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Volumn 84, Issue 18, 2010, Pages 9301-9309

Exploiting drug repositioning for discovery of a novel HIV combination therapy

Author keywords

[No Author keywords available]

Indexed keywords

3,4 DIHYDROXYBENZOHYDROXAMIC ACID; 3,4,5 TRIHYDROXYBENZOHYDROXAMIDOXIME; 5 AZA 2' DEOXYCYTIDINE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; AZACITIDINE; CYTARABINE; FLOXURIDINE; FLUOROURACIL; GEMCITABINE; GUANAZOLE; HYDROXYUREA; LUTEOLIN; METHOTREXATE; MYCOPHENOLIC ACID; UNCLASSIFIED DRUG; DEOXYCYTIDINE;

EID: 77956040787     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.01006-10     Document Type: Article
Times cited : (81)

References (42)
  • 1
    • 4344668661 scopus 로고    scopus 로고
    • Drug repositioning: Identifying and developing new uses for existing drugs
    • Ashburn, T. T., and K. B. Thor. 2004. Drug repositioning: identifying and developing new uses for existing drugs. Nat. Rev. Drug Discov. 3:673-683.
    • (2004) Nat. Rev. Drug Discov. , vol.3 , pp. 673-683
    • Ashburn, T.T.1    Thor, K.B.2
  • 2
    • 0023636684 scopus 로고
    • Ribavirin antagonizes inhibitory effects of pyrimidine 2′,3′- deoxynucleosides but enhances inhibitory effects of purine 2′,3′- dideoxynucleosides on replication of human immunodeficiency virus in vitro
    • Baba, M., R. Pauwels, J. Balzarini, P. Herdewijn, E. De Clercq, and J. Desmyter. 1987. Ribavirin antagonizes inhibitory effects of pyrimidine 2′,3′- deoxynucleosides but enhances inhibitory effects of purine 2′,3′- dideoxynucleosides on replication of human immunodeficiency virus in vitro. Antimicrob. Agents Chemother. 31:1613-1617.
    • (1987) Antimicrob. Agents Chemother. , vol.31 , pp. 1613-1617
    • Baba, M.1    Pauwels, R.2    Balzarini, J.3    Herdewijn, P.4    De Clercq, E.5    Desmyter, J.6
  • 3
    • 0023502171 scopus 로고
    • 2′,3′-Dideoxycytidine: Regulation of its metabolism and anti-retroviral potency by natural pyrimidine nucleosides and by inhibitors of pyrimidine nucleotide synthesis
    • Balzarini, J., D. A. Cooney, M. Dalal, G.-J. Kang, J. E. Cupp, E. De Clercq, S. Broder, and D. G. Johns. 1987. 2′,3′-Dideoxycytidine: regulation of its metabolism and anti-retroviral potency by natural pyrimidine nucleosides and by inhibitors of pyrimidine nucleotide synthesis. Mol. Pharmacol. 32: 798-806.
    • (1987) Mol. Pharmacol. , vol.32 , pp. 798-806
    • Balzarini, J.1    Cooney, D.A.2    Dalal, M.3    Kang, G.-J.4    Cupp, J.E.5    De Clercq, E.6    Broder, S.7    Johns, D.G.8
  • 4
    • 0026714957 scopus 로고
    • The effects of dNTP pool imbalances on frameshift fidelity during DNA replication
    • Bebenek, K., J. D. Roberts, and T. A. Kunkel. 1992. The effects of dNTP pool imbalances on frameshift fidelity during DNA replication. J. Biol. Chem. 267:3589-3596.
    • (1992) J. Biol. Chem. , vol.267 , pp. 3589-3596
    • Bebenek, K.1    Roberts, J.D.2    Kunkel, T.A.3
  • 5
    • 0025411135 scopus 로고
    • Inactivation of the HIV LTR by DNA CpG methylation: Evidence for a role in latency
    • Bednarik, D. P., J. A. Cook, and P. M. Pitha. 1990. Inactivation of the HIV LTR by DNA CpG methylation: evidence for a role in latency. EMBO J. 9:1157-1164.
