
    • Cappelletti, V.1    Celio, L.2    Bajetta, E.3
  • 32
    • 52649152266 scopus 로고    scopus 로고
    • Nuclear and cytoplasmic expression of ERbeta1, ERbeta2, and ERbeta5 identifies distinct prognostic outcome for breast cancer patients
    • Shaaban AM, Green AR, Karthik S et al. Nuclear and cytoplasmic expression of ERbeta1, ERbeta2, and ERbeta5 identifies distinct prognostic outcome for breast cancer patients. Clin Cancer Res 2008; 14: 5228-35.
    • (2008) Clin Cancer Res , vol.14 , pp. 5228-5235
    • Shaaban, A.M.1    Green, A.R.2    Karthik, S.3
  • 33
    • 34548186909 scopus 로고    scopus 로고
    • Association of oestrogen receptor beta 2 (ER beta 2/ER beta cx) with outcome of adjuvant endocrine treatment for primary breast cancer-a retrospective study
    • Vinayagam R, Sibson DR, Holcombe C, Aachi V, Davies MP. Association of oestrogen receptor beta 2 (ER beta 2/ER beta cx) with outcome of adjuvant endocrine treatment for primary breast cancer-a retrospective study. BMC Cancer 2007; 7: 131.
    • (2007) BMC Cancer , vol.7 , pp. 131
    • Vinayagam, R.1    Sibson, D.R.2    Holcombe, C.3    Aachi, V.4    Davies, M.P.5
  • 34
    • 0036735297 scopus 로고    scopus 로고
    • Expression of estrogen receptor (ER) (beta)cx protein in ER(alpha)-positive breast cancer: specific correlation with progesterone receptor
    • Saji S, Omoto Y, Shimizu C et al. Expression of estrogen receptor (ER) (beta)cx protein in ER(alpha)-positive breast cancer: specific correlation with progesterone receptor. Cancer Res 2002; 62: 4849-53.
    • (2002) Cancer Res , vol.62 , pp. 4849-4853
    • Saji, S.1    Omoto, Y.2    Shimizu, C.3
  • 35
    • 37049222627 scopus 로고
    • Endocrine control of prostatic cancer
    • Huggins C. Endocrine control of prostatic cancer. Science 1943; 97: 541-4.
    • (1943) Science , vol.97 , pp. 541-544
    • Huggins, C.1
  • 36
    • 84924839303 scopus 로고
    • The effects of castration and stilboestrol on prostatic tumours in mice
    • Horning ES. The effects of castration and stilboestrol on prostatic tumours in mice. Br J Cancer 1949; 3: 211-30.
    • (1949) Br J Cancer , vol.3 , pp. 211-230
    • Horning, E.S.1
  • 37
    • 78651141915 scopus 로고
    • Management of early prostatic carcinoma
    • Barnes RW, Emery DS. Management of early prostatic carcinoma. Calif Med 1959; 91: 57-61.
    • (1959) Calif Med , vol.91 , pp. 57-61
    • Barnes, R.W.1    Emery, D.S.2
  • 38
    • 0035881269 scopus 로고    scopus 로고
    • Estrogen imprinting of the developing prostate gland is mediated through stromal estrogen receptor alpha: studies with alphaERKO and betaERKO mice
    • Prins GS, Birch L, Couse JF, Choi I, Katzenellenbogen B, Korach KS. Estrogen imprinting of the developing prostate gland is mediated through stromal estrogen receptor alpha: studies with alphaERKO and betaERKO mice. Cancer Res 2001; 61: 6089-97.
    • (2001) Cancer Res , vol.61 , pp. 6089-6097
    • Prins, G.S.1    Birch, L.2    Couse, J.F.3    Choi, I.4    Katzenellenbogen, B.5    Korach, K.S.6
  • 39
    • 50449099940 scopus 로고    scopus 로고
    • Estrogen receptor-alpha signaling in growth of the ventral prostate: comparison of neonatal growth and postcastration regrowth
    • Omoto Y. Estrogen receptor-alpha signaling in growth of the ventral prostate: comparison of neonatal growth and postcastration regrowth. Endocrinology 2008; 149: 4421-7.
