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Volumn 5, Issue 10, 2014, Pages

Polycomb protein EZH2 suppresses apoptosis by silencing the proapoptotic miR-31

Author keywords

[No Author keywords available]

Indexed keywords

DOCETAXEL; HISTONE H3; LYSINE; LYSINE 27; MICRORNA 205; MICRORNA 31; POLYCOMB PROTEIN EZH2; PROTEIN BCL W; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR E2F6; TRANSCRIPTION FACTOR EZH2; UNCLASSIFIED DRUG; EZH2 PROTEIN, HUMAN; HISTONE; MICRORNA; MIRN205 MICRORNA, HUMAN; MIRN31 MICRORNA, HUMAN; POLYCOMB REPRESSIVE COMPLEX 2; TAXOID;

EID: 84928017601     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2014.454     Document Type: Article
Times cited : (74)

References (43)
  • 1
    • 0036830642 scopus 로고    scopus 로고
    • Role of histone H3 lysine 27 methylation in polycomb-group silencing
    • Cao R, Wang L, Wang H, Xia L, Erdjument-Bromage H, Tempst P et al. Role of histone H3 lysine 27 methylation in polycomb-group silencing. Science 2002; 298: 1039-1043.
    • (2002) Science , vol.298 , pp. 1039-1043
    • Cao, R.1    Wang, L.2    Wang, H.3    Xia, L.4    Erdjument-Bromage, H.5    Tempst, P.6
  • 2
    • 55949136562 scopus 로고    scopus 로고
    • Roles of the EZH2 histone methyltransferase in cancer epigenetics
    • Simon JA, Lange CA. Roles of the EZH2 histone methyltransferase in cancer epigenetics. Mutat Res 2008; 647: 21-29.
    • (2008) Mutat Res , vol.647 , pp. 21-29
    • Simon, J.A.1    Lange, C.A.2
  • 3
    • 79955513100 scopus 로고    scopus 로고
    • Aberrations of EZH2 in cancer
    • Chase A, Cross NC. Aberrations of EZH2 in cancer. Clin Cancer Res 2011; 17: 2613-2618.
    • (2011) Clin Cancer Res , vol.17 , pp. 2613-2618
    • Chase, A.1    Cross, N.C.2
  • 5
    • 33748951908 scopus 로고    scopus 로고
    • Essential role for activation of the polycomb group (PcG) protein chromatin silencing pathway in metastatic prostate cancer
    • Berezovska OP, Glinskii AB, Yang Z, Li XM, Hoffman RM, Glinsky GV et al. Essential role for activation of the polycomb group (PcG) protein chromatin silencing pathway in metastatic prostate cancer. Cell Cycle 2006; 5: 1886-1901.
    • (2006) Cell Cycle , vol.5 , pp. 1886-1901
    • Berezovska, O.P.1    Glinskii, A.B.2    Yang, Z.3    Li, X.M.4    Hoffman, R.M.5    Glinsky, G.V.6
  • 6
    • 0141816752 scopus 로고    scopus 로고
    • EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells
    • Kleer CG, Cao Q, Varambally S, Shen R, Ota I, Tomlins SA et al. EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells. Proc Natl Acad Sci USA 2003; 100: 11606-11611.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 11606-11611
    • Kleer, C.G.1    Cao, Q.2    Varambally, S.3    Shen, R.4    Ota, I.5    Tomlins, S.A.6
  • 7
    • 33644822360 scopus 로고    scopus 로고
    • EZH2 expression is associated with high proliferation rate and aggressive tumor subgroups in cutaneous melanoma and cancers of the endometrium, prostate, and breast
    • Bachmann IM, Halvorsen OJ, Collett K, Stefansson IM, Straume O, Haukaas SA et al. EZH2 expression is associated with high proliferation rate and aggressive tumor subgroups in cutaneous melanoma and cancers of the endometrium, prostate, and breast. J Clin Oncol 2006; 24: 268-273.
