Drug delivery to tumours: Recent strategies

Journal of Pharmacy and Pharmacology

Volumn 57, Issue 10, 2005, Pages 1231-1242

  Reddy, L Harivardhan ^a  

^a M S UNIVERSITY OF BARODA   (India)

Author keywords

[No Author keywords available]

Indexed keywords

9 (3 HYDROXY 2 PHOSPHONOMETHOXYPROPYL)ADENINE; ALPHA TOCOPHEROL; ANTINEOPLASTIC AGENT; BH3 PROTEIN; CHITOSAN; CHOLESTEROL; DEXTRAN; DOXORUBICIN; DRUG CARRIER; GLUTAMINE DERIVATIVE; GLYCOL; GONADORELIN; HT 498; HYDRAZONE DERIVATIVE; LIPID; LIPOSOME; MACROGOL; MALEIC ACID; MITOMYCIN C; N,N BIS(2 CHLOROETHYL) 4 PHENYLENEDIAMINE; NANOPARTICLE; OLEIC ACID; POLY[N (2 HYDROXYETHYL)GLUTAMINE]; POLYASPARTIC ACID; POLYCAPROLACTONE; POLYMACON; PRODRUG; STYRENE; TAMOXIFEN; UNCLASSIFIED DRUG; UNINDEXED DRUG; VINCRISTINE;

BLOOD VISCOSITY; BRAIN; CANCER; CANCER CHEMOTHERAPY; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG IMPLANT; DRUG PENETRATION; DRUG RECEPTOR BINDING; DRUG RETENTION; DRUG TUMOR LEVEL; HUMAN; INTERSTITIUM; NONHUMAN; PH; REVIEW; TUMOR RESISTANCE; TUMOR VASCULARIZATION; ULTRASOUND;

ANIMALS; ANTINEOPLASTIC AGENTS; DRUG DELIVERY SYSTEMS; HUMANS; NEOPLASMS;

EID: 27544446121     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/jpp.57.10.0001     Document Type: Review

References (92)