    • (2008) Endocrinology , vol.149 , pp. 4421-4427
    • Omoto, Y.1
  • 40
    • 0035878926 scopus 로고    scopus 로고
    • Frequent loss of estrogen receptor-beta expression in prostate cancer
    • Horvath LG, Henshall SM, Lee CS et al. Frequent loss of estrogen receptor-beta expression in prostate cancer. Cancer Res 2001; 61: 5331-5.
    • (2001) Cancer Res , vol.61 , pp. 5331-5335
    • Horvath, L.G.1    Henshall, S.M.2    Lee, C.S.3
  • 41
    • 0030992380 scopus 로고    scopus 로고
    • Neonatal estrogen exposure up-regulates estrogen receptor expression in the developing and adult rat prostate lobes
    • Prins GS, Birch L. Neonatal estrogen exposure up-regulates estrogen receptor expression in the developing and adult rat prostate lobes. Endocrinology 1997; 138: 1801-9.
    • (1997) Endocrinology , vol.138 , pp. 1801-1809
    • Prins, G.S.1    Birch, L.2
  • 42
    • 13444283731 scopus 로고    scopus 로고
    • Estrogen receptor alpha and imprinting of the neonatal mouse ventral prostate by estrogen
    • Omoto Y, Imamov O, Warner M, Gustafsson JA. Estrogen receptor alpha and imprinting of the neonatal mouse ventral prostate by estrogen. Proc Natl Acad Sci U S A 2005; 102: 1484-9.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 1484-1489
    • Omoto, Y.1    Imamov, O.2    Warner, M.3    Gustafsson, J.A.4
  • 43
    • 0034126666 scopus 로고    scopus 로고
    • Expression of estrogen receptor (ER)-alpha and ER-beta in normal and malignant prostatic epithelial cells: regulation by methylation and involvement in growth regulation
    • Lau KM, LaSpina M, Long J, Ho SM. Expression of estrogen receptor (ER)-alpha and ER-beta in normal and malignant prostatic epithelial cells: regulation by methylation and involvement in growth regulation. Cancer Res 2000; 60: 3175-82.
    • (2000) Cancer Res , vol.60 , pp. 3175-3182
    • Lau, K.M.1    LaSpina, M.2    Long, J.3    Ho, S.M.4
  • 44
    • 2442626721 scopus 로고    scopus 로고
    • Expression of estrogen receptor beta in prostate carcinoma cells inhibits invasion and proliferation and triggers apoptosis
    • Cheng J, Lee EJ, Madison LD, Lazennec G. Expression of estrogen receptor beta in prostate carcinoma cells inhibits invasion and proliferation and triggers apoptosis. FEBS Lett 2004; 566: 169-72.
    • (2004) FEBS Lett , vol.566 , pp. 169-172
    • Cheng, J.1    Lee, E.J.2    Madison, L.D.3    Lazennec, G.4
  • 46
    • 84870316458 scopus 로고    scopus 로고
    • Estrogen receptors beta1 and beta2 have opposing roles in regulating proliferation and bone metastasis genes in the prostate cancer cell line PC3
    • Dey P, Jonsson P, Hartman J, Williams C, Strom A, Gustafsson JA. Estrogen receptors beta1 and beta2 have opposing roles in regulating proliferation and bone metastasis genes in the prostate cancer cell line PC3. Mol Endocrinol 2012; 26: 1991-2003.
    • (2012) Mol Endocrinol , vol.26 , pp. 1991-2003
    • Dey, P.1    Jonsson, P.2    Hartman, J.3    Williams, C.4    Strom, A.5    Gustafsson, J.A.6
  • 47
    • 0035912874 scopus 로고    scopus 로고
    • Estrogen receptor beta expression in human prostate tissue
    • Pasquali D, Staibano S, Prezioso D et al. Estrogen receptor beta expression in human prostate tissue. Mol Cell Endocrinol 2001; 178: 47-50.