    • (2006) J Clin Oncol , vol.24 , pp. 268-273
    • Bachmann, I.M.1    Halvorsen, O.J.2    Collett, K.3    Stefansson, I.M.4    Straume, O.5    Haukaas, S.A.6
  • 8
    • 84877330098 scopus 로고    scopus 로고
    • Multifaceted role of EZH2 in breast and prostate tumorigenesis: Epigenetics and beyond
    • Deb G, Thakur VS, Gupta S. Multifaceted role of EZH2 in breast and prostate tumorigenesis: epigenetics and beyond. Epigenetics 2013; 8: 464-476.
    • (2013) Epigenetics , vol.8 , pp. 464-476
    • Deb, G.1    Thakur, V.S.2    Gupta, S.3
  • 9
    • 78650062951 scopus 로고    scopus 로고
    • EZH2-mediated epigenetic silencing in germinal center B cells contributes to proliferation and lymphomagenesis
    • Velichutina I, Shaknovich R, Geng H, Johnson NA, Gascoyne RD, Melnick AM et al. EZH2-mediated epigenetic silencing in germinal center B cells contributes to proliferation and lymphomagenesis. Blood 2010; 116: 5247-5255.
    • (2010) Blood , vol.116 , pp. 5247-5255
    • Velichutina, I.1    Shaknovich, R.2    Geng, H.3    Johnson, N.A.4    Gascoyne, R.D.5    Melnick, A.M.6
  • 10
    • 57649124289 scopus 로고    scopus 로고
    • Repression of E-cadherin by the polycomb group protein EZH2 in cancer
    • Cao Q, Yu J, Dhanasekaran SM, Kim JH, Mani RS, Tomlins SA et al. Repression of E-cadherin by the polycomb group protein EZH2 in cancer. Oncogene 2008; 27: 7274-7284.
    • (2008) Oncogene , vol.27 , pp. 7274-7284
    • Cao, Q.1    Yu, J.2    Dhanasekaran, S.M.3    Kim, J.H.4    Mani, R.S.5    Tomlins, S.A.6
  • 11
    • 84905174595 scopus 로고    scopus 로고
    • MicroRNA-124 inhibits proliferation and induces apoptosis by directly repressing EZH2 in gastric cancer
    • Xie L, Zhang Z, Tan Z, He R, Zeng X, Xie Y et al. MicroRNA-124 inhibits proliferation and induces apoptosis by directly repressing EZH2 in gastric cancer. Mol Cell Biochem 2014; 392: 153-159.
    • (2014) Mol Cell Biochem , vol.392 , pp. 153-159
    • Xie, L.1    Zhang, Z.2    Tan, Z.3    He, R.4    Zeng, X.5    Xie, Y.6
  • 12
    • 84892396920 scopus 로고    scopus 로고
    • Methyl jasmonate sensitizes human bladder cancer cells to gambogic acid-induced apoptosis through down-regulation of EZH2 expression by miR-101
    • Wang Y, Xiang W, Wang M, Huang T, Xiao X, Wang L et al. Methyl jasmonate sensitizes human bladder cancer cells to gambogic acid-induced apoptosis through down-regulation of EZH2 expression by miR-101. Br J Pharmacol 2014; 171: 618-635.
    • (2014) Br J Pharmacol , vol.171 , pp. 618-635
    • Wang, Y.1    Xiang, W.2    Wang, M.3    Huang, T.4    Xiao, X.5    Wang, L.6
  • 13
    • 34247625135 scopus 로고    scopus 로고
    • Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells
    • Tan J, Yang X, Zhuang L, Jiang X, Chen W, Lee PL et al. Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells. Genes Dev 2007; 21: 1050-1063.
