N-terminal amphipathic helix as a trigger of hemolytic activity in antimicrobial peptides: A case study in latarcins

FEBS Letters

Volumn 583, Issue 14, 2009, Pages 2425-2428

  Polyansky, Anton A ^a   Vassilevski, Alexander A ^a   Volynsky, Pavel E ^a   Vorontsova, Olga V ^a   Samsonova, Olga V ^a   Egorova, Natalya S ^a   Krylov, Nicolay A ^a   Feofanov, Alexei V ^a   Arseniev, Alexander S ^a   Grishin, Eugene V ^a   Efremov, Roman G ^a  

^a SHEMYAKIN OVCHINNIKOV INSTITUTE OF BIOORGANIC CHEMISTRY   (Russian Federation)

Author keywords

Antimicrobial peptide; Cytolytic peptide; Hemolytic activity; Molecular hydrophobicity potential; Molecular modeling; Protein engineering

Indexed keywords

LATARCIN DERIVATIVE; POLYPEPTIDE ANTIBIOTIC AGENT; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANTIMICROBIAL ACTIVITY; ARTICLE; BACILLUS SUBTILIS; COMPUTER MODEL; CONTROLLED STUDY; CYTOTOXICITY; GENE MUTATION; HEMOLYSIS; HUMAN; HUMAN CELL; HYDROPHILICITY; HYDROPHOBICITY; MINIMUM INHIBITORY CONCENTRATION; PRIORITY JOURNAL; STAPHYLOCOCCUS AUREUS; STRUCTURE ANALYSIS;

AMINO ACID SEQUENCE; ANIMALS; ANTIMICROBIAL CATIONIC PEPTIDES; HEMOLYSIS; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN STRUCTURE, SECONDARY; SPIDER VENOMS;

EID: 67650144822     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2009.06.044     Document Type: Article

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