메뉴 건너뛰기




Volumn 42, Issue 22, 2014, Pages 13662-13672

Identification by high-throughput imaging of the histone methyltransferase EHMT2 AS an epigenetic regulator of VEGFA alternative splicing

Author keywords

[No Author keywords available]

Indexed keywords

HETEROCHROMATIN PROTEIN 1; HETEROCHROMATIN PROTEIN 1GAMMA; HISTONE METHYLTRANSFERASE; MESSENGER RNA; PEPTIDES AND PROTEINS; PROTEIN EHMT1; PROTEIN EHMT2; PROTEIN SRSF1; UNCLASSIFIED DRUG; CBX3 PROTEIN, HUMAN; CHROMATIN; EHMT2 PROTEIN, HUMAN; HISTOCOMPATIBILITY ANTIGEN; HISTONE LYSINE METHYLTRANSFERASE; NONHISTONE PROTEIN; NUCLEAR PROTEIN; RNA BINDING PROTEIN; SERINE ARGININE RICH SPLICING FACTOR; VASCULOTROPIN A; VEGFA PROTEIN, HUMAN;

EID: 84927585191     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gku1226     Document Type: Article
Times cited : (42)

References (64)
  • 1
    • 0037041395 scopus 로고    scopus 로고
    • An extensive network of coupling among gene expression machines
    • Maniatis, T. and Reed, R. (2002) An extensive network of coupling among gene expression machines. Nature, 416, 499-506.
    • (2002) Nature , vol.416 , pp. 499-506
    • Maniatis, T.1    Reed, R.2
  • 3
    • 84894318075 scopus 로고    scopus 로고
    • Coupling mRNA processing with transcription in time and space
    • Bentley, D. L. (2014) Coupling mRNA processing with transcription in time and space. Nat. Rev. Genet., 15, 163-175.
    • (2014) Nat. Rev. Genet. , vol.15 , pp. 163-175
    • Bentley, D.L.1
  • 4
    • 0035252410 scopus 로고    scopus 로고
    • Alternative splicing: Increasing diversity in the proteomic world
    • Graveley, B. R. (2001) Alternative splicing: increasing diversity in the proteomic world. Trends Genet., 17, 100-107.
    • (2001) Trends Genet. , vol.17 , pp. 100-107
    • Graveley, B.R.1
  • 5
    • 56749098074 scopus 로고    scopus 로고
    • Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing
    • Pan, Q., Shai, O., Lee, L. J., Frey, B. J. and Blencowe, B. J. (2008) Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing. Nat. Genet., 40, 1413-1415.
    • (2008) Nat. Genet. , vol.40 , pp. 1413-1415
    • Pan, Q.1    Shai, O.2    Lee, L.J.3    Frey, B.J.4    Blencowe, B.J.5
  • 8
    • 84861961269 scopus 로고    scopus 로고
    • Alternative splicing: Decoding an expansive regulatory layer
    • Irimia, M. and Blencowe, B. J. (2012) Alternative splicing: decoding an expansive regulatory layer. Curr. Opin. Cell Biol., 24, 323-332.
    • (2012) Curr. Opin. Cell Biol. , vol.24 , pp. 323-332
    • Irimia, M.1    Blencowe, B.J.2
  • 9
    • 69949132191 scopus 로고    scopus 로고
    • Chromatin organization marks exon-intron structure
    • Schwartz, S., Meshorer, E. and Ast, G. (2009) Chromatin organization marks exon-intron structure. Nat. Struct. Mol. Biol., 16, 990-995.
    • (2009) Nat. Struct. Mol. Biol. , vol.16 , pp. 990-995
    • Schwartz, S.1    Meshorer, E.2    Ast, G.3
  • 10
    • 70349333201 scopus 로고    scopus 로고
    • Nucleosomes are well positioned in exons and carry characteristic histone modifications
    • Andersson, R., Enroth, S., Rada-Iglesias, A., Wadelius, C. and Komorowski, J. (2009) Nucleosomes are well positioned in exons and carry characteristic histone modifications. Genome Res., 19, 1732-1741.