    • (2007) Genes Dev , vol.21 , pp. 1050-1063
    • Tan, J.1    Yang, X.2    Zhuang, L.3    Jiang, X.4    Chen, W.5    Lee, P.L.6
  • 14
    • 50549103560 scopus 로고    scopus 로고
    • The enhancer of zeste homolog 2 gene contributes to cell proliferation and apoptosis resistance in renal cell carcinoma cells
    • Wagener N, Holland D, Bulkescher J, Crnković-Mertens I, Hoppe-Seyler K, Zentgraf H et al. The enhancer of zeste homolog 2 gene contributes to cell proliferation and apoptosis resistance in renal cell carcinoma cells. Int J Cancer 2008; 123: 1545-1550.
    • (2008) Int J Cancer , vol.123 , pp. 1545-1550
    • Wagener, N.1    Holland, D.2    Bulkescher, J.3    Crnković-Mertens, I.4    Hoppe-Seyler, K.5    Zentgraf, H.6
  • 15
    • 77950866779 scopus 로고    scopus 로고
    • Polycomb protein EZH2 regulates E2F1-dependent apoptosis through epigenetically modulating Bim expression
    • Wu ZL, Zheng SS, Li ZM, Qiao YY, Aau MY, Yu Q et al. Polycomb protein EZH2 regulates E2F1-dependent apoptosis through epigenetically modulating Bim expression. Cell Death Differ 2010; 17: 801-810.
    • (2010) Cell Death Differ , vol.17 , pp. 801-810
    • Wu, Z.L.1    Zheng, S.S.2    Li, Z.M.3    Qiao, Y.Y.4    Aau, M.Y.5    Yu, Q.6
  • 18
    • 58249088751 scopus 로고    scopus 로고
    • MicroRNAs: Target recognition and regulatory functions
    • Bartel DP. MicroRNAs: target recognition and regulatory functions. Cell 2009; 136: 215-233.
    • (2009) Cell , vol.136 , pp. 215-233
    • Bartel, D.P.1
  • 19
    • 66449136951 scopus 로고    scopus 로고
    • Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer model
    • Kota J, Chivukula RR, O'Donnell KA, Wentzel EA, Montgomery CL, Hwang HW et al. Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer model. Cell 2009; 137: 1005-1017.
    • (2009) Cell , vol.137 , pp. 1005-1017
    • Kota, J.1    Chivukula, R.2    O'Donnell, K.A.3    Wentzel, E.A.4    Montgomery, C.L.5    Hwang, H.W.6
  • 20
    • 0346727524 scopus 로고    scopus 로고
    • MicroRNAs modulate hematopoietic lineage differentiation
    • Chen CZ, Li L, Lodish HF, Bartel DP. MicroRNAs modulate hematopoietic lineage differentiation. Science 2004; 303: 83-86.
    • (2004) Science , vol.303 , pp. 83-86
    • Chen, C.Z.1    Li, L.2    Lodish, H.F.3    Bartel, D.P.4
  • 21
    • 66549101276 scopus 로고    scopus 로고
    • Patterns of microRNA expression characterize stages of human B-cell differentiation
    • Zhang J, Jima DD, Jacobs C, Fischer R, Gottwein E, Huang G et al. Patterns of microRNA expression characterize stages of human B-cell differentiation. Blood 2009; 113: 4586-4594.
    • (2009) Blood , vol.113 , pp. 4586-4594
    • Zhang, J.1    Jima, D.D.2    Jacobs, C.3    Fischer, R.4    Gottwein, E.5    Huang, G.6
  • 23
    • 35148886434 scopus 로고    scopus 로고
    • Tumour invasion and metastasis initiated by microRNA-10b in breast cancer
    • Ma L, Teruya-Feldstein J, Weinberg RA. Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. Nature 2007; 449: 682-688.
    • (2007) Nature , vol.449 , pp. 682-688
    • Ma, L.1    Teruya-Feldstein, J.2    Weinberg, R.A.3
  • 24
    • 74249123570 scopus 로고    scopus 로고
    • The miR-34 family in cancer and apoptosis
    • Hermeking H. The miR-34 family in cancer and apoptosis. Cell Death Differ 2010; 17: 193-199.