    • (2001) Mol Cell Endocrinol , vol.178 , pp. 47-50
    • Pasquali, D.1    Staibano, S.2    Prezioso, D.3
  • 48
    • 0035408472 scopus 로고    scopus 로고
    • Comparative studies of the estrogen receptors beta and alpha and the androgen receptor in normal human prostate glands, dysplasia, and in primary and metastatic carcinoma
    • Leav I, Lau KM, Adams JY et al. Comparative studies of the estrogen receptors beta and alpha and the androgen receptor in normal human prostate glands, dysplasia, and in primary and metastatic carcinoma. Am J Pathol 2001; 159: 79-92.
    • (2001) Am J Pathol , vol.159 , pp. 79-92
    • Leav, I.1    Lau, K.M.2    Adams, J.Y.3
  • 49
    • 0035824392 scopus 로고    scopus 로고
    • Differential expression of estrogen receptor beta (ERbeta) and its C-terminal truncated splice variant ERbetacx as prognostic predictors in human prostatic cancer
    • Fujimura T, Takahashi S, Urano T et al. Differential expression of estrogen receptor beta (ERbeta) and its C-terminal truncated splice variant ERbetacx as prognostic predictors in human prostatic cancer. Biochem Biophys Res Commun 2001; 289: 692-9.
    • (2001) Biochem Biophys Res Commun , vol.289 , pp. 692-699
    • Fujimura, T.1    Takahashi, S.2    Urano, T.3
  • 50
    • 33645665487 scopus 로고    scopus 로고
    • Estrogen receptor beta polymorphism is associated with prostate cancer risk
    • Thellenberg-Karlsson C, Lindstrom S, Malmer B et al. Estrogen receptor beta polymorphism is associated with prostate cancer risk. Clin Cancer Res 2006; 12: 1936-41.
    • (2006) Clin Cancer Res , vol.12 , pp. 1936-1941
    • Thellenberg-Karlsson, C.1    Lindstrom, S.2    Malmer, B.3
  • 51
    • 84861098741 scopus 로고    scopus 로고
    • Opposing roles of ERalpha and ERbeta in the genesis and progression of adenocarcinoma in the rat ventral prostate
    • Attia DM, Ederveen AG. Opposing roles of ERalpha and ERbeta in the genesis and progression of adenocarcinoma in the rat ventral prostate. Prostate 2012; 72: 1013-22.
    • (2012) Prostate , vol.72 , pp. 1013-1022
    • Attia, D.M.1    Ederveen, A.G.2
  • 52
    • 58849083630 scopus 로고    scopus 로고
    • The evolving role of oestrogens and their receptors in the development and progression of prostate cancer
    • Bonkhoff H, Berges R. The evolving role of oestrogens and their receptors in the development and progression of prostate cancer. Eur Urol 2009; 55: 533-42.
    • (2009) Eur Urol , vol.55 , pp. 533-542
    • Bonkhoff, H.1    Berges, R.2
  • 53
    • 77957843261 scopus 로고    scopus 로고
    • Expression of estrogen related proteins in hormone refractory prostate cancer: association with tumor progression
    • Celhay O, Yacoub M, Irani J, Dore B, Cussenot O, Fromont G. Expression of estrogen related proteins in hormone refractory prostate cancer: association with tumor progression. J Urol 2010; 184: 2172-8.
    • (2010) J Urol , vol.184 , pp. 2172-2178
    • Celhay, O.1    Yacoub, M.2    Irani, J.3    Dore, B.4    Cussenot, O.5    Fromont, G.6
  • 54
    • 0032973606 scopus 로고    scopus 로고
    • Estrogen receptor-beta: implications for the prostate gland
    • Chang WY, Prins GS. Estrogen receptor-beta: implications for the prostate gland. Prostate 1999; 40: 115-24.
