-
1
-
-
67449138207
-
International trends in colorectal cancer incidence rates
-
Center, M.M. et al. (2009) International trends in colorectal cancer incidence rates. Cancer Epidemiol. Biomarkers Prev., 18, 1688-1694.
-
(2009)
Cancer Epidemiol. Biomarkers Prev
, vol.18
, pp. 1688-1694
-
-
Center, M.M.1
-
2
-
-
22644440007
-
Chemoradiotherapy for colorectal cancer
-
Andre, N. et al. (2005) Chemoradiotherapy for colorectal cancer. Gut, 54, 1194-1202.
-
(2005)
Gut
, vol.54
, pp. 1194-1202
-
-
Andre, N.1
-
3
-
-
79955564023
-
Intestinal inflammation and cancer
-
Ullman, T.A. et al. (2011) Intestinal inflammation and cancer. Gastroenterology, 140, 1807-1816.
-
(2011)
Gastroenterology
, vol.140
, pp. 1807-1816
-
-
Ullman, T.A.1
-
4
-
-
58649108302
-
IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer
-
Grivennikov, S. et al. (2009) IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer. Cancer Cell, 15, 103-113.
-
(2009)
Cancer Cell
, vol.15
, pp. 103-113
-
-
Grivennikov, S.1
-
5
-
-
58649101347
-
gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis
-
Bollrath, J. et al. (2009) gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis. Cancer Cell, 15, 91-102.
-
(2009)
Cancer Cell
, vol.15
, pp. 91-102
-
-
Bollrath, J.1
-
6
-
-
84897561550
-
IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis
-
Rokavec, M. et al. (2014) IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis. J. Clin. Invest., 124, 1853-1867.
-
(2014)
J. Clin. Invest
, vol.124
, pp. 1853-1867
-
-
Rokavec, M.1
-
7
-
-
84875402648
-
Inhibition of the IL-6 signaling pathway: a strategy to combat chronic inflammatory diseases and cancer
-
Ataie-Kachoie, P. et al. (2013) Inhibition of the IL-6 signaling pathway: a strategy to combat chronic inflammatory diseases and cancer. Cytokine Growth Factor Rev., 24, 163-173.
-
(2013)
Cytokine Growth Factor Rev
, vol.24
, pp. 163-173
-
-
Ataie-Kachoie, P.1
-
8
-
-
0031854656
-
Interleukin-6 levels in colorectal cancer tissues
-
Komoda, H. et al. (1998) Interleukin-6 levels in colorectal cancer tissues. World J. Surg., 22, 895-898.
-
(1998)
World J. Surg
, vol.22
, pp. 895-898
-
-
Komoda, H.1
-
9
-
-
77649239393
-
Serum interleukin-6 levels in colorectal cancer patients-a summary of published results
-
Knüpfer, H. et al. (2010) Serum interleukin-6 levels in colorectal cancer patients-a summary of published results. Int. J. Colorectal Dis., 25, 135-140.
-
(2010)
Int. J. Colorectal Dis
, vol.25
, pp. 135-140
-
-
Knüpfer, H.1
-
10
-
-
33747361621
-
Fra-1 a target for cancer prevention or intervention
-
Young, M.R. et al. (2006) Fra-1 a target for cancer prevention or intervention. Gene, 379, 1-11.
-
(2006)
Gene
, vol.379
, pp. 1-11
-
-
Young, M.R.1
-
11
-
-
0031756337
-
Fra-1 induces morphological transformation and increases in vitro invasiveness and motility of epithelioid adenocarcinoma cells
-
Kustikova, O. et al. (1998) Fra-1 induces morphological transformation and increases in vitro invasiveness and motility of epithelioid adenocarcinoma cells. Mol. Cell. Biol., 18, 7095-7105.
-
(1998)
Mol. Cell. Biol
, vol.18
, pp. 7095-7105
-
-
Kustikova, O.1
-
12
-
-
33644834687
-
E-cadherin transcriptional downregulation by promoter methylation but not mutation is related to epithelial-to-mesenchymal transition in breast cancer cell lines
-
Lombaerts, M. et al. (2006) E-cadherin transcriptional downregulation by promoter methylation but not mutation is related to epithelial-to-mesenchymal transition in breast cancer cell lines. Br. J. Cancer, 94, 661-671.