    • (2010) Cell Death Differ , vol.17 , pp. 193-199
    • Hermeking, H.1
  • 25
    • 79959811503 scopus 로고    scopus 로고
    • Downregulation of miR-205 and miR-31 confers resistance to chemotherapy-induced apoptosis in prostate cancer cells
    • Bhatnagar N, Li X, Padi SK, Zhang Q, Tang MS, Guo B et al. Downregulation of miR-205 and miR-31 confers resistance to chemotherapy-induced apoptosis in prostate cancer cells. Cell Death Dis 2010; 1: e105.
    • (2010) Cell Death Dis , vol.1 , pp. e105
    • Bhatnagar, N.1    Li, X.2    Padi, S.K.3    Zhang, Q.4    Tang, M.S.5    Guo, B.6
  • 26
    • 84862907856 scopus 로고    scopus 로고
    • Polycombmediated loss of miR-31 activates NIK-dependent NF-kappaB pathway in adult T cell leukemia and other cancers
    • Yamagishi M, Nakano K, Miyake A, Yamochi T, Kagami Y, Tsutsumi A et al. Polycombmediated loss of miR-31 activates NIK-dependent NF-kappaB pathway in adult T cell leukemia and other cancers. Cancer Cell 2012; 21: 121-135.
    • (2012) Cancer Cell , vol.21 , pp. 121-135
    • Yamagishi, M.1    Nakano, K.2    Miyake, A.3    Yamochi, T.4    Kagami, Y.5    Tsutsumi, A.6
  • 27
    • 80052680422 scopus 로고    scopus 로고
    • The histone methyltransferase inhibitor, DZNep, up-regulates TXNIP, increases ROS production, and targets leukemia cells in AML
    • Zhou J, Bi C, Cheong LL, Mahara S, Liu SC, Tay KG et al. The histone methyltransferase inhibitor, DZNep, up-regulates TXNIP, increases ROS production, and targets leukemia cells in AML. Blood 2011; 118: 2830-2839.
    • (2011) Blood , vol.118 , pp. 2830-2839
    • Zhou, J.1    Bi, C.2    Cheong, L.L.3    Mahara, S.4    Liu, S.C.5    Tay, K.G.6
  • 28
    • 33947359114 scopus 로고    scopus 로고
    • E2F6 negatively regulates ultraviolet-induced apoptosis via modulation of BRCA1
    • Yang WW, Wang ZH, Zhu Y, Yang HT. E2F6 negatively regulates ultraviolet-induced apoptosis via modulation of BRCA1. Cell Death Differ 2007; 14: 807-817.
    • (2007) Cell Death Differ , vol.14 , pp. 807-817
    • Yang, W.W.1    Wang, Z.H.2    Zhu, Y.3    Yang, H.T.4
  • 29
    • 55549125229 scopus 로고    scopus 로고
    • E2F6 inhibits cobalt chloride-mimetic hypoxia-induced apoptosis through E2F1
    • Yang WW, Shu B, Zhu Y, Yang HT. E2F6 inhibits cobalt chloride-mimetic hypoxia-induced apoptosis through E2F1. Mol Biol Cell 2008; 19: 3691-3700.
    • (2008) Mol Biol Cell , vol.19 , pp. 3691-3700
    • Yang, W.W.1    Shu, B.2    Zhu, Y.3    Yang, H.T.4
  • 30
    • 65549115615 scopus 로고    scopus 로고
    • MiR-205 exerts tumor-suppressive functions in human prostate through down-regulation of protein kinase Cepsilon
    • Gandellini P, Folini M, Longoni N, Pennati M, Binda M, Colecchia M et al. MiR-205 exerts tumor-suppressive functions in human prostate through down-regulation of protein kinase Cepsilon. Cancer Res 2009; 69: 2287-2295.
