Regulatory effects of curcumin on lipid accumulation in monocytes/macrophages

Journal of Cellular Biochemistry

Volumn 113, Issue 3, 2012, Pages 833-840

  Zingg, Jean Marc ^a   Hasan, Syeda T ^a   Cowan, Danica ^a   Ricciarelli, Roberta ^b   Azzi, Angelo ^a   Meydani, Mohsen ^a  

^a TUFTS UNIVERSITY   (United States)

^b UNIVERSITY OF GENOA   (Italy)

Author keywords

Curcumin; Foxo3a; Lipids; Macrophages; Monocytes; Tetrahydrocurcumin

Indexed keywords

CD36 ANTIGEN; CURCUMIN; FATTY ACID BINDING PROTEIN 4; FATTY ACID TRANSPORTER; LOW DENSITY LIPOPROTEIN RECEPTOR; TETRAHYDROCURCUMIN; TRANSCRIPTION FACTOR FKHRL1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIOXIDANT ACTIVITY; ARTICLE; GENE EXPRESSION; HUMAN; HUMAN CELL; LIPID DIET; LIPID STORAGE; LIPID TRANSPORT; MACROPHAGE; MALE; MONOCYTE; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; STRESS; TRANSCRIPTION INITIATION; UPREGULATION;

ANIMALS; ANTIGENS, CD36; CELL LINE; CURCUMIN; DIET, HIGH-FAT; FATTY ACID-BINDING PROTEINS; FORKHEAD TRANSCRIPTION FACTORS; LIPID METABOLISM; MACROPHAGES; MICE; MICE, KNOCKOUT; MONOCYTES; PHOSPHORYLATION; PROMOTER REGIONS, GENETIC; RECEPTORS, LDL; TRANSCRIPTION, GENETIC; UP-REGULATION;

MUS;

EID: 84857512307     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.23411     Document Type: Article

References (61)

