메뉴 건너뛰기




Volumn 80, Issue 4, 2014, Pages 261-270

Evaluation of Immune Response Elicited by Inulin as an Adjuvant with Filarial Antigens in Mice Model

Author keywords

[No Author keywords available]

Indexed keywords

ALUMINUM HYDROXIDE; ANTIGEN; IMMUNOGLOBULIN G2A ANTIBODY; IMMUNOGLOBULIN G3 ANTIBODY; IMMUNOLOGICAL ADJUVANT; INDUCIBLE NITRIC OXIDE SYNTHASE; INULIN; NITRIC OXIDE; SECRETED LARVAL ACIDIC PROTEIN 1; UNCLASSIFIED DRUG; VENOM ALLERGEN HOMOLOGUE; ALUMINUM POTASSIUM SULFATE; ALUMINUM SULFATE; HELMINTH ANTIBODY; HELMINTH PROTEIN; IMMUNOGLOBULIN G; MESSENGER RNA; PARASITE ANTIGEN; PROTOZOAL VACCINE;

EID: 84927565142     PISSN: 03009475     EISSN: 13653083     Source Type: Journal    
DOI: 10.1111/sji.12208     Document Type: Article
Times cited : (9)

References (47)
  • 1
    • 33744531872 scopus 로고    scopus 로고
    • Global programme to eliminate lymphatic filariasis
    • World Health Organization. Global programme to eliminate lymphatic filariasis. Wkly Epidemiol Rec 2006;22:221-32.
    • (2006) Wkly Epidemiol Rec , vol.22 , pp. 221-232
  • 3
    • 0026715009 scopus 로고
    • Diethylcarbamazine treatment of bancroftian and Malayan filariasis with emphasis on side effects
    • Fan PC. Diethylcarbamazine treatment of bancroftian and Malayan filariasis with emphasis on side effects. Ann Trop Med Parasitol 1992;86:399-405.
    • (1992) Ann Trop Med Parasitol , vol.86 , pp. 399-405
    • Fan, P.C.1
  • 4
    • 0034115183 scopus 로고    scopus 로고
    • Identification of potential vaccine and drug target candidates by expressed sequence tag analysis and immunoscreening of Onchocerca volvulus larval cDNA libraries
    • Lizotte-Waniewski M, Tawe W, Guiliano DB et al. Identification of potential vaccine and drug target candidates by expressed sequence tag analysis and immunoscreening of Onchocerca volvulus larval cDNA libraries. Infect Immun 2000;68:3491-501.
    • (2000) Infect Immun , vol.68 , pp. 3491-3501
    • Lizotte-Waniewski, M.1    Tawe, W.2    Guiliano, D.B.3
  • 5
    • 0033917103 scopus 로고    scopus 로고
    • The abundant larval transcript-1 and -2 genes of Brugia malayi encode stage-specific candidate vaccine antigens for filariasis
    • Gregory WF, Atmadja AK, Allen JE, Maizels RM. The abundant larval transcript-1 and -2 genes of Brugia malayi encode stage-specific candidate vaccine antigens for filariasis. Infect Immun 2000;68:4174-9.
    • (2000) Infect Immun , vol.68 , pp. 4174-4179
    • Gregory, W.F.1    Atmadja, A.K.2    Allen, J.E.3    Maizels, R.M.4
  • 6
    • 0034074494 scopus 로고    scopus 로고
    • O. volvulus: comparative analysis of antibody responses to recombinant antigens in two animal models of onchocerciasis
    • Graham SP, Lustigman S, Trees AJ, Bianco AE. O. volvulus: comparative analysis of antibody responses to recombinant antigens in two animal models of onchocerciasis. Exp Parasitol 2000;94:158-62.
    • (2000) Exp Parasitol , vol.94 , pp. 158-162
    • Graham, S.P.1    Lustigman, S.2    Trees, A.J.3    Bianco, A.E.4
  • 7
    • 1542319253 scopus 로고    scopus 로고
    • The secreted larval acidic proteins (SLAPs) of Onchocerca spp. are encoded by orthologues of the alt gene family of Brugia malayi and have host protective potential
    • Wu Y, Egerton G, Pappin JCD et al. The secreted larval acidic proteins (SLAPs) of Onchocerca spp. are encoded by orthologues of the alt gene family of Brugia malayi and have host protective potential. Mol Biochem Parasitol 2000;134:213-24.
