Curcumin attenuates adhesion molecules and matrix metalloproteinase expression in hypercholesterolemic rabbits

Nutrition Research

Volumn 34, Issue 10, 2014, Pages 886-893

  Um, Min Young ^a   Hwang, Kwang Hyun ^b   Choi, Won Hee ^a,c   Ahn, Jiyun ^a,c   Jung, Chang Hwa ^a,c   Ha, Tae Youl ^a,c  

^a Korea Food Research Institute   (South Korea)

^b Korea Institute of Toxicology   (South Korea)

^c University of Science and Technology (UST)   (South Korea)

Author keywords

Adhesion molecules; Atherosclerosis; Curcumin; Inflammation; Matrix metalloproteinase; Rabbit

Indexed keywords

C REACTIVE PROTEIN; CD36 ANTIGEN; CHOLESTEROL; CURCUMIN; GELATINASE A; GELATINASE B; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERSTITIAL COLLAGENASE; LIPID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; PADGEM PROTEIN; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA; VASCULAR CELL ADHESION MOLECULE 1; ANTIOXIDANT; CELL ADHESION MOLECULE; CYTOKINE; MATRIX METALLOPROTEINASE; PLANT EXTRACT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIATHEROSCLEROSIS ACTIVITY; ANTIGEN EXPRESSION; AORTA; ARTERY INTIMA PROLIFERATION; ARTICLE; ATHEROSCLEROSIS; BLOOD SAMPLING; CHOLESTEROL DIET; CONTROLLED STUDY; DIET SUPPLEMENTATION; DIET THERAPY; DRUG ACTIVITY; ELISA KIT; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; HYPERCHOLESTEROLEMIA; LIPID BLOOD LEVEL; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RABBIT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; ANIMAL; BLOOD; CHEMISTRY; CURCUMA; DRUG EFFECTS; GENETICS; METABOLISM; PATHOLOGY; PHYTOTHERAPY; UPREGULATION;

CURCUMA LONGA; ORYCTOLAGUS CUNICULUS;

ANIMALS; ANTIGENS, CD36; ANTIOXIDANTS; AORTA; ATHEROSCLEROSIS; CELL ADHESION MOLECULES; CHEMOKINE CCL2; CHOLESTEROL; CURCUMA; CURCUMIN; CYTOKINES; HYPERCHOLESTEROLEMIA; INTERCELLULAR ADHESION MOLECULE-1; MALE; MATRIX METALLOPROTEINASES; P-SELECTIN; PHYTOTHERAPY; PLANT EXTRACTS; RABBITS; RNA, MESSENGER; TRIGLYCERIDES; UP-REGULATION; VASCULAR CELL ADHESION MOLECULE-1;

EID: 84927657312     PISSN: 02715317     EISSN: 18790739     Source Type: Journal    
DOI: 10.1016/j.nutres.2014.09.001     Document Type: Article

References (44)

