Palbociclib, a selective inhibitor of cyclin-dependent kinase4/6, blocks HIV-1 reverse transcription through the control of sterile a motif and HD domain-containing protein-1 (SAMHD1) activity

AIDS

Volumn 28, Issue 15, 2014, Pages 2213-2222

  Pauls, Eduardo ^a   Badia, Roger ^a   Torres Torronteras, Javier ^b   Ruiz, Alba ^a   Permanyer, Marc ^a   Riveira Muñoz, Eva ^a   Clotet, Bonaventura ^a   Marti, Ramón ^b   Ballana, Ester ^a   Esté, José A ^a  

^a UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^b HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

Author keywords

CDK2; CDK6; HIV 1; Restriction factor; SAMHD1

Indexed keywords

AT 7519; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 6; GREEN FLUORESCENT PROTEIN; INTERLEUKIN 2; PALBOCICLIB; PROTEIN; PURVALANOL A; RALTEGRAVIR; ROSCOVITINE; STERIL ALPHA MOTIF AND HD DOMAIN CONTAINING PROTEIN 1; UNCLASSIFIED DRUG; VIRUS DNA; ZIDOVUDINE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; CDK2 PROTEIN, HUMAN; CDK6 PROTEIN, HUMAN; MONOMERIC GUANINE NUCLEOTIDE BINDING PROTEIN; PIPERAZINE DERIVATIVE; PROTEIN KINASE INHIBITOR; PYRIDINE DERIVATIVE; SAMHD1 PROTEIN, HUMAN;

ANTIVIRAL ACTIVITY; ARTICLE; CD4+ T LYMPHOCYTE; ENZYME ACTIVATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; LYMPHOCYTE PROLIFERATION; MACROPHAGE; MONOCYTE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION; VIRUS REPLICATION; ANTAGONISTS AND INHIBITORS; CELL CULTURE; METABOLISM; MONONUCLEAR CELL; PHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION; VIROLOGY;

ANTI-HIV AGENTS; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE 2; CYCLIN-DEPENDENT KINASE 6; DNA, VIRAL; HIV-1; HUMANS; LEUKOCYTES, MONONUCLEAR; MONOMERIC GTP-BINDING PROTEINS; PIPERAZINES; PROTEIN KINASE INHIBITORS; PYRIDINES; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION;

EID: 84927911970     PISSN: 02699370     EISSN: 14735571     Source Type: Journal    
DOI: 10.1097/QAD.0000000000000399     Document Type: Article

References (39)

