Grape seed procyanidin B2 ameliorates mitochondrial dysfunction and inhibits apoptosis via the AMP-Activated protein kinase-silent mating type information regulation 2 homologue 1-PPARγ co-Activator-1α axis in rat mesangial cells under high-dose glucosamine

British Journal of Nutrition

Volumn 113, Issue 1, 2015, Pages 35-44

  Bao, Lei ^a   Cai, Xiaxia ^a   Zhang, Zhaofeng ^a   Li, Yong ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

Apoptosis; Diabetic nephropathy; Grape seed procyanidin B2; Mesangial cells; Mitochondrial dysfunction

Indexed keywords

ADVANCED GLYCATION END PRODUCT RECEPTOR; DEOXYURIDINE TRIPHOSPHATE PYROPHOSPHATASE; GLUCOSAMINE; GLUTATHIONE PEROXIDASE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; GRAPE SEED PROCYANIDIN B2; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MANNITOL; MESSENGER RNA; MITOCHONDRIAL DNA; MITOCHONDRIAL TRANSCRIPTION FACTOR A; NUCLEAR RESPIRATORY FACTOR 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; POLY(ADENOSINE DIPHOSPHATE RIBOSE); POLYPHENOL DERIVATIVE; SIRTUIN 1; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG; BIFLAVONOID; CATECHIN; GRAPE SEED EXTRACT; PPARGC1A PROTEIN, RAT; PROANTHOCYANIDIN; PROCYANIDIN B2; SIRT1 PROTEIN, RAT; TRANSCRIPTION FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BETA ACTIN GENE; CELL DAMAGE; CELL VIABILITY; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENZYME ACTIVITY; FLOW CYTOMETRY; GENE; GENE DOSAGE; MESANGIUM CELL; MTDNA GENE; NICK END LABELING; NONHUMAN; NRF 1 GENE; OXIDATIVE STRESS; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; TFAM GENE; ANIMAL; CHEMISTRY; DIABETIC NEPHROPATHIES; DOSE RESPONSE; DRUG EFFECTS; GENETICS; METABOLISM; MITOCHONDRION; PLANT SEED; TUNEL ASSAY; VITIS;

RATTUS; VITACEAE;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; APOPTOSIS; BIFLAVONOIDS; CATECHIN; DIABETIC NEPHROPATHIES; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUCOSAMINE; GRAPE SEED EXTRACT; IN SITU NICK-END LABELING; MESANGIAL CELLS; MITOCHONDRIA; OXIDATIVE STRESS; PROANTHOCYANIDINS; RATS; SEEDS; SIRTUIN 1; TRANSCRIPTION FACTORS; VITIS;

EID: 84927562014     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S000711451400347X     Document Type: Article

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