1. Allen, T. M., Hansen, C. B., Guo, L. S. S. (1993) Subcutaneous administration of liposomes: a comparison with the intravenous and intraperitoneal routes of injection. Biochim. Biophys. Acta 1150: 9-16
2. Almond, B. A., Hadba, A. R., Freeman, S. T., Cuevas, B. J., York, A. M., Detrisac, C. J., Goldberg, E. P. (2003) Efficacy of mitoxantrone-loaded albumin microspheres for intratumoral chemotherapy of breast cancer. J. Control. Release 91: 147-155
3. Ambudkar, S. V., Dey, S., Hrycyna, C. A., Ranmachandra, M., Pastan, I., Gottesman, M. M. (1999) Biochemical, cellular and pharmacological aspects of the multidrug transporter. Annu. Rev. Pharmacol. Toxicol. 39: 361-398
4. Au, J. L.-S., Jang, S. H., Zheng, J., Chen, C.-T., Song, S., Hu, L., Wientjes, M. G. (2001) Determinants of drug delivery and transport to solid tumors. J. Control. Release 74: 31-46
5. Babincova, M., Altanerova, V., Lampert, M., Altaner, C., Machova, E., Sramka, M., Babinec, P. (2000) Site-specific in vivo targeting of magnetoliposomes using externally applied magnetic field. Z. Naturforsch. (C) 55: 278-281
6. Babincova, M., Cicmanec, P., Altanerova, V., Altaner, C., Babinec, P. (2002) AC-magnetic field controlled drug release from magnetoliposomes: design of a method for site-specific chemotherapy. Bioelectrochemistry 55: 1-19
7. Bulmus, V., Woodward, M., Lin, L., Murthy, N., Stayton, P., Hoffman, A. (2003) A new pH-responsive and glutathione-reactive, endosomal membrane-disruptive polymeric carrier for intracellular delivery of biomolecular drugs. J. Control. Release 93: 105-120
8. Bulte, J. W., Cuyper, M. D., Despres, D., Frank, J. A. (1999) Short vs. long-circulating magnetoliposomes as bone marrow-seeking MR contrast agents. J. Magn. Reson. Imaging 9: 329-335
9. Caiolfa, V. R., Zamai, M., Fiorino, A., Frigerio, E., Pellizzoni, C., d'Argy, R., Ghiglieri, A., Castelli, M. G., Farao, M., Pesenti, E., Gigli, M., Angelucci, F., Suarato, A. (2000) J. Control. Release 65: 105-119
10. Casper, E. S., Kelsen, D. P., Alcock, N. W., Lewis, J. L. (1983) IP cisplatin in patients with malignant ascites: pharmacokinetic evaluation and comparison with the iv route. Cancer Treat. Rep. 67: 235-238
11. Chawla, J. S., Amiji, M. M. (2002) Biodegradable poly(ε- caprolactone) nanoparticles for tumor-targeted delivery of tamoxifen. Int. J. Pharm. 249: 127-138
12. Chawla, J. S., Amiji, M. M. (2003) Cellular uptake and concentrations of tamoxifen upon administration in poly(ε-caprolactone) nanoparticles. AAPS Journal 5: Article 3
13. De Cuyper, M., Joniau, M. (1988) Magnetoliposomes: formation and structural characterization. Eur. Biophys. J. 15: 311-319
14. de Verdiere, A. C., Dubernet, C., Nemati, F., Soma, E., Appel, M., Ferte, J., Bernard, S., Puisieux, F., Couvreur, P. (1997) Reversion of multidrug resistance with polyalkyl cyanoacrylate nanoparticles; towards a mechanism of action. Br. J. Cancer 76: 198-205
15. Dharap, S. S., Qui, B., Williams, G. C., Sinko, P., Stein, S., Minko, T. (2003) Molecular targeting of the drug delivery systems to ovarian cancer by BH3 and LHRH peptides. J. Control. Release 91: 61-73
16. Doyle, L. A., Yang, W., Abruzzo, L. V., Krogmann, T., Gao, Y., Rishi, A. K., Ross, D. D. (1998) A multidrug resistance transporter from human MCF-7 breast cancer cells. Proc. Natl Acad. Sci. 95: 15665-15670
17. Fenton, R. G., Longo, D. I. (1998) Cell biology of cancer. In: Fauci, A. S., Braunwald, E., Isselbacher, K. J., Wilson, J. D., Martin, J. B., Kasper, D. L., Hauser, S. L., Longo, D. I. (eds) Harrison's internal medicine. Vol. 1, 14th edn, McGraw Hill, New York, pp 505-511
