A protein interaction map of the LSU processome

Genes and Development

Volumn 29, Issue 8, 2015, Pages 862-875

  McCann, Kathleen L ^a   Charette, J Michael ^a,b   Vincent, Nicholas G ^a   Baserga, Susan J ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BRANDON UNIVERSITY   (Canada)

Author keywords

LSU processome; Ribosome; RNA; Yeast two hybrid

Indexed keywords

ADENOSINE TRIPHOSPHATASE; GUANOSINE TRIPHOSPHATASE; HELICASE; METHYLTRANSFERASE; NOP4 PROTEIN; PHOSPHOTRANSFERASE; PROTEIN; UNCLASSIFIED DRUG; RIBOSOME PROTEIN; SACCHAROMYCES CEREVISIAE PROTEIN;

ARTICLE; BIOGENESIS; CELL MATURATION; CONTROLLED STUDY; EXOSOME; HIGH THROUGHPUT SCREENING; LARGE RIBOSOMAL SUBUNIT; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; YEAST; GENETICS; METABOLISM; REPRODUCIBILITY; SACCHAROMYCES CEREVISIAE; TWO HYBRID SYSTEM;

EUKARYOTA;

PROTEIN INTERACTION MAPS; REPRODUCIBILITY OF RESULTS; RIBOSOMAL PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; TWO-HYBRID SYSTEM TECHNIQUES;

EID: 84927750343     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.256370.114     Document Type: Article

References (99)