1. Zhu C, Gao W, Zhao K, Qin X, Zhang Y, Peng X, et al. Structural insight into dGTP-dependent activation of tetramericSAMHD1 deoxynucleoside triphosphate triphosphohydrolase. Nat Commun 2013; 4:2722.
2. Lahouassa H, Daddacha W, Hofmann H, Ayinde D, Logue EC, Dragin L, et al. SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates. Nat Immunol 2012; 13:223-228.
3. Baldauf HM, Pan X, Erikson E, Schmidt S, Daddacha W, Burggraf M, et al. SAMHD1 restricts HIV-1 infection in resting CD4(R) T cells. Nat Med 2012; 18:1682-1689.
4. Laguette N, Sobhian B, Casartelli N, Ringeard M, Chable-Bessia C, Segeral E, et al. SAMHD1 is the dendritic- And myeloid-cellspecific HIV-1 restriction factor counteracted by Vpx. Nature 2011; 474:654-657.
5. Descours B, Cribier A, Chable-Bessia C, Ayinde D, Rice G, Crow Y, et al. SAMHD1 restricts HIV-1 reverse transcription in quiescent CD4R T-cells. Retrovirology 2012; 9:87.
6. Goldstone DC, Ennis-Adeniran V, Hedden JJ, Groom HC, Rice GI, Christodoulou E, et al. HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase. Nature 2011; 480:379-382.
7. Pauls E, Ballana E, Este JA. Nucleotide embargo by SAMHD1: A strategy to block retroviral infection. Antiviral Res 2013; 97:180-182.
8. Behrendt R, Schumann T, Gerbaulet A, Nguyen LA, Schubert N, Alexopoulou D, et al. Mouse SAMHD1 has antiretroviral activity and suppresses a spontaneous cell-intrinsic antiviral response. Cell Rep 2013; 4:689-696.
9. Rehwinkel J, Maelfait J, Bridgeman A, Rigby R, Hayward B, Liberatore RA, et al. SAMHD1-dependent retroviral control and escape in mice. EMBO J 2013; 32:2454-2462.
10. Hrecka K, Hao C, Gierszewska M, Swanson SK, Kesik-Brodacka M, Srivastava S, et al. Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein. Nature 2011; 474:658-661.
11. Cribier A, Descours B, Valadão Ana Luiza C, Laguette N, Benkirane M. Phosphorylation of SAMHD1 by Cyclin A2/CDK1 Regulates Its Restriction Activity toward HIV-1. Cell Reports 2013; 3:1036-1043.
12. White Tommy E, Brandariz-Nuñez A, Valle-Casuso Jose C, Amie S, Nguyen Laura A, Kim B, et al. The retroviral restriction ability of SAMHD1, but not its deoxynucleotide triphosphohydrolase activity, is regulated by phosphorylation. Cell Host Microbe 2013; 13:441-451.
13. St Gelais C, de Silva S, Hach JC, White TE, Diaz-Griffero F, Yount JS, et al. Identification of cellular proteins interacting with the retroviral restriction factor SAMHD1. J Virol 2014; 88:5834-5844.
14. Malumbres M, Harlow E, Hunt T, Hunter T, Lahti JM, Manning G, et al. Cyclin-dependent kinases: A family portrait. Nat Cell Biol 2009; 11:1275-1276.
15. Joaquin M, Gubern A, Gonzalez-Nunez D, Josue Ruiz E, Ferreiro I, de Nadal E, et al. The p57 CDKi integrates stress signals into cell-cycle progression to promote cell survival upon stress. EMBO J 2012; 31:2952-2964.
16. Hochegger H, Takeda S, Hunt T. Cyclin-dependent kinases and cell-cycle transitions: does one fit all? Nat Rev Mol Cell Biol 2008; 9:910-916.
17. Wells AD, Morawski PA. New roles for cyclin-dependent kinases in T cell biology: linking cell division and differentiation. Nat Rev Immunol 2014; 14:261-270.
18. Korin YD, Zack JA. Progression to the G1b phase of the cell cycle is required for completion of human immunodeficiency virus type 1 reverse transcription in T cells. J Virol 1998; 72:3161-3168.
19. Leonard JP, LaCasce AS, Smith MR, Noy A, Chirieac LR, Rodig SJ, et al. Selective CDK4/6 inhibition with tumor responses by PD0332991 in patients with mantle cell lymphoma. Blood 2012; 119:4597-4607.
20. Chiron D, Martin P, Di Liberto M, Huang X, Ely S, Lannutti BJ, et al. Induction of prolonged early G1 arrest by CDK4/CDK6 inhibition reprograms lymphoma cells for durable PI3Kdelta inhibition through PIK3IP1. Cell Cycle 2013; 12:1892-1900.