-
(2006)
Br. J. Cancer
, vol.94
, pp. 661-671
-
-
Lombaerts, M.1
-
13
-
-
84883621632
-
Protein kinase C a is a central signaling node and therapeutic target for breast cancer stem cells
-
Tam, W.L. et al. (2013) Protein kinase C a is a central signaling node and therapeutic target for breast cancer stem cells. Cancer Cell, 24, 347-364.
-
(2013)
Cancer Cell
, vol.24
, pp. 347-364
-
-
Tam, W.L.1
-
14
-
-
84885377160
-
A switch in the expression of embryonic EMTinducers drives the development of malignant melanoma
-
Caramel, J. et al. (2013) A switch in the expression of embryonic EMTinducers drives the development of malignant melanoma. Cancer Cell, 24, 466-480.
-
(2013)
Cancer Cell
, vol.24
, pp. 466-480
-
-
Caramel, J.1
-
15
-
-
84899114827
-
Widespread FRA1-dependent control of mesenchymal transdifferentiation programs in colorectal cancer cells
-
Diesch, J. et al. (2014) Widespread FRA1-dependent control of mesenchymal transdifferentiation programs in colorectal cancer cells. PLoS One, 9, e88950.
-
(2014)
PLoS One
, vol.9
-
-
Diesch, J.1
-
16
-
-
12244251445
-
Stat3 dimerization regulated by reversible acetylation of a single lysine residue
-
Yuan, Z.L. et al. (2005) Stat3 dimerization regulated by reversible acetylation of a single lysine residue. Science, 307, 269-273.
-
(2005)
Science
, vol.307
, pp. 269-273
-
-
Yuan, Z.L.1
-
17
-
-
38849199799
-
STAT3 as a target for inducing apoptosis in solid and hematological tumors
-
Al Zaid Siddiquee, K. et al. (2008) STAT3 as a target for inducing apoptosis in solid and hematological tumors. Cell Res., 18, 254-267.
-
(2008)
Cell Res
, vol.18
, pp. 254-267
-
-
Al Zaid Siddiquee, K.1
-
18
-
-
0035964349
-
Variable beta-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment
-
Brabletz, T. et al. (2001) Variable beta-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment. Proc. Natl. Acad. Sci. U. S. A., 98, 10356-10361.
-
(2001)
Proc. Natl. Acad. Sci. U. S. A
, vol.98
, pp. 10356-10361
-
-
Brabletz, T.1
-
19
-
-
44449144396
-
Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis
-
Yang, J. et al. (2008) Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis. Dev. Cell, 14, 818-829.
-
(2008)
Dev. Cell
, vol.14
, pp. 818-829
-
-
Yang, J.1
-
20
-
-
25144451812
-
The epithelial-mesenchymal transition (EMT) and colorectal cancer progression
-
Bates, R.C. et al. (2005) The epithelial-mesenchymal transition (EMT) and colorectal cancer progression. Cancer Biol. Ther., 4, 365-370.
-
(2005)
Cancer Biol. Ther
, vol.4
, pp. 365-370
-
-
Bates, R.C.1
-
21
-
-
33749004556
-
Regulation of transforming growth factor-beta 1-induced apoptosis and epithelial-to-mesenchymal transition by protein kinase A and signal transducers and activators of transcription 3
-
Yang, Y. et al. (2006) Regulation of transforming growth factor-beta 1-induced apoptosis and epithelial-to-mesenchymal transition by protein kinase A and signal transducers and activators of transcription 3. Cancer Res., 66, 8617-8624.
-
(2006)
Cancer Res
, vol.66
, pp. 8617-8624
-
-
Yang, Y.1
-
22
-
-
35148832569
-
Epidermal growth factor receptor cooperates with signal transducer and activator of transcription 3 to induce epithelial-mesenchymal transition in cancer cells via up-regulation of TWIST gene expression
-
Lo, H.W. et al. (2007) Epidermal growth factor receptor cooperates with signal transducer and activator of transcription 3 to induce epithelial-mesenchymal transition in cancer cells via up-regulation of TWIST gene expression. Cancer Res., 67, 9066-9076.