1. Bassler J, Grandi P, Gadal O, Lessmann T, Petfalski E, Tollervey D, Lechner J, Hurt E. 2001. Identification of a 60S preribosomal particle that is closely linked to nuclear export. Mol Cell 8: 517–529.
2. Bassler J, Kallas M, Pertschy B, Ulbrich C, Thoms M, Hurt E. 2010. The AAA–ATPase Rea1 drives removal of biogenesis factors during multiple stages of 60S ribosome assembly. Mol Cell 38: 712–721.
3. Bleichert F, Baserga SJ. 2007. The long unwinding road of RNA helicases. Mol Cell 27: 339–352.
4. Blow N. 2009. Systems biology: untangling the protein web. Nature 460: 415–418.
5. Bradatsch B, Leidig C, Granneman S, Gnädig M, Tollervey D, Böttcher B, Beckmann R, Hurt E. 2012. Structure of the pre- 60S ribosomal subunit with nuclear export factor Arx1 bound at the exit tunnel. Nat Struct Mol Biol 19: 1234–1241.
6. Brohee S, van Helden J. 2006. Evaluation of clustering algorithms for protein–protein interaction networks. BMC Bioinformatics 7: 488.
7. Brückner A, Polge C, Lentze N, Auerbach D, Schlattner U. 2009. Yeast two-hybrid, a powerful tool for systems biology. Int J Mol Sci 10: 2763–2788.
8. Castle CD, Sardana R, Dandekar V, Borgianini V, Johnson AW, Denicourt C. 2013. Las1 interacts with Grc3 polynucleotide kinase and is required for ribosome synthesis in Saccharomyces cerevisiae. Nucleic Acids Res 41: 1135–1150.
9. Charette JM, Baserga SJ. 2010. The DEAD-box RNA helicase-like Utp25 is an SSU processome component.RNA16: 2156–2169.
10. de Folter S, Immink RG. 2011. Yeast protein–protein interaction assays and screens. Methods Mol Biol 754: 145–165.
11. De Las Rivas J, Fontanillo C. 2012. Protein–protein interaction networks: unraveling the wiring of molecular machines within the cell. Brief Funct Genomics 11: 489–496.
12. De Marchis ML, Giorgi A, Schinina ME, Bozzoni I, Fatica A. 2005. Rrp15p, a novel component of pre-ribosomal particles required for 60S ribosome subunit maturation. RNA 11: 495–502.
13. Dragon F, Gallagher JE, Compagnone-Post PA, Mitchell BM, Porwancher KA,Wehner KA,Wormsley S, Settlage RE, Shabanowitz J, Osheim Y, et al. 2002. A large nucleolar U3 ribonucleoprotein required for 18S ribosomal RNA biogenesis. Nature 417: 967–970.
14. Drees BL, Sundin B, Brazeau E, Caviston JP, Chen G-C, Guo W, Kozminski KG, Lau MW, Moskow JJ, Tong A, et al. 2001. A protein interaction map for cell polarity development. J Cell Biol 154: 549–571.
15. Enright AJ, Van Dongen S, Ouzounis CA. 2002. An efficient algorithm for large-scale detection of protein families. Nucleic Acids Res 30: 1575–1584.
16. Fatica A, Tollervey D. 2002. Making ribosomes. Curr Opin Cell Biol 14: 313–318.
17. Fatica A, Cronshaw AD, Dlakic M, Tollervey D. 2002. Ssf1p prevents premature processing of an early pre-60S ribosomal particle. Mol Cell 9: 341–351.
18. Fernandez-Pevida A, Kressler D, de la Cruz J. 2015. Processing of preribosomal RNA in Saccharomyces cerevisiae.Wiley Interdiscip Rev RNA 6: 191–209.
19. Fromont-Racine M, Senger B, Saveanu C, Fasiolo F. 2003. Ribosome assembly in eukaryotes. Gene 313: 17–42.
20. Galani K, Nissan TA, Petfalski E, Tollervey D, Hurt E. 2004. Rea1, a dynein-related nuclear AAA–ATPase, is involved in late rRNA processing and nuclear export of 60 S subunits. J Biol Chem 279: 55411–55418.
21. Gallagher JE, Dunbar DA, Granneman S, Mitchell BM, Osheim Y, Beyer AL, Baserga SJ. 2004. RNA polymerase I transcription and pre-rRNA processing are linked by specific SSU processome components. Genes Dev 18: 2506–2517.
22. Gelbart ME, Rechsteiner T, Richmond TJ, Tsukiyama T. 2001. Interactions of Isw2 chromatin remodeling complex with nucleosomal arrays: analyses using recombinant yeast histones and immobilized templates. Mol Cell Biol 21: 2098–2106.