    • (1990) EMBO J. , vol.9 , pp. 1157-1164
    • Bednarik, D.P.1    Cook, J.A.2    Pitha, P.M.3
  • 6
    • 0023952030 scopus 로고
    • Carcinogenicity and haemoglobin synthesis induction by cytidine analogues
    • Carr, B. I., S. Rahbar, Y. Asmeron, A. Riggs, and C. D. Winberg. 1988. Carcinogenicity and haemoglobin synthesis induction by cytidine analogues. Br. J. Cancer 57:395-402.
    • (1988) Br. J. Cancer , vol.57 , pp. 395-402
    • Carr, B.I.1    Rahbar, S.2    Asmeron, Y.3    Riggs, A.4    Winberg, C.D.5
  • 7
    • 4644241496 scopus 로고    scopus 로고
    • Development of a real-time PCR assay using SYBR Green I for provirus load quantification in a murine model of AIDS
    • Casabianca, A., C. Orlandi, A. Fraternale, and M. Magnani. 2004. Development of a real-time PCR assay using SYBR Green I for provirus load quantification in a murine model of AIDS. J. Clin. Microbiol. 42:4361-4364.
    • (2004) J. Clin. Microbiol. , vol.42 , pp. 4361-4364
    • Casabianca, A.1    Orlandi, C.2    Fraternale, A.3    Magnani, M.4
  • 8
    • 0037068379 scopus 로고    scopus 로고
    • 5-Azacytidine and 5-aza-2′-deoxycytidine as inhibitors of DNA methylation: Mechanistic studies and their implications for cancer therapy
    • Christman, J. K. 2002. 5-Azacytidine and 5-aza-2′-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy. Oncogene 21:5483-5495.
    • (2002) Oncogene , vol.21 , pp. 5483-5495
    • Christman, J.K.1
  • 9
    • 70350291512 scopus 로고    scopus 로고
    • 5-Azacytidine can induce lethal mutagenesis in human immunodeficiency virus type 1
    • Dapp, M. J., C. L. Clouser, S. Patterson, and L. M. Mansky. 2009. 5-Azacytidine can induce lethal mutagenesis in human immunodeficiency virus type 1. J. Virol. 83:11950-11958.
    • (2009) J. Virol. , vol.83 , pp. 11950-11958
    • Dapp, M.J.1    Clouser, C.L.2    Patterson, S.3    Mansky, L.M.4
  • 10
    • 0033028259 scopus 로고    scopus 로고
    • Suppression of replication of multidrug-resistant HIV type 1 variants by combinations of thymidylate synthase inhibitors with zidovudine or stavudine
    • Gao, W.-Y., D. G. Johns, M. Tanaka, and H. Mitsuya. 1999. Suppression of replication of multidrug-resistant HIV type 1 variants by combinations of thymidylate synthase inhibitors with zidovudine or stavudine. Mol. Pharmacol. 55:535-540.
    • (1999) Mol. Pharmacol. , vol.55 , pp. 535-540
    • Gao, W.-Y.1    Johns, D.G.2    Tanaka, M.3    Mitsuya, H.4
  • 11
    • 0027377963 scopus 로고
    • Low levels of deoxynucleotides in peripheral blood lymphocytes: A strategy to inhibit human immunodeficiency virus type 1 replication
    • Gao, W. Y., A. Cara, R. C. Gallo, and F. Lori. 1993. Low levels of deoxynucleotides in peripheral blood lymphocytes: a strategy to inhibit human immunodeficiency virus type 1 replication. Proc. Natl. Acad. Sci. U. S. A. 90:8925-8928.
    • (1993) Proc. Natl. Acad. Sci. U. S. A. , vol.90 , pp. 8925-8928
    • Gao, W.Y.1    Cara, A.2    Gallo, R.C.3    Lori, F.4
  • 15
    • 0027321495 scopus 로고
    • Cofactor requirement for human immunodeficiency virus type 1 entry into a CD4-expressing human cell line
    • Harrington, R. D., and A. P. Geballe. 1993. Cofactor requirement for human immunodeficiency virus type 1 entry into a CD4-expressing human cell line. J. Virol. 67:5939-5947.