1. Ahn J, Lee H, Kim S, Ha T. 2010. Curcumin-induced suppression of adipogenic differentiation is accompanied by activation of Wnt/beta-catenin signaling. Am J Physiol Cell Physiol 298:C1510-C1516.
2. Alessio M, De Monte L, Scirea A, Gruarin P, Tandon NN, Sitia R. 1996. Synthesis, processing, and intracellular transport of CD36 during monocytic differentiation. J Biol Chem 271:1770-1775. (Pubitemid 26028665)
3. Asai A, Miyazawa T. 2001. Dietary curcuminoids prevent high-fat dietinduced lipid accumulation in rat liver and epididymal adipose tissue. J Nutr 131:2932-2935. (Pubitemid 33063126)
4. Barreyro FJ, Kobayashi S, Bronk SF, Werneburg NW, Malhi H, Gores GJ. 2007. Transcriptional regulation of Bim by FoxO3A mediates hepatocyte lipoapoptosis. J Biol Chem 282:27141-27154. (Pubitemid 47501972)
5. Bastie CC, Nahle Z, McLoughlin T, Esser K, Zhang W, Unterman T, Abumrad NA. 2005. FoxO1 stimulates fatty acid uptake and oxidation in muscle cells through CD36-dependent and -independent mechanisms. J Biol Chem 280: 14222-14229. (Pubitemid 40517324)
6. Beevers CS, Chen L, Liu L, Luo Y, Webster NJ, Huang S. 2009. Curcumin disrupts the mammalian target of rapamycin-raptor complex. Cancer Res 69:1000-1008.
7. Begum AN, Jones MR, Lim GP, Morihara T, Kim P, Heath DD, Rock CL, Pruitt MA, Yang F, Hudspeth B, Hu S, Faull KF, Teter B, Cole GM, Frautschy SA. 2008. Curcumin structure-function, bioavailability, and efficacy in models of neuroinflammation and Alzheimer's disease. J Pharmacol Exp Ther 326: 196-208. (Pubitemid 351872144)
8. Brookheart RT, Michel CI, Schaffer JE. 2009. As a matter of fat. Cell Metab 10:9-12.
9. Calnan DR, Brunet A. 2008. The FoxO code. Oncogene 27:2276-2288. (Pubitemid 351501779)
10. Campbell SE, Tandon NN, Woldegiorgis G, Luiken JJ, Glatz JF, Bonen A. 2004. A novel function for fatty acid translocase (FAT)/CD36: Involvement in long chain fatty acid transfer into the mitochondria. J Biol Chem 279:36235-36241. (Pubitemid 39128959)
11. Collins AR, Lyon CJ, Xia X, Liu JZ, Tangirala RK, Yin F, Boyadjian R, Bikineyeva A, Pratico D, Harrison DG, Hsueh WA. 2009. Age-accelerated atherosclerosis correlates with failure to upregulate antioxidant genes. Circ Res 104:e42-e54.
12. Dansen TB, Kops GJ, Denis S, Jelluma N, Wanders RJ, Bos JL, Burgering BM, Wirtz KW. 2004. Regulation of sterol carrier protein gene expression by the forkhead transcription factor FOXO3a. J Lipid Res 45:81-88. (Pubitemid 38176617)
13. de Kreutzenberg SV, Ceolotto G, Papparella I, Bortoluzzi A, Semplicini A, Dalla Man C, Cobelli C, Fadini GP, Avogaro A. 2010. Downregulation of the longevity-associated protein sirtuin 1 in insulin resistance and metabolic syndrome: Potential biochemical mechanisms. Diabetes 59:1006-1015.
14. Dejean AS, Hedrick SM, Kerdiles YM. 2011. Highly specialized role of Forkhead box O transcription factors in the immune system. Antioxid Redox Signal 14:663-674.
15. Dinkova-Kostova AT, Talalay P. 1999. Relation of structure of curcumin analogs to their potencies as inducers of Phase 2 detoxification enzymes. Carcinogenesis 20:911-914. (Pubitemid 29191875)
16. Dinkova-Kostova AT, Talalay P. 2008. Direct and indirect antioxidant properties of inducers of cytoprotective proteins. Mol Nutr Food Res 52(Suppl 1): S128-S138.
17. Dou X, Fan C, Wo L, Yan J, Qian Y, Wo X. 2008. Curcumin up-regulates LDL receptor expression via the sterol regulatory element pathway in HepG2 cells. Planta Med 74:1374-1379.
18. Ejaz A, Wu D, Kwan P, Meydani M. 2009. Curcumin inhibits adipogenesis in 3T3-L1 adipocytes and angiogenesis and obesity in C57/BL mice. J Nutr 139: 919-925.
19. Erbay E, Babaev VR, Mayers JR, Makowski L, Charles KN, Snitow ME, Fazio S, Wiest MM, Watkins SM, Linton MF, Hotamisligil GS. 2009. Reducing endoplasmic reticulum stress through a macrophage lipid chaperone alleviates atherosclerosis. Nat Med 15:1383-1391.
20. Fan C, Wo X, Qian Y, Yin J, Gao L. 2006. Effect of curcumin on the expression of LDL receptor in mouse macrophages. J Ethnopharmacol 105:251-254.
21. Fu Y, Luo N, Lopes-Virella MF. 2000. Oxidized LDL induces the expression of ALBP/aP2 mRNA and protein in human THP-1 macrophages. J Lipid Res 41: 2017-2023. (Pubitemid 32038997)