23. Gelperin DM, White MA, Wilkinson ML, Kon Y, Kung LA, Wise KJ, Lopez-Hoyo N, Jiang L, Piccirillo S, Yu H, et al. 2005. Biochemical and genetic analysis of the yeast proteome with a movable ORF collection. Genes Dev 19: 2816–2826.
24. Giot L, Bader JS, Brouwer C, Chaudhuri A, Kuang B, Li Y, Hao YL, Ooi CE, Godwin B, Vitols E, et al. 2003. A protein interaction map of Drosophila melanogaster. Science 302: 1727–1736.
25. Grandi P, Rybin V, Bassler J, Petfalski E, Strauss D, Marzioch M, Schäfer T, Kuster B, Tschochner H, Tollervey D, et al. 2002. 90S pre-ribosomes include the 35S pre-rRNA, the U3 snoRNP, and 40S subunit processing factors but predominantly lack 60S synthesis factors. Mol Cell 10: 105–115.
26. Granneman S, Petfalski E, Tollervey D. 2011. A cluster of ribosome synthesis factors regulate pre-rRNA folding and 5.8S rRNA maturation by the Rat1 exonuclease. EMBO J 30: 4006–4019.
27. Grob A, Colleran C, McStay B. 2014. Construction of synthetic nucleoli in human cells reveals how a major functional nuclear domain is formed and propagated through cell division. Genes Dev 28: 220–230.
28. Han JD, Bertin N, Hao T, Goldberg DS, Berriz GF, Zhang LV, Dupuy D, Walhout AJ, Cusick ME, Roth FP, et al. 2004. Evidence for dynamically organized modularity in the yeast protein–protein interaction network. Nature 430: 88–93.
29. Harnpicharnchai P, Jakovljevic J, Horsey E, Miles T, Roman J, Rout M, Meagher D, Imai B, Guo Y, Brame CJ, et al. 2001. Composition and functional characterization of yeast 66S ribosome assembly intermediates. Mol Cell 8: 505–515.
30. Hart GT, Lee I, Marcotte ER. 2007. A high-accuracy consensus map of yeast protein complexes reveals modular nature of gene essentiality. BMC Bioinformatics 8: 236.
31. Hegele A, Kamburov A, Grossmann A, Sourlis C, Wowro S, Weimann M, Will CL, Pena V, Lührmann R, Stelzl U. 2012. Dynamic protein–protein interaction wiring of the human spliceosome. Mol Cell 45: 567–580.
32. Henras AK, Soudet J, Gérus M, Lebaron S, Caizergues-Ferrer MM, Mougin A, Henry Y. 2008. The post-transcriptional steps of eukaryotic ribosome biogenesis. Cell Mol Life Sci 65: 2334–2359.
33. Hierlmeier T, Merl J, Sauert M, Perez-Fernandez J, Schultz P, Bruckmann A, Hamperl S, Ohmayer U, Rachel R, Jacob A, et al. 2013. Rrp5p, Noc1p and Noc2p form a protein module which is part of early large ribosomal subunit precursors in S. cerevisiae. Nucleic Acids Res 41: 1191–1210.
34. Ito T, ChibaT, Ozawa R, Yoshida M, Hattori M, SakakiY. 2001.A comprehensive two-hybrid analysis to explore the yeast protein interactome. Proc Natl Acad Sci 98: 4569–4574.
35. Ivanic J, Yu X, Wallqvist A, Reifman J. 2009. Influence of protein abundance on high-throughput protein–protein interaction detection. PLoS One 4: e5815.
36. James P, Halladay J, Craig EA. 1996. Genomic libraries and a host strain designed for highly efficient two-hybrid selection in yeast. Genetics 144: 1425–1436.
37. Jeong H, Mason SP, Barabási AL, Oltvai ZN. 2001. Lethality and centrality in protein networks. Nature 411: 41–42.
38. Koegl M, Uetz P. 2007. Improving yeast two-hybrid screening systems. Brief Funct Genomic Proteomic 6: 302–312.
39. Kressler D, Roser D, Pertschy B, Hurt E. 2008. The AAA ATPase Rix7 powers progression of ribosome biogenesis by stripping Nsa1 from pre-60S particles. J Cell Biol 181: 935–944.
40. Kressler D, Hurt E, Bassler J. 2010. Driving ribosome assembly. Biochim Biophys Acta 1803: 673–683.
41. Kressler D, Hurt E, Bergler H, Bassler J. 2012. The power of AAA–ATPases on the road of pre-60S ribosome maturation–molecular machines that strip pre-ribosomal particles. Biochim Biophys Acta 1823: 92–100.
42. Krogan NJ, Peng WT, Cagney G, Robinson MD, Haw R, Zhong G, Guo X, Zhang X, Canadien V, Richards DP, et al. 2004. Highdefinition macromolecular composition of yeast RNA-processing complexes. Mol Cell 13: 225–239.