18. Fonseca, C., Siomes, S., Gaspar, R. (2002) Paclitaxel-loaded PLGA nanoparticles: preparation, physicochemical characterization and in vitro anti-tumoral activity. J. Control. Release 83: 273-286
19. Fricker, J. (2001) Drugs with a magnetic attraction to tumors. Drug Discov. Today 6: 387-389
20. Garrec, D. L., Ranger, M., Leroux, J. C. (2004) Micelles in anticancer drug delivery. Am. J. Drug Deliv. 2: 15-42
21. Greish, K., Sawa, T., Fang, J., Akaike, T., Maeda, H. (2004) SMA-doxorubicin, a new polymeric micellar drug for effective targeting to solid tumours. J. Control. Release 97: 219-230
22. Han, S. K., Na, K., Bae, Y. H. (2003) Sulfonamide based pH-sensitive polymeric micelles: physicochemical characteristics and pH dependant aggregation. Colloids Surf. A Physicochem. Eng. Aspects 214: 49-59
23. Hobbs, S. K., Monsky, W. L., Yuan, F., Roberts, W. G., Griffith, L., Torchilin, V. P., Jain, R. K. (1998) Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment. Proc. Natl Acad. Sci. 95: 4607-4612
24. Hu, Y.-P., Jarillon, S., Dubernet, C., Couvreur, P., Robert, J. (1996) On the mechanism of action of doxorubicin encapsulation in nanospheres for the reversal of multidrug resistance. Cancer Chemother. Pharmacol. 37: 556-560
25. Husseini, G. A., Myrup, G. D., Pitt, W. G., Christensen, D. A., Rapoport, N. Y. (2000) Factors affecting acoustically triggered release of drugs from polymeric micelles. J. Control. Release 69: 43-52
26. Jain, R. K. (1994) Barriers to drug delivery in solid tumors. Sci. Am. 271: 58-65
27. Johannsen, M., Thiesen, B., Jordan, A., Taymoorian, K., Gneveckow, U., Waldofner, N., Scholz, R., Koch, M., Lein, M., Jung, K., Loening, S. A. (2005) Magnetic fluid hyperthermia (MFH) reduces prostate cancer growth in the orthotopic Dunning R3327 rat model. Prostate 64: 283-292
28. Jordan, A., Wust, P., Scholz, R., Tesche, B., Fahling, H., Mitrovics, T., Vogl, T., Cervos-Navarro, J., Felix, R. (1996) Cellular uptake of magnetic fluid particles and their effects on human adenocarcinoma cells exposed to AC magnetic fields in vitro. Int. J. Hyperthermia 12: 705-722
29. Jordan, A., Scholz, R., Wust, P., Fahling, H., Krause, J., Wlodarczyk, W., Sander, B., Vogl, T., Felix, R. (1997) Effects of magnetic fluid hyperthermia (MFH) on C3H mammary carcinoma in vivo. Int. J. Hyperthermia 13: 587-605
30. Josef, D., Zdenek, Z., Bohuslav, M., Pavel, J., Jindriska, M., Ivana, M., Dagmar, D., Jiri, P. (2002) Pegylated liposomal doxorubicin in combination with hyperthermia in the treatment of a case of advanced hepatocellular carcinoma. J. Clin. Gastroenterol. 34: 96-98
31. Juliano, R. L., Alahari, S., Yoo, H., Kole, R., Cho, M. (1999) Antisense pharmacodynamics: critical issues in the transport and delivery of antisense oligonucleotides. Pharm. Res. 16: 494-502
32. Junping, W., Takayama, K., Nagai, T., Maitani, Y. (2003) Pharmacokinetics and antitumor effects of vincristine carried by microemulsions composed of PEG-lipid, oleic acid, vitamin E and cholesterol. Int. J. Pharm. 251: 13-21
33. Kartner, N., Evernden-Porelle, D., Bradley, G., Ling, V. (1985) Detection of P-glycoprotein in multidrug-resistant cell lines by monoclonal antibodies. Nature 316: 820-823
34. Kerr, J. F., Wyllie, A. H., Curie, A. R. (1972) Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br. J. Cancer 26: 239-257
35. Kobayashi, H., Takamura, Y., Miyachi, H. (2001) Novel approaches to reversing anti-cancer drug resistance using gene-specific therapeutics. Hum. Cell 14: 172-184
36. Koziara, J. M., Lockman, P. R., Allen, D. D., Mumper, R. J. (2004) Paclitaxel nanoparticles for the potential treatment of brain tumors. J. Conrol. Release 99: 259-269