    • (1999) Prostate , vol.40 , pp. 115-124
    • Chang, W.Y.1    Prins, G.S.2
  • 55
    • 84055187654 scopus 로고    scopus 로고
    • Estrogen receptor beta and 17beta-hydroxysteroid dehydrogenase type 6, a growth regulatory pathway that is lost in prostate cancer
    • Muthusamy S, Andersson S, Kim HJ et al. Estrogen receptor beta and 17beta-hydroxysteroid dehydrogenase type 6, a growth regulatory pathway that is lost in prostate cancer. Proc Natl Acad Sci U S A 2011; 108: 20090-4.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 20090-20094
    • Muthusamy, S.1    Andersson, S.2    Kim, H.J.3
  • 56
    • 14344284951 scopus 로고    scopus 로고
    • A role for estrogen receptor beta in the regulation of growth of the ventral prostate
    • Weihua Z, Makela S, Andersson LC et al. A role for estrogen receptor beta in the regulation of growth of the ventral prostate. Proc Natl Acad Sci U S A 2001; 98: 6330-5.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 6330-6335
    • Weihua, Z.1    Makela, S.2    Andersson, L.C.3
  • 57
    • 3042586045 scopus 로고    scopus 로고
    • Estrogen receptor beta regulates epithelial cellular differentiation in the mouse ventral prostate
    • Imamov O, Morani A, Shim GJ et al. Estrogen receptor beta regulates epithelial cellular differentiation in the mouse ventral prostate. Proc Natl Acad Sci U S A 2004; 101: 9375-80.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 9375-9380
    • Imamov, O.1    Morani, A.2    Shim, G.J.3
  • 58
    • 77950476293 scopus 로고    scopus 로고
    • ERbeta impedes prostate cancer EMT by destabilizing HIF-1alpha and inhibiting VEGF-mediated snail nuclear localization: implications for Gleason grading
    • Mak P, Leav I, Pursell B et al. ERbeta impedes prostate cancer EMT by destabilizing HIF-1alpha and inhibiting VEGF-mediated snail nuclear localization: implications for Gleason grading. Cancer Cell 2010; 17: 319-32.
    • (2010) Cancer Cell , vol.17 , pp. 319-332
    • Mak, P.1    Leav, I.2    Pursell, B.3
  • 59
    • 61749095503 scopus 로고    scopus 로고
    • The dual, opposing roles of estrogen in the prostate
    • Ellem SJ, Risbridger GP. The dual, opposing roles of estrogen in the prostate. Ann N Y Acad Sci 2009; 1155: 174-86.
    • (2009) Ann N Y Acad Sci , vol.1155 , pp. 174-186
    • Ellem, S.J.1    Risbridger, G.P.2
  • 60
    • 0035862917 scopus 로고    scopus 로고
    • Evidence that epithelial and mesenchymal estrogen receptor-alpha mediates effects of estrogen on prostatic epithelium
    • Risbridger G, Wang H, Young P et al. Evidence that epithelial and mesenchymal estrogen receptor-alpha mediates effects of estrogen on prostatic epithelium. Dev Biol 2001; 229: 432-42.
    • (2001) Dev Biol , vol.229 , pp. 432-442
    • Risbridger, G.1    Wang, H.2    Young, P.3
  • 61
    • 43249092379 scopus 로고    scopus 로고
    • Prostatic hormonal carcinogenesis is mediated by in situ estrogen production and estrogen receptor alpha signaling
    • Ricke WA, McPherson SJ, Bianco JJ, Cunha GR, Wang Y, Risbridger GP. Prostatic hormonal carcinogenesis is mediated by in situ estrogen production and estrogen receptor alpha signaling. FASEB J 2008; 22: 1512-20.