43. Krogan NJ, Cagney G, Yu H, Zhong G, Guo X, Ignatchenko A, Li J, Pu S, Datta N, Tikuisis AP, et al. 2006. Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Nature 440: 637–643.
44. Lebaron S, Segerstolpe A, French SL, Dudnakova T, de Lima Alves F, Granneman S, Rappsilber J, Beyer AL,Wieslander L, Tollervey D. 2013. Rrp5 binding at multiple sites coordinates prerRNA processing and assembly. Mol Cell 52: 707–719.
45. Lebreton A, Saveanu C, Decourty L, Jacquier A, Fromont-Racine M. 2006. Nsa2 is an unstable, conserved factor required for the maturation of 27 SB pre-rRNAs. J Biol Chem 281: 27099–27108.
46. Lebreton A, Rousselle J-C, Lenormand P, Namane A, Jacquier A, Fromont-Racine M, Saveanu C. 2008. 60S ribosomal subunit assembly dynamics defined by semi-quantitative mass spectrometry of purified complexes. Nucleic Acids Res 36: 4988–4999.
47. Li S, Armstrong CM, Bertin N, Ge H, Milstein S, Boxem M, Vidalain PO, Han JD, Chesneau A, Hao T, et al. 2004. A map of the interactome network of the metazoan C. elegans. Science 303: 540–543.
48. Li Z, Lee I, Moradi E, Hung NJ, Johnson AW, Marcotte EM. 2009. Rational extension of the ribosome biogenesis pathway using network-guided genetics. PLoS Biol 7: e1000213.
49. Liang WQ, Fournier MJ. 1997. Synthesis of functional eukaryotic ribosomal RNAs in trans: development of a novel in vivo rDNA system for dissecting ribosome biogenesis. Proc Natl Acad Sci 94: 2864–2868.
50. Lim YH, Charette JM, Baserga SJ. 2011. Assembling a protein–protein interaction map of the SSU processome from existing datasets. PLoS One 6: e17701.
51. Longtine MS, McKenzie A III, Demarini DJ, Shah NG, Wach A, Brachat A, Philippsen P, Pringle JR. 1998. Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae. Yeast 14: 953–961.
52. Merl J, Jakob S, Ridinger K, Hierlmeier T, Deutzmann R, Milkereit P, Tschochner H. 2010. Analysis of ribosome biogenesis factor-modules in yeast cells depleted from pre-ribosomes. Nucleic Acids Res 38: 3068–3080.
53. Miles TD, Jakovljevic J, Horsey EW, Harnpicharnchai P, Tang L, Woolford JL Jr. 2005. Ytm1, Nop7, and Erb1 form a complex necessary for maturation of yeast 66S preribosomes. Mol Cell Biol 25: 10419–10432.
54. Milkereit P, Gadal O, Podtelejnikov A, Trumtel S, Gas N, Petfalski E, Tollervey D, Mann M, Hurt E, Tschochner H. 2001. Maturation and intranuclear transport of pre-ribosomes requires Noc proteins. Cell 105: 499–509.
55. Morita D, Miyoshi K, Matsui Y, Toh EA, Shinkawa H, Miyakawa T, Mizuta K. 2002. Rpf2p, an evolutionarily conserved protein, interacts with ribosomal protein L11 and is essential for the processing of 27 SB Pre-rRNA to 25 S rRNA and the 60 S ribosomal subunit assembly in Saccharomyces cerevisiae. J Biol Chem 277: 28780–28786.
56. Morris JH, Apeltsin L, Newman AM, Baumbach J, Wittkop T, Su G, Bader GD, Ferrin TE. 2011. clusterMaker: a multi-algorithm clustering plugin for Cytoscape. BMC Bioinformatics 12: 436.
57. Moschopoulos CN, Pavlopoulos GA, Iacucci E, Aerts J, Likothanassis S, Schneider R, Kossida S. 2011. Which clustering algorithm is better for predicting protein complexes? BMC Res Notes 4: 549.
58. Mumberg D, Müller R, Funk M. 1995. Yeast vectors for the controlled expression of heterologous proteins in different genetic backgrounds. Gene 156: 119–122.
59. Nastou KC, Tsaousis GN, Kremizas KE, Litou ZI, Hamodrakas SJ. 2014. The human plasma membrane peripherome: visualization and analysis of interactions. BioMedResInt 2014: 397145.
60. Nissan TA, Bassler J, Petfalski E, Tollervey D, Hurt E. 2002. 60S pre-ribosome formation viewed from assembly in the nucleolus until export to the cytoplasm. EMBO J 21: 5539–5547.
61. Nogi Y, Yano R, Dodd J, Carles C, Nomura M. 1992. Gene RRN4 in Saccharomyces cerevisiae encodes the A12.2 subunit of RNA polymerase I and is essential only at high temperatures. Mol Cell Biol 13: 114–122.