    • (2000) Mol Biochem Parasitol , vol.134 , pp. 213-224
    • Wu, Y.1    Egerton, G.2    Pappin, J.C.D.3
  • 8
    • 34249899966 scopus 로고    scopus 로고
    • Brugia malayi: comparison of protective immune responses induced by Bm-alt-2-DNA, recombinant Bm-ALT-2 protein and prime-boost vaccine regimens in a jird model
    • Thirugnanam S, Pandiaraja P, Ramaswamy K et al. Brugia malayi: comparison of protective immune responses induced by Bm-alt-2-DNA, recombinant Bm-ALT-2 protein and prime-boost vaccine regimens in a jird model. Exp Parasitol 2007;116:483-91.
    • (2007) Exp Parasitol , vol.116 , pp. 483-491
    • Thirugnanam, S.1    Pandiaraja, P.2    Ramaswamy, K.3
  • 9
    • 80655144721 scopus 로고    scopus 로고
    • A combination of two Brugia malayi filarial vaccine candidate antigens (BmALT-2 and BmVAH) enhances immune responses and protection in jirds
    • Anand SB, Kodumudi KN, Reddy MVR, Kaliraj P. A combination of two Brugia malayi filarial vaccine candidate antigens (BmALT-2 and BmVAH) enhances immune responses and protection in jirds. J Helminthol 2011;85:442-52.
    • (2011) J Helminthol , vol.85 , pp. 442-452
    • Anand, S.B.1    Kodumudi, K.N.2    Reddy, M.V.R.3    Kaliraj, P.4
  • 10
    • 84879806732 scopus 로고    scopus 로고
    • Bacterial lipid modification enhances immunoprophylaxis of filarial abundant larval transcript-2 protein in Mastomys model
    • Sharmila S, Christiana I, Kiran P, Reddy MVR, Sankaran K, Kaliraj P. Bacterial lipid modification enhances immunoprophylaxis of filarial abundant larval transcript-2 protein in Mastomys model. Parasite Immunol 2013;35:201-13.
    • (2013) Parasite Immunol , vol.35 , pp. 201-213
    • Sharmila, S.1    Christiana, I.2    Kiran, P.3    Reddy, M.V.R.4    Sankaran, K.5    Kaliraj, P.6
  • 11
    • 40549113071 scopus 로고    scopus 로고
    • Freeing vaccine adjuvants from dangerous immunological dogma
    • Petrovsky N. Freeing vaccine adjuvants from dangerous immunological dogma. Expert Rev Vaccines 2008;7:7-10.
    • (2008) Expert Rev Vaccines , vol.7 , pp. 7-10
    • Petrovsky, N.1
  • 12
    • 63149126030 scopus 로고    scopus 로고
    • Towards an understanding of the adjuvant action of aluminium
    • Marrack P, McKee AS, Munks MW. Towards an understanding of the adjuvant action of aluminium. Nat Rev Immunol 2009;9:287-93.
    • (2009) Nat Rev Immunol , vol.9 , pp. 287-293
    • Marrack, P.1    McKee, A.S.2    Munks, M.W.3
  • 13
    • 0027222833 scopus 로고
    • Adjuvants: current status, clinical perspectives and future prospects
    • Audibert FM, Lise LD. Adjuvants: current status, clinical perspectives and future prospects. Immunol Today 1993;14:281-4.
    • (1993) Immunol Today , vol.14 , pp. 281-284
    • Audibert, F.M.1    Lise, L.D.2
  • 14
    • 0027250010 scopus 로고
    • Studies on the toxicities of aluminium hydroxide and calcium phosphate as immunological adjuvants for vaccines
    • Goto N, Kato H, Maeyama J, Eto K, Yoshihara S. Studies on the toxicities of aluminium hydroxide and calcium phosphate as immunological adjuvants for vaccines. Vaccine 1993;11:914-8.
    • (1993) Vaccine , vol.11 , pp. 914-918
    • Goto, N.1    Kato, H.2    Maeyama, J.3    Eto, K.4    Yoshihara, S.5
  • 15
    • 41949083057 scopus 로고    scopus 로고
    • B-cell pseudolymphoma caused by aluminium hydroxide following hyposensitization therapy
    • Hernandez I, Sanmartin O, Carda C, Gome S, Alfaro A. B-cell pseudolymphoma caused by aluminium hydroxide following hyposensitization therapy. Actas Dermosifiliogr 2008;99:213-6.