37. Krishna, R., Mayer, L. D. (2000) Multidrug resistance (MDR) in cancer mechanisms, reversal using modulators of MDR and the role of MDR modulators in influencing the pharmacokinetics of anticancer drugs, Eur. J. Cancer Sci. 11: 265-283
38. Kubo, T., Sugita, T., Shimose, S., Nitta, Y., Ikuta, Y., Murakami, T. (2000) Targeted delivery of anticancer drugs with intravenously administered magnetic liposomes in osteosarcoma-bearing hamsters. Int. J. Oncol. 17: 309-315
39. Kubo, T., Sugita, T., Shimose, S., Nitta, Y., Ikuta, Y., Murakami, T. (2001) Targeted systemic chemotherapy using magnetic liposomes with incorporated adriamycin for osteosarcoma in hamsters. Int. J. Oncol. 18: 121-125
40. Lackey, C., Murthy, N., Press, O., Tirrell, D., Hoffman, A., Stayton, P. (1999) Hemolytic activity of pH-responsive polymer-streptavidin bioconjugate. Bioconjug. Chem. 10: 401-405
41. Lackey, C., Press, O., Hoffman, A., Stayton, P. (2002) A biomimetic pH-responsive polymer directs endosomal release and intracellular delivery of an endocytosed antibody complex, Bioconjug. Chem. 13: 996-1001
42. Lee, E. S., Na, K., Bae, Y. H. (2003) Polymeric micelle for tumor pH and folate mediated targeting. J. Control. Release 91: 103-113
43. Lopes de Menezes, D. E., Pilarski, L. M., Allen, T. M. (1998) In vivo and in vitro targeting of immunoliposomal doxorubicin to human B-cell lymphoma. Cancer Res. 58: 3320-3330
44. Lopez, J. A., Krikorian, J. G., Reich, S. D., Smyth, R. D., Lee, F. H., Issell, B. F. (1985) Clinical pharmacology of intraperitoneal cisplatin. Gynecol. Oncol. 20: 1-9
45. Lukyanov, A. N., Elbayoumi, T. A., Chakilam, A. R., Torchilin, V. P. (2004) Tumor-targeted liposomes: doxorubicin-loaded long-circulating liposomes modified with anti-cancer antibody. J. Control. Release 100: 135-144
46. Lundberg, B. B., Griffiths, G., Hansen, H. J. (2004) Cellular association and cytotoxicity of anti-CD74-targeted lipid drug-carriers in B lymphoma cells. J. Control. Release 94: 155-161
47. Maeda, H., Matsumura, Y. (1989) Tumoritropic and lymphotropic principles of macromolecular drugs. Crit. Rev. Ther. Drug Carrier Syst. 6: 183-210
48. Maeda, H., Takeshita, J., Kanamaru, R. (1979) A lipophilic derivative of neocarzinpstatin. A polymer conjugation of an antitumor protein antibiotic. Int. J. Pept. Protein Res. 14: 81-87
49. Maeda, H., Wu, J., Sawa, T., Matsumura, Y., Hori, K. (2000) Tumor vascular permeability and the EPR effect in macromolecular therapeutics. A review. J. Control. Release 65: 271-284
50. Maeda, H., Sawa, T., Konno, T. (2001) Mechanism of tumor-targeted delivery of macromolecular drugs, including the EPR effect in solid tumor and clinical overview of the prototype polymeric drug SMANCS. J. Control. Release 74: 47-61
51. Margolis, L. B., Namiot, V. A., Kljukin, L. M. (1983) Magnetoliposomes: another principle of cell sorting. Biochim. Biophys. Act. 735: 193-195
52. Markman, M. (1998) Intraperitoneal therapy of ovarian cancer. Semin. Oncol. 25: 356-360
53. Markman, M., Francis, P., Rowinsky, E., Hoskins, W. (1995) Intra-peritoneal paclitaxel: a possible role in the management of ovarian cancer. Semin. Oncol. 22: 84-87
54. Moghimi, S. M., Hunter, A. C., Murray, J. C. (2001) Long-circulating and target-specific nanoparticles: theory to practice. Pharmacol. Rev. 53: 283-318
55. Murthy, N., Robichaud, J., Tirrell, D., Stayton, P., Hoffman, A. (1999) The design and synthesis of polymers for eukaryotic membrane disruption. J. Control. Release 61: 137-143
56. Murthy, N., Chang, I., Stayton, P., Hoffman A. (2001) pH-sensitive hemolysis by random copolymer of alkyl acrylates and acrylic acid. Macromol. Symp. 172: 49-55