62. Nousbeck J, Spiegel R, Ishida-Yamamoto A, Indelman M, Shani- Adir A, Adir N, Lipkin E, Bercovici S, Geiger D, van Steensel MA, et al. 2008. Alopecia, neurological defects, and endocrinopathy syndrome caused by decreased expression of RBM28, a nucleolar protein associated with ribosome biogenesis. Am J Hum Genet 82: 1114–1121.
63. Oeffinger M,Wei KE, Rogers R, DeGrasse JA, Chait BT, Aitchison JD, Rout MP. 2007. Comprehensive analysis of diverse ribonucleoprotein complexes. Nat Methods 4: 951–956.
64. Orchard S, Ammari M, Aranda B, Breuza L, Briganti L, Broackes- Carter F, Campbell NH, Chavali G, Chen C, del-Toro N, et al. 2014. The MIntAct project—IntAct as a common curation platform for 11 molecular interaction databases. Nucleic Acids Res 42: D358–D363.
65. Osheim YN, French SL, Keck KM, Champion EA, Spasov K, Dragon F, Baserga SJ, Beyer AL. 2004. Pre-18S ribosomal RNAis structurally compacted into the SSU processome prior to being cleaved from nascent transcripts in Saccharomyces cerevisiae. Mol Cell 16: 943–954.
66. Pereira-Leal JB, Enright AJ, Ouzounis CA. 2004. Detection of functional modules from protein interaction networks. Proteins 54: 49–57.
67. Pérez-Fernández J, Román A, De Las Rivas J, Bustelo XR, Dosil M. 2007. The 90S preribosome is a multimodular structure that is assembled through a hierarchical mechanism. Mol Cell Biol 27: 5414–5429.
68. Pu S, Vlasblom J, Emili A, Greenblatt J,Wodak SJ. 2007. Identifying functional modules in the physical interactome of Saccharomyces cerevisiae. Proteomics 7: 944–960.
69. Puig O, Caspary F, Rigaut G, Rutz B, Bouveret E, Bragado-Nilsson E,Wilm M, Séraphin B. 2001. The tandem affinity purification (TAP) method: a general procedure of protein complex purification. Methods 24: 218–229.
70. Rajagopala SV, Uetz P. 2008. Analysis of protein–protein interactions using array-based yeast two-hybrid screens. Methods Mol Biology 548: 223–245.
71. Rodríguez-Galán O, García-Gómez JJ, de la Cruz J. 2013. Yeast and human RNA helicases involved in ribosome biogenesis: current status and perspectives. Biochim Biophys Acta 1829: 775–790.
72. Rolland T, Taşan M, Charloteaux B, Pevzner Samuel J, Zhong Q, Sahni N, Yi S, Lemmens I, Fontanillo C, Mosca R, et al. 2014. A proteome-scale map of the human interactome network. Cell 159: 1212–1226.
73. Rosado IV, de la Cruz J. 2004. Npa1p, a component of very early pre-60S ribosomal particles, associates with a subset of small nucleolar RNPs required for peptidyl transferase center modification. Mol Cell Biol 24: 6324–6337.
74. Rosado IV, Dez C, Lebaron S, Caizergues-Ferrer M, Henry Y, de la Cruz J. 2007. Characterization of Saccharomyces cerevisiae Npa2p (Urb2p) reveals a low-molecular-mass complex containing Dbp6p, Npa1p (Urb1p), Nop8p, and Rsa3p involved in early steps of 60S ribosomal subunit biogenesis. Mol Cell Biol 27: 1207–1221.
75. Sahasranaman A, Dembowski J, Strahler J, Andrews P, Maddock J, Woolford JL. 2011. Assembly of Saccharomyces cerevisiae 60S ribosomal subunits: role of factors required for 27S prerRNA processing. EMBO J 30: 4020–4032.
76. Sa-Moura B, Funakoshi M, Tomko RJ Jr, Dohmen RJ, Wu Z, Peng J, Hochstrasser M. 2013. A conserved protein with AN1 zinc finger and ubiquitin-like domains modulates Cdc48 (p97) function in the ubiquitin-proteasome pathway. J Biol Chem 288: 33682–33696.
77. Saveanu C, Namane A, Gleizes PE, Lebreton A, Rousselle JC, Noaillac-Depeyre J, Gas N, Jacquier A, Fromont-Racine M. 2003. Sequential protein association with nascent 60S ribosomal particles. Mol Cell Biol 23: 4449–4460.
78. Saveanu C, Rousselle JC, Lenormand P, Namane A, Jacquier A, Fromont-Racine M. 2007. The p21-activated protein kinase inhibitor Skb15 and its budding yeast homologue are 60S ribosome assembly factors. Mol Cell Biol 27: 2897–2909.
79. Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, Amin N, Schwikowski B, Ideker T. 2003. Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res 13: 2498–2504.
80. Shimoji K, Jakovljevic J, Tsuchihashi K,Umeki Y,Wan K,Kawasaki S, Talkish J, Woolford JL Jr, Mizuta K. 2012. Ebp2 and Brx1 function cooperatively in 60S ribosomal subunit assembly in Saccharomyces cerevisiae. Nucleic Acids Res 40: 4574–4588.
81. Sikorski RS, Hieter P. 1989. A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics 122: 19–27.
82. Stelzl U,Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, et al. 2005. A human protein–protein interaction network: a resource for annotating the proteome. Cell 122: 957–968.
83. Strunk BS, Karbstein K. 2009. Powering through ribosome assembly. RNA 15: 2083–2104.
84. Suter B. 2012. The Cross-and-Capture system: a versatile tool in yeast proteomics. Methods 58: 360–366.
85. Suter B, Fetchko MJ, Imhof R, Graham CI, Stoffel-Studer I, Zbinden C, Raghavan M, Lopez L, Beneti L, Hort J, et al. 2007. Examining protein–protein interactions using endogenously tagged yeast arrays: the cross-and-capture system. Genome Res 17: 1774–1782.
86. Talkish J, Zhang J, Jakovljevic J, Horsey EW,Woolford JL Jr. 2012. Hierarchical recruitment into nascent ribosomes of assembly factors required for 27SB pre-rRNA processing in Saccharomyces cerevisiae. Nucleic Acids Res 40: 8646–8661.
87. Tang L, Sahasranaman A, Jakovljevic J, Schleifman E,Woolford JL Jr. 2008. Interactions among Ytm1, Erb1, and Nop7 required for assembly of the Nop7-subcomplex in yeast preribosomes. Mol Biol Cell 19: 2844–2856.
88. Tarassov K, Messier V, Landry CR, Radinovic S, Serna Molina MM, Shames I, Malitskaya Y, Vogel J, Bussey H, Michnick SW. 2008. An in vivo map of the yeast protein interactome. Science 320: 1465–1470.
89. Thomson E, Ferreira-Cerca S, Hurt E. 2013. Eukaryotic ribosome biogenesis at a glance. J Cell Sci 126: 4815–4821.
90. Tschochner H, Hurt E. 2003. Pre-ribosomes on the road from the nucleolus to the cytoplasm. Trends Cell Biol 13: 255–263.
91. Uetz P, Giot L, Cagney G, Mansfield TA, Judson RS, Knight JR, Lockshon D, Narayan V, Srinivasan M, Pochart P, et al. 2000. A comprehensive analysis of protein–protein interactions in Saccharomyces cerevisiae. Nature 403: 623–627.
92. Ulbrich C, Diepholz M, Bassler J, Kressler D, Pertschy B, Galani K, Böttcher B, Hurt E. 2009. Mechanochemical removal of ribosome biogenesis factors from nascent 60S ribosomal subunits. Cell 138: 911–922.
93. Venkatesan K, Rual J-F, Vazquez A, Stelzl U, Lemmens I, Hirozane- Kishikawa T, Hao T, Zenkner M, Xin X, Goh K-I, et al. 2009. An empirical framework for binary interactome mapping. Nat Methods 6: 83–90.
94. Vidal M, Cusick ME, Barabási A-L. 2011. Interactome networks and human disease. Cell 144: 986–998.
95. Wälde S, King MC. 2014. The KASH protein Kms2 coordinates mitotic remodeling of the spindle pole body. J Cell Sci 127: 3625–3640.
96. Wang J, Huo K, Ma L, Tang L, Li D, Huang X, Yuan Y, Li C,Wang W, Guan W, et al. 2011. Toward an understanding of the protein interaction network of the human liver. Mol Syst Biol 7: 536.
97. Wong J, Nakajima Y,Westermann S, Shang C, Kang J-S, Goodner C, Houshmand P, Fields S, Chan CS, Drubin D, et al. 2007. A protein interaction map of the mitotic spindle. Mol Biol Cell 18: 3800–3809.
98. Woolford JL Jr, Baserga SJ. 2013. Ribosome biogenesis in the yeast Saccharomyces cerevisiae. Genetics 195: 643–681.
99. Yu H, Braun P, Yildirim MA, Lemmens I, Venkatesan K, Sahalie J, Hirozane-Kishikawa T, Gebreab F, Li N, Simonis N, et al. 2008. High-quality binary protein interaction map of the yeast interactome network. Science 322: 104–110.