    • (2009) Genome Res. , vol.19 , pp. 1732-1741
    • Andersson, R.1    Enroth, S.2    Rada-Iglesias, A.3    Wadelius, C.4    Komorowski, J.5
  • 11
    • 84893210532 scopus 로고    scopus 로고
    • Regulation of alternative splicing by local histone modifications: Potential roles for RNA-guided mechanisms
    • Zhou, H. L., Luo, G., Wise, J. A. and Lou, H. (2014) Regulation of alternative splicing by local histone modifications: potential roles for RNA-guided mechanisms. Nucleic Acids Res., 42, 701-713.
    • (2014) Nucleic Acids Res. , vol.42 , pp. 701-713
    • Zhou, H.L.1    Luo, G.2    Wise, J.A.3    Lou, H.4
  • 12
    • 73349116881 scopus 로고    scopus 로고
    • Acetylation by the transcriptional coactivator Gcn5 plays a novel role in co-transcriptional spliceosome assembly
    • Gunderson, F. Q. and Johnson, T. L. (2009) Acetylation by the transcriptional coactivator Gcn5 plays a novel role in co-transcriptional spliceosome assembly. PLoS Genet., 5, e1000682.
    • (2009) PLoS Genet. , vol.5 , pp. e1000682
    • Gunderson, F.Q.1    Johnson, T.L.2
  • 14
    • 0030761276 scopus 로고    scopus 로고
    • Functional association between promoter structure and transcript alternative splicing
    • Cramer, P., Pesce, C. G., Baralle, F. E. and Kornblihtt, A. R. (1997) Functional association between promoter structure and transcript alternative splicing. Proc. Natl Acad. Sci. U. S. A., 94, 11456-11460.
    • (1997) Proc. Natl Acad. Sci. U. S. A. , vol.94 , pp. 11456-11460
    • Cramer, P.1    Pesce, C.G.2    Baralle, F.E.3    Kornblihtt, A.R.4
  • 18
    • 84863654457 scopus 로고    scopus 로고
    • Psip1/Ledgf p52 binds methylated histone H3K36 and splicing factors and contributes to the regulation of alternative splicing
    • Pradeepa, M. M., Sutherland, H. G., Ule, J., Grimes, G. R. and Bickmore, W. A. (2012) Psip1/Ledgf p52 binds methylated histone H3K36 and splicing factors and contributes to the regulation of alternative splicing. PLoS Genet., 8, e1002717.
    • (2012) PLoS Genet. , vol.8 , pp. e1002717
    • Pradeepa, M.M.1    Sutherland, H.G.2    Ule, J.3    Grimes, G.R.4    Bickmore, W.A.5
  • 19
    • 36249027156 scopus 로고    scopus 로고
    • Recognition of trimethylated histone H3 lysine 4 facilitates the recruitment of transcription postinitiation factors and pre-mRNA splicing
    • Sims, R. J. III, Millhouse, S., Chen, C. F., Lewis, B. A., Erdjument-Bromage, H., Tempst, P., Manley, J. L. and Reinberg, D. (2007) Recognition of trimethylated histone H3 lysine 4 facilitates the recruitment of transcription postinitiation factors and pre-mRNA splicing. Mol. Cell, 28, 665-676.
    • (2007) Mol. Cell , vol.28 , pp. 665-676
    • Sims, R.J.1    Millhouse, S.2    Chen, C.F.3    Lewis, B.A.4    Erdjument-Bromage, H.5    Tempst, P.6    Manley, J.L.7    Reinberg, D.8
  • 22
    • 0037164741 scopus 로고    scopus 로고
    • Gene-specific targeting of H3K9 methylation is sufficient for initiating repression in vivo
    • Snowden, A. W., Gregory, P. D., Case, C. C. and Pabo, C. O. (2002) Gene-specific targeting of H3K9 methylation is sufficient for initiating repression in vivo. Curr. Biol., 12, 2159-2166.
    • (2002) Curr. Biol. , vol.12 , pp. 2159-2166
    • Snowden, A.W.1    Gregory, P.D.2    Case, C.C.3    Pabo, C.O.4
  • 24
    • 33749381471 scopus 로고    scopus 로고
    • Analysis of cell-based RNAi screens
    • Boutros, M., Bras, L. P. and Huber, W. (2006) Analysis of cell-based RNAi screens. Genome Biol., 7, R66.