    • (2009) Cancer Res , vol.69 , pp. 2287-2295
    • Gandellini, P.1    Folini, M.2    Longoni, N.3    Pennati, M.4    Binda, M.5    Colecchia, M.6
  • 31
    • 84868622986 scopus 로고    scopus 로고
    • Genetic and epigenetic loss of microRNA-31 leads to feed-forward expression of EZH2 in melanoma
    • Asangani IA, Harms PW, Dodson L, Pandhi M, Kunju LP, Maher CA et al. Genetic and epigenetic loss of microRNA-31 leads to feed-forward expression of EZH2 in melanoma. Oncotarget 2012; 3: 1011-1025.
    • (2012) Oncotarget , vol.3 , pp. 1011-1025
    • Asangani, I.A.1    Harms, P.W.2    Dodson, L.3    Pandhi, M.4    Kunju, L.P.5    Maher, C.A.6
  • 32
    • 57149107384 scopus 로고    scopus 로고
    • Activation of the enhancer of zeste homologue 2 gene by the human papillomavirus E7 oncoprotein
    • Holland D, Hoppe-Seyler K, Schuller B, Lohrey C, Maroldt J, Dürst M et al. Activation of the enhancer of zeste homologue 2 gene by the human papillomavirus E7 oncoprotein. Cancer Res 2008; 68: 9964-9972.
    • (2008) Cancer Res , vol.68 , pp. 9964-9972
    • Holland, D.1    Hoppe-Seyler, K.2    Schuller, B.3    Lohrey, C.4    Maroldt, J.5    Dürst, M.6
  • 33
    • 33744519651 scopus 로고    scopus 로고
    • Expression of the enhancer of zeste homolog 2 is correlated with poor prognosis in human gastric cancer
    • Matsukawa Y, Semba S, Kato H, Ito A, Yanagihara K, Yokozaki H et al. Expression of the enhancer of zeste homolog 2 is correlated with poor prognosis in human gastric cancer. Cancer Sci 2006; 97: 484-491.
    • (2006) Cancer Sci , vol.97 , pp. 484-491
    • Matsukawa, Y.1    Semba, S.2    Kato, H.3    Ito, A.4    Yanagihara, K.5    Yokozaki, H.6
  • 34
    • 84889263268 scopus 로고    scopus 로고
    • Role of EZH2 in the growth of prostate cancer stem cells isolated from LNCaP cells
    • Li K, Liu C, Zhou B, Bi L, Huang H, Lin T et al. Role of EZH2 in the growth of prostate cancer stem cells isolated from LNCaP cells. Int J Mol Sci 2013; 14: 11981-11993.
    • (2013) Int J Mol Sci , vol.14 , pp. 11981-11993
    • Li, K.1    Liu, C.2    Zhou, B.3    Bi, L.4    Huang, H.5    Lin, T.6
  • 35
    • 84879672675 scopus 로고    scopus 로고
    • MicroRNA-205, a novel regulator of the anti-apoptotic protein Bcl2, is downregulated in prostate cancer
    • Verdoodt B, Neid M, Vogt M, Kuhn V, Liffers ST, Palisaar RJ et al. MicroRNA-205, a novel regulator of the anti-apoptotic protein Bcl2, is downregulated in prostate cancer. Int J Oncol 2013; 43: 307-314.
    • (2013) Int J Oncol , vol.43 , pp. 307-314
    • Verdoodt, B.1    Neid, M.2    Vogt, M.3    Kuhn, V.4    Liffers, S.T.5    Palisaar, R.J.6
  • 36
    • 58149239686 scopus 로고    scopus 로고
    • Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer
    • Varambally S, Cao Q, Mani RS, Shankar S, Wang X, Ateeq B et al. Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer. Science 2008; 322: 1695-1699.