    • (1993) J. Virol. , vol.67 , pp. 5939-5947
    • Harrington, R.D.1    Geballe, A.P.2
  • 16
    • 20444414897 scopus 로고    scopus 로고
    • KP-1212/1461, a nucleoside designed for the treatment of HIV by viral mutagenesis
    • Harris, K. S., W. Brabant, S. Styrchak, A. Gall, and R. Daifuku. 2005. KP-1212/1461, a nucleoside designed for the treatment of HIV by viral mutagenesis. Antiviral Res. 67:1-9.
    • (2005) Antiviral Res. , vol.67 , pp. 1-9
    • Harris, K.S.1    Brabant, W.2    Styrchak, S.3    Gall, A.4    Daifuku, R.5
  • 17
    • 0028853961 scopus 로고
    • Human immunodeficiency virus type 1 viral protein R (Vpr) arrests cells in the G2 phase of the cell cycle by inhibiting p34cdc2 activity
    • He, J., S. Choe, R. Walker, P. Di Marzio, D. O. Morgan, and N. R. Landau. 1995. Human immunodeficiency virus type 1 viral protein R (Vpr) arrests cells in the G2 phase of the cell cycle by inhibiting p34cdc2 activity. J. Virol. 69:6705-6711.
    • (1995) J. Virol. , vol.69 , pp. 6705-6711
    • He, J.1    Choe, S.2    Walker, R.3    Di Marzio, P.4    Morgan, D.O.5    Landau, N.R.6
  • 19
    • 0025284804 scopus 로고
    • Mutation frequencies at defined single codon sites in vesicular stomatitis virus and poliovirus can be increased only slightly by chemical mutagenesis
    • Holland, J. J., E. Domingo, J. C. De La Torre, and D. A. Steinhauer. 1990. Mutation frequencies at defined single codon sites in vesicular stomatitis virus and poliovirus can be increased only slightly by chemical mutagenesis. J. Virol. 64:3960-3962.
    • (1990) J. Virol. , vol.64 , pp. 3960-3962
    • Holland, J.J.1    Domingo, E.2    De La Torre, J.C.3    Steinhauer, D.A.4
  • 20
    • 33947482804 scopus 로고
    • Nucleosides. V. The monomesylates of 1-(2′-deoxy-β-D- lyxofuranosyl)thymine
    • Horwitz, J. P., J. Chua, and M. Noel. 1964. Nucleosides. V. The monomesylates of 1-(2′-deoxy-β-D-lyxofuranosyl)thymine. J. Org. Chem. 29:2076-2078.
    • (1964) J. Org. Chem. , vol.29 , pp. 2076-2078
    • Horwitz, J.P.1    Chua, J.2    Noel, M.3
  • 21
    • 0019484137 scopus 로고
    • The use of Chinese hamster ovary cells to quantify specific locus mutation and to determine mutagenicity of chemicals. A report of the gene-tox program
    • Hsie, A. W., D. A. Casciano, D. B. Couch, D. F. Krahn, J. P. O'Neill, and B. L. Whitfield. 1981. The use of Chinese hamster ovary cells to quantify specific locus mutation and to determine mutagenicity of chemicals. A report of the gene-tox program. Mutat. Res. 86:193-214.
    • (1981) Mutat. Res. , vol.86 , pp. 193-214
    • Hsie, A.W.1    Casciano, D.A.2    Couch, D.B.3    Krahn, D.F.4    O'Neill, J.P.5    Whitfield, B.L.6
  • 22
    • 0026324313 scopus 로고
    • Action of 2′,2′-difluorodeoxycytidine on DNA synthesis
    • Huang, P., S. Chubb, L. W. Hertel, G. B. Grindey, and W. Plunkett. 1991. Action of 2′,2′-difluorodeoxycytidine on DNA synthesis. Cancer Res. 51: 6110-6117.