    • (2008) Actas Dermosifiliogr , vol.99 , pp. 213-216
    • Hernandez, I.1    Sanmartin, O.2    Carda, C.3    Gome, S.4    Alfaro, A.5
  • 16
    • 0032919943 scopus 로고    scopus 로고
    • Screening early renal failure: cut-off values for serum creatinine as an indicator of renal impairment
    • Couchoud C, Pozet N, Labeeuw M, Pouteil-Noble C. Screening early renal failure: cut-off values for serum creatinine as an indicator of renal impairment. Kidney Int 1999;55:1878-84.
    • (1999) Kidney Int , vol.55 , pp. 1878-1884
    • Couchoud, C.1    Pozet, N.2    Labeeuw, M.3    Pouteil-Noble, C.4
  • 17
    • 0025730587 scopus 로고
    • The adjuvanticity of Algammulin, a new vaccine adjuvant
    • Cooper PD, McComb C, Steele EJ. The adjuvanticity of Algammulin, a new vaccine adjuvant. Vaccine 1991;9:408-15.
    • (1991) Vaccine , vol.9 , pp. 408-415
    • Cooper, P.D.1    McComb, C.2    Steele, E.J.3
  • 18
    • 0029176545 scopus 로고
    • Vaccine adjuvants based on gamma inulin
    • Cooper PD. Vaccine adjuvants based on gamma inulin. Pharm Biotechnol 1995;6:559-80.
    • (1995) Pharm Biotechnol , vol.6 , pp. 559-580
    • Cooper, P.D.1
  • 19
    • 0022446293 scopus 로고
    • Anticomplementary action of polymorphic solubility forms of particulate inulin
    • Cooper PD, Carter M. Anticomplementary action of polymorphic solubility forms of particulate inulin. Mol Immunol 1986;23:895-901.
    • (1986) Mol Immunol , vol.23 , pp. 895-901
    • Cooper, P.D.1    Carter, M.2
  • 20
    • 0022869958 scopus 로고
    • A re-evaluation of the role of C3 in B cell activation
    • Klaus GGN, Humphery JH. A re-evaluation of the role of C3 in B cell activation. Immunol Today 1986;7:163-5.
    • (1986) Immunol Today , vol.7 , pp. 163-165
    • Klaus, G.G.N.1    Humphery, J.H.2
  • 21
    • 47749151024 scopus 로고    scopus 로고
    • Comparison of immunogenicity, protective efficacy of single and cocktail DNA vaccine of Brugia malayi abundant larval transcript (ALT-2) and thioredoxin peroxidase (TPX) in mice
    • Anand SB, Murugan V, Prabhu PR, Anandharaman V, Reddy MVR, Kaliraj P. Comparison of immunogenicity, protective efficacy of single and cocktail DNA vaccine of Brugia malayi abundant larval transcript (ALT-2) and thioredoxin peroxidase (TPX) in mice. Acta Trop 2008;107:106-12.
    • (2008) Acta Trop , vol.107 , pp. 106-112
    • Anand, S.B.1    Murugan, V.2    Prabhu, P.R.3    Anandharaman, V.4    Reddy, M.V.R.5    Kaliraj, P.6
  • 22
    • 0025172251 scopus 로고
    • Antibody mediated cytotoxicity effects in vitro and in vivo of rat cells on infective larvae of Brugia malayi
    • Chandrashekar R, Rao UR, Subramanyam D. Antibody mediated cytotoxicity effects in vitro and in vivo of rat cells on infective larvae of Brugia malayi. Int J Parasitol 1990;20:725-30.
    • (1990) Int J Parasitol , vol.20 , pp. 725-730
    • Chandrashekar, R.1    Rao, U.R.2    Subramanyam, D.3
  • 23
    • 0026637523 scopus 로고
    • Generation of B cell memory and affinity maturation: induction of Th1 and Th2 cell clones
    • Rizzo LV, DeKruyff RH, Umetsu DT. Generation of B cell memory and affinity maturation: induction of Th1 and Th2 cell clones. J Immunol 1992;148:3733-9.
    • (1992) J Immunol , vol.148 , pp. 3733-3739
    • Rizzo, L.V.1    DeKruyff, R.H.2    Umetsu, D.T.3
  • 24
    • 0030054511 scopus 로고    scopus 로고
    • Role of nitric oxide in host defense against an extracellular metazoan parasite, Brugia malayi
    • Rajan TV, Porte P, Yates JA, Keefer L, Shultz LD. Role of nitric oxide in host defense against an extracellular metazoan parasite, Brugia malayi. Infect Immun 1996;64:3351-3.