-
(2007)
Cancer Res
, vol.67
, pp. 9066-9076
-
-
Lo, H.W.1
-
23
-
-
84881303278
-
Stat3-coordinated Lin-28-let-7-HMGA2 and miR-200-ZEB1 circuits initiate and maintain oncostatin M-driven epithelial-mesenchymal transition
-
Guo, L. et al. (2013) Stat3-coordinated Lin-28-let-7-HMGA2 and miR-200-ZEB1 circuits initiate and maintain oncostatin M-driven epithelial-mesenchymal transition. Oncogene, 32, 5272-5282.
-
(2013)
Oncogene
, vol.32
, pp. 5272-5282
-
-
Guo, L.1
-
24
-
-
77953765709
-
Nonhistone protein acetylation as cancer therapy targets
-
Singh, B.N. et al. (2010) Nonhistone protein acetylation as cancer therapy targets. Expert Rev. Anticancer Ther., 10, 935-954.
-
(2010)
Expert Rev. Anticancer Ther
, vol.10
, pp. 935-954
-
-
Singh, B.N.1
-
25
-
-
84859744042
-
Interferon regulatory factor 1 transactivates expression of human DNA polymerase η in response to carcinogen N-methyl-N'-nitro-N-nitrosoguanidine
-
Qi, H. et al. (2012) Interferon regulatory factor 1 transactivates expression of human DNA polymerase η in response to carcinogen N-methyl-N'-nitro-N-nitrosoguanidine. J. Biol. Chem., 287, 12622-12633.
-
(2012)
J. Biol. Chem
, vol.287
, pp. 12622-12633
-
-
Qi, H.1
-
26
-
-
70349737858
-
Cutting edge: negative regulation of dendritic cells through acetylation of the nonhistone protein STAT-3
-
Sun, Y. et al. (2009) Cutting edge: negative regulation of dendritic cells through acetylation of the nonhistone protein STAT-3. J. Immunol., 182, 5899-5903.
-
(2009)
J. Immunol
, vol.182
, pp. 5899-5903
-
-
Sun, Y.1
-
27
-
-
84863308707
-
Novel interactions between NFATc1 (nuclear factor of activated T cells c1) and STAT-3 (signal transducer and activator of transcription-3) mediate G protein-coupled receptor agonist, thrombin-induced biphasic expression of cyclin D1, with first phase influencing cell migration and second phase directing cell proliferation
-
Kundumani-Sridharan, V. et al. (2012) Novel interactions between NFATc1 (nuclear factor of activated T cells c1) and STAT-3 (signal transducer and activator of transcription-3) mediate G protein-coupled receptor agonist, thrombin-induced biphasic expression of cyclin D1, with first phase influencing cell migration and second phase directing cell proliferation. J. Biol. Chem., 287, 22463-22482.
-
(2012)
J. Biol. Chem
, vol.287
, pp. 22463-22482
-
-
Kundumani-Sridharan, V.1
-
28
-
-
84861215508
-
Acetylated STAT3 is crucial for methylation of tumor-suppressor gene promoters and inhibition by resveratrol results in demethylation
-
Lee, H. et al. (2012) Acetylated STAT3 is crucial for methylation of tumor-suppressor gene promoters and inhibition by resveratrol results in demethylation. Proc. Natl. Acad. Sci. U. S. A., 109, 7765-7769.
-
(2012)
Proc. Natl. Acad. Sci. U. S. A
, vol.109
, pp. 7765-7769
-
-
Lee, H.1
-
29
-
-
84878171024
-
STAT3 acetylation-induced promoter methylation is associated with downregulation of the ARHI tumor-suppressor gene in ovarian cancer
-
Li, J. et al. (2013) STAT3 acetylation-induced promoter methylation is associated with downregulation of the ARHI tumor-suppressor gene in ovarian cancer. Oncol. Rep., 30, 165-170.