    • (2008) FASEB J , vol.22 , pp. 1512-1520
    • Ricke, W.A.1    McPherson, S.J.2    Bianco, J.J.3    Cunha, G.R.4    Wang, Y.5    Risbridger, G.P.6
  • 62
    • 77649253043 scopus 로고    scopus 로고
    • Estrogen receptor-beta activated apoptosis in benign hyperplasia and cancer of the prostate is androgen independent and TNFalpha mediated
    • McPherson SJ, Hussain S, Balanathan P et al. Estrogen receptor-beta activated apoptosis in benign hyperplasia and cancer of the prostate is androgen independent and TNFalpha mediated. Proc Natl Acad Sci U S A 2010; 107: 3123-8.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 3123-3128
    • McPherson, S.J.1    Hussain, S.2    Balanathan, P.3
  • 63
    • 77956382505 scopus 로고    scopus 로고
    • Estrogen receptor beta and the progression of prostate cancer: role of 5alpha-androstane-3beta,17beta-diol
    • Dondi D, Piccolella M, Biserni A et al. Estrogen receptor beta and the progression of prostate cancer: role of 5alpha-androstane-3beta, 17beta-diol. Endocr Relat Cancer 2010; 17: 731-42.
    • (2010) Endocr Relat Cancer , vol.17 , pp. 731-742
    • Dondi, D.1    Piccolella, M.2    Biserni, A.3
  • 64
    • 20444457578 scopus 로고    scopus 로고
    • The androgen derivative 5alpha-androstane-3beta,17beta-diol inhibits prostate cancer cell migration through activation of the estrogen receptor beta subtype
    • Guerini V, Sau D, Scaccianoce E et al. The androgen derivative 5alpha-androstane-3beta, 17beta-diol inhibits prostate cancer cell migration through activation of the estrogen receptor beta subtype. Cancer Res 2005; 65: 5445-53.
    • (2005) Cancer Res , vol.65 , pp. 5445-5453
    • Guerini, V.1    Sau, D.2    Scaccianoce, E.3
  • 65
    • 0037081891 scopus 로고    scopus 로고
    • Dietary genistein down-regulates androgen and estrogen receptor expression in the rat prostate
    • Fritz WA, Wang J, Eltoum IE, Lamartiniere CA. Dietary genistein down-regulates androgen and estrogen receptor expression in the rat prostate. Mol Cell Endocrinol 2002; 186: 89-99.
    • (2002) Mol Cell Endocrinol , vol.186 , pp. 89-99
    • Fritz, W.A.1    Wang, J.2    Eltoum, I.E.3    Lamartiniere, C.A.4
  • 67
    • 0036196191 scopus 로고    scopus 로고
    • In the prostatic epithelium, dietary isoflavones from red clover significantly increase estrogen receptor beta and E-cadherin expression but decrease transforming growth factor beta1
    • Slater M, Brown D, Husband A. In the prostatic epithelium, dietary isoflavones from red clover significantly increase estrogen receptor beta and E-cadherin expression but decrease transforming growth factor beta1. Prostate Cancer Prostatic Dis 2002; 5: 16-21.
    • (2002) Prostate Cancer Prostatic Dis , vol.5 , pp. 16-21
    • Slater, M.1    Brown, D.2    Husband, A.3
  • 68
    • 80053562371 scopus 로고    scopus 로고
    • Development of subtype-selective oestrogen receptor-based therapeutics
    • Nilsson S, Koehler KF, Gustafsson JA. Development of subtype-selective oestrogen receptor-based therapeutics. Nat Rev Drug Discovery 2011; 10: 778-92.
    • (2011) Nat Rev Drug Discovery , vol.10 , pp. 778-792
    • Nilsson, S.1    Koehler, K.F.2    Gustafsson, J.A.3
  • 69
    • 34249659228 scopus 로고    scopus 로고
    • Estrogen receptor beta (ERbeta) and inhibition of prostate cancer cell proliferation: studies on the possible mechanism of action in DU145 cells
    • Pravettoni A, Mornati O, Martini PG et al. Estrogen receptor beta (ERbeta) and inhibition of prostate cancer cell proliferation: studies on the possible mechanism of action in DU145 cells. Mol Cell Endocrinol 2007; 263: 46-54.