    • (1996) Infect Immun , vol.64 , pp. 3351-3353
    • Rajan, T.V.1    Porte, P.2    Yates, J.A.3    Keefer, L.4    Shultz, L.D.5
  • 25
    • 0029975067 scopus 로고    scopus 로고
    • Susceptibility of Brugia malayi and Onchocerca lienalis microfilariae to nitric oxide and hydrogen peroxide in cell-free culture and from IFN-γ activated macrophages
    • Taylor MJ, Cross HF, Mohammed AA, Trees AJ, Binaco AE. Susceptibility of Brugia malayi and Onchocerca lienalis microfilariae to nitric oxide and hydrogen peroxide in cell-free culture and from IFN-γ activated macrophages. Parasitology 1996;112:315-22.
    • (1996) Parasitology , vol.112 , pp. 315-322
    • Taylor, M.J.1    Cross, H.F.2    Mohammed, A.A.3    Trees, A.J.4    Binaco, A.E.5
  • 26
    • 0022342130 scopus 로고
    • Serum dependent cell-mediated immune reactions to Brugia pahangi infective larvae
    • Chandrashekar R, Rao UR, Subrahmanyam D. Serum dependent cell-mediated immune reactions to Brugia pahangi infective larvae. Parasite Immunol 1985;7:633-41.
    • (1985) Parasite Immunol , vol.7 , pp. 633-641
    • Chandrashekar, R.1    Rao, U.R.2    Subrahmanyam, D.3
  • 27
    • 0032126559 scopus 로고    scopus 로고
    • Immunogenicity of hepatitis B vaccines: implications for persons at occupational risk of hepatitis B virus infection
    • Averhoff F, Mahoney F, Coleman P, Schatz G, Hurwitz E. Immunogenicity of hepatitis B vaccines: implications for persons at occupational risk of hepatitis B virus infection. Am J Prev Med 1998;15:1-8.
    • (1998) Am J Prev Med , vol.15 , pp. 1-8
    • Averhoff, F.1    Mahoney, F.2    Coleman, P.3    Schatz, G.4    Hurwitz, E.5
  • 28
    • 0033020623 scopus 로고    scopus 로고
    • Twelve-year follow-up of a prospective randomized trial of hepatitis B recombinant DNA yeast vaccine versus plasma-derived vaccine without booster doses in children
    • Yuen MF, Lim WL, Cheng CC, Lam SK, Lai CL. Twelve-year follow-up of a prospective randomized trial of hepatitis B recombinant DNA yeast vaccine versus plasma-derived vaccine without booster doses in children. Hepatology 1999;29:924-7.
    • (1999) Hepatology , vol.29 , pp. 924-927
    • Yuen, M.F.1    Lim, W.L.2    Cheng, C.C.3    Lam, S.K.4    Lai, C.L.5
  • 30
    • 34547728746 scopus 로고    scopus 로고
    • Immune response studies with Wuchereria boncrofti vespid allergen homologue (WbVAH) in human lymphatic filariasis
    • Anand SB, Gnanasekar M, Thangadurai M, Prince PR, Kaliraj P, Ramaswamy K. Immune response studies with Wuchereria boncrofti vespid allergen homologue (WbVAH) in human lymphatic filariasis. Parasitol Res 2007;101:981-8.
    • (2007) Parasitol Res , vol.101 , pp. 981-988
    • Anand, S.B.1    Gnanasekar, M.2    Thangadurai, M.3    Prince, P.R.4    Kaliraj, P.5    Ramaswamy, K.6
  • 31
    • 0015124635 scopus 로고
    • The C3-activator system: an alternative pathway of complement activation
    • Gotze O, Muller-Eberhard HJ. The C3-activator system: an alternative pathway of complement activation. J Exp Med 1971;134:90s-108s.
    • (1971) J Exp Med , vol.134 , pp. 90s-108s
    • Gotze, O.1    Muller-Eberhard, H.J.2
  • 32
    • 0035151599 scopus 로고    scopus 로고
    • Adjuvant effect of gamma-inulin is mediated by C3 fragments deposited on antigen-presenting cells
    • Kerekes K, Cooper PD, Prechl J, Józsi M, Bajtay Z, Erdei Al. Adjuvant effect of gamma-inulin is mediated by C3 fragments deposited on antigen-presenting cells. J Leukoc Biol 2001;69:69-74.