1. Zheng Z.J., Sharrett A.R., Chambless L.E., Rosamond W.D., Nieto F.J., Sheps D.S., et al. Associations of ankle-brachial index with clinical coronary heart disease, stroke and preclinical carotid and popliteal atherosclerosis: the Atherosclerosis Risk in Communities (ARIC) Study. Atherosclerosis 1997, 131:115-125.
2. Steinberg D., Parthasarathy S., Carew T.E., Khoo J.C., Witztum J.L. Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity. N Engl J Med 1989, 320:915-924.
3. Lusis A.J. Atherosclerosis. Nature 2000, 407:233-241.
4. Pounis G., Costanzo S., di Giuseppe R., de Lucia F., Santimone I., Sciarretta A., et al. Consumption of healthy foods at different content of antioxidant vitamins and phytochemicals and metabolic risk factors for cardiovascular disease in men and women of the Moli-sani study. Eur J Clin Nutr 2013, 67:207-213.
5. McCullough M.L., Peterson J.J., Patel R., Jacques P.F., Shah R., Dwyer J.T. Flavonoid intake and cardiovascular disease mortality in a prospective cohort of US adults. Am J Clin Nutr 2012, 95:454-464.
6. Berbee J.F., Wong M.C., Wang Y., van der Hoorn J.W., Khedoe P.P., van Klinken J.B., et al. Resveratrol protects against atherosclerosis, but does not add to the antiatherogenic effect of atorvastatin, in APOE*3-Leiden.CETP mice. J Nutr Biochem 2013, 24:1423-1430.
7. Zingg J.M., Hasan S.T., Meydani M. Molecular mechanisms of hypolipidemic effects of curcumin. Biofactors 2013, 39:101-121.
8. Shehzad A., Rehman G., Lee Y.S. Curcumin in inflammatory diseases. Biofactors 2013, 39:69-77.
9. Yang C.H., Yue J., Sims M., Pfeffer L.M. The curcumin analog EF24 targets NF-kappaB and miRNA-21, and has potent anticancer activity in vitro and in vivo. PLoS One 2013, 8:e71130.
10. Yu Y.M., Lin H.C. Curcumin prevents human aortic smooth muscle cells migration by inhibiting of MMP-9 expression. Nutr Metab Cardiovasc Dis 2010, 20:125-132.
11. Yuan H.Y., Kuang S.Y., Zheng X., Ling H.Y., Yang Y.B., Yan P.K., et al. Curcumin inhibits cellular cholesterol accumulation by regulating SREBP-1/caveolin-1 signaling pathway in vascular smooth muscle cells. Acta Pharmacol Sin 2008, 29:555-563.
12. Um M.Y., Hwang K.H., Ahn J., Ha T.Y. Curcumin attenuates diet-induced hepatic steatosis by activating AMP-activated protein kinase. Basic Clin Pharmacol Toxicol 2013, 113:152-157.
13. Shin S.K., Ha T.Y., McGregor R.A., Choi M.S. Long-term curcumin administration protects against atherosclerosis via hepatic regulation of lipoprotein cholesterol metabolism. Mol Nutr Food Res 2011, 55:1829-1840.
14. Shang Q., Pan L., Saumoy M., Chiang J.Y., Tint G.S., Salen G., et al. The stimulatory effect of LXRalpha is blocked by SHP despite the presence of a LXRalpha binding site in the rabbit CYP7A1 promoter. J Lipid Res 2006, 47:997-1004.
15. Eugene J., McColgan S.J., Pollock M.E., Hammer-Wilson M., Moore-Jeffries E.W., Berns M.W. Experimental arteriosclerosis treated by conventional and laser endarterectomy. J Surg Res 1985, 39:31-38.
16. Asai A., Miyazawa T. Dietary curcuminoids prevent high-fat diet-induced lipid accumulation in rat liver and epididymal adipose tissue. J Nutr 2001, 131:2932-2935.
17. Na L.X., Zhang Y.L., Li Y., Liu L.Y., Li R., Kong T., et al. Curcumin improves insulin resistance in skeletal muscle of rats. Nutr Metab Cardiovasc Dis 2011, 21:526-533.
18. Prasad K. Dietary flax seed in prevention of hypercholesterolemic atherosclerosis. Atherosclerosis 1997, 132:69-76.
19. Friedewald W.T., Levy R.I., Fredrickson D.S. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972, 18:499-502.
20. Yamazaki K., Murata M. Frequency of atherogenic risk factors in Japanese obese children. Diabetes Res Clin Pract 1990, 10(Suppl 1):S211-S219.
21. Wielinga P.Y., Yakala G.K., Heeringa P., Kleemann R., Kooistra T. Beneficial effects of alternate dietary regimen on liver inflammation, atherosclerosis and renal activation. PLoS One 2011, 6:e18432.
22. Elseweidy M.M., Abdallah F.R., Younis N.N., Aldohmy S., Kassem H.M. 10-Dehydrogingerdione raises HDL-cholesterol through a CETP inhibition and wards off oxidation and inflammation in dyslipidemic rabbits. Atherosclerosis 2013, 231:334-340.
