The inflammasome: Firing up innate immunity

Immunological Reviews

Volumn 265, Issue 1, 2015, Pages 1-5

  Kanneganti, Thirumala Devi ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 5; CRYOPYRIN; INFLAMMASOME; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME;

ARTICLE; CELL FREE SYSTEM; ENZYME ACTIVATION; GENE OVEREXPRESSION; GENETIC ANALYSIS; HUMAN; INNATE IMMUNITY; MACROPHAGE; NONHUMAN; PRIORITY JOURNAL; SALMONELLA ENTERICA SUBSP. ENTERICA SEROVAR TYPHIMURIUM; TYPHOID FEVER; ANIMAL; IMMUNOLOGY; INFLAMMATION; METABOLISM;

ANIMALS; HUMANS; IMMUNITY, INNATE; INFLAMMASOMES; INFLAMMATION;

EID: 84927766906     PISSN: 01052896     EISSN: 1600065X     Source Type: Journal    
DOI: 10.1111/imr.12297     Document Type: Article

References (24)

1. Martinon F, Burns K, Tschopp J. The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol Cell 2002;10:417-426.
2. Mariathasan S, et al. Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf. Nature 2004;430:213-218.
3. Mariathasan S, et al. Cryopyrin activates the inflammasome in response to toxins and ATP. Nature 2006;440:228-232.
4. Kanneganti TD, et al. Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3. Nature 2006;440:233-236.
5. Martinon F, Petrilli V, Mayor A, Tardivel A, Tschopp J. Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature 2006;440:237-241.
6. Man SM, Kanneganti TD. Regulation of inflammasome activation. Immunol Rev 2015;265:6-21.
7. Chavarría-Smith J, Vance RE. The NLRP1 inflammasomes. Immunol Rev 2015;265:22-34.
8. Elliott EI, Sutterwala FS. Initiation and perpetuation of NLRP3 inflammasome activation and assembly. Immunol Rev 2015;265:35-52.
9. Haneklaus M, O'Neill LAJ. NLRP3 at the interface of metabolism and inflammation. Immunol Rev 2015;265:53-62.
10. Goldberg EL, Dixit VD. Drivers of age-related inflammation and strategies for healthspan extension. Immunol Rev 2015;265:63-74.
11. Kayagaki N, et al. Non-canonical inflammasome activation targets caspase-11. Nature 2011;479:117-121.
12. Stowe I, Lee B, Kayagaki N. Caspase-11: arming the guards against bacterial infection. Immunol Rev 2015;265:75-84.
13. Zhao Y, Shao F. The NAIP-NLRC4 inflammasome in innate immune detection of bacterial flagellin and type III secretion apparatus. Immunol Rev 2015;265:85-102.
14. Xiao TS. The nucleic acid-sensing inflammasomes. Immunol Rev 2015;265:103-111.
15. Storek KM, Monack DM. Bacterial recognition pathways that lead to inflammasome activation. Immunol Rev 2015;265:112-129.
16. Jorgensen I, Miao EA. Pyroptotic cell death defends against intracellular pathogens. Immunol Rev 2015;265:130-142.
17. Negash AA, Gale M, Jr. Hepatitis regulation by the inflammasome signaling pathway. Immunol Rev 2015;265:143-155.
18. Zamboni DS, Lima-Junior DS. Inflammasomes in host response to protozoan parasites. Immunol Rev 2015;265:156-171.
19. van de Veerdonk FL, Joosten LAB, Netea MG. The interplay between inflammasome activation and antifungal host defense. Immunol Rev 2015;265:172-180.
20. Monie TP, Bryant CE. Caspase-8 functions as a key mediator of inflammation and pro-IL-1β processing via both canonical and non-canonical pathways. Immunol Rev 2015;265:181-193.
21. Abdelaziz DHA, Khalil H, Cormet-Boyaka E, Amer AO. The cooperation between the autophagy machinery and the inflammasome to implement an appropriate innate immune response: do they regulate each other? Immunol Rev 2015;265:194-204.
22. Dorfleutner A, Chu L, Stehlik C. Inhibiting the inflammasome: one domain at a time. Immunol Rev 2015;265:205-216.
23. Matusiak M, Van Opdenbosch N, Lamkanfi M. CARD- and pyrin-only proteins regulating inflammasome activation and immunity. Immunol Rev 2015;265:217-230.
24. Pedraza-Alva G, Pérez-Martínez L, Valdez-Hernández A, Meza-Sosa KF, Ando-Kuri M. Negative regulation of the inflammasome: keeping inflammation under control. Immunol Rev 2015;265:231-257.