    • (2006) Genome Biol. , vol.7 , pp. R66
    • Boutros, M.1    Bras, L.P.2    Huber, W.3
  • 25
    • 49649108878 scopus 로고    scopus 로고
    • A high-throughput screening strategy identifies cardiotonic steroids as alternative splicing modulators
    • Stoilov, P., Lin, C. H., Damoiseaux, R., Nikolic, J. and Black, D. L. (2008) A high-throughput screening strategy identifies cardiotonic steroids as alternative splicing modulators. Proc. Natl Acad. Sci. U. S. A., 105, 11218-11223.
    • (2008) Proc. Natl Acad. Sci. U. S. A. , vol.105 , pp. 11218-11223
    • Stoilov, P.1    Lin, C.H.2    Damoiseaux, R.3    Nikolic, J.4    Black, D.L.5
  • 26
    • 0038819945 scopus 로고    scopus 로고
    • Mutations in tau gene exon 10 associated with FTDP-17 alter the activity of an exonic splicing enhancer to interact with Tra2 beta
    • Jiang, Z., Tang, H., Havlioglu, N., Zhang, X., Stamm, S., Yan, R. and Wu, J. Y. (2003) Mutations in tau gene exon 10 associated with FTDP-17 alter the activity of an exonic splicing enhancer to interact with Tra2 beta. J. Biol. Chem., 278, 18997-19007.
    • (2003) J. Biol. Chem. , vol.278 , pp. 18997-19007
    • Jiang, Z.1    Tang, H.2    Havlioglu, N.3    Zhang, X.4    Stamm, S.5    Yan, R.6    Wu, J.Y.7
  • 29
    • 0036510378 scopus 로고    scopus 로고
    • Functional interaction between coactivators CBP/p300, PCAF, and transcription factor FKLF2
    • Song, C. Z., Keller, K., Murata, K., Asano, H. and Stamatoyannopoulos, G. (2002) Functional interaction between coactivators CBP/p300, PCAF, and transcription factor FKLF2. J. Biol. Chem., 277, 7029-7036.
    • (2002) J. Biol. Chem. , vol.277 , pp. 7029-7036
    • Song, C.Z.1    Keller, K.2    Murata, K.3    Asano, H.4    Stamatoyannopoulos, G.5
  • 31
    • 33747888770 scopus 로고    scopus 로고
    • Analysis of a multifactor microarray study using Partek genomics solution
    • Downey, T. (2006) Analysis of a multifactor microarray study using Partek genomics solution. Methods Enzymol., 411, 256-270.
    • (2006) Methods Enzymol. , vol.411 , pp. 256-270
    • Downey, T.1
  • 32
    • 84860470337 scopus 로고    scopus 로고
    • JETTA: Junction and exon toolkits for transcriptome analysis
    • Seok, J., Xu, W., Gao, H., Davis, R. W. and Xiao, W. (2012) JETTA: junction and exon toolkits for transcriptome analysis. Bioinformatics, 28, 1274-1275.
    • (2012) Bioinformatics , vol.28 , pp. 1274-1275
    • Seok, J.1    Xu, W.2    Gao, H.3    Davis, R.W.4    Xiao, W.5
  • 33
    • 20144388930 scopus 로고    scopus 로고
    • Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9
    • Tachibana, M., Ueda, J., Fukuda, M., Takeda, N., Ohta, T., Iwanari, H., Sakihama, T., Kodama, T., Hamakubo, T. and Shinkai, Y. (2005) Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9. Genes Dev., 19, 815-826.
    • (2005) Genes Dev. , vol.19 , pp. 815-826
    • Tachibana, M.1    Ueda, J.2    Fukuda, M.3    Takeda, N.4    Ohta, T.5    Iwanari, H.6    Sakihama, T.7    Kodama, T.8    Hamakubo, T.9    Shinkai, Y.10
  • 34
    • 79955460159 scopus 로고    scopus 로고
    • H3K9 methyltransferase G9a and the related molecule GLP
    • Shinkai, Y. and Tachibana, M. (2011) H3K9 methyltransferase G9a and the related molecule GLP. Genes Dev., 25, 781-788.