    • (2007) Mol Cell Endocrinol , vol.263 , pp. 46-54
    • Pravettoni, A.1    Mornati, O.2    Martini, P.G.3
  • 70
    • 34548825107 scopus 로고    scopus 로고
    • Delay of postnatal maturation sensitizes the mouse prostate to testosterone-induced pronounced hyperplasia: protective role of estrogen receptor-beta
    • Savolainen S, Pakarainen T, Huhtaniemi I, Poutanen M, Makela S. Delay of postnatal maturation sensitizes the mouse prostate to testosterone-induced pronounced hyperplasia: protective role of estrogen receptor-beta. Am J Pathol 2007; 171: 1013-22.
    • (2007) Am J Pathol , vol.171 , pp. 1013-1022
    • Savolainen, S.1    Pakarainen, T.2    Huhtaniemi, I.3    Poutanen, M.4    Makela, S.5
  • 71
    • 84906283646 scopus 로고    scopus 로고
    • Estrogen receptor beta upregulates FOXO3a and causes induction of apoptosis through PUMA in prostate cancer
    • Dey P, Strom A, Gustafsson JA. Estrogen receptor beta upregulates FOXO3a and causes induction of apoptosis through PUMA in prostate cancer. Oncogene 2014; 33: 4213-25.
    • (2014) Oncogene , vol.33 , pp. 4213-4225
    • Dey, P.1    Strom, A.2    Gustafsson, J.A.3
  • 72
    • 84907210114 scopus 로고    scopus 로고
    • Targeting the PI3K/Akt pathway in prostate cancer: Challenges and opportunities (Review)
    • Toren P, Zoubeidi A. Targeting the PI3K/Akt pathway in prostate cancer: Challenges and opportunities (Review). Int J Oncol 2014; 45: 1793-801.
    • (2014) Int J Oncol , vol.45 , pp. 1793-1801
    • Toren, P.1    Zoubeidi, A.2
  • 73
    • 84874676963 scopus 로고    scopus 로고
    • Dose-dependent effect of tamoxifen in tamoxifen-resistant breast cancer cells via stimulation by the ERK1/2 and AKT signaling pathways
    • Wang LJ, Han SX, Bai E et al. Dose-dependent effect of tamoxifen in tamoxifen-resistant breast cancer cells via stimulation by the ERK1/2 and AKT signaling pathways. Oncol Rep 2013; 29: 1563-9.
    • (2013) Oncol Rep , vol.29 , pp. 1563-1569
    • Wang, L.J.1    Han, S.X.2    Bai, E.3
  • 74
    • 84901986884 scopus 로고    scopus 로고
    • Targeting the PI3K/AKT/mTOR pathway in estrogen receptor-positive breast cancer
    • Ciruelos Gil EM. Targeting the PI3K/AKT/mTOR pathway in estrogen receptor-positive breast cancer. Cancer Treat Rev 2014; 40: 862-71.
    • (2014) Cancer Treat Rev , vol.40 , pp. 862-871
    • Ciruelos Gil, E.M.1
  • 75
    • 84901438787 scopus 로고    scopus 로고
    • Use of mTOR inhibitors in the treatment of breast cancer: an evaluation of factors that influence patient outcomes
    • Jerusalem G, Rorive A, Collignon J. Use of mTOR inhibitors in the treatment of breast cancer: an evaluation of factors that influence patient outcomes. Breast Cancer 2014; 6: 43-57.
    • (2014) Breast Cancer , vol.6 , pp. 43-57
    • Jerusalem, G.1    Rorive, A.2    Collignon, J.3
  • 76
    • 84863078767 scopus 로고    scopus 로고
    • Everolimus in postmenopausal hormone-receptor-positive advanced breast cancer
    • Baselga J, Campone M, Piccart M et al. Everolimus in postmenopausal hormone-receptor-positive advanced breast cancer. N Engl J Med 2012; 366: 520-9.
    • (2012) N Engl J Med , vol.366 , pp. 520-529
    • Baselga, J.1    Campone, M.2    Piccart, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.