    • (1991) Cancer Res. , vol.51 , pp. 6110-6117
    • Huang, P.1    Chubb, S.2    Hertel, L.W.3    Grindey, G.B.4    Plunkett, W.5
  • 24
    • 0017919703 scopus 로고
    • Synthesis and biological activity of several amino analogues of thymidine
    • Lin, T.-S., and W. H. Prusoff. 1978. Synthesis and biological activity of several amino analogues of thymidine. J. Med. Chem. 21:109-112.
    • (1978) J. Med. Chem. , vol.21 , pp. 109-112
    • Lin, T.-S.1    Prusoff, W.H.2
  • 26
    • 0027948936 scopus 로고
    • Hydroxyurea as an inhibitor of human immunodeficiency virus-type 1 replication
    • Lori, F., A. Malykh, A. Cara, D. Sun, J. N. Weinstein, J. Lisziewicz, and R. C. Gallo. 1994. Hydroxyurea as an inhibitor of human immunodeficiency virus-type 1 replication. Science 266:801-805.
    • (1994) Science , vol.266 , pp. 801-805
    • Lori, F.1    Malykh, A.2    Cara, A.3    Sun, D.4    Weinstein, J.N.5    Lisziewicz, J.6    Gallo, R.C.7
  • 27
    • 0027946446 scopus 로고
    • Hypermutagenesis of RNA using human immunodeficiency virus type 1 and biased dNTP concentrations
    • Martinez, M. A., J.-P. Vartanian, and S. Wain-Hobson. 1994. Hypermutagenesis of RNA using human immunodeficiency virus type 1 and biased dNTP concentrations. Proc. Natl. Acad. Sci. U. S. A. 91:11787-11791.
    • (1994) Proc. Natl. Acad. Sci. U. S. A. , vol.91 , pp. 11787-11791
    • Martinez, M.A.1    Vartanian, J.-P.2    Wain-Hobson, S.3
  • 28
    • 0027976787 scopus 로고
    • Restriction and enhancement of human immunodeficiency virus type 1 replication by modulation of intracellular deoxynucleoside triphosphate pools
    • Meyerhans, A., J.-P. Vartanian, C. Hultgren, U. Plikat, A. Karlsson, L. Wang, S. Eriksson, and S. Wain-Hobson. 1994. Restriction and enhancement of human immunodeficiency virus type 1 replication by modulation of intracellular deoxynucleoside triphosphate pools. J. Virol. 68:535-540.
    • (1994) J. Virol. , vol.68 , pp. 535-540
    • Meyerhans, A.1    Vartanian, J.-P.2    Hultgren, C.3    Plikat, U.4    Karlsson, A.5    Wang, L.6    Eriksson, S.7    Wain-Hobson, S.8
  • 30
    • 21844466446 scopus 로고    scopus 로고
    • Pharmacology of 5-aza-2′-deoxycytidine (decitabine)
    • Momparler, R. L. 2005. Pharmacology of 5-aza-2′-deoxycytidine (decitabine). Semin. Hematol. 42:S9-S16.