    • (2011) Genes Dev. , vol.25 , pp. 781-788
    • Shinkai, Y.1    Tachibana, M.2
  • 35
    • 0035815360 scopus 로고    scopus 로고
    • Role of histone H3 lysine 9 methylation in epigenetic control of heterochromatin assembly
    • Nakayama, J., Rice, J. C., Strahl, B. D., Allis, C. D. and Grewal, S. I. (2001) Role of histone H3 lysine 9 methylation in epigenetic control of heterochromatin assembly. Science, 292, 110-113.
    • (2001) Science , vol.292 , pp. 110-113
    • Nakayama, J.1    Rice, J.C.2    Strahl, B.D.3    Allis, C.D.4    Grewal, S.I.5
  • 36
    • 54349095323 scopus 로고    scopus 로고
    • G9a/GLP complexes independently mediate H3K9 and DNA methylation to silence transcription
    • Tachibana, M., Matsumura, Y., Fukuda, M., Kimura, H. and Shinkai, Y. (2008) G9a/GLP complexes independently mediate H3K9 and DNA methylation to silence transcription. EMBO J., 27, 2681-2690.
    • (2008) EMBO J. , vol.27 , pp. 2681-2690
    • Tachibana, M.1    Matsumura, Y.2    Fukuda, M.3    Kimura, H.4    Shinkai, Y.5
  • 37
    • 0037699954 scopus 로고    scopus 로고
    • The biology of VEGF and its receptors
    • Ferrara, N., Gerber, H. P. and LeCouter, J. (2003) The biology of VEGF and its receptors. Nat. Med., 9, 669-676.
    • (2003) Nat. Med. , vol.9 , pp. 669-676
    • Ferrara, N.1    Gerber, H.P.2    LeCouter, J.3
  • 38
    • 0032925156 scopus 로고    scopus 로고
    • Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188
    • Carmeliet, P., Ng, Y. S., Nuyens, D., Theilmeier, G., Brusselmans, K., Cornelissen, I., Ehler, E., Kakkar, V. V., Stalmans, I., Mattot, V. et al. (1999) Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188. Nat. Med., 5, 495-502.
    • (1999) Nat. Med. , vol.5 , pp. 495-502
    • Carmeliet, P.1    Ng, Y.S.2    Nuyens, D.3    Theilmeier, G.4    Brusselmans, K.5    Cornelissen, I.6    Ehler, E.7    Kakkar, V.V.8    Stalmans, I.9    Mattot, V.10
  • 39
    • 0034129125 scopus 로고    scopus 로고
    • The 121 amino acid isoform of vascular endothelial growth factor is more strongly tumorigenic than other splice variants in vivo
    • Zhang, H. T., Scott, P. A., Morbidelli, L., Peak, S., Moore, J., Turley, H., Harris, A. L., Ziche, M. and Bicknell, R. (2000) The 121 amino acid isoform of vascular endothelial growth factor is more strongly tumorigenic than other splice variants in vivo. Br. J. Cancer, 83, 63-68.
    • (2000) Br. J. Cancer , vol.83 , pp. 63-68
    • Zhang, H.T.1    Scott, P.A.2    Morbidelli, L.3    Peak, S.4    Moore, J.5    Turley, H.6    Harris, A.L.7    Ziche, M.8    Bicknell, R.9
  • 40
    • 38749149555 scopus 로고    scopus 로고
    • Overexpression of vascular endothelial growth factor 189 in breast cancer cells leads to delayed tumor uptake with dilated intratumoral vessels
    • Herve, M. A., Buteau-Lozano, H., Vassy, R., Bieche, I., Velasco, G., Pla, M., Perret, G., Mourah, S. and Perrot-Applanat, M. (2008) Overexpression of vascular endothelial growth factor 189 in breast cancer cells leads to delayed tumor uptake with dilated intratumoral vessels. Am. J. Pathol., 172, 167-178.
    • (2008) Am. J. Pathol. , vol.172 , pp. 167-178
    • Herve, M.A.1    Buteau-Lozano, H.2    Vassy, R.3    Bieche, I.4    Velasco, G.5    Pla, M.6    Perret, G.7    Mourah, S.8    Perrot-Applanat, M.9
  • 41
    • 0033830523 scopus 로고    scopus 로고
    • Isoforms of vascular endothelial growth factor act in a coordinate fashion to recruit and expand tumor vasculature
    • Grunstein, J., Masbad, J. J., Hickey, R., Giordano, F. and Johnson, R. S. (2000) Isoforms of vascular endothelial growth factor act in a coordinate fashion To recruit and expand tumor vasculature. Mol. Cell. Biol., 20, 7282-7291.
