A FRET-based assay for screening SIRT6 modulators

European Journal of Medicinal Chemistry

Volumn 96, Issue , 2015, Pages 245-249

  Li, Yan ^a   You, Ling ^a   Huang, Wenfei ^a   Liu, Jie ^b   Zhu, Hong ^a   He, Bin ^a  

^a GUIZHOU MEDICAL UNIVERSITY   (China)

^b SICHUAN UNIVERSITY   (China)

Author keywords

Deacetylation; Defatty acylation; Fluorogenic assay; FRET assay; Sirtuin

Indexed keywords

FLUORESCENT DYE; GLUTAMATE DEHYDROGENASE; HYDROLASE INHIBITOR; NICOTINAMIDE; SIRTINOL; SIRTUIN 1; SIRTUIN 2; SIRTUIN 3; SIRTUIN 6; SIRTUIN 6 INHIBITOR; SPLITOMICIN; UNCLASSIFIED DRUG; 7-AMINO-4-METHYLCOUMARIN; COUMARIN DERIVATIVE; ENZYME INHIBITOR; SIRT6 PROTEIN, HUMAN; SIRTUIN;

ARTICLE; DEACYLATION; DRUG SCREENING; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME KINETICS; FLUORESCENCE RESONANCE ENERGY TRANSFER; FLUORESCENCE RESONANCE ENERGY TRANSFER BASED ASSAY; HIGH THROUGHPUT SCREENING; PEPTIDE SYNTHESIS; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; HUMAN; METABOLISM; PRECLINICAL STUDY; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

COUMARINS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; FLUORESCENCE RESONANCE ENERGY TRANSFER; FLUORESCENT DYES; HUMANS; MOLECULAR STRUCTURE; SIRTUINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84927590509     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2015.04.008     Document Type: Article

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