    • (2001) J Leukoc Biol , vol.69 , pp. 69-74
    • Kerekes, K.1    Cooper, P.D.2    Prechl, J.3    Józsi, M.4    Bajtay, Z.5    Erdei, A.6
  • 33
    • 7044263390 scopus 로고    scopus 로고
    • Vaccine adjuvants: current state and future trends
    • Petrovsky N, Aguilar JC. Vaccine adjuvants: current state and future trends. Immunol Cell Biol 2004;82:488-96.
    • (2004) Immunol Cell Biol , vol.82 , pp. 488-496
    • Petrovsky, N.1    Aguilar, J.C.2
  • 34
    • 0035850548 scopus 로고    scopus 로고
    • Immunity to filarial nematodes
    • Lawrence RA. Immunity to filarial nematodes. Vet Parasitol 2001;100:33-44.
    • (2001) Vet Parasitol , vol.100 , pp. 33-44
    • Lawrence, R.A.1
  • 35
    • 0032529397 scopus 로고    scopus 로고
    • Fc receptors are not required for antibody-mediated protection against lethal malaria challenge in a mouse model
    • Rotman HL, Daly TM, Clynes R, Long CA. Fc receptors are not required for antibody-mediated protection against lethal malaria challenge in a mouse model. J Immunol 1998;161:1908-12.
    • (1998) J Immunol , vol.161 , pp. 1908-1912
    • Rotman, H.L.1    Daly, T.M.2    Clynes, R.3    Long, C.A.4
  • 36
    • 84885380977 scopus 로고    scopus 로고
    • Alum directly modulates murine B lymphocytes to produce IgG1 isotype
    • Jin BR, Kim SJ, Lee JM et al. Alum directly modulates murine B lymphocytes to produce IgG1 isotype. Immune Netw 2013;13:10-5.
    • (2013) Immune Netw , vol.13 , pp. 10-15
    • Jin, B.R.1    Kim, S.J.2    Lee, J.M.3
  • 37
    • 0024809849 scopus 로고
    • Human IgG1 and mouse IgG3 but not monomeric IgM or IgE facilitate antibody-dependent cell-mediated cytotoxicity by human natural killer cells
    • Shenoy AM, Brahmi Z. Human IgG1 and mouse IgG3 but not monomeric IgM or IgE facilitate antibody-dependent cell-mediated cytotoxicity by human natural killer cells. Nat Immun Cell Growth Regul 1989;8:338-48.
    • (1989) Nat Immun Cell Growth Regul , vol.8 , pp. 338-348
    • Shenoy, A.M.1    Brahmi, Z.2
  • 38
    • 0020016678 scopus 로고
    • Immune responses in human Brugia malayi infections: serum dependent cell mediated destruction of infective larvae in vitro
    • Sim BK, Kwa BH, Mak JW. Immune responses in human Brugia malayi infections: serum dependent cell mediated destruction of infective larvae in vitro. Trans R Soc Trop Med Hyg 1982;76:362-9.
    • (1982) Trans R Soc Trop Med Hyg , vol.76 , pp. 362-369
    • Sim, B.K.1    Kwa, B.H.2    Mak, J.W.3
  • 39
    • 77952717965 scopus 로고    scopus 로고
    • An inactivated Vero cell-grown Japanese encephalitis vaccine formulated with Advax, a novel inulin-based adjuvant, induces protective neutralizing antibody against homologous and heterologous flaviviruses
    • Lobigs M, Pavy M, Hall RA et al. An inactivated Vero cell-grown Japanese encephalitis vaccine formulated with Advax, a novel inulin-based adjuvant, induces protective neutralizing antibody against homologous and heterologous flaviviruses. J Gen Virol 2010;91:1407-17.
    • (2010) J Gen Virol , vol.91 , pp. 1407-1417
    • Lobigs, M.1    Pavy, M.2    Hall, R.A.3
  • 40
    • 0034061485 scopus 로고    scopus 로고
    • Interleukin-5 is essential for vaccine-mediated immunity buy not innate resistance to a filarial parasite
    • Le Goff L, Loke P, Ali HF, Taylor DW, Allen JE. Interleukin-5 is essential for vaccine-mediated immunity buy not innate resistance to a filarial parasite. Infect Immun 2000;68:2513-7.
