Discovery of a small-molecule inhibitor of STAT3 by ligand-based pharmacophore screening

Methods

Volumn 71, Issue C, 2015, Pages 38-43

  Leung, Ka Ho ^a   Liu, Li Juan ^b   Lin, Sheng ^a   Lu, Lihua ^a   Zhong, Hai Jing ^b   Susanti, Dewi ^c   Rao, Weidong ^c   Wang, Modi ^a   Che, Weng Ian ^b   Chan, Daniel Shiu Hin ^a   Leung, Chung Hang ^b   Chan, Philip Wai Hong ^c   Ma, Dik Lung ^a  

^a HONG KONG BAPTIST UNIVERSITY   (Hong Kong)

^b University of Macau   (Macao)

^c Nanyang Technological University   (Singapore)

Author keywords

Pharmacophore; Protein protein interaction; STAT3; Virtual screening

Indexed keywords

PROTEIN INHIBITOR; STAT1 PROTEIN; STAT3 PROTEIN; STAT5 PROTEIN;

APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; CELL FUNCTION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; DNA BINDING; DRUG SCREENING; FEMALE; FLUORESCENCE POLARIZATION; HELA CELL LINE; HUMAN; HUMAN CELL; IN VITRO STUDY; MOLECULAR DOCKING; PHARMACOPHORE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; ANTAGONISTS AND INHIBITORS; CHEMICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; DRUG DEVELOPMENT; PROCEDURES;

DRUG DISCOVERY; DRUG EVALUATION, PRECLINICAL; HELA CELLS; HUMANS; MODELS, CHEMICAL; MODELS, MOLECULAR; STAT3 TRANSCRIPTION FACTOR;

EID: 84927728260     PISSN: 10462023     EISSN: 10959130     Source Type: Journal    
DOI: 10.1016/j.ymeth.2014.07.010     Document Type: Article

References (53)

