The potential role of leptin in the vascular remodeling associated with obesity

International Journal of Obesity

Volumn 38, Issue 12, 2014, Pages 1565-1572

  Martinez Martinez E ^a   Miana, M ^b   Jurado Lopez R ^c   Bartolome M V ^c   Souza Neto, F V ^a   Salaices, M ^d   Lopez Andres N ^b   Cachofeiro, V ^a  

^a SCHOOL OF MEDICINE   (Spain)

^b Atención Primaria Y Promoción de La Salud   (Spain)

^c UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^d UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

Author keywords

extracellular matrix proteins; leptin; oxidative stress; vascular remodeling

Indexed keywords

COLLAGEN TYPE 1; CONNECTIVE TISSUE GROWTH FACTOR; FIBRONECTIN; GALECTIN 3; LEPTIN; MELATONIN; PROTEIN KINASE B; SUPEROXIDE; TRANSFORMING GROWTH FACTOR BETA;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTERIAL STIFFNESS; ARTICLE; BODY WEIGHT; CARDIOVASCULAR MORTALITY; CONTROLLED STUDY; DIET INDUCED OBESITY; EXTRACELLULAR MATRIX; FAT MASS; GENE EXPRESSION; MALE; NONHUMAN; OBESITY; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SMOOTH MUSCLE FIBER; VASCULAR REMODELING; VASCULAR SMOOTH MUSCLE; ANIMAL; AORTA; CELL CULTURE; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHOSPHORYLATION; WISTAR RAT;

RATTUS; RATTUS NORVEGICUS;

ANIMALS; AORTA; CELLS, CULTURED; LEPTIN; MALE; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; OBESITY; OXIDATIVE STRESS; PHOSPHORYLATION; RATS; RATS, WISTAR; VASCULAR REMODELING;

EID: 84927176269     PISSN: 03070565     EISSN: 14765497     Source Type: Journal    
DOI: 10.1038/ijo.2014.37     Document Type: Article

References (48)