    • (2005) Semin. Hematol. , vol.42
    • Momparler, R.L.1
  • 31
    • 0030974771 scopus 로고    scopus 로고
    • Pilot phase I-II study on 5-aza-2'-deoxycytidine (Decitabine) in patients with metastatic lung cancer
    • Momparler, R. L., D. Y. Bouffard, L. F. Momparler, J. Dionne, K. Belanger, and J. Ayoub. 1997. Pilot phase I-II study on 5-aza-2′- deoxycytidine (Decitabine) in patients with metastatic lung cancer. Anticancer Drugs 8:358-368. (Pubitemid 27204954)
    • (1997) Anti-Cancer Drugs , vol.8 , Issue.4 , pp. 358-368
    • Momparler, R.L.1    Bouffard, D.Y.2    Momparler, L.F.3    Dionne, J.4    Belanger, K.5    Ayoub, J.6
  • 34
    • 0038278911 scopus 로고    scopus 로고
    • Mutagenesis versus inhibition in the efficiency of extinction of foot-and-mouth disease virus
    • DOI 10.1128/JVI.77.12.7131-7138.2003
    • Pariente, N., A. Airaksinen, and E. Domingo. 2003. Mutagenesis versus inhibition in the efficiency of extinction of foot-and-mouth disease virus. J. Virol. 77:7131-7138. (Pubitemid 36666908)
    • (2003) Journal of Virology , vol.77 , Issue.12 , pp. 7131-7138
    • Pariente, N.1    Airaksinen, A.2    Domingo, E.3
  • 35
    • 0034813056 scopus 로고    scopus 로고
    • Efficient virus extinction by combinations of a mutagen and antiviral inhibitors
    • Pariente, N., S. Sierra, P. R. Lowenstein, and E. Domingo. 2001. Efficient virus extinction by combinations of a mutagen and antiviral inhibitors. J. Virol. 75:9723-9730.
    • (2001) J. Virol. , vol.75 , pp. 9723-9730
    • Pariente, N.1    Sierra, S.2    Lowenstein, P.R.3    Domingo, E.4
  • 36
    • 17344392308 scopus 로고    scopus 로고
    • A new mathematical model for relative quantification in real-time RT-PCR
    • Pfaffl, M. W. 2001. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res. 29:e45.
    • (2001) Nucleic Acids Res. , vol.29
    • Pfaffl, M.W.1
  • 37
    • 0345578679 scopus 로고    scopus 로고
    • Lethal mutagenesis of the prototypic arenavirus lymphocytic choriomeningitis virus (LCMV)
    • Ruiz-Jarabo, C. M., C. Ly, E. Domingo, and J. C. Torre. 2003. Lethal mutagenesis of the prototypic arenavirus lymphocytic choriomeningitis virus (LCMV). Virology 308:37-47.
    • (2003) Virology , vol.308 , pp. 37-47
    • Ruiz-Jarabo, C.M.1    Ly, C.2    Domingo, E.3    Torre, J.C.4
  • 38
    • 0033850837 scopus 로고    scopus 로고
    • Response of foot-and-mouth disease virus to increased mutagenesis: Influence of viral load and fitness in loss of infectivity
    • Sierra, S., M. Davila, P. R. Lowenstein, and E. Domingo. 2000. Response of foot-and-mouth disease virus to increased mutagenesis: influence of viral load and fitness in loss of infectivity. J. Virol. 74:8316-8323.
    • (2000) J. Virol. , vol.74 , pp. 8316-8323
    • Sierra, S.1    Davila, M.2    Lowenstein, P.R.3    Domingo, E.4
  • 39
    • 0024355087 scopus 로고
    • Differential effects of 5-azacytidine and 5-azadeoxycytidine on cytotoxicity, DNA-strand breaking and repair of X-ray-induced DNA damage in HeLa cells
    • Snyder, R. D., and P. J. Lachmann. 1989. Differential effects of 5-azacytidine and 5-azadeoxycytidine on cytotoxicity, DNA-strand breaking and repair of X-ray-induced DNA damage in HeLa cells. Mutat. Res. 226:185-190.
    • (1989) Mutat. Res. , vol.226 , pp. 185-190
    • Snyder, R.D.1    Lachmann, P.J.2
  • 41
    • 0242333218 scopus 로고    scopus 로고
    • Replication kinetics for divergent type 1 human immunodeficiency viruses using quantitative SYBR Green I real-time polymerase chain reaction
    • Victoria, J. G., D. J. Lee, B. R. McDougall, and W. E. Robinson. 2003. Replication kinetics for divergent type 1 human immunodeficiency viruses using quantitative SYBR Green I real-time polymerase chain reaction. AIDS Res. Hum. Retroviruses 19:865-874.
    • (2003) AIDS Res. Hum. Retroviruses , vol.19 , pp. 865-874
    • Victoria, J.G.1    Lee, D.J.2    McDougall, B.R.3    Robinson, W.E.4


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