57. Murthy, N., Campbell, J., Fausto, N., Hoffman, A. S., Stayton, P. S. (2003) Bioinspired pH-responsive polymers for the intracellular delivery of biomolecular drugs. Bioconjug. Chem. 14: 412-419
58. Na, K., Lee, E. S., Bae, Y. H. (2003) Adriamycin loaded pullulan acetate/sulfonamide conjugate nanoparticles responding to tumor pH: pH dependant cell interaction, internalization and cytotoxicity in vitro. J. Control. Release 87: 3-13
59. Nakanishi, T., Fukushima, S., Okamoto, K., Suzuki, M., Matsumura, Y., Yokoyama, M., Okano, T., Sakurai, Y., Kataoka, K. (2001) Development of the polymeric micelle carrier system for doxorubicin. J. Control. Release 74: 295-302
60. Nativ, O., Aronson, M., Medalia, O., Moldavsky, T., Sabo, E., Ringel, I., Kravtsov, V. (1997) Anti-neoplastic activity of paclitaxel on experimental superficial bladder cancer: in vivo and in vitro studies. Int. J. Cancer 70: 297-301
61. Nomura, T., Saikawa, A., Morita, S., Sakaeda Kakutani, T., Yamashita, F., Honda, K., Takakura, Y., Hashida, M. (1998) Pharmacokinetic conjugates after intratumoral injection. J. Control. Release 52: 239-252
62. 31P probes. NMR Biomed. 12: 495-504
63. Oyewumi, M. O., Mumper, R. J. (2003) Influence of formulation parameters on gadolinium entrapment and tumor cell uptake using folate-coated nanoparticles. Int. J. Pharm. 251: 85-97
64. Paranjpe, P. V., Chen, Y., Kholodovych, V., Welsh, W., Stein, S., Sinko, P. J. (2004) Tumor-targeted bioconjugate based delivery of camptothecin: design, synthesis and in vitro evaluation. J. Control. Release 100: 275-292
65. Pepin, X., Attali, L., Domrault, C., Gallet, S., Metreau, J. M., Reault, Y., Cardot, P. J., Imalalen, M., Dubernet, C., Soma, E., Couvreur, P. (1997) On the use of ion-pair chromatography to elucidate doxorubicin release mechanism from polyalkyl cyanoacrylate nanoparticles at the cellular level. J. Chromatogr. B 702: 181-197
66. Porter, C. J. H. (1997) Drug delivery to the lymphatic system. Crit. Rev. Ther. Drug Carrier Syst. 14: 333-393
67. Poupaert, J. H., Couvreur, P. (2003) A computationally derived structural model of doxorubicin interacting with oligomeric polyalkylcyanoacrylate in nanoparticles. J. Control. Release 92: 19-26
68. Rapaport, N., Pitt, W. G., Sun, H., Nelson, J. L. (2003) Drug delivery in polymeric micelles: from in vitro to in vivo. J. Control. Release 91: 85-95
69. Reddy, L. H., Sharma, R. K., Murthy, R. S. R. (2004a) Enhanced tumor uptake of doxorubicin loaded Poly(butyl cyanoacrylate) nanoparticles in mice bearing Dalton's lymphoma tumor. J Drug Target. 12: 443-451
70. Reddy, L. H., Sharma, R. K., Murthy, R. S. R. (2004b) Tumor retention and biodistribution studies of etoposide loaded tripalmitin nanoparticles after intratumoral administration in Dalton's lymphoma tumor bearing mice. Alasbimn. J. 6: 1-15
71. Reddy, L. H., Sharma, R. K., Chuttani, K., Mishra, A. K., Murthy, R. S. R. (2005) Influence of administration route on tumor uptake and biodistribution of etoposide loaded tripalmitin nanoparticles in Dalton's Lymphoma tumor bearing mice. J. Control. Release 105: 185-198
72. Richardson, S., Ferruti, S., Duncan, R. (1999) Poly(amidoamine)s as potential endosomolytic polymers: evaluation in vitro and body distribution in normal and tumour bearing animals. J. Drug Target. 6: 391-404
73. Sadzuka, Y., Hirota, R., Sonobe, T. (2000) Intraperitoneal administration of doxorubicin encapsulating liposomes against peritoneal dissemination. Toxicol. Lett. 116: 51-59
74. Sadzuka, Y., Hirama, R., Sonobe, T. (2002) Effects of intraperitoneal administration of liposomes and methods of preparing liposomes for local therapy. Toxicol. Lett. 126: 83-90
