메뉴 건너뛰기




Volumn 12, Issue 3, 2010, Pages 151-154

PCSK9 as a therapeutic target in atherosclerosis

Author keywords

[No Author keywords available]

Indexed keywords

LOW DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN RECEPTOR; MEVINOLIN; MONOCLONAL ANTIBODY; PCSK9 MONOCLONAL ANTIBODY 1; UNCLASSIFIED DRUG;

EID: 77953535433     PISSN: 15233804     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11883-010-0099-2     Document Type: Note
Times cited : (13)

References (12)
  • 1
    • 33750597734 scopus 로고    scopus 로고
    • Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic mice
    • Lagace TA, Curtis DE, Garuti R, et al.: Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic mice. J Clin Invest 2006, 116:2995-3005.
    • (2006) J Clin Invest , vol.116 , pp. 2995-3005
    • Lagace, T.A.1    Curtis, D.E.2    Garuti, R.3
  • 2
    • 0037603589 scopus 로고    scopus 로고
    • Mutations in PCSK9 cause autosomal dominant hypercholesterolemia
    • Abifadel M, Varret M, Rabes JP, et al.: Mutations in PCSK9 cause autosomal dominant hypercholesterolemia. Nat Genet 2003, 34:154-156.
    • (2003) Nat Genet , vol.34 , pp. 154-156
    • Abifadel, M.1    Varret, M.2    Rabes, J.P.3
  • 3
    • 13944265645 scopus 로고    scopus 로고
    • Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9
    • Cohen J, Pertsemlidis A, Kotowski IK, et al.: Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9. Nat Genet 2005, 37:161-165.
    • (2005) Nat Genet , vol.37 , pp. 161-165
    • Cohen, J.1    Pertsemlidis, A.2    Kotowski, I.K.3
  • 4
    • 33645103550 scopus 로고    scopus 로고
    • Sequence variations in PCSK9, low LDL, and protection against coronary heart disease
    • Cohen JC, Boerwinkle E, Mosley TH Jr, Hobbs HH: Sequence variations in PCSK9, low LDL, and protection against coronary heart disease. N Engl J Med 2006, 354:1264-1272.
    • (2006) N Engl J Med , vol.354 , pp. 1264-1272
    • Cohen, J.C.1    Boerwinkle, E.2    Mosley Jr., T.H.3    Hobbs, H.H.4
  • 5
    • 18944392912 scopus 로고    scopus 로고
    • A common PCSK9 haplotype, encompassing the E670G coding single nucleotide polymorphism, is a novel genetic marker for plasma low-density lipoprotein cholesterol levels and severity of coronary atherosclerosis
    • Chen SN, Ballantyne CM, Gotto AM Jr, et al.: A common PCSK9 haplotype, encompassing the E670G coding single nucleotide polymorphism, is a novel genetic marker for plasma low-density lipoprotein cholesterol levels and severity of coronary atherosclerosis. J Am Coll Cardiol 2005, 45:1611-1619.
    • (2005) J Am Coll Cardiol , vol.45 , pp. 1611-1619
    • Chen, S.N.1    Ballantyne, C.M.2    Gotto Jr., A.M.3
  • 6
    • 50149101511 scopus 로고    scopus 로고
    • Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates
    • Frank-Kamenetsky M, Grefhorst A, Anderson NN, et al.: Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates. Proc Natl Acad Sci U S A 2008, 105:11915-11920.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 11915-11920
    • Frank-Kamenetsky, M.1    Grefhorst, A.2    Anderson, N.N.3
  • 7
    • 63649095045 scopus 로고    scopus 로고
    • Reduction in Creactive protein and LDL cholesterol and cardiovascular event rates after initiation of rosuvastatin: A prospective study of the JUPITER trial
    • Ridker PM, Danielson E, Fonseca FA, et al.: Reduction in Creactive protein and LDL cholesterol and cardiovascular event rates after initiation of rosuvastatin: a prospective study of the JUPITER trial. Lancet 2009, 373:1175-1182.
    • (2009) Lancet , vol.373 , pp. 1175-1182
    • Ridker, P.M.1    Danielson, E.2    Fonseca, F.A.3
  • 8
    • 3943060193 scopus 로고    scopus 로고
    • Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia
    • Dubuc G, Chamberland A, Wassef H, et al.: Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia. Arterioscler Thromb Vasc Biol 2004, 24:1454-1459.
    • (2004) Arterioscler Thromb Vasc Biol , vol.24 , pp. 1454-1459
    • Dubuc, G.1    Chamberland, A.2    Wassef, H.3
  • 9
    • 77449112270 scopus 로고    scopus 로고
    • Nature's genetic gradients and the clinical phenotype
    • Marian AJ: Nature's genetic gradients and the clinical phenotype. Circ Cardiovasc Genet 2009, 2:537-539.
    • (2009) Circ Cardiovasc Genet , vol.2 , pp. 537-539
    • Marian, A.J.1
  • 10
    • 33748661502 scopus 로고    scopus 로고
    • Molecular characterization of loss-of-function mutations in PCSK9 and identification of a compound heterozygote
    • Zhao Z, Tuakli-Wosornu Y, Lagace TA, et al.: Molecular characterization of loss-of-function mutations in PCSK9 and identification of a compound heterozygote. Am J Hum Genet 2006, 79:514-523.
    • (2006) Am J Hum Genet , vol.79 , pp. 514-523
    • Zhao, Z.1    Tuakli-Wosornu, Y.2    Lagace, T.A.3
  • 11
    • 34147136507 scopus 로고    scopus 로고
    • Antisense inhibition of proprotein convertase subtilisin/kexin type 9 reduces serum LDL in hyperlipidemic mice
    • Graham MJ, Lemonidis KM, Whipple CP, et al.: Antisense inhibition of proprotein convertase subtilisin/kexin type 9 reduces serum LDL in hyperlipidemic mice. J Lipid Res 2007, 48:763-767.
    • (2007) J Lipid Res , vol.48 , pp. 763-767
    • Graham, M.J.1    Lemonidis, K.M.2    Whipple, C.P.3
  • 12
    • 64849093564 scopus 로고    scopus 로고
    • Antibody-mediated disruption of the interaction between PCSK9 and the lowdensity lipoprotein receptor
    • Duff CJ, Scott MJ, Kirby IT, et al.: Antibody-mediated disruption of the interaction between PCSK9 and the lowdensity lipoprotein receptor. Biochem J 2009, 419:577-584.
    • (2009) Biochem J , vol.419 , pp. 577-584
    • Duff, C.J.1    Scott, M.J.2    Kirby, I.T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.