1. Croker B.A., Kiu H., Nicholson S.E. Semin. Cell Dev. Biol. 2008, 19:414-422.
2. Braun D.A., Fribourg M., Sealfon S.C. J. Biol. Chem. 2013, 288:2986-2993.
3. Fu X.Y. Cell Res. 2006, 16:214-219.
4. Levy D.E., Inghirami G. Proc. Natl. Acad. Sci. U.S.A. 2006, 103:10151-10152.
5. Aggarwal B.B., Kunnumakkara A.B., Harikumar K.B., Gupta S.R., Tharakan S.T., Koca C., Dey S., Sung B. Ann. N. Y. Acad. Sci. 2009, 1171:59-76.
6. Johnston P.A., Grandis J.R. Mol. Interv. 2011, 11:18-26.
7. Vartoukian S.R., Tilakaratne W.M., Seoudi N., Bombardieri M., Bergmeier L., Tappuni A.R., Fortune F. Clin. Exp. Immunol. 2014, 177:618-629.
8. Leeman R.J., Lui V.W.Y., Grandis J.R. Expert Opin. Biol. Ther. 2006, 6:231-241.
9. Furqan M., Akinleye A., Mukhi N., Mittal V., Chen Y.M., Liu D.L. J. Hematol. Oncol. 2013, 6:90-100.
10. Yu H., Pardoll D., Jove R. Nat. Rev. Cancer 2009, 9:798-809.
11. Miklossy G., Hilliard T.S., Turkson J. Nat. Rev. Drug Discovery 2013, 12:611-629.
12. Coleman D.R., Ren Z.Y., Mandal P.K., Cameron A.G., Dyer G.A., Muranjan S., Campbell M., Chen X.M., McMurray J.S. J. Med. Chem. 2005, 48:6661-6670.
13. McMurray J.S. Biopolymers 2008, 90:69-79.
14. Nagel-Wolfrum K., Buerger C., Wittig I., Butz K., Hoppe-Seyler F., Groner B. Mol. Cancer Res. 2004, 2:170-182.
15. Sen M., Thomas S.M., Kim S., Yeh J.I., Ferris R.L., Johnson J.T., Duvvuri U., Lee J., Sahu N., Joyce S., Freilino M.L., Shi H.B., Li C.Y., Ly D., Rapireddy S., Etter J.P., Li P.K., Wang L., Chiosea S., Seethala R.R., Gooding W.E., Chen X.M., Kaminski N., Pandit K., Johnson D.E., Grandis J.R. Cancer Discov. 2012, 2:694-705.
16. Leong P.L., Andrews G.A., Johnson D.E., Dyer K.F., Xi S.C., Mai J.C., Robbins P.D., Gadiparthi S., Burke N.A., Watkins S.F., Grandis J.R. Proc. Natl. Acad. Sci. U.S.A. 2003, 100:4138-4143.
17. Park Y.G., Nesterova M., Agrawal S., Cho-Chung Y.S. J. Biol. Chem. 1999, 274:1573-1580.
18. Konnikova L., Kotecki M., Kruger M.M., Cochran B.H. BMC Cancer 2003, 3:23-31.
19. Wang X., Liu P., Liu H., Yang W., Liu Z., Zhuo Z., Gao Y. Cancer Gene Ther. 2012, 19:822-827.
20. Kijima T., Niwa H., Steinman R.A., Drenning S.D., Gooding W.E., Wentzel A.L., Xi S., Grandis J.R. Cell Growth Differ. 2002, 13:355-362.
21. Bai A., Hu P., Chen J., Song X., Chen W., Peng W., Zeng Z., Gao X. Int. J. Colorectal Dis. 2007, 22:625-635.
22. Chang C.J., Chiang C.H., Song W.S., Tsai S.K., Woung L.C., Chang C.H., Jeng S.Y., Tsai C.Y., Hsu C.C., Lee H.F., Huang C.S., Yung M.C., Liu J.H., Lu K.H. Childs Nerv. Syst. 2012, 28:363-373.
23. Liu T.Y., Peng H.G., Zhang M.X., Deng Y.H., Wu Z.H. Eur. J. Pharmacol. 2010, 641:15-22.
24. Yang C.L., Liu Y.Y., Ma Y.G., Xue Y.X., Liu D.G., Ren Y., Liu X.B., Li Y., Li Z. PLoS ONE 2012, 7:e37960.
25. Tu S.P., Jin H.Y., Shi J.D., Zhu L.M., Suo Y., Lu G., Liu A., Wang T.C., Yang C.S. Cancer Prev. Res. (Phila, PA) 2012, 5:205-215.
26. Siddiquee K., Zhang S., Guida W.C., Blaskovich M.A., Greedy B., Lawrence H.R., Yip M.L., Jove R., McLaughlin M.M., Lawrence N.J., Sebti S.M., Turkson J. Proc. Natl. Acad. Sci. U.S.A. 2007, 104:7391-7396.
27. Liu L.-J., Leung K.-H., Chan D.S., Wang Y.T., Ma D.-L., Leung C.-H. Cell Death Dis. 2014, 5:e1293.
28. Ma D.-L., Liu L.-J., Leung K.-H., Chen Y.-T., Zhong H.-J., Chan D.S.-H., Wang H.-M.D., Leung C.-H. Angew. Chem. Int. Ed. 2014, 53:9178-9182.
29. Bajorath J. Nat. Rev. Drug Discovery 2002, 1:882-894.
30. Shoichet B.K. Nature 2004, 432:862-865.
31. Chan D.S.-H., Lee H.-M., Yang F., Che C.-M., Wong C.C.L., Abagyan R., Leung C.-H., Ma D.-L. Angew. Chem. Int. Ed. 2010, 49:2860-2864.
32. Lee H.-M., Chan D.S.-H., Yang F., Lam H.-Y., Yan S.-C., Che C.-M., Ma D.-L., Leung C.-H. Chem. Commun. 2010, 46:4680-4682.
33. Leung C.-H., Chan D.S.-H., Yang H., Abagyan R., Lee S.M.-Y., Zhu G.-Y., Fong W.-F., Ma D.-L. Chem. Commun. 2011, 47:2511-2513.
34. Ma D.-L., Chan D.S.-H., Leung C.-H. Chem. Sci. 2011, 2:1656-1665.
35. Ma D.-L., Chan D.S.-H., Leung C.-H. Chem. Soc. Rev. 2013, 42:2130-2141.
36. Leung C.-H., Chan S.-H.D., Li Y.-W., Fong W.-F., Ma D.-L. BMC Pharmacol. Toxicol. 2013, 14:3.
37. Leung C.-H., Chan D.S.-H., Kwan M.H.-T., Cheng Z., Wong C.-Y., Zhu G.-Y., Fong W.-F., Ma D.-L. ChemMedChem 2011, 6:765-768.
38. Chan D.S.-H., Yang H., Kwan M.H.-T., Cheng Z., Lee P., Bai L.-P., Jiang Z.-H., Wong C.-Y., Fong W.-F., Leung C.-H., Ma D.-L. Biochimie 2011, 93:1055-1064.
39. Ma D.-L., Chan D.S.-H., Lee P., Kwan M.H.-T., Leung C.-H. Biochimie 2011, 93:1252-1266.
40. Ma D.-L., Ma V.P.-Y., Chan D.S.-H., Leung K.-H., Zhong H.-J., Leung C.-H. Methods 2012, 57:106-114.
41. Wolber G., Seidel T., Bendix F., Langer T. Drug Discov. Today 2008, 13:23-29.
42. Yang S.Y. Drug Discov. Today 2010, 15:444-450.
43. Caporuscio F., Tafi A. Curr. Med. Chem. 2011, 18:2543-2553.
44. D. Studio, Accelrys, San Diego, CA, 2007.
45. Mandal P.K., Gao F., Lu Z., Ren Z., Ramesh R., Birtwistle J.S., Kaluarachchi K.K., Chen X., Bast R.C., Liao W.S., McMurray J.S. J. Med. Chem. 2011, 54:3549-3563.
46. Chen J., Bai L., Bernard D., Nikolovska-Coleska Z., Gomez C., Zhang J., Yi H., Wang S. ACS Med. Chem. Lett. 2010, 1:85-89.
47. Zhang X., Sun Y., Pireddu R., Yang H., Urlam M.K., Lawrence H.R., Guida W.C., Lawrence N.J., Sebti S.M. Cancer Res. 2013, 73:1922-1933.
48. Zhang X., Yue P., Page B.D., Li T., Zhao W., Namanja A.T., Paladino D., Zhao J., Chen Y., Gunning P.T., Turkson J. Proc. Natl. Acad. Sci. U.S.A. 2012, 109:9623-9628.
49. Siddiquee K.A., Gunning P.T., Glenn M., Katt W.P., Zhang S., Schrock C., Sebti S.M., Jove R., Hamilton A.D., Turkson J. ACS Chem. Biol. 2007, 2:787-798.
50. Zhang X., Yue P., Fletcher S., Zhao W., Gunning P.T., Turkson J. Biochem. Pharmacol. 2010, 79:1398-1409.
51. Susanti D., Koh F., Kusuma J.A., Kothandaraman P., Chan P.W.H. J. Org. Chem. 2012, 77:7166-7175.
52. Rao W., Koh M.J., Kothandaraman P., Chan P.W.H. J. Am. Chem. Soc. 2012, 134:10811-10814.
53. Ton T.M.U., Tejo C., Tiong D.L., Chan P.W.H. J. Am. Chem. Soc. 2012, 134:7344-7350.