23. Setorki M., Asgary S., Eidi A., Haeri Rohani A. Effects of acute verjuice consumption with a high-cholesterol diet on some biochemical risk factors of atherosclerosis in rabbits. Med Sci Monit 2010, 16:BR124-BR130.
24. Livak K.J., Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001, 25:402-408.
25. Teplyakov A.I., Pryschepova E.V., Kruchinsky N.G., Chegerova T.I. Cytokines and soluble cell adhesion molecules. Possible markers of inflammatory response in atherosclerosis. Ann N Y Acad Sci 2000, 902:320-322.
26. Le N.A. Hyperlipidemia and cardiovascular disease: cardiovascular update. Curr Opin Lipidol 2008, 19:545-547.
27. Mahfouz M.M., Zhou S.Q., Kummerow F.A. Curcumin prevents the oxidation and lipid modification of LDL and its inhibition of prostacyclin generation by endothelial cells in culture. Prostaglandins Other Lipid Mediat 2009, 90:13-20.
28. Libby P. Inflammation in atherosclerosis. Nature 2002, 420:868-874.
29. Zingg J.M., Hasan S.T., Cowan D., Ricciarelli R., Azzi A., Meydani M. Regulatory effects of curcumin on lipid accumulation in monocytes/macrophages. J Cell Biochem 2012, 113:833-840.
30. Coban D., Milenkovic D., Chanet A., Khallou-Laschet J., Sabbe L., Palagani A., et al. Dietary curcumin inhibits atherosclerosis by affecting the expression of genes involved in leukocyte adhesion and transendothelial migration. Mol Nutr Food Res 2012, 56:1270-1281.
31. Febbraio M., Guy E., Silverstein R.L. Stem cell transplantation reveals that absence of macrophage CD36 is protective against atherosclerosis. Arterioscler Thromb Vasc Biol 2004, 24:2333-2338.
32. Min K.J., Um H.J., Cho K.H., Kwon T.K. Curcumin inhibits oxLDL-induced CD36 expression and foam cell formation through the inhibition of p38 MAPK phosphorylation. Food Chem Toxicol 2013, 58:77-85.
33. Kumar A., Dhawan S., Hardegen N.J., Aggarwal B.B. Curcumin (Diferuloylmethane) inhibition of tumor necrosis factor (TNF)-mediated adhesion of monocytes to endothelial cells by suppression of cell surface expression of adhesion molecules and of nuclear factor-kappaB activation. Biochem Pharmacol 1998, 55:775-783.
34. Lijnen H.R., Silence J., Van Hoef B., Collen D. Stromelysin-1 (MMP-3)-independent gelatinase expression and activation in mice. Blood 1998, 91:2045-2053.
35. Shah P.K., Falk E., Badimon J.J., Fernandez-Ortiz A., Mailhac A., Villareal-Levy G., et al. Human monocyte-derived macrophages induce collagen breakdown in fibrous caps of atherosclerotic plaques. Potential role of matrix-degrading metalloproteinases and implications for plaque rupture. Circulation 1995, 92:1565-1569.
36. Orbe J., Rodriguez J.A., Arias R., Belzunce M., Nespereira B., Perez-Ilzarbe M., et al. Antioxidant vitamins increase the collagen content and reduce MMP-1 in a porcine model of atherosclerosis: implications for plaque stabilization. Atherosclerosis 2003, 167:45-53.
37. Soumyarani V.S., Jayakumari N. Oxidized HDL induces cytotoxic effects: implications for atherogenic mechanism. J Biochem Mol Toxicol 2014, [in press].
38. Inoue N., Takeshita S., Gao D., Ishida T., Kawashima S., Akita H., et al. Lysophosphatidylcholine increases the secretion of matrix metalloproteinase 2 through the activation of NADH/NADPH oxidase in cultured aortic endothelial cells. Atherosclerosis 2001, 155:45-52.
39. Blankenberg S., Rupprecht H.J., Poirier O., Bickel C., Smieja M., Hafner G., et al. Plasma concentrations and genetic variation of matrix metalloproteinase 9 and prognosis of patients with cardiovascular disease. Circulation 2003, 107:1579-1585.
40. Nilsson L., Jonasson L., Nijm J., Hamsten A., Eriksson P. Increased plasma concentration of matrix metalloproteinase-7 in patients with coronary artery disease. Clin Chem 2006, 52:1522-1527.
41. Cheng A.L., Hsu C.H., Lin J.K., Hsu M.M., Ho Y.F., Shen T.S., et al. Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions. Anticancer Res 2001, 21:2895-2900.
42. Yu H., Huang Q. Improving the oral bioavailability of curcumin using novel organogel-based nanoemulsions. J Agric Food Chem 2012, 60:5373-5379.
43. Maradana M.R., Thomas R., O'Sullivan B.J. Targeted delivery of curcumin for treating type 2 diabetes. Mol Nutr Food Res 2013, 57:1550-1556.
44. Jager R., Lowery R.P., Calvanese A.V., Joy J.M., Purpura M., Wilson J.M. Comparative absorption of curcumin formulations. Nutr J 2014, 13:11.