-
(2013)
Oncol. Rep
, vol.30
, pp. 165-170
-
-
Li, J.1
-
30
-
-
67449123326
-
Acetylation and activation of STAT3 mediated by nuclear translocation of CD44
-
Lee, J.L. et al. (2009) Acetylation and activation of STAT3 mediated by nuclear translocation of CD44. J. Cell Biol., 185, 949-957.
-
(2009)
J. Cell Biol
, vol.185
, pp. 949-957
-
-
Lee, J.L.1
-
31
-
-
79961026922
-
Direct reprogramming of stem cell properties in colon cancer cells by CD44
-
Su, Y.J. et al. (2011) Direct reprogramming of stem cell properties in colon cancer cells by CD44. EMBO J., 30, 3186-3199.
-
(2011)
EMBO J
, vol.30
, pp. 3186-3199
-
-
Su, Y.J.1
-
32
-
-
35349017886
-
LIF-and IL-6-induced acetylation of STAT3 at Lys-685 through PI3K/Akt activation
-
Ohbayashi, N. et al. (2007) LIF-and IL-6-induced acetylation of STAT3 at Lys-685 through PI3K/Akt activation. Biol. Pharm. Bull., 30, 1860-1864.
-
(2007)
Biol. Pharm. Bull
, vol.30
, pp. 1860-1864
-
-
Ohbayashi, N.1
-
33
-
-
64049109876
-
STAT3 inhibition of gluconeogenesis is downregulated by SirT1
-
Nie, Y. et al. (2009) STAT3 inhibition of gluconeogenesis is downregulated by SirT1. Nat. Cell Biol., 11, 492-500.
-
(2009)
Nat. Cell Biol
, vol.11
, pp. 492-500
-
-
Nie, Y.1
-
34
-
-
84869874931
-
The HAT/HDAC interplay: multilevel control of STAT signaling
-
Icardi, L. et al. (2012) The HAT/HDAC interplay: multilevel control of STAT signaling. Cytokine Growth Factor Rev., 23, 283-291.
-
(2012)
Cytokine Growth Factor Rev
, vol.23
, pp. 283-291
-
-
Icardi, L.1
-
35
-
-
64849111865
-
Targeting STAT3 in cancer: how successful are we?
-
Yue, P. et al. (2009) Targeting STAT3 in cancer: how successful are we? Expert Opin. Investig. Drugs, 18, 45-56.
-
(2009)
Expert Opin. Investig. Drugs
, vol.18
, pp. 45-56
-
-
Yue, P.1
-
36
-
-
40349116206
-
Fra-1 regulates vimentin during Ha-RASinduced epithelial-mesenchymal transition in human colon carcinoma cells
-
Andreolas, C. et al. (2008) Fra-1 regulates vimentin during Ha-RASinduced epithelial-mesenchymal transition in human colon carcinoma cells. Int. J. Cancer, 122, 1745-1756.
-
(2008)
Int. J. Cancer
, vol.122
, pp. 1745-1756
-
-
Andreolas, C.1
-
37
-
-
79959216175
-
TRPS1 targeting by miR-221/222 promotes the epithelial-to-mesenchymal transition in breast cancer
-
Stinson, S. et al. (2011) TRPS1 targeting by miR-221/222 promotes the epithelial-to-mesenchymal transition in breast cancer. Sci Signal, 4, ra41.
-
(2011)
Sci Signal
, vol.4
-
-
Stinson, S.1
-
38
-
-
69249221254
-
Interleukin-6 induces an epithelial-mesenchymal transition phenotype in human breast cancer cells
-
Sullivan, N.J. et al. (2009) Interleukin-6 induces an epithelial-mesenchymal transition phenotype in human breast cancer cells. Oncogene, 28, 2940-2947.
-
(2009)
Oncogene
, vol.28
, pp. 2940-2947
-
-
Sullivan, N.J.1
-
39
-
-
34249289041
-
Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?
-
Peinado, H. et al. (2007) Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype? Nat. Rev. Cancer, 7, 415-428.
-
(2007)
Nat. Rev. Cancer
, vol.7
, pp. 415-428
-
-
Peinado, H.1
-
40
-
-
80052903715
-
The effects and mechanisms of blockage of STAT3 signaling pathway on IL-6 inducing EMT in human pancreatic cancer cells in vitro
-
Huang, C. et al. (2011) The effects and mechanisms of blockage of STAT3 signaling pathway on IL-6 inducing EMT in human pancreatic cancer cells in vitro. Neoplasma, 58, 396-405.