22. Fu Y, Luo N, Lopes-Virella MF, Garvey WT. 2002. The adipocyte lipid binding protein (ALBP/aP2) gene facilitates foam cell formation in human THP-1 macrophages. Atherosclerosis 165:259-269. (Pubitemid 35333352)
23. Fu Y, Luo L, Luo N, Garvey WT. 2006. Lipid metabolism mediated by adipocyte lipid binding protein (ALBP/aP2) gene expression in human THP-1 macrophages. Atherosclerosis 188:102-111. (Pubitemid 44142544)
24. Grimaldi PA, Knobel SM, Whitesell RR, Abumrad NA. 1992. Induction of aP2 gene expression by nonmetabolized long-chain fatty acids. Proc Natl Acad Sci USA 89:10930-10934
25. Huang SC, Wu TC, Yu HC, Chen MR, Liu CM, Chiang WS, Lin KM. 2010. Mechanical strain modulates age-related changes in the proliferation and differentiation of mouse adipose-derived stromal cells. BMC Cell Biol 11:18.
26. Hussain AR, Al-Rasheed M, Manogaran PS, Al-Hussein KA, Platanias LC, Al Kuraya K, Uddin S. 2006. Curcumin induces apoptosis via inhibition of PI3'-kinase/AKT pathway in acute T cell leukemias. Apoptosis 11:245-254. (Pubitemid 43291024)
27. Ireson C, Orr S, Jones DJ, Verschoyle R, Lim CK, Luo JL, Howells L, Plummer S, Jukes R, Williams M, Steward WP, Gescher A. 2001. Characterization of metabolites of the chemopreventive agent curcumin in human and rat hepatocytes and in the rat in vivo, and evaluation of their ability to inhibit phorbol ester-induced prostaglandin E2 production. Cancer Res 61:1058-1064. (Pubitemid 32174425)
28. Kang Q, Chen A. 2009. Curcumin suppresses expression of low-density lipoprotein (LDL) receptor, leading to the inhibition of LDL-induced activation of hepatic stellate cells. Br J Pharmacol 157:1354-1367.
29. Kempna P, Reiter E, Arock M, Azzi A, Zingg JM. 2004. Inhibition of HMC-1 mast cell proliferation by vitamin E: Involvement of the protein kinase B pathway. J Biol Chem 279:50700-50709. (Pubitemid 40017807)
30. Kim M, Kim Y. 2010. Hypocholesterolemic effects of curcumin via up-regulation of cholesterol 7a-hydroxylase in rats fed a high fat diet. Nutr Res Pract 4:191-195.
31. Li M, Chiu JF, Mossman BT, Fukagawa NK. 2006. Down-regulation of manganese-superoxide dismutase through phosphorylation of FOXO3a by Akt in explanted vascular smooth muscle cells from old rats. J Biol Chem 281:40429-40439. (Pubitemid 46041846)
32. Lima CF, Pereira-Wilson C, Rattan SI. 2011. Curcumin induces heme oxygenase-1 in normal human skin fibroblasts through redox signaling: Relevance for anti-aging intervention. Mol Nutr Food Res 55:430-442.
33. Lin JK, Lin-Shiau SY. 2006. Mechanisms of hypolipidemic and anti-obesity effects of tea and tea polyphenols. Mol Nutr Food Res 50:211-217.
34. Miyauchi H, Minamino T, Tateno K, Kunieda T, Toko H, Komuro I. 2004. Akt negatively regulates the in vitro lifespan of human endothelial cells via a p53/p21-dependent pathway. EMBO J 23:212-220. (Pubitemid 38165761)
35. Murakami S. 2006. Stress resistance in long-lived mouse models. Exp Gerontol 41:1014-1019. (Pubitemid 44821697)
36. Na LX, Zhang YL, Li Y, Liu LY, Li R, Kong T, Sun CH. 2011. Curcumin improves insulin resistance in skeletal muscle of rats. Nutr Metab Cardiovasc Dis 21:526-533.
37. Nadal A, Marrero PF, Haro D. 2002. Down-regulation of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene by insulin: The role of the forkhead transcription factor FKHRL1. Biochem J 366:289-297. (Pubitemid 34971829)
38. Nahle Z, Hsieh M, Pietka T, Coburn CT, Grimaldi PA, Zhang MQ, Das D, Abumrad NA. 2008. CD36-dependent regulation of muscle FoxO1 and PDK4 in the PPAR delta/beta-mediated adaptation to metabolic stress. J Biol Chem 283:14317-14326.
39. Nakae J, Cao Y, Oki M, Orba Y, Sawa H, Kiyonari H, Iskandar K, Suga K, Lombes M, Hayashi Y. 2008. Forkhead transcription factor FoxO1 in adipose tissue regulates energy storage and expenditure. Diabetes 57:563-576.
40. Nunn AV, Guy GW, Bell JD. 2009. Endocannabinoids, FOXO and the metabolic syndrome: Redox, function and tipping point-The view from two systems. Immunobiology 215:617-628.
41. Okamura DM, Pennathur S, Pasichnyk K, Lopez-Guisa JM, Collins S, Febbraio M, Heinecke J, Eddy AA. 2009. CD36 regulates oxidative stress and inflammation in hypercholesterolemic CKD. J Am Soc Nephrol 20:495-505.