    • (2008) Science , vol.322 , pp. 1695-1699
    • Varambally, S.1    Cao, Q.2    Mani, R.S.3    Shankar, S.4    Wang, X.5    Ateeq, B.6
  • 37
    • 84876211114 scopus 로고    scopus 로고
    • MiR-101 inhibits autophagy and enhances cisplatin-induced apoptosis in hepatocellular carcinoma cells
    • Xu Y, An Y, Wang Y, Zhang C, Zhang H, Huang C et al. MiR-101 inhibits autophagy and enhances cisplatin-induced apoptosis in hepatocellular carcinoma cells. Oncol Rep 2013; 29: 2019-2024.
    • (2013) Oncol Rep , vol.29 , pp. 2019-2024
    • Xu, Y.1    An, Y.2    Wang, Y.3    Zhang, C.4    Zhang, H.5    Huang, C.6
  • 38
    • 84859189630 scopus 로고    scopus 로고
    • Myc enforces overexpression of EZH2 in early prostatic neoplasia via transcriptional and posttranscriptional mechanisms
    • Koh CM, Iwata T, Zheng Q, Bethel C, Yegnasubramanian S, De Marzo AM et al. Myc enforces overexpression of EZH2 in early prostatic neoplasia via transcriptional and posttranscriptional mechanisms. Oncotarget 2011; 2: 669-683.
    • (2011) Oncotarget , vol.2 , pp. 669-683
    • Koh, C.M.1    Iwata, T.2    Zheng, Q.3    Bethel, C.4    Yegnasubramanian, S.5    De Marzo, A.M.6
  • 39
    • 77952103123 scopus 로고    scopus 로고
    • An integrated network of androgen receptor, polycomb, and TMPRSS2-ERG gene fusions in prostate cancer progression
    • Yu J, Mani RS, Cao Q, Brenner CJ, Cao X,Wang X et al. An integrated network of androgen receptor, polycomb, and TMPRSS2-ERG gene fusions in prostate cancer progression. Cancer Cell 2010; 17: 443-454.
    • (2010) Cancer Cell , vol.17 , pp. 443-454
    • Yu, J.1    Mani, R.S.2    Cao, Q.3    Brenner, C.J.4    Cao, X.5    Wang, X.6
  • 40
    • 84873507539 scopus 로고    scopus 로고
    • Epigenetic repression of miR-31 disrupts androgen receptor homeostasis and contributes to prostate cancer progression
    • Lin PC, Chiu YL, Banerjee S, Park K, Mosquera JM, Giannopoulou E et al. Epigenetic repression of miR-31 disrupts androgen receptor homeostasis and contributes to prostate cancer progression. Cancer Res 2013; 73: 1232-1244.
    • (2013) Cancer Res , vol.73 , pp. 1232-1244
    • Lin, P.C.1    Chiu, Y.L.2    Banerjee, S.3    Park, K.4    Mosquera, J.M.5    Giannopoulou, E.6
  • 41
    • 72249107533 scopus 로고    scopus 로고
    • Gene silencing of MIR22 in acute lymphoblastic leukaemia involves histone modifications independent of promoter DNA methylation
    • Li X, Liu J, Zhou R, Huang S, Huang S, Chen XM et al. Gene silencing of MIR22 in acute lymphoblastic leukaemia involves histone modifications independent of promoter DNA methylation. Br J Haematol 2009.
    • (2009) Br J Haematol
    • Li, X.1    Liu, J.2    Zhou, R.3    Huang, S.4    Huang, S.5    Chen, X.M.6
  • 42
    • 84870573126 scopus 로고    scopus 로고
    • EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations
    • McCabe MT, Ott HM, Ganji G, Korenchuk S, Thompson C, Van Aller GS et al. EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations. Nature 2012; 492: 108-112.
    • (2012) Nature , vol.492 , pp. 108-112
    • McCabe, M.T.1    Ott, H.M.2    Ganji, G.3    Korenchuk, S.4    Thompson, C.5    Van Aller, G.S.6


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