    • (2000) Infect Immun , vol.68 , pp. 2513-2517
    • Le Goff, L.1    Loke, P.2    Ali, H.F.3    Taylor, D.W.4    Allen, J.E.5
  • 41
    • 0034131208 scopus 로고    scopus 로고
    • A new mechanism for IL-5 dependent helminth control: neutrophil accumulation and neutrophil-mediated worm encapsulation in murine filariasis are abolished in the absence of IL-5
    • Al-Qaoud KM, Pearlman E, Hartung T, Klukowski J, Fleischer B, Hoeruf A. A new mechanism for IL-5 dependent helminth control: neutrophil accumulation and neutrophil-mediated worm encapsulation in murine filariasis are abolished in the absence of IL-5. Int Immunol 2000;12:899-908.
    • (2000) Int Immunol , vol.12 , pp. 899-908
    • Al-Qaoud, K.M.1    Pearlman, E.2    Hartung, T.3    Klukowski, J.4    Fleischer, B.5    Hoeruf, A.6
  • 42
    • 15644369352 scopus 로고    scopus 로고
    • Activation of interferon-gamma inducing factor mediated by interleukin-1 beta converting enzyme
    • Gu Y, Kuida K, Tsutsui H et al. Activation of interferon-gamma inducing factor mediated by interleukin-1 beta converting enzyme. Science 1997;275:206-9.
    • (1997) Science , vol.275 , pp. 206-209
    • Gu, Y.1    Kuida, K.2    Tsutsui, H.3
  • 43
    • 0031590302 scopus 로고    scopus 로고
    • Cytokines and nitric oxide as effector molecule against parasitic infections
    • Liew FY, Wei X, Proudfoot L. Cytokines and nitric oxide as effector molecule against parasitic infections. Philos Trans R Soc Lond B Biol Sci 1997;352:1311-5.
    • (1997) Philos Trans R Soc Lond B Biol Sci , vol.352 , pp. 1311-1315
    • Liew, F.Y.1    Wei, X.2    Proudfoot, L.3
  • 44
    • 0028321418 scopus 로고
    • IL-4 and IL-5-dependent protective immunity to Onchocerca volvulus infective larvae in BALB/cBYJ mice
    • Lange AM, Yutanawiboonchai W, Scott P, Abraham D. IL-4 and IL-5-dependent protective immunity to Onchocerca volvulus infective larvae in BALB/cBYJ mice. J Immunol 1994;153:205-11.
    • (1994) J Immunol , vol.153 , pp. 205-211
    • Lange, A.M.1    Yutanawiboonchai, W.2    Scott, P.3    Abraham, D.4
  • 45
    • 34247157292 scopus 로고    scopus 로고
    • Interleukin-10 protects against inflammation-mediated degeneration of dopaminergic neurons in substantia nigra
    • Arimoto T, Choi DY, Lu X et al. Interleukin-10 protects against inflammation-mediated degeneration of dopaminergic neurons in substantia nigra. Neurobiol Aging 2007;28:894-906.
    • (2007) Neurobiol Aging , vol.28 , pp. 894-906
    • Arimoto, T.1    Choi, D.Y.2    Lu, X.3
  • 46
    • 77954759726 scopus 로고    scopus 로고
    • Identification of nematode specific protective epitopes of B. malayi TRX towards development of synthetic vaccine construct for lymphatic filariasis
    • Madhumathi J, Prince PR, Anugraha G et al. Identification of nematode specific protective epitopes of B. malayi TRX towards development of synthetic vaccine construct for lymphatic filariasis. Vaccine 2010;28:5038-48.
    • (2010) Vaccine , vol.28 , pp. 5038-5048
    • Madhumathi, J.1    Prince, P.R.2    Anugraha, G.3
  • 47
    • 17144423210 scopus 로고    scopus 로고
    • rOv-ASP-1, a recombinant secreted protein of the helminth Onchocerca volvulus, is a potent adjuvant for inducing antibodies to ovalbumin, HIV-1 polypetide and SARS-CoV peptide antigens
    • MacDonald AJ, Cao L, He Y, Zhao Q, Jiang S, Lustigman S. rOv-ASP-1, a recombinant secreted protein of the helminth Onchocerca volvulus, is a potent adjuvant for inducing antibodies to ovalbumin, HIV-1 polypetide and SARS-CoV peptide antigens. Vaccine 2005;23:3446-52.
    • (2005) Vaccine , vol.23 , pp. 3446-3452
    • MacDonald, A.J.1    Cao, L.2    He, Y.3    Zhao, Q.4    Jiang, S.5    Lustigman, S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.