42. Pae HO, Jeong SO, Jeong GS, Kim KM, Kim HS, Kim SA, Kim YC, Kang SD, Kim BN, Chung HT. 2007. Curcumin induces pro-apoptotic endoplasmic reticulum stress in human leukemia HL-60 cells. Biochem Biophys Res Commun 353:1040-1045. (Pubitemid 46080402)
43. Peschel D, Koerting R, Nass N. 2007. Curcumin induces changes in expression of genes involved in cholesterol homeostasis. J Nutr Biochem 18:113-119. (Pubitemid 46048987)
44. Reiter E, Azzi A, Zingg JM. 2007. Enhanced anti-proliferative effects of combinatorial treatment of delta-tocopherol and resveratrol in human HMC-1 cells. Biofactors 30:67-77. (Pubitemid 351496173)
45. Relling DP, Esberg LB, Fang CX, Johnson WT, Murphy EJ, Carlson EC, Saari JT, Ren J. 2006. High-fat diet-induced juvenile obesity leads to cardiomyocyte dysfunction and upregulation of Foxo3a transcription factor independent of lipotoxicity and apoptosis. J Hypertens 24:549-561. (Pubitemid 43261920)
46. Ricciarelli R, Zingg JM, Azzi A. 2000. Vitamin E reduces the uptake of oxidized LDL by inhibiting CD36 scavenger receptor expression in cultured human aortic smooth muscle cells. Circulation 102:82-87. (Pubitemid 30430557)
47. Rival Y, Stennevin A, Puech L, Rouquette A, Cathala C, Lestienne F, Dupont- Passelaigue E, Patoiseau JF, Wurch T, Junquero D. 2004. Human adipocyte fatty acid-binding protein (aP2) gene promoter-driven reporter assay discriminates nonlipogenic peroxisome proliferator-activated receptor gamma ligands. J Pharmacol Exp Ther 311:467-475. (Pubitemid 39391530)
48. Salih DA, Brunet A. 2008. FoxO transcription factors in the maintenance of cellular homeostasis during aging. Curr Opin Cell Biol 20:126-136.
49. Shehzad A, Ha T, Subhan F, Lee YS. 2011. New mechanisms and the anti-inflammatory role of curcumin in obesity and obesity-related metabolic diseases. Eur J Nutr 50:151-161.
50. Song J, Ren P, Zhang L, Wang XL, Chen L, Shen YH. 2010. Metformin reduces lipid accumulation in macrophages by inhibiting FOXO1-mediated transcription of fatty acid-binding protein 4. Biochem Biophys Res Commun 393:89-94.
51. Strissel KJ, Stancheva Z, Miyoshi H, Perfield JW II, DeFuria J, Jick Z, Greenberg AS, Obin MS. 2007. Adipocyte death, adipose tissue remodeling, and obesity complications. Diabetes 56:2910-2918. (Pubitemid 350223625)
52. Su X, Abumrad NA. 2009. Cellular fatty acid uptake: A pathway under construction. Trends Endocrinol Metab 20:72-77.
53. Tang Y, Chen A. 2010. Curcumin protects hepatic stellate cells against leptininduced activation in vitro by accumulating intracellular lipids. Endocrinology 151:4168-4177.
54. Tontonoz P, Nagy L, Alvarez JG, Thomazy VA, Evans RM. 1998. PPARgamma promotes monocyte/macrophage differentiation and uptake of oxidized LDL. Cell 93:241-252. (Pubitemid 28180857)
55. Van Der Heide LP, Hoekman MF, Smidt MP. 2004. The ins and outs of FoxO shuttling: Mechanisms of FoxO translocation and transcriptional regulation. Biochem J 380:297-309. (Pubitemid 38788101)
56. Weisberg SP, Leibel R, Tortoriello DV. 2008. Dietary curcumin significantly improves obesity-associated inflammation and diabetes in mouse models of diabesity. Endocrinology 149:3549-3558. (Pubitemid 351919581)
57. Wilson A, Shehadeh LA, Yu H, Webster KA. 2010. Age-related molecular genetic changes of murine bone marrow mesenchymal stem cells. BMC Genomics 11:229.
58. Zhao J, Sun XB, Ye F, Tian WX. 2011. Suppression of fatty acid synthase, differentiation and lipid accumulation in adipocytes by curcumin. Mol Cell Biochem 351:19-128.
59. Zhou X, He W, Huang Z, Gotto AM, Jr., Hajjar DP, Han J. 2008. Genetic deletion of low density lipoprotein receptor impairs sterol-induced mouse macrophage ABCA1 expression. A new SREBP1-dependent mechanism. J Biol Chem 283:2129-2138.
60. Zingg JM, Ricciarelli R, Azzi A. 2000. Scavenger receptors and modified lipoproteins: Fatal attractions? IUBMB Life 49:397-403. (Pubitemid 30436174)
61. Zingg JM, Ricciarelli R, Andorno E, Azzi A. 2002. Novel 5' exon of scavenger receptor CD36 is expressed in cultured human vascular smooth muscle cells and atherosclerotic plaques. Arterioscler Thromb Vasc Biol 22:412-417. (Pubitemid 34218747)