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 7282-7291
    • Grunstein, J.1    Masbad, J.J.2    Hickey, R.3    Giordano, F.4    Johnson, R.S.5
  • 45
    • 0035282573 scopus 로고    scopus 로고
    • Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins
    • Lachner, M., O'Carroll, D., Rea, S., Mechtler, K. and Jenuwein, T. (2001) Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins. Nature, 410, 116-120.
    • (2001) Nature , vol.410 , pp. 116-120
    • Lachner, M.1    O'Carroll, D.2    Rea, S.3    Mechtler, K.4    Jenuwein, T.5
  • 46
    • 84901470319 scopus 로고    scopus 로고
    • Mechanisms of functional promiscuity by HP1 proteins
    • Canzio, D., Larson, A. and Narlikar, G. J. (2014) Mechanisms of functional promiscuity by HP1 proteins. Trends Cell Biol., 24, 377-386.
    • (2014) Trends Cell Biol. , vol.24 , pp. 377-386
    • Canzio, D.1    Larson, A.2    Narlikar, G.J.3
  • 50
    • 79955717337 scopus 로고    scopus 로고
    • Hypoxia-induced down-regulation of neprilysin by histone modification in mouse primary cortical and hippocampal neurons
    • Wang, Z., Yang, D., Zhang, X., Li, T., Li, J., Tang, Y. and Le, W. (2011) Hypoxia-induced down-regulation of neprilysin by histone modification in mouse primary cortical and hippocampal neurons. PLoS One, 6, e19229.
    • (2011) PLoS One , vol.6 , pp. e19229
    • Wang, Z.1    Yang, D.2    Zhang, X.3    Li, T.4    Li, J.5    Tang, Y.6    Le, W.7
  • 51
    • 33749494456 scopus 로고    scopus 로고
    • Hypoxic stress induces dimethylated histone H3 lysine 9 through histone methyltransferase G9a in mammalian cells
    • Chen, H., Yan, Y., Davidson, T. L., Shinkai, Y. and Costa, M. (2006) Hypoxic stress induces dimethylated histone H3 lysine 9 through histone methyltransferase G9a in mammalian cells. Cancer Res., 66, 9009-9016.
    • (2006) Cancer Res. , vol.66 , pp. 9009-9016
    • Chen, H.1    Yan, Y.2    Davidson, T.L.3    Shinkai, Y.4    Costa, M.5
  • 52
    • 58249123443 scopus 로고    scopus 로고
    • Hypoxic silencing of tumor suppressor RUNX3 by histone modification in gastric cancer cells
    • Lee, S. H., Kim, J., Kim, W. H. and Lee, Y. M. (2009) Hypoxic silencing of tumor suppressor RUNX3 by histone modification in gastric cancer cells. Oncogene, 28, 184-194.
    • (2009) Oncogene , vol.28 , pp. 184-194
    • Lee, S.H.1    Kim, J.2    Kim, W.H.3    Lee, Y.M.4
  • 54
    • 84884971183 scopus 로고    scopus 로고
    • VEGF-A mRNA processing, stability and translation: A paradigm for intricate regulation of gene expression at the post-transcriptional level
    • Arcondeguy, T., Lacazette, E., Millevoi, S., Prats, H. and Touriol, C. (2013) VEGF-A mRNA processing, stability and translation: a paradigm for intricate regulation of gene expression at the post-transcriptional level. Nucleic Acids Res., 41, 7997-8010.
    • (2013) Nucleic Acids Res. , vol.41 , pp. 7997-8010
    • Arcondeguy, T.1    Lacazette, E.2    Millevoi, S.3    Prats, H.4    Touriol, C.5
  • 55
    • 80052981486 scopus 로고    scopus 로고
    • Transcription and splicing: When the twain meet
    • Brody, Y. and Shav-Tal, Y. (2011) Transcription and splicing: when the twain meet. Transcription, 2, 216-220.
