Cooperative stabilization of the SIR complex provides robust epigenetic memory in a model of SIR silencing in Saccharomyces cerevisiae

Epigenetics

Volumn 10, Issue 4, 2015, Pages 293-302

  Sneppen, Kim ^a   Dodd, Ian B ^b  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

Budding yeast; Epigenetic inheritance; Heterochromatin; Mathematical modeling; Nucleosome modifications; Positive feedback

Indexed keywords

SILENT INFORMATION REGULATOR PROTEIN; SILENT INFORMATION REGULATOR PROTEIN 2; SILENT INFORMATION REGULATOR PROTEIN 3; SILENT INFORMATION REGULATOR PROTEIN 4; UNCLASSIFIED DRUG; DOT1 PROTEIN, S CEREVISIAE; HISTONE; HISTONE LYSINE METHYLTRANSFERASE; NUCLEAR PROTEIN; NUCLEOSOME; SACCHAROMYCES CEREVISIAE PROTEIN; SIR2 PROTEIN, S CEREVISIAE; SIRTUIN 2;

ARTICLE; BINDING SITE; DEACETYLATION; DNA METHYLATION; EPIGENETICS; GENE DOSAGE; GENE LOCUS; GENE SILENCING; GENETIC STABILITY; HISTONE MODIFICATION; NONHUMAN; NUCLEOSOME; PROTEIN EXPRESSION; PROTEIN STRUCTURE; REGULATORY MECHANISM; RNA TRANSCRIPTION; SACCHAROMYCES CEREVISIAE; SIMULATION; TELOMERE; BIOLOGICAL MODEL; COMPUTER SIMULATION; GENETIC EPIGENESIS; GENETICS; METABOLISM; METHYLATION; SILENCER ELEMENT;

SACCHAROMYCES CEREVISIAE; SACCHAROMYCETALES;

COMPUTER SIMULATION; EPIGENESIS, GENETIC; GENE SILENCING; HISTONE-LYSINE N-METHYLTRANSFERASE; HISTONES; METHYLATION; MODELS, BIOLOGICAL; NUCLEAR PROTEINS; NUCLEOSOMES; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SILENCER ELEMENTS, TRANSCRIPTIONAL; SILENT INFORMATION REGULATOR PROTEINS, SACCHAROMYCES CEREVISIAE; SIRTUIN 2;

EID: 84927760336     PISSN: 15592294     EISSN: 15592308     Source Type: Journal    
DOI: 10.1080/15592294.2015.1017200     Document Type: Article

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