-
(2011)
Neoplasma
, vol.58
, pp. 396-405
-
-
Huang, C.1
-
41
-
-
79952116291
-
Annexin A1 attenuates EMT and metastatic potential in breast cancer
-
Maschler, S. et al. (2010) Annexin A1 attenuates EMT and metastatic potential in breast cancer. EMBO Mol. Med., 2, 401-414.
-
(2010)
EMBO Mol. Med
, vol.2
, pp. 401-414
-
-
Maschler, S.1
-
42
-
-
19444385692
-
Stat3 regulates genes common to both wound healing and cancer
-
Dauer, D.J. et al. (2005) Stat3 regulates genes common to both wound healing and cancer. Oncogene, 24, 3397-3408.
-
(2005)
Oncogene
, vol.24
, pp. 3397-3408
-
-
Dauer, D.J.1
-
43
-
-
79956126860
-
IL-6 promotes prostate tumorigenesis and progression through autocrine cross-activation of IGF-IR
-
Rojas, A. et al. (2011) IL-6 promotes prostate tumorigenesis and progression through autocrine cross-activation of IGF-IR. Oncogene, 30, 2345-2355.
-
(2011)
Oncogene
, vol.30
, pp. 2345-2355
-
-
Rojas, A.1
-
44
-
-
20544438825
-
Mitogen regulated induction of FRA-1 proto-oncogene is controlled by the transcription factors binding to both serum and TPA response elements
-
Adiseshaiah, P. et al. (2005) Mitogen regulated induction of FRA-1 proto-oncogene is controlled by the transcription factors binding to both serum and TPA response elements. Oncogene, 24, 4193-4205.
-
(2005)
Oncogene
, vol.24
, pp. 4193-4205
-
-
Adiseshaiah, P.1
-
45
-
-
84883742665
-
MicroRNA-34 suppresses breast cancer invasion and metastasis by directly targeting Fra-1
-
Yang, S. et al. (2013) MicroRNA-34 suppresses breast cancer invasion and metastasis by directly targeting Fra-1. Oncogene, 32, 4294-4303.
-
(2013)
Oncogene
, vol.32
, pp. 4294-4303
-
-
Yang, S.1
-
46
-
-
84870066326
-
The PKCθ pathway participates in the aberrant accumulation of Fra-1 protein in invasive ER-negative breast cancer cells
-
Belguise, K. et al. (2012) The PKCθ pathway participates in the aberrant accumulation of Fra-1 protein in invasive ER-negative breast cancer cells. Oncogene, 31, 4889-4897.
-
(2012)
Oncogene
, vol.31
, pp. 4889-4897
-
-
Belguise, K.1
-
47
-
-
0034312317
-
Fra-1 replaces c-Fos-dependent functions in mice
-
Fleischmann, A. et al. (2000) Fra-1 replaces c-Fos-dependent functions in mice. Genes Dev., 14, 2695-2700.
-
(2000)
Genes Dev
, vol.14
, pp. 2695-2700
-
-
Fleischmann, A.1
-
48
-
-
33847738172
-
Role of heterodimerization of c-Fos and Fra1 proteins in osteoclast differentiation
-
Bakiri, L. et al. (2007) Role of heterodimerization of c-Fos and Fra1 proteins in osteoclast differentiation. Bone, 40, 867-875.
-
(2007)
Bone
, vol.40
, pp. 867-875
-
-
Bakiri, L.1
-
49
-
-
77956178360
-
EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer
-
Singh, A. et al. (2010) EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer. Oncogene, 29, 4741-4751.
-
(2010)
Oncogene
, vol.29
, pp. 4741-4751
-
-
Singh, A.1
-
50
-
-
84856088337
-
EMT and dissemination precede pancreatic tumor formation
-
Rhim, A.D. et al. (2012) EMT and dissemination precede pancreatic tumor formation. Cell, 148, 349-361.
-
(2012)
Cell
, vol.148
, pp. 349-361
-
-
Rhim, A.D.1
|