75. Safarik, I., Safarikova M. (2002) Magnetic nanoparticles and biosciences. Mon. Chem. 133: 737-759
76. Seong, H., An, T. K., Khang, G., Choi, S.-U., Lee, C. O., Lee, H. B. (2003) BCNU loaded poly(D, L-lactide-co-glycolide) wafer and antitumor activity against XF-498 human CNS tumor cells in vitro. Int. J. Pharm. 251: 1-12.
77. Silverman, J. A. (1999) Multidrug resistance transporters. In: Amidon, G. L., Sadee, W. (eds) Membrane transporters as drug targets. Vol. 12, Kluwer Academic/Plenum, New York, pp 353-386
78. Soma, C. E., Dubernet, C., Bentolila, D., Benita, S., Couvreur, P. (2000) Reversion of multidrug resistance by co-encapsulation of doxorubicin and cyclosporin A in polyalkylcyanoacrylate nanopartieles. Biomaterials 21: 1-7
79. Son, Y. J., Jang, J.-S., Cho, Y. W., Chung, H., Park, R.-W., Kwon, I. C., Kim, I.-S., Park, J. Y., Seo, S. B., Park, C. R., Jeong, S. Y. (2003) Biodistribution and anti-tumor efficacy of doxorubicin loaded glycol-chitosan nanoaggregates by EPR effect. J. Control. Release 91: 135-145
80. Song, D., Wientjes, M. G., Au, J. L. S. (1997) Bladder tissue pharmacokinetics of intravesical taxol. Cancer Chemother. Pharmacol. 40: 285-292
81. Soyez, H., Seymour, L. W., Schacht, E. (1999) Macromolecular derivatives of N, N-di-(2-chloroethyl)-4-phenylene diamine mustard. 2. In vitro cytotoxicity and in vivo anticancer efficacy. J. Control. Release 57: 187-196
82. Stouch, T. R., Gudmundsson, O. (2002) Progress in understanding the structure-activity relationships of P-glycoprotein. Adv. Drug Del. Rev. 54: 315-328
83. Stubbs, M., Mcsheehy, R. M. J., Griffiths, J. R., Bashford, L. (2000) Causes and consequences of tumor acidity and implications for treatment. Mol. Med. Today 6: 15-19
84. Tamura, T., Fujita, F., Tanimoto, M., Koike, M., Suzuki, A., Fujita, M., Horikiri, Y., Sakamoto, Y., Suzuki, T., Yoshino, H. (2002) Anti-tumor effect of intraperitoneal administration of cisplatin-loaded microspheres to human tumor xenografted nude mice. J. Control. Release 80: 295-307
85. Ulbrich, K., Etrych, T., Chytil, P., Jelinkova, M., Rihova, B. (2003) HPMA copolymers with pH-controlled release of doxorubicin. In vitro cytotoxicity and antitumor activity. J. Control. Release 87: 33-47
86. Vauthier, C., Dubernet, C., Chauvierre, C., Brigger, I., Couvreur, P. (2003) Drug delivery to resistant tumors: the potential of polyalkyl cyanoacrylate nanoparticles. J. Control. Release 93: 151-160
87. Vinogradov, S. V., Bronich, T. K., Kabanov, A. V. (1998) Self-assembly of polyamine-poly(ethylene glycol) copolymers with phosphorothioate oligonucleotides. Bioconjug. Chem. 9: 805-812
88. Vogelhuber, W., Spruß, T., Bernhardt, G., Buschauer, A., Gopferich, A. (2002) Efficacy of BCNU and paclitaxel loaded subcutaneous implants in the interstitial chemotherapy of U-87 MG human glioblastoma xenografts. Int. J. Pharm. 238: 111-121
89. Walker, J., Martin, C., Callaghan, R. (2004) Inhibition of P-glycoprotein function by XR9576 in a solid tumor model can restore anticancer drug efficacy. Eur. J. Cancer 40: 594-605
90. Wang, S., Low, P. S. (1998) Folate-mediated targeting of anti-neoplastic agents, imaging agents and nucleic acids to cancer cells. J. Control. Release 53: 39-48
91. Williams, J., Lansdown, R., Sweitzer, R., Romanowski, M., LaBell, R., Ramaswami, R., Unger, E. (2003) Nanoparticle drug delivery system for intravenous delivery of topoisomerase inhibitors. J. Control. Release 91: 167-172
92. Yoo, H. S., Park, T. G. (2004) Folate-receptor-targeted delivery of doxorubicin nano-aggregates stabilized by doxorubicin-PEG-folate conjugate. J. Control Release 100: 247-256