21. Pauls E, Jimenez E, Ruiz A, Permanyer M, Ballana E, Costa H, et al. Restriction of HIV-1 replication in primary macrophages by IL-12 and IL-18 through the upregulation of SAMHD1. J Immunol 2013; 190:4736-4741.
22. Mangeot PE, Negre D, Dubois B, Winter AJ, Leissner P, Mehtali M, et al. Development of minimal lentivirus vectors derived from simian immunodeficiency virus (SIVmac251) and their use for gene transfer into human dendritic cells. J Virol 2000; 74:8307-8315.
23. Ballana E, Senserrich J, Pauls E, Faner R, Mercader E, Uyttebroeck F, et al. Zinc ribbon domain-containing 1 (ZNRD1) is a host cellular factor influencing HIV-1 replication and disease progression. Clin Infect Dis 2010; 50:1022-1032.
24. Ferraro P, Franzolin E, Pontarin G, Reichard P, Bianchi V. Quantitation of cellular deoxynucleoside triphosphates. Nucleic Acids Res 2010; 38:e85.
25. Ballana E, Pauls E, Perron-Sierra F, Clotet B, Tucker G, Este JA. Beta5 integrin is the major contributor to the alphav integrinmediated blockade of HIV-1 replication. J Immunol 2011; 186: 464-470.
26. Lori F, Malykh A, Cara A, Sun D, Weinstein JN, Lisziewicz J, et al. Hydroxyurea as an inhibitor of human immunodeficiency virus-type 1 replication. Science 1994; 266:801-805.
27. Kootstra NA, Zwart BM, Schuitemaker H. Diminished human immunodeficiency virus type 1 reverse transcription and nuclear transport in primary macrophages arrested in early G(1) phase of the cell cycle. J Virol 2000; 74:1712-1717.
28. Gao WY, Cara A, Gallo RC, Lori F. Low levels of deoxynucleotides in peripheral blood lymphocytes: A strategy to inhibit human immunodeficiency virus type 1 replication. Proc Natl Acad Sci U S A 1993; 90:8925-8928.
29. Meyerhans A, Vartanian JP, Hultgren C, Plikat U, Karlsson A, Wang L, et al. Restriction and enhancement of human immunodeficiency virus type 1 replication by modulation of intracellular deoxynucleoside triphosphate pools. J Virol 1994; 68:535-540.
30. Clouser CL, Patterson SE, Mansky LM. Exploiting drug repositioning for discovery of a novel HIV combination therapy. J Virol 2010; 84:9301-9309.
31. Pauls E, Ruiz A, Badia R, Permanyer M, Gubern A, RiveiraMuñoz E, et al. Cell cycle control and HIV1 susceptibility are linked by CDK6-dependent CDK2 phosphorylation of SAMHD1 in myeloid and lymphoid cells. J Immunol 2014; doi: 10.4049/jimmunol. 1400873.
32. Pauls E, Ruiz A, Riveira-Munoz E, Permanyer M, Badia R, Clotet B, et al. p21 regulates the HIV-1 restriction factor SAMHD1. Proc Natl Acad Sci U S A 2014; 111:E1322-E1324.
33. Allouch A, David A, Amie SM, Lahouassa H, Chartier L, Margottin- Goguet F, et al. p21-mediated RNR2 repression restricts HIV-1 replication in macrophages by inhibiting dNTP biosynthesis pathway. Proc Natl Acad Sci U S A 2013; 110:E3997-4006.
34. Wang D, de la Fuente C, Deng L, Wang L, Zilberman I, Eadie C, et al. Inhibition of human immunodeficiency virus type 1 transcription by chemical cyclin-dependent kinase inhibitors. J Virol 2001; 75:7266-7279.
35. Malumbres M, Barbacid M. Cell cycle, CDKs and cancer: A changing paradigm. Nat Rev Cancer 2009; 9:153-166.
36. Combadere B, Blanc C, Li T, Carcelain G, Delaugerre C, Calvez V, et al. CD4RKi67R lymphocytes in HIV-infected patients are effector T cells accumulated in the G1 phase of the cell cycle. Eur J Immunol 2000; 30:3598-3603.
37. Chomont N, El-Far M, Ancuta P, Trautmann L, Procopio FA, Yassine-Diab B, et al. HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation. Nat Med 2009; 15:893-900.
38. Cohen J. HIV/AIDS. Cancer genes help HIV persist, complicating cure efforts. Science 2014; 343:1188.
39. Bullen CK, Laird GM, Durand CM, Siliciano JD, Siliciano RF. New ex vivo approaches distinguish effective and ineffective single agents for reversing HIV-1 latency in vivo. Nat Med 2014; 20:425-429.