    • (2011) Transcription , vol.2 , pp. 216-220
    • Brody, Y.1    Shav-Tal, Y.2
  • 56
    • 70350013550 scopus 로고    scopus 로고
    • Biased chromatin signatures around polyadenylation sites and exons
    • Spies, N., Nielsen, C. B., Padgett, R. A. and Burge, C. B. (2009) Biased chromatin signatures around polyadenylation sites and exons. Mol. Cell, 36, 245-254.
    • (2009) Mol. Cell , vol.36 , pp. 245-254
    • Spies, N.1    Nielsen, C.B.2    Padgett, R.A.3    Burge, C.B.4
  • 59
    • 79952364016 scopus 로고    scopus 로고
    • Histone H3 lysine 9 trimethylation and HP1gamma favor inclusion of alternative exons
    • Saint-Andre, V., Batsche, E., Rachez, C. and Muchardt, C. (2011) Histone H3 lysine 9 trimethylation and HP1gamma favor inclusion of alternative exons. Nat. Struct. Mol. Biol., 18, 337-344.
    • (2011) Nat. Struct. Mol. Biol. , vol.18 , pp. 337-344
    • Saint-Andre, V.1    Batsche, E.2    Rachez, C.3    Muchardt, C.4
  • 60
    • 73449092184 scopus 로고    scopus 로고
    • Discovery and annotation of functional chromatin signatures in the human genome
    • Hon, G., Wang, W. and Ren, B. (2009) Discovery and annotation of functional chromatin signatures in the human genome. PLoS Comput. Biol., 5, e1000566.
    • (2009) PLoS Comput. Biol. , vol.5 , pp. e1000566
    • Hon, G.1    Wang, W.2    Ren, B.3
  • 61
    • 84882452116 scopus 로고    scopus 로고
    • Intragenic epigenetic changes modulate NCAM alternative splicing in neuronal differentiation
    • Schor, I. E., Fiszbein, A., Petrillo, E. and Kornblihtt, A. R. (2013) Intragenic epigenetic changes modulate NCAM alternative splicing in neuronal differentiation. EMBO J., 32, 2264-2274.
    • (2013) EMBO J. , vol.32 , pp. 2264-2274
    • Schor, I.E.1    Fiszbein, A.2    Petrillo, E.3    Kornblihtt, A.R.4
  • 62
    • 0041856366 scopus 로고    scopus 로고
    • The CD44 alternative v9 exon contains a splicing enhancer responsive to the SR proteins 9G8, ASF/SF2, and SRp20
    • Galiana-Arnoux, D., Lejeune, F., Gesnel, M. C., Stevenin, J., Breathnach, R. and Del Gatto-Konczak, F. (2003) The CD44 alternative v9 exon contains a splicing enhancer responsive to the SR proteins 9G8, ASF/SF2, and SRp20. J. Biol. Chem., 278, 32943-32953.
    • (2003) J. Biol. Chem. , vol.278 , pp. 32943-32953
    • Galiana-Arnoux, D.1    Lejeune, F.2    Gesnel, M.C.3    Stevenin, J.4    Breathnach, R.5    Del Gatto-Konczak, F.6
  • 63
    • 84863611382 scopus 로고    scopus 로고
    • Abnormal histone methylation is responsible for increased vascular endothelial growth factor 165a secretion from airway smooth muscle cells in asthma
    • Clifford, R. L., John, A. E., Brightling, C. E. and Knox, A. J. (2012) Abnormal histone methylation is responsible for increased vascular endothelial growth factor 165a secretion from airway smooth muscle cells in asthma. J. Immunol., 189, 819-831.
    • (2012) J. Immunol. , vol.189 , pp. 819-831
    • Clifford, R.L.1    John, A.E.2    Brightling, C.E.3    Knox, A.J.4
  • 64
    • 84866270239 scopus 로고    scopus 로고
    • The Splicing Factor SRSF1 as a Marker for Endothelial Senescence
    • Blanco, F. J. and Bernabeu, C. (2012) The Splicing Factor SRSF1 as a Marker for Endothelial Senescence. Front. Physiol., 3, 54.
    • (2012) Front. Physiol. , vol.3 , pp. 54
    • Blanco, F.J.1    Bernabeu, C.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.