1. Laurent S, Boutouyrie P, Asmar R, Gautier I, Laloux B, Guize L et al. Aortic stiffness is an inDepenDent predictor of all-cause and cardiovascular mortality in hypertensive patients. Hypertension 2001; 37: 1236-1241
2. Laurent S, Boutouyrie P, LacolLey P. Structural and genetic bases of arterial stiffnes. Hypertension 2005; 45: 1050-1055
3. Redon J, Cifkova R, Laurent S, Nilsson P, Narkiewicz K, Erdine S et al. Mechanisms of hypertension in the cardiometabolic syndrome. J Hypertens 2009; 27: 441-451
4. Lu P, Takai K, Weaver VM, Werb Z. Extracellular matrix Degradation and remoDeling in Development and disease. Cold Spring Harb Perspect Biol 2011; 3: a005058
5. Miana M, De Las Heras N, Rodriguez C, Sanz-Rosa D, Martin-FernanDez B, Mezzano S et al. Effect of epLerenone on hypertension-Associated renal damage in rats: potential roLe of peroxisome proliferator activated receptor gamma (PPAR-γ). J Physiol Pharmacol 2011; 62: 87-94
6. Rossoni LV, Oliveira RA, Caffaro RR, Miana M, Sanz-Rosa D, Koike MK et al. Cardiac benefits of exercise training in aging spontaneously hypertensive rats. J Hypertens 2011; 29: 2349-2358
7. Ruiz-Ortega M, Rodrguez-Vita J, Sanchez-Lopez E, Carvajal G, Egido J. TGF-beta signaling in vascular fibrosis. Cardiovasc Res 2007; 74: 196-206
8. Oemar BS, Werner A, Garnier JM, Do DD, Godoy N, Nauck M et al. Human connective tissue growth factor is expressed in adVanced atheroscLerotic Lesions. Circulation 1997; 95: 831-839
9. Chen MM, Lam A, Abraham JA, Schreiner GF, Joly AH. CTGF expression is induced by TGF-beta in cardiac fibroblasts and cardiac myocytes: a potential roLe in heart fibrosis. J Mol Cell Cardiol 2000; 32: 1805-1819
10. Finckenberg P, Lassila M, Inkinen K, Pere AK, Krogerus L, Lindgren L et al. Cyclosporine induces myocardial connective tissue growth factor in spontaneously hypertensive rats on high-sodium diet. Transplantation 2001; 71: 951-958
11. Ruprez M, Lorenzo O, Blanco-Colio LM, Esteban V, Egido J, Ruiz-Ortega M. Connective tissue growth factor is a mediator of angiotensin II-induced fibrosis. Circulation 2003; 108: 1499-1505
12. Yu M, Zheng Y, Sun HX, Yu DJ. Inhibitory effects of enalaprilat on rat cardiac fibroblast proliferation via ROS/P38MAPK/TGF-β1 signaling pathway. MoLecuLes 2012; 17: 2738-2751
13. Papaspyridonos M, McNeill E, De Bono JP, Smith A, Burnand KG, Channon KM et al. GaLectin-3 is an amplifier of inflammation in atheroscLerotic plaque progression through macrophage activation and monocyte chemoattraction. ArterioscLer Thromb Vasc Biol 2008; 28: 433-440
14. Lopez-Andrs N, Rossignol P, Iraqi W, Fay R, Nue J, Ghio S et al. Association of gaLectin-3 and fibrosis markers with long-term cardiovascular outcomes in patients with heart failure, Left ventricular dysfunction, and dyssynchrony: insights from the CARE-HF (Cardiac Resynchronization in Heart Failure) trial. Eur J Heart Fail 2012; 14: 74-81
15. Van KimmenaDe RR, Januzzi JL Jr., Ellinor PT, Sharma UC, Bakker JA, Low AF et al. Utility of amino-terminal pro-brain natriuretic peptiDe, gaLectin-3, and apelin for the evaluation of patients with acute heart failure. J Am Coll Cardiol 2006; 48: 1217-1224
16. Calvier L, Miana M, Reboul P, Cachofeiro V, Martinez-Martinez E, De Boer RA et al. GaLectin-3 mediates aldosterone-induced vascular fibrosis. ArterioscLer Thromb Vasc Biol 2013; 33: 67-75
17. Schulze PC, Kratzsch J. Leptin as a new diagnostic tool in chronic heart failure. Clin Chim Acta 2005; 362: 1-11
18. Sweeney G. Leptin signalling. Cell Signal 2002; 14: 655-663
19. Ciccone M, Vettor R, Pannacciulli N, Minenna A, Bellacicco M, Rizzon P et al. Plasma Leptin is inDepenDently associated with the intima-media thickness of the common carotid artery. Int J Obes Relat Metab Disord 2001; 25: 805-810
20. Bodary PF, Gu S, Shen Y, Hasty AH, BuckLer JM, Eitzman DT. Recombinant Leptin promotes atheroscLerosis and thrombosis in apolipoprotein E-Deficient mice. ArterioscLer Thromb Vasc Biol 2005; 25: e119-e122
21. Bodary PF, Shen Y, Ohman M, Bahrou KL, Vargas FB, Cudney SS et al. Leptin regulates neointima formation after arterial injury through mechanisms inDepenDent of blood pressure and the Leptin receptor/STAT3 signaling pathways involved in energy balance. ArterioscLer Thromb Vasc Biol 2007; 27: 70-76
22. Schafer K, HalLe M, Goeschen C, Dellas C, Pynn M, Loskutoff DJ et al. Leptin promotes vascular remoDeling and neointimal growth in mice. ArterioscLer Thromb Vasc Biol 2004; 24: 112-117
23. Yamagishi SI, EDelstein D, Du XL, Kaneda Y, Guzmn M, BrownLee M. Leptin induces mitochondrial superoxiDe production and monocyte chemoattractant protein-1 expression in aortic endothelial cells by increasing fatty acid oxidation via protein kinase A. J Biol Chem 2001; 276: 25096-25100
24. Han DC, Isono M, Chen S, Casaretto A, Hong SW, Wolf G et al. Leptin stimulates type I collagen production in db/db mesangial cells: glucose uptake and TGF-beta type II receptor expression. Kidney Int 2001; 59: 1315-1323
25. Madani S, De Girolamo S, Muoz DM, Li RK, Sweeney G. Direct effects of Leptin on size and extracellular matrix components of human pediatric ventricular myocytes. Cardiovasc Res 2006; 69: 716-725
26. Marra F, Navari N, Vivoli E, Galastri S, Provenzano A. Modulation of liver fibrosis by adipokines. Dig Dis 2011; 29: 371-376
27. Frhbeck G. Intracellular signalling pathways activated by Leptin. Biochem J 2006; 393 : 7-20
28. Donato J Jr., Frazao R, Elias CF. The PI3K signaling pathway mediates the biological effects of Leptin. Arq Bras Endocrinol Metabol 2010; 54: 591-602
29. Zhou Y, Jia X, Wang G, Wang X, Liu J. PI-3 K/AKT and ERK signaling pathways mediate Leptin-induced inhibition of PPARgamma gene expression in primary rat hepatic stellate cells. Mol Cell Biochem 2009; 325: 131-139
30. Martnez-Martnez E, Jurado-Lpez R, VaLero-Muoz M, Bartolom MV, BalLesteros S, Luaces M et al. Leptin induces cardiac fibrosis through gaLectin-3, mTOR and oxidative stress. Potential roLe in obesity. J Hypertens (in press).
31. Alvarez G, Visitacion BM, Miana M, Jurado-Lopez R, Martin R, Zuluaga P et al. The effects of adiponectin and Leptin on human endothelial cell proliferation: a livecell study. J Vasc Res 2012; 49: 111-122
32. Maeso R, Rodrigo E, Munoz-Garcia R, Navarro-Cid J, Ruilope LM, Cachofeiro V et al. Chronic treatment with losartan ameliorates vascular dysfunction induced by aging in spontaneously hypertensive rats. J Hypertens 1998; 16: 665-672
33. De las Heras N, Aragoncillo P, Maeso R, Vazquez-Perez S, Navarro-Cid J, DeGasparo M et al. AT(1) receptor antagonism reduces endothelial dysfunction and intimal thickening in atheroscLerotic rabbits. Hypertension 1999; 34: 969-975
34. Ram E, Vishne T, Maayan R, Lerner I, Weizman A, Dreznik Z et al. The relationship between BMI, plasma Leptin, insulin and proinsulin before and after laparoscopic adjustabLe gastric banding. Obes Surg 2005; 15: 1456-1462
35. Terra X, Quintero Y, Auguet T, Porras JA, HernanDez M, Sabench F et al. FABP 4 is associated with inflammatory markers and metabolic syndrome in morbidly obese women. Eur J Endocrinol 2011; 164: 539-547
36. Testelmans D, Tamisier R, Barone-Rochette G, Baguet JP, Roux-Lombard P, Pepin JL et al. ProfiLe of circulating cytokines: impact of OSA, obesity and acute cardiovascular events. Cytokine 2013; 62: 210-216
37. Wolf G, ZiyaDeh FN.. Leptin and renal fibrosis. Contrib Nephrol 2006; 151: 175-183
38. FernnDez-Alfonso MS, Gil-Ortega M, Garca-Prieto CF, Aranguez I, Ruiz-Gayo M, Somoza B. Mechanisms of perivascular adipose tissue dysfunction in obesity. Int J Endocrinol 2013; 2013: 402053
39. Montani JP, Carroll JF, Dwyer TM, Antic V, Yang Z, Dulloo AG. Ectopic fat storage in heart, blood vessels and kidneys in the pathogenesis of cardiovascular diseases. Int. J Obes Relat Metab Disord 2004; 28 : S58-S65
40. Diez J. Arterial stiffness and ECM. Adv Cardiol 2007; 44: 76-95
41. LacolLey P, Labat C, Pujol A, Delcayre C, Benetos A, Safar M. Increased carotid wall elastic modulus and fibronectin in aldosterone-salt-treated rats: effects of epLerenone. Circulation 2002; 106: 2848-2853
42. Sutton-Tyrrell K, Newman A, Simonsick EM, Havlik R, Pahor M, Lakatta E et al. Aortic stiffness is associated with visceral adiposity in olDer adults enrolLed in the study of health, aging, and body composition. Hypertension 2001; 38: 429-433
43. Singhal A, Farooqi IS, CoLe TJ, O'Rahilly S, Fewtrell M, Kattenhorn M et al. Influence of Leptin on arterial distensibility: a novel link between obesity and cardiovascular disease? Circulation 2002; 106: 1919-1924
44. De las Heras N, Martin-FernanDez B, Miana M, BalLesteros S, Oubina MP, Lopez-Farre AJ et al. The protective effect of irbesartan in rats fed a high fat diet is associated with modification of Leptin-Adiponectin imbalance. J Hypertens Suppl 2009; 27: S37-S41
45. Li L, Dong H, Song E, Xu X, Liu L, Song Y. Nrf2/ARE pathway activation, HO-1 and NQO1 induction by polychlorinated biphenyl quinone is associated with reactive oxygen species and PI3K/AKT signaling. Chem Biol Interact 2013; 209C: 56-67
46. Urtasun R, Lopategi A, George J, Leung TM, Lu Y, Wang X et al. Osteopontin, an oxidant stress sensitive cytokine, up-regulates collagen-I via integrin alpha(V)beta (3) engagement and PI3K/pAkt/NFkappaB signaling. Hepatology 2012; 55: 594-608
47. Chen Y, Ohmori K, Mizukawa M, Yoshida J, Zeng Y, Zhang L et al. Differential impact of atorvastatin vs pravastatin on progressive insulin resistance and Left ventricular diastolic dysfunction in a rat moDel of type II diabetes. Circ J 2007; 71: 144-152
48. Yu Y, Ohmori K, Chen Y, Sato C, Kiyomoto H. Differential impact of atorvastatin vs pravastatin on progressive insulin resistance and Left ventricular diastolic dysfunction in a rat moDel of type II diabetes. Effects of pravastatin on progression of glucose intoLerance and cardiovascular remoDeling in a type II diabetes moDel. J Am Coll